International journal of health sciences
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Could serum serotonin be used as a marker for portal vein invasion in patients with hepatocellular carcinoma?
Get PDFIntroduction: Hepatocellular carcinoma represents the sixth and the fourth cause of cancer in the world and Egypt, respectively. In Egypt, HCC mortality and morbidity is high. Serotonin is a precious neurotransmitter and vascular viable molecule. Serotonin plays an important role in hepatocytes mitosis and tumor genesis leading to hepatocellular carcinoma. Aim of Work: To investigate if serum serotonin can be used as a marker for portal vein invasion in patient with hepatocellular carcinoma. Methods: Cross-sectionla analytic study was performed in Suez Canal University Hospitals. The study included 90 participants; 10 normal healthy control individuals and 80 chronic liver disease patients divided into four groups ( 20 cirrhotic; 20 early HCC; 20 advanced HCC and 20 ablated HCC). All study groups were subjected to the following; history, clinical examination, and investigations including hematological, biochemical, serum Alpha fetoprotein and Serotonin levels) with pelviabdominal ultrasound and Triphasic computerized tomography. Results: Portal Vein Thrombosis (PVT), abnormal liver function tests, and AFP were positively correlate with serum serotonin level. In comparison between study groups, mean serum serotonin level was (117±84, 693±65,1613±37) for patients with normal, dilated, and portal vein invasion respectively with a statistically significant difference ( p value <0.001). 
Frequency of common factors leading to nutritional rickets among children under 2 years of age
Get PDFIntroduction: Ricket is a disorder of developing bones. It is secondary to the mineralization defect at growth plate matrix. In industrialization countries, the elimination of nutritional rickets or vitamin D deficiency has been done by prophylactic means. In under developed countries of Asia,it remains major health problem. There are a lot of factors which take part in synthesis of vitamin D. These factors include sun exposure, pigmentation of skin and pollution etc. Objective: To determine the frequency of common factors leading to nutritional rickets among the children under 2 years of age. Results: Total 147 children under age of 2 years suffering with rickets were included in the study.1.5:1 was male to female ratio.13.74 months + 6.4SD was the average age of the patients with range 3-24 months .120(81.6%) sufferers have been observed with the lack of vitamin D supplementation followed by low maternal education 111 (75.5%). Conclusion: Vitamin D supplementation deficiency is main factor for children suffering from nutritional rickets.It is considered in the management of such patients
Effects of 12 -week home - based aerobic exercise on insulin resistance and body composition among polycystic ovary syndrome
Get PDFBackground: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that is characterized by menstrual irregularity and elevated serum androgens, and is often accompanied by insulin resistance. Materials & Methods: In these 12- week prospective study included 86 patients diagnosed with PCOS, aged 24 to 32 years. Excercise are with choice of participants within aerobics. The pre and post assessment were taken to measure the fasting glucose, fasting insulin, HOMA-IR and body composition. Result: The HOMA-IR baseline was 1.24(±0.63) which decreased to 0.86(±0.36) after 12 weeks. The Body composition baseline BMI (kg/m2), Waist circumference, Waist Hip ratio, Neck circumference and Body fat percentage was 28.44 (±2.05), 82.56 (±3.43), 0.87 (±0.06), 32.16 (±2.57), and 37.79 (±3.15) was significantly reduced to 27.49(±2.01), 81.16(±3.56), 0.86 (±0.07), 31.97 (±2.43) and 36.55 (±3.36)after the exercise programme (p<0.00001). In contrast, paired T-test analysis showed no such significant difference for variables Hip circumference when compared with the post test. Conclusion: The home-based aerobic exercise programme reduced HOMA-IR, and body composition. Although more research on the effects of aerobic exercises in PCOS is needed, these findings support aerobic exercise's effectiveness in reducing inflammation and enhancing insulin sensitivity in these patients
Covid-19 in India: An initial situation, advisories, and strategies
Get PDFToday, the whole world is struggling with the COVID 2019 disaster, and it has spread to India too. Given the many densely populated countries in the world, the condition of corona infection in India is now under control, the biggest reason being the lockdown in India at the right time and the strategy of timely treatment and isolation of positive cases. Initially, the situation was found to have deteriorated even in India, mainly because of the negligence of the people, breaking the lockdown, not checking themselves, keeping their foreign travel hidden, and a shabby system of health facilities. In this report, the initial steps taken by the Government of India to prevent corona infection, omissions and negligence in implementing them, are discussed. In view of the current status of the Health Department of India, the test strategy adopted by the Government of India is also discussed here. Originally in this review, India's situation was critically reviewed and further strategies, and assumptions to way forward has discussed, which would further expand the strategy to fight the corona like viruses, and would serve as a good document in the future
Comparison of lipid profiles and hypertension in type 02 diabetes mellitus patients with and without hypertension a multi center study
Get PDFIntroduction: Persistent hyperglycemia and anomalies in the metabolism of proteins, lipids, and carbohydrates are hallmarks of diabetes mellitus, which is brought on by insufficient insulin synthesis or action. Other associated systemic problems, such dyslipidemia and hypertension, may result from this. Dyslipidemia increases cardiovascular events such persistent high blood pressure by raising serum triglycerides, free fatty acids, and HDL cholesterol and lowering it. This research examined hyperlipidemia. Type 2 diabetics, regardless of hypertension. Objective: to compare T2DM with and without hypertension, the present study evaluated the blood lipid profiles of both groups. Layout of the study An experimental research approach is used, along with a comparative study methodology. Methodology: the multi-center study conducted in department of medicine HMC hospital Peshawar OPDs and Out Door Patients hosted the research. From January 2021 to January 2022, performed lab tests. The Multi center study achieved our aim. The study comprised 100 type 2 diabetics divided into cases and controls. Cases had type 02 diabetes and hypertension, but controls did not. Both groups estimated cholesterol, triglycerides, LDL, and HDL levels. The statistical analysis uses SPSS version 28. Mean values and an independent student T-test were used to compare groups
Effect of the enhanced recovery after surgery (ERAS®) program on postoperative complications in the Whipple operation: A prospective cohort
Get PDFBackground: The Whipple operation treats pancreatic, bile duct, and intestinal malignancies. ERAS® usage in the Whipple surgery is seldom documented. So, this study examined how the ERAS® regimen affected postoperative complications in Whipple patients. Method: From January 2017 to December 2022, 97 patients were admitted to the general surgery department at Hayatabad Medical Complex, Peshawar, Pakistan, a tertiary care hospital. This study recruited Whipple patients. The prospective group was treated with ERAS methods, whereas the control group was handled using the non-ERAS treatment (Jan 2017–Dec 2018). The Whipple technique was performed on 18-year-olds with pancreatic, duodenum, and bile duct cancer. The present study's primary outcomes were CDC grading, surgical complications, 30-day readmission rate, 30-day re-operation for any reason, and hospital stay. SPSS 26.0 examined data. Results: This study has 97 patients. Both groups had equal comorbidities. The ERAS® technique minimized postoperative complications, as seen by the considerable drop in CDC grading (p = 0.003). Non-ERAS® patients had increased mortality (2 vs. 8). ERAS® also decreased stay duration (p = 0.001). ERAS® patients also had a lower readmission rate (p = 0.001). Conclusion: The Whipple procedure's ERAS® protocol has lowered postoperative complications, duration of stay, and readmission rates. 
The impact of electronic dealing on the quality of health service delivery
Get PDFThe current study aimed to determine the extent to which electronic transactions affect the quality of healthcare services. To achieve the study's goal, a descriptive and analytical approach was adopted to evaluate healthcare services, and a questionnaire was distributed to administrative staff in Saudi hospitals. The data was processed, classified, hypotheses tested, and results analyzed, and conclusions and appropriate recommendations were drawn. A total of 120 questionnaires were distributed, and it was found that all were valid for statistical analysis. The research found that the level of electronic transactions in all its requirements (administrative, human, financial, technical, and security) in Saudi hospitals is high, and there is a high level of quality in the provision of healthcare services in Saudi hospitals. There is a direct effect of electronic transactions in all their requirements (administrative, human, financial, technical, and security) on the quality of healthcare services in Saudi hospitals. 
Effects of powerball on grip strength in children with developmental delay
Get PDFObjective: Developmental delay refers to the child who attain milestones in a slower time as compared to normal. Compromised grip strength is one of the common issue in these children which restricts them to perform their daily tasks while improvement in body functions, position of elbow and muscle strength can improve the manual dexterity, grip strength and fine motor skills which will help them to perform the daily activities of life. So the study aimed to determine the effects of Powerball on grip strength in children with developmental delay. Methods: Twenty six children with age 7 to 12 years with developmental delay assigned into two groups. Group A received isometric hand grip training exercises while group B received Powerball exercises along with isometrics. 3 sessions per week and total 12 sessions were given and evaluation of grip strength was measured by using hand held dynamometer and ABIL-HAND kids tool. Results: The mean age of children was 10.08 ± 1.49 years while 23.1% (6) children were of age 9 and 12 years each, while there were 61.5% (16) boys and 38.5% (10) girls. 
The impact of misoprostol in inducing labor in patients having intrauterine foetal death
Get PDFBackground: The most detrimental outcome of pregnancy, intrauterine foetal death (IUFD), causes psychological suffering to the expectant mother and the entire family. Objective: The purpose of this study was to evaluate the effectiveness as well as safety of misoprostol for labour induction in IUFD. Methods: The Department of Obstetrics and Gynecology at the MTI-HMC, Peshawar, conducted this clinical research on 120 women who had IUFD from 09 September 2020 to 09 March 2021. With the patient's informed agreement, labour was induced with vaginal misoprostol pills at a dose of 50 mcg four times per day. Results: In research including 120 women, the majority of the women (n=55; 45.83%) were between the ages of 21 and 30, with a median gestational age of 37.61 ± 4.17 weeks. The majority of patients (n=83; 69.17%) did not have appointments, were from rural areas (n=79; 65.83%), and had no formal education (n=91; 75.83%). In our study, 49 women (40.83%) were primigravidas, whereas 71 women (59.17%) were multigravidas. Following misoprostol introduction, the average Bishop's score increased to 6.89 ± 2.3 from 2.32 ± 1.28 at baseline, a difference of 4.57 on average. 
Variability in depth of curve of Spee and its associated skeletal and dental implications in population of Pakistan: A cross sectional study
Get PDFBackground and Aim: The curve of Spee (COS) is a physiological entity in human dentition. A functional masticatory system necessitates an appropriate occlusal curvature. The primary objective of this investigation was to assess the skeletal and dental parameters in individuals with variation in the depth of curve of Spee. Materials and Methods: A total of 276 patients with pre-treatment lateral cephalograms and dental cast models were investigated in the Orthodontics and Dentofacial Orthopedics Unit of a Tertiary Care Hospital of Mardan, Pakistan from January 2021 to December 2022. Patients with no prior history of orthopedic treatment for functional jaw, prosthodontic treatment, no prior history of cleft lip and palate and cranio-facial disorders were enrolled. Ethical approval was obtained and all the patients were categorized into three groups based on the depth of curve of Spee (COS): Group-I (flat curvature < 2 mm), Group-II (normal curvature 2-3 mm), and Group-III (deep curvature > 3 mm). Lateral cephalometric analysiswas done to measure the four angular and four linear parameters. Molar relation, overbite, COS depth, and overjet were measured based on the occlusal classification. SPSS version 27 was used for data analysis.