International journal of health sciences
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Bacterial spectrum and antibiotic susceptibility among hospitalized pediatric cardiac patients: A cross sectional study
Get PDFAim: To determine the bacterial spectrum and antibiotic susceptibility among hospitalized pediatric cardiac patients. Material and Methods: A cross sectional study was conducted at at Department of Paediatrics Cardiology, National institute of Cardiovascular Disease Karachi in the duration from January, 2023 to June, 2023. Total 146 cardiac patients admitted in cardiology department having age between 1 to 16 years of either gender. Bacterial spectrum and antibiotic susceptibility were determined. Results: Escherichia Coli, Staphylococcus aureus and Klebsiella pneumonia were the most prevalent bacterial isolates. Meropenem, Linezolid and Clindamycin showed high sensitivity against majority of the bacterial isolates. Conclusion: From our study we conclude that Escherichia Coli and Klebsiella pneumonia were the most prevalent gram negative isolates while Staphylococcus aureus was the most prevalent gram positive isolate in hospitalized cardiac children in our study. We found Meropenem, Linezolid and Clindamycin showed high sensitivity against majority of the gram positive and negative isolates
The efficacy of low energy fractional carbon dioxide laser therapy in management of post-surgical hypertrophic scars
Get PDFBackground: aberrant & accelerated wound-healing process that results in hypertrophic scarring causes extracellular matrix & collagen to deposit abnormally in the dermis. After tissue damage occurs, a defensive reaction called tissue repair occurs. Aim; in this review; we aimed to present the effectiveness of low-energy fractional carbon dioxide laser therapy in treating hypertrophic scars following surgery. Summary: A safe & effective approach for treating hypertrophic burn scars is fractional ablative CO2 laser therapy. Even though more treatment sessions have been necessary for satisfying outcomes, a big improvement can be seen after just one round of therapy. Combination therapy with other modalities can decrease the need for repetition of therapy as efficacy increases. Though, in some studies, combination therapy may shorten the duration of studied case downtime & in others, combination therapy may increase side effects. essential for laser energy setting needs to be adjusted for each hypertrophic scar condition. larger research population & longer follow-up period are recommended
Electronic nursing documentation interventions to promote or improve patient safety and/or quality care in an acute setting: Rapid review
Get PDFResearch has demonstrated that the implementation of electronic nursing documentation interventions can enhance the precision and comprehensiveness of records, thereby providing a significant benefit. Electronic documentation systems help to reduce errors resulting from factors such as indecipherable handwriting, incomplete or absent documentation, and transcription errors. In May 2022, a comprehensive research was conducted in CINAHL, MEDLINE, Cochrane, and Web of Science to identify relevant literature for their study. The study focuses on the use of electronic health systems in nursing, specifically in the documentation of care plans, records, reports, and charts. Individuals utilizing any given database employ the tools at their disposal to conduct searches for document abstracts and titles. This rapid review comprised one cross-sectional, one randomised control trial, two quasi-experimental, one qualitative, and one cohort study. The US, Taiwan, and Jordan each held two tests. The six trials included a medical-surgical and telemetry hospital with 446 beds, an acute care hospital with 1037 beds, a medical-surgical unit, and an urgent care clinic. The results revealed that electronic nursing documentation has improved quality of nursing.
Comparison of C - reactive protein and erythrocyte sedimentation rate biomarkers for identification of immunological disorders in Tertiary Care Hospital
Get PDFBackground: In this exploratory study, a cross-comparison was made between CRP, ESR, RA-Factor, and ASO tests for 300 individuals of both males and females in tertiary care hospitals to find an association that is not identified through the immunological marker. The quantitative approach was utilized to check the high ESR rate for an individual who has a positive CRP. The data were analyzed using SPSS version 25. Results: suggest that CRP and ESR play a role in patients with immunological disorders, and a significant relationship was identified between CRP and ESR. The mean and standard deviation of CRP were n=1.4 ± 0.4, ESR 25 ± 15.9 mm/minute, n =RA-Factor 1.6 ± 0.4, and ASO 1.3 ± 0.4, respectively CRP are mostly positive in serological disorders. Linear regression showed a strong positive association between ESR and CRP, with a significant P value less than 0.05
Anti-tumor effect of Fasudil, a ROCK inhibitor, on gastric cancer in mice
Get PDFGastric cancer remains one of the most common malignant tumors and a leading cause of death. However, there are few reports about the anti-tumor effect of Fasudil (Fas) on the stomach. Establishment of nude mice model of gastric cancer to evaluate the anti-tumor effect of Fas. The mice in each group were weighed every week. Serum and tumor tissue cytokines are detected by commercial kits. Serum and tumor tissue superoxide dismutase and malondialdehyde were detected by commercial kits. Histopathological changes in the tumor were detected by HE staining. Expression of ROS/ TXNIP/NLRP3/Caspase-1 pathway in tumor tissues was detected by Western blot. Our results showed that Fas increased and decreased the body weight of tumor mice, increased serum and tumor tissue cytokines contents of tumor mice, increased serum and tumor tissue oxidative stress of tumor mice, and increased Bax, Caspase-3, Caspase-9 protein expression, reduced Bcl-2 protein expression, also regulated ROS/TXNIP/NLRP3/Caspase-1 pathway expression. Our experiments show that Fas has a significant anti-gastric cancer effect, and its mechanism is related to the regulation of oxidative stress, inflammation and apoptosis in vivo
Midwifery care for Mrs "Y" at BPM Soraya Palembang
Get PDFAccording to the World Health Organization (WHO) in 2015 the Maternal Mortality Rate (MMR) was recorded as many as 303,000 mothers died during pregnancy to childbirth. Based on the 2012 Indonesian Health Demographic Survey (IDHS), the MMR was recorded at 359 per 100,000 live births.While the number of MMR in Palembang City from 2013 to 2014 has decreased from 13 people/29,911 KH to 12 people/29,235 KH. The purpose of this study was to determine the provision of continuous midwifery care from pregnancy to the postpartum period for Mrs. "Y" at BPM Soraya Palembang. The method used was a midwifery management framework using SOAP at BPM Soraya Palembang on Mrs. “Y” aged 33 years and data was collected through interviews, observation, physical examination, documentation study and literature study. The results of this study after carrying out Midwifery Care during pregnancy, childbirth, postpartum, and newborns to Mrs. "Y" aged 33 years at BPM Soraya, the results of care obtained from all health education and care can be provided properly, as well as all processes can run smoothly and normally. In the study of Midwifery Care on Mrs. "Y" aged 33 years showed that overall there was no gap between theory and practice
Ban of alcohol sales and its effects on drinking of staff in a college of education in southern Nigeria
Get PDFAvailability and accessibility have been associated in previous studies with binge and heavy drinking. In a College of Education in Delta stale ,Nigeria from 2012 till date the sales of alcohol was officially prohibited in all the sales outlets within the school premises except in the Staff club . This study examined the effects of the ban on the drinking habit of staff. Data was collected from 190 academic and non academic staff working in College of Education, Agbor. Delta State. A self administered questionnaire was used to collect data from the respondents. Descriptive and inferential statistics were used to analyse the data collected. The results showed no significant differences as reported by the drinkers between when alcohol was sold within the premise and now that it is sold outside. The major reason for this insignificant difference might be because the students and staff live outside the campus, so it is still easy to obtain alcohol outside the school. It was therefore concluded that a positive reduction can only be achieved if there is restriction in the sales of alcohol close to the school
Pathology and clinical practice: A review of the latest diagnostic techniques and tools in cancer diagnosis
Get PDFBackground: The advent of molecular biomarkers has revolutionized cancer diagnosis and treatment, enhancing the precision of therapeutic strategies for solid tumors. However, the complexity of clinical decision-making has escalated with the increasing number of prognostic and predictive biomarkers. The integration of deep learning (DL) in histology image analysis promises to streamline these processes. Aim: This review aims to evaluate the latest diagnostic techniques and tools in cancer diagnosis, focusing on the role of molecular biomarkers and deep learning in enhancing clinical outcomes. Methods: A comprehensive review of recent studies and clinical trials was conducted, examining the impact of molecular biomarkers on cancer treatment and the application of DL in histology image analysis. The review covered fundamental DL applications in tumor identification, grading, subtyping, and advanced applications in predicting genetic mutations, treatment responses, and survival outcomes. Results: DL-based methods have shown high accuracy in automating histopathology workflows, matching or surpassing human performance in tumor detection and classification. Advanced DL applications offer new insights by predicting genetic alterations and clinical outcomes directly from histology images, which could significantly impact clinical decision-making
Synthesis of silica nanoparticles incorporating triazolyl macrocycle
Get PDFIncorporating of silica nanoparticles with crown ethers is of interest regarding the excellent stability of these inorganic polymers against various acidic and basic conditions. The attachments of silica nanoparticles to macrocycles are involved many reactions to attach the active site of crown ether with modified silica nanoparticles. To achieve the goal, the selection of 3,5-dihydroxybenzolic acid as a model for the synthesis of macrocycle base the reaction of esterification of acid residue followed by etherification with propargyl chloride and finally the cyclization reaction with di azide residue to form macrocycle 4. From the other side, the silica nanoparticle both magnetic and mesoporous were prepared in different size and properties according to the literature. The final step involving the attachment of macrocycle to the silica nanoparticles of different type, two methods are used. First method was included the crafting of macrocycle with the ready synthesized nanoparticles under basic medium. Second method is the one-pot synthesis of nanoparticles and adding the macrocycle 4, directly before finish the reaction. All the compounds have been characterized by the instrumental techniques include FT-IR, 1H NMR, 13C NMR, EXD, XRD, FESEM, TEM and BET
How to assess nurse learning needs through training needs analysis: Mixed methods study
Get PDFTraining has a very important role in improving the performance of nurses. This study aims to assess nurses' learning needs through the training needs of nurses. This study used a mixed-methods design. The first phase involved an online survey. The second phase of qualitative research involved conducting structured interviews with 8 nurses. A total of 413 nurses participated in this survey. Nurses' competence was found in the competence of meeting fluid and electrolyte needs with a mean of 3.8 (SD: 0.7), the most expected training model was mixed training (47.2%), the most expected form of audio-visual media (94.7%), internal training (95.2%), and the flexibility of the training time (68%). The results of the interviews indicate that it is necessary to map the nurse’s competence. Learning needs can describe the competence of nurses and the training needed to improve their self-competence. Training Needs Assessment should be carried out thoroughly, including the need for forms of learning and media, which need to be facilitated by nurse management to motivate nurses to learn and improve their skills