International journal of health sciences
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Impact of malocclusion of oral health related quality of life among 13-18 years visiting dental hospital
Get PDFMalocclusion is one of the most significant factors affecting oral health, and it is significant not only for financial and physical comfort but also for quality of life (QoL) by impairing appearance, interpersonal connections, function, self-confidence, socializing, and psychological well-being. Objectives: This study was piloted to evaluate OHRQoL in children between the ages of 13 and 18 who were seeking orthodontic treatment at Abbottabad International Medical and Dental College, Abbottabad and to determine the relationship between the need for orthodontic management, gender, age and OHRQoL. Methodology: A descriptive cross-sectional study using a questionnaire was done among 900 young individuals, ages 13 to 18, who visited the department of orthodontics. The OASIS survey was completed by the participants. All patients aged 13 to 18 who reported for treatment at the orthodontic department between January 2023 till June 2023 were included while those having a history of jaw trauma, those who are undergoing orthodontic therapy, and those who have undergone orthodontic treatment were omitted from the study.
The impact of implementing the health transformation strategy on servic delivery from employee’s point of view
Get PDFThe study aimed to assess the impact of the health transformation strategy on the provision of healthcare services from the perspective of employees in the Kingdom. The descriptive and analytical methodology was used, along with a questionnaire, to collect data from administrative staff in hospitals and healthcare centers. After analyzing the data, the study found that there is a high level of health transformation in the Kingdom across its three dimensions, and there is also a high level of healthcare service provision. The study also found a statistically significant positive correlation between the level of health transformation across its three dimensions and the level of healthcare service provision in the Kingdom. Important findings from the study include the need to improve the level of healthcare staff and provide a supportive and stimulating environment for their work, as well as improving communication with beneficiaries of healthcare services. The study recommended maintaining the Kingdom's excellent level of healthcare services by providing all the necessary resources and requirements to achieve the goals of Vision 2030
Impact of the mediated role of employee morale on innovative work behavior in context of healthcare sector; Pakistan
Get PDFThis study aimed to investigate the impact of various factors on employee morale and well-being in an organization. A survey was conducted among 294 employees from different health care organizations, and statistical analysis was performed using Sem PLS. The results showed that task complexity, innovative climate, and social cohesion had a significant positive impact on employee morale and well-being, while job stress had a negative impact. Perceived fairness also played a significant role in enhancing employee morale and well-being in context of healthcare sector. Mediator variables, such as innovative work behavior and task complexity, positively impacted the relationship between independent and dependent variables. The study has important implications for policy and theory, highlighting the significance of task innovation, social cohesion, and perceived fairness for improving employee morale and well-being. In our research, limitations include the lack of exposure to the healthcare workplace among some participants and the inability to control employee turnover and training effects. Future research could explore the impact of technology on employee morale and well-being in organizations
Mechanisms of ginseng in pancreatic cancer metastasis: A network pharmacology analysis
Get PDFIt has been shown that ginsenosides can inhibit proliferation, migration, and invasion of pancreatic cancer (PC) cells, and promote apoptosis of PC cells. However, the potential mechanisms of ginseng in treating PC metastasis (PCM) have not been fully elucidated. In this study, we employed an integrated bioinformatics approach of network pharmacology analysis. By selecting common targets of diseases and drugs, a drug-component-target-disease network was constructed to analyze the biological functions and signaling pathways involved in the targets. A total of 6 PC samples were includedd, which were divided into primary PC group (PANC-1, n=3) and metastatic PC group. A total of 9263 differentially expressed genes (DEGs) and 14 PC target genes were identified. According to the network pharmacology analysis, we found that ginsenoside Rg3 was associated with the treatment of PCM and identified 6 potential targets. Among them, CD44, EGFR, KRAS, and PRNP were the main DEGs related to the treatment of PC by ginsenoside Rg3. These genes were mainly enriched in the Proteoglycans in Cancer pathway, and KRAS, EGFR, and CD44 were upregulated in the pathway, which may be affected by the ginsenoside Rg3. This provides a new direction for further research on the mechanisms of ginseng in PCM
Effects of combining both mobilization with movement and spencer’s technique in diabetic adhesive capsulitis patients
Get PDFAdhesive capsulitis causes pain, stiffness and motion restriction in the shoulder joint and it is due to the adhesions in the glenohumeral joint capsule. First line treatment is conservative treatment by medications and physical therapy. It includes exercises, manual mobilization techniques and electrotherapeutic modalities for relieving pain and to gain full range of motion. The objective of the study was to compare the combined effects of Mulligan’s MWM and Spencer’s MET with MWM, Spencer’s MET and conventional therapy individually. A RCT was conducted for 6 months in THQ hospital Gujar Khan. 44 patients with mean age (55.57±7.422) meeting inclusion criteria were included. Participants were randomly allocated into 4 groups that are combined, MWM, Spencer and conventional group. Conventional treatment was given in all four groups and combined group received both the MWM and Spencer’s technique. 3 sessions/week was given for 4 weeks. Outcome measures used were VAS, SPADI and goniometry. ANOVA was done for inter group analysis, post hoc test was done for between group analysis. There was a significant difference (p-value 0.000<0.05) in outcome measures SPADI and ROMs Flexion and Abduction of combined group as compared to the rest of three
Homology modeling – a step towards vaccine development by analyzing structure of haemophilus influenza protein, transcriptional regulator H10994
Get PDFIntroduction: Haemophilus influenza is a type of bacterium that is non motile, gram negative and causes poisoning and infection including pneumonia,bronchitis etc. In order to study the resistivity of H.influenza protein, transcription regulator: HI0433, homology modeling is an important step to predict structure. Material and methods: Bioinformatics such as CMR, BLAST, modeller Prcheck and Prosa was carried out to find 3D structure of protein. Results and Discussion: H.influenza has 1792 proteins. Out of these, 456 hypothetical proteins were found. Homology modeling of transcriptional regulator H10994 was done it consists of 8 helices and 7 beta sheets. Ramachandran plot has shown that it consists of 95.2% particles in maximum allowed regions, 2.9 % particles in fewer allowed region, 1.4% particles in inadequate allowed region, 5% particles in disallowed region. Conclusion: By homology modeling of H. influenza, transcriptional regulator protein (HI0433), structure was designed which has provided enough information for vaccine development to control its transcription for causing disease
Association between hyperuricemia and coronary artery disease severity among patients undergoing coronary angiography
Get PDFAim: To determine the association between hyperuricemia and coronary artery disease severity among patients undergoing coronary angiography. Methods: This study was conducted at multi centers including Al- Aleem Medical College (Gulab Devi Teaching Hospital) Lahore and Fatima Memorial Hospital Lahore in the duration from December, 2022 to May, 2023. Total 180 patients were presented with Coronary Artery Disease, Coronary angiography was performed to determine the presence of coronary artery disease, with patients having luminal stenosis of greater than 50% in at least one of the coronary arteries. Relation between hyperuricemia and coronary artery disease was assessed using Chi Square test keeping P < 0.05 as significant. Results: The mean age was 49.59±6.11 years. The frequency of hyperuricemia was 120 (66.7%), around 32.3% patients had mild CAD, about 37.2% patients had moderate CAD while 30.6% patients had severe CAD. We found a significant association between hyperuricemia and severity of CAD. Conclusion: We conclude that hyperuricemia is significantly associated with the severity of coronary artery disease (CAD)
Congenital heart diseases pattern among children presenting to tertiary care hospital: A cross sectional study
Get PDFAim: To determine the pattern of congenital heart diseases among children presenting to tertiary care hospital. Material and Methods: A cross sectional study was carried out at Department of Paediatrics Cardiology, National institute of Cardiovascular Disease Karachi in the duration from November, 2022 to April, 2023. Total 171 patients were presented with CHD. Patients aged between 1 to 12 months of both genders. Pattern of CHD among the patients was determined. Results: Acyanotic CHD was seen in 74.26% patients. Cyanotic CHD was seen in 25.73% patients. Atrial Septal Defect (48.8%) was the most common presentation in acyanotic CHD patients while Tetralogy of Fallot was common presentation (40.9%) in cyanotic CHD patients. Conclusion: From our study we conclude that majority of the patients had acyanotic CHD as compared to cyanotic CHD, Ventricular Septal Defect and Atrial Septal Defect were more prevalent in cyanotic CHD while Tetralogy of Fallot was more common in cyanotic CHD
Trend analysis of common disabilities and causes among in-patients of paraplegic center Peshawar during last five year
Get PDFObjectives: To assess the trend of common disabilities in paraplegic Centre Peshawar during last 5 years. To assess the trend of common causes of disabilities in Paraplegic Centre Peshawar. Methodology: - A retrospective study was conducted in The Paraplegic Centre Peshawar irrespective of age and gender to assess the common disabilities, causes and which gender, age and occupational group is more susceptible in the patients presented during last 5 years. The Data was collected manually through chart review. The data was collected from 600 charts. All relevant data will be recorded and analyzed using the SPSS 19.0 Software package. Results: A total of 500 patients including both Genders of all age groups & profession were included in this study. Male were the most commonly affected gender (77.6%) Followed by Female (22.4%). Disability was found highest among age group 21-30 third decade (33.4%). Disability is common in uneducated people (45.2 %). Among disabilities type paraplegia was most common (79.6%) followed by tetraplegia (20%) & others (0.4%). In all disabilities the most important cause was Fall from height. 
Compare between intraorala and extraoral approaches of subcondylar mandibular fracture management
Get PDFBackground: Mandibular fractures, including fractures of the subcondylar and condylar regions, are common facial fractures. Sub condylar fractures account for 20–62% of all mandibular fractures. But their management remains controversial. Although closed reduction is the most useful method, it can be difficult to achieve anatomical reduction with this technique compared with open reduction and internal fixation (ORIF). Aim of the work: To compare between intraoral and extraoral approaches in management of submandibular fracture. Patients and methods: This comparative study was conducted in the plastic surgery department, Faculty of medicine-Menoufia University on 20 patients complaining of sub condylar fracture of mandible. Patients were classified into two groups based on surgical approach: Group A: included ten patients undergoing surgical fixation via the intraoral approach. Group B: included ten patients undergoing surgical fixation via extraoral approach Group. Results: A statistically significant difference was found between groups regarding operating and time. Intraoral approach had a signifcanlty longer operating time compared to extraoral. A statistically significant difference was found between groups regarding interincisal distance. Intraoral approach had a significantly larger interincisal distance compared to extraoral approaches. A statistically significant difference was found between groups regrading field of exposure extraoral have wide field of exposure