International journal of health sciences
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Synthesis, analgesic and anti-inflammatory activities of some pyrazolo[3,4-c]pyrazole derivatives
Get PDFHistorically, heterocyclic compounds containing Nitrogen, and their derivatives have been invaluable as a source of therapeutic agents. Pyrazole, with two nitrogen atoms and aromatic character, provides diverse functionality and stereochemical complexity in a five-membered ring structure. In Knorr pyrazole synthesis, diimine compound gets deprotonated to regenerate the acid catalyst and provide the final pyrazole product. Formation of pyrazole derivatives from hydrazines, hydrazides, semicarbazides, thiosemicarbazide and aminoguanidines by condensation with 1,3-dicarbonyl compounds is possible. As fused pyrazoles are reported to be well known pharmacophores, this has motivated to synthesize some of the pyrazolopyrazole derivatives by using hydrazine hydrate, thiosemicarbazide and semicarbazide. A series of 3-(aryl)-4-methyl-3a,6-dihydropyrazolo[3,4-c]pyrazole-2(3H)-carboxamides (IVa3-e3), 3-(aryl)-4-methyl-3a,6-dihydropyrazolo[3,4-c]pyrazole-2(3H)-carbothioamide (IVa2-e2) and 4-(aryl)-3-methyl-1,3a,4,5-tetrahydropyrazolo[3,4-c]pyrazoles (IVa1-e1) were synthesized by conventional method where fused pyrazopyrazoles were prepared. All the compounds were synthesized with good yield (56-81 %) and characterized by IR, 1H NMR spectral data and C, H, N elemental analysis. All the synthesized compounds exhibited analgesic and anti-inflammatory activities
Agriculture product' sustainable growth in Thailand through top management commitment and organizational management: Mediating role of eco-innovation strategies
Get PDFThe current study addressed the sustainable product development in agriculture industry of Thailand. The objective of this study is to examine the role of top management commitment, organizational management and eco innovation strategies in agriculture sustainable product growth. To achieve this objective, the current study considered quantitative research. While using quantitative research approach, this study preferred cross sectional research design. A sample of 210 respondents were used to examine the relationship between variables. Structural equation modelling was used to analyze the data with the help of partial least square (PLS). Results of the study highlighted the top management commitment and organizational management has substantial role to promote sustainable product in agriculture industry of Thailand. According to the results of the current study, top management commitment and organizational management has significant influence to promote strategies in agriculture industry. For the promotion of eco innovation strategies, it is important to highlight the commitment of management. It has the ability to enhance sustainable product growth in agriculture industry. This study has major practical insights for the practitioners to enhance sustainable product development in Thailand
Role of MRI with diffusion and whole tumor volume calculation in detection of response in rectal cancer patients under therapy
Get PDFBackground: MRI examination of the rectum has evolved as the standard technique in the assessment of cancer rectum having multiplaner capabilities and high tissue contrast imaging. The aim of this study: The aim of this study is to evaluate the role of MRI in assessment of rectal neoplasm. Patients and methods: In this study we prospectively evaluated 40 patients (24 male -60%) and (16 females -40%), who referred to the MRI unit, Radiology department, (Minia Oncology Center) for further assessment of histopathology proven rectal carcinoma, during the period of (August 2019 ) to (August 2021). Results: 10% of patients (4 participants) had high rectal cancer while 55% of them (22 patients) had middle rectal cancer. On the other hand, 35% of them (14 patients) had low rectal cancer. 85% of participants (34 patients) were diagnosed as adenocarcinoma while the remaining 6 participants (15% of patients) were diagnosed as mucinous adenocarcinoma. 77.5% of patients (31 participants) had grade II rectal cancer while 9 patients (22.5% of participants) were diagnosed as grade III rectal cancer. On performing TNM staging, we found that the majority of cases; 37.5% of participants (15 patients); were found to be in stage IIA
Detention of children in conflict with the law in the child criminal justice system
Get PDFThe present study aims at; first, reviewing and Analyzing the terms of detention of children in conflict with the law are in balance with the best interests of children according to the Juvenile Criminal Justice System; second, reviewing and analyzing the considerations of law enforcement officers in detaining children in conflict with the law in the Juvenile Criminal Justice System. The research was conducted using a empirical normative research method using a statutory approach, a case approach and an analytical approach by connecting problems related to issues and strengthened by data / information on field facts so that answers to the problems being studied are obtained. The results of the research that has been carried out, the concluded: (1) The terms of detention in the criminal justice system for adults are the same as the detention conditions set by the juvenile criminal justice system. However, the implementation of child detention is always focused on the best interests of the child and the balance of interests so that the child will not be harmed in the applicable law
Food recommender: Deep Learning approach for predicting daily diet based on body prakriti
Get PDFDaily diet plays crucial role in maintaining human body healthy. A healthy diet protects us from diseases such as obesity, diabetes, cancer and heart disease. According to Ayurveda, body is made up of aakash, jala, prithvi, teja, and vayu. Combination of these five elements decides the body prakriti called as doshas i.e. Vaat, pitta, and kapha. Human body has a unique proportion of these doshas and it is decided at the time of birth. Depending upon which dosha present in more quantity human body will be either Vata, pitta or kapha. Imbalance in these doshas leads to illness and different diseases. This can be avoided by following diet based on body prakriti. The proposed system uses deep learning and knowledge of suitable diet based on body prakriti as per the different season to recommend best possible diet chart
An empirical study on knowledge sharing practices of it sector managers in telengana region
Get PDFAn online questionnaire was used to collect data from 203 information technology managers in the Telagana region about their knowledge-sharing procedures and their organization's overall success. Model validation and hypothesis evaluation relied on data analysis via structural equation modelling. According to the data, there appears to be a strong connection between the model structures. Because of this, we have gotten a better understanding of the elements that impact knowledge exchange in the information technology sector. A beneficial influence on an organization's performance in terms of cost savings, revenue growth, and other intangible benefits can be deduced from these researches. Using the conclusions of this study, the IT industry can benefit from better information-sharing practises. To help practitioners improve their knowledge-sharing procedures within their own businesses, this study provides critical information. Web 2.0 and other knowledge-sharing technologies, for example, should be prioritised by management in their IT infrastructure to allow both tacit and explicit information interchange. According to the findings, businesses can pass expert knowledge to younger generations of employees via knowledge-sharing events. That means organisations in the information technology field can benefit from this approach by better retaining employee expertise and reducing employee departures
A study to analyse the major challenges and strategies to overcome work life imbalance among women academicians with special reference to kumbakonam district
Get PDFIn the modern-day working environment, it is highly important for employees and employers to achieve proper work life balance. The increased demands and expectations on the role of academicians have results in balancing their responsibilities at work and at home is gaining more importance. Previous research has stated that the women academicians need to focus in class preparation creation of lesson plan involve in counselling and guidance of the students etc and also need to manage their personal life and other activities at home. Moreover, the ever-changing trends in the higher education like application of technology, online class modalities, support in increasing the brand image of the institutions. The increased job responsibilities in the work area tend to impact the management of personal life of the women academicians. This may lead to unpleasant issues in the family and their health and wellbeing are also impacted greatly. Hence, coping up with these extremities are not an easy task and hence, the current study is more involved in understanding the challenges and strategies to overcome the work life imbalance among women academicians
Impact of different light curing modes on the cuspal deflection of maxillary premolars restored with nanohybrid resin restoration: An in vitro study
Get PDFINTRODUCTION: The influence of various light-curing modes may lead to polymerization shrinkage resulting in contraction stresses in composite resin. These stresses leads to linear movement of the cusp tips of the tooth as a result of interactions between polymerization shrinkage stress of the composite and adherence of the cavity wall of the tooth. That may lead to restoration failure. AIM: Comparative evaluation of the effect of different light-curing modes on the cuspal deflection of class II Mesio-occlusal-distal cavity restored with Nano-hybrid composite resin restorative material. METHOD: Thirty-six standardized MOD preparations were prepared on maxillary first premolars. Three groups(n=12) were divided according to different light-curing modes of Blue phase LED curing light- Group 1: soft-start curing mode; Group 2: pulse curing mode; Group 3: continuous curing mode. 1mm diameter glass beads were fixed to each cusp tip as a reference point for intercuspal distance to measure initial cuspal deflection for each group. MOD Preparations were etched and bonded with adhesive resin to provide micromechanical attachment and restored with Nano-hybrid composite restoration using the incremental technique. The cuspal deflection was then measured with the Digital micrometer gauge and the mean difference was measured for each group
A deep study on real-time atmospheric aerosols and variability over Indian subcontinent environment
Get PDFStudy of atmospheric aerosols is very complex owing to their short life time and, chemical constituents. Aerosol loading is highly regional and there life time is very short. An attempt has been made in this paper to study the variability of atmospheric aerosols over Indian subcontinent using a statistical parameter Coefficient of Variation (COV). The magnitude of variability over this region is studied. The factors influencing the variability are studied to find the reasons for difference in magnitude over different regions. Rainfall naturally influences the variability aerosols due to scavenging, but if it is the only factor influencing the variability, the study is absurd. It is found that the influence of rainfall on COV is not pronounced as it is not a seasonal phenomenon. Influence of other parameters viz. Topography, wind vector, thermal power plants and population on variability of aerosols is clearly found. These results help in classifying aerosol zones on the basis of variability of aerosol optical depth. The study also helps in finding the cause of aerosol loading over a region. Measures can be taken to decrease the loading if it is due to local sources
Media exposure through new media
Get PDFThis study on “Media Exposure through new media” is a survey research undertaken with the objective to explore the advertising forms through current new media and examine consumption behavior of Thai people in view of media exposure, information perception and advertising media exposure behavior through new media of consumers. The results of the analysis revealed that Media was a communication channel presenting contents of information such as news, entertainment information or advertisements to consumers. A change in technology system led to change of media forms that have improved from personal media to print media and print media has been later developed to electronic form, namely radio and television ones. At present, the technology system has developed continuously whereas Internet media has been also developed for increasing communication. The role of current communication technology such as computer, communication satellite, telephone network, audio and visual equipment has caused an effect on "Traditional Media"; newspapers, magazines, radio broadcasting, television, leading to so-called "Digital Revolution”