International journal of health sciences
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The effect of cognitive-behavioral group therapy on depression and quality of life in patients with chronic renal failure
Get PDFBackground and purpose: The aim of this study was to determine the effect of cognitive-behavioral group therapy on depression and quality of life in patients with chronic renal failure. Materials and methods: The present study was a quasi-experimental study with pretest, posttest design in experimental and control groups. The statistical population included all patients with chronic renal failure who were present for treatment in Mehr Madar Hospital in Torbat-e-Jam (A city in Iran) in the 2020 and among them 30 patients with Cochran statistical formula were selected as the research sample. And 15 people in the control group were randomly assigned. The research process was performed for both groups once a week during 8 sessions of 90 minutes (Experiment: Psychoeducation / control: to evaluate the effect of placebo, round-the-clock sessions to share their experiences with each other without the active role of psychologist and facilitator). Measurement tools included Beck Depression Inventory (II) and Quality of Life Questionnaire (SF-36). Statistical analysis of data was performed using SPSS-23 software. Results: The results showed that there was a significant difference between the experimental and control groups in both variables of depression and quality of life
Antibacterial activity and cytotoxic effect of bisphosphonate conjugated gold nanoparticle synthesized using cissus quadrangularis extract
Get PDFNanoparticles are being widely used in the field of medicine called Nanomedicine. Biological membranes in the human body are selectively permeable to Nanoparticles. The nanoparticles can be surface modified to attach a variety of ligands which enable them to be biosensors, molecular-scale fluorescent tags, imaging agents, and targeted drug delivery vehicles. Green synthesis of nanoparticles is a type of bottom-up approach in which reaction occurs with the help of reducing and stabilizing agents. Bisphosphonates are increasingly being used to treat a wide range of skeletal issues, including hereditary skeletal disorders in children, cancer-related bone metastases and osteoporosis. Cissus Quadrangularis is a green edible medicinal plant used in Ayurvedic preparations to treat osteoporosis, general inflammatory conditions, ulcers, menstrual disorders, hemorrhoids, and a variety of other ailments. It has been shown to have a variety of pharmacological properties, including antioxidant, antimicrobial, anti-inflammatory, and antiseptic properties. Bisphosphonate conjugated with gold nanoparticle have shown to produce more targeted actionThe purpose of this study was to green synthesize Bisphosphonate conjugated gold nanoparticles with Cissus quadrangularis extract and test their antimicrobial and cytotoxic activity.  
Evaluation of the protective effect of simvastatin on genotoxic effects of doxorubicin via comet assay
Get PDFBackground and purpose: Doxorubicin (Adriamycin) a chemotherapeutic agent belonging to Anthracycline family, is frequently used in the treatment of cancers. Despite its effectiveness, a vast variety of adverse effects have been attributed to this drug with the suggested mechanisms of inducing ROS and mitochondrial damage causing hepatic and cardiac toxicity. In addition to cancer cells, doxorubicin also interferes with the normal cell genome and consequently induce secondary malignancy. Simvastatin, Simvastatin is a fat-lowering drug that has cytoprotective and antioxidant effects. This study attempts to examine the protective effect of simvastatin against doxorubicin induced genotoxicity in the culture medium using the Comte method. Materials and Methods: For this purpose, we measured the DNA damage level with comet assay in HepG2 and HGF cells treated with doxorubicin and simvastatin in pre-treatment condition. Results were reported based on mean ± SEM. p<0.05 considered as significant deference. The mean values were compared using SPSS and ANOVA test followed by tukey posttest. 
Potential use of low-cost herbs against contaminated water for health issues
Get PDFThe main objective of this study is to identify the most suitable herbal plants for removing contaminants to reduce the use of chemicals for water contamination. The microbial studies were performed in the contaminated kitchen and household wastewater treated (with various medicinal plants, i.e., Azardichta Indica, Ocimum tenuiflorum, and Pinus roxburghii) using the serial dilution method. Aqueous extracts of the dried powdered plant material were used directly to treat the collected water samples. We examined that the enumeration of bacterial load in the treated water was reduced as compared to contaminated water. Enumeration of Bacterial load in the kitchen wastewater were ranging from 80x104 to 17x1010, However, the Cfu (colony forming unit) in treated kitchen water with Ocimum tenuiflorum were ranging from 13x103 to 2x1010. Bacterial load in the household sewage wastewater were ranging from 105 x 107 to 19 x 1010. However, the Cfu in treated household sewage wastewater with Pinus roxburghii were ranging from 75 x 104 to 4 x 1010. We found that Ocimum tenuiflorum was more effective against kitchen runoff compared to other selected medicinal plants
To evaluate the drug resistance pattern in various antibiotics with biofilm-producing capability of Klebsiella pneumoniae
Get PDFAim: Objective of study was to evaluate the drug resistance pattern in various antibiotics with the biofilm-producing capability of Klebsiella pneumoniae. Methods: Klebsiella pneumoniae was isolated for identification from total of 83 OPD and IPD patients by analysing colony morphology, microscopic examination, and performed biochemical testing. Antibiotics susceptibility Tests and biofilm-producing capacity was done by the Kirby-Bauer disk diffusion method and adherence quantitative assays. Chi-square test was used and P < 0.05 was measured as statistically significant. Results: Out of 83 isolates, 47 (56.6%) were Biofilm Producer and 36 (43.4%) were non-biofilm producers by tissue culture method, and tube method 62.7% and 37.3% respectively. Among biofilm producer and non-biofilm producer isolates, Klebsiella pneumoniae had the most Resistant to Ceftazidime (100%) & (61.0%), followed by Ceftriaxone (56.0%) & (95.7%) respectively. The association between biofilm and antibiotic resistance was checked to be statistically significant for aminoglycosides, fluoroquinolones, Cephalosporin’s, Imipenem, Meropenem, Amoxyclav, and Piperacillin Tazobactam. No resistance was observed against Colistin and Polymyxin B. Conclusion: The strain Klebsiella pneumoniae isolated from different samples showed drug resistance to all broad-spectrum antibiotics whereas there is no drug resistance was found with narrow-spectrum drugs. This study supports the use of narrow-spectrum antibiotics for most of infections. 
Nanobubbles: Fundamentals and recent drug delivery applications
Get PDFThe emerging branch in pharmaceutical sciences known as pharmaceutical nanotechnology presents new tools, opportunities and scope, which are expected to have significant applications, in disease diagnostics and therapeutics. There is a growing interest in nanobubble (NB) technology because of its wide range of potential applications in theranostics and targeted drug delivery including anticancer drug delivery, antibiotic delivery, gene delivery etc. Nanobubbles could offer several features in anticancer drug delivery, improving cellular uptake of chemotherapy drugs into cancer cell lines. Nanobubbles opened a new field of ultrasound imaging and were used as a diagnostic method. Generally, the delivery of drugs to organs and tissues is affected by two main ultrasound effects including the cavitation and sonoporation effects. This review describes the history of nanobubble, nomenclature, stability of nanobubble, physicochemical properties, characterization of nanobubble, method of preparation and applications. This article aims at highlighting the most recent and promising research trends including oxygen nanobubble, silica nanobubble and pluronicnanobubble and enlist the various drug delivery approaches involving the application of nanobubbles
Assessment of endovenous microwave catheter ablation in the treatment of primary lower limb varicose veins
Get PDFBackground: Lower limbs varicose veins are common in the adult population, The CEAP classification is a conventional way of staging varicose vein disease.Traditional treatment is surgery, which involves disconnection of sapheno-femoral and/or sapheno-opopliteal junctions with or without stripping of the superficial axial vein. the endovenous ablation is now the most widely used procedure and approximately occlusion rate of 95%. the Endovenous ablation techniques is Endovenous Microwave Ablation (EMA) which works by generating radio-frequency energy. It generates radiofrequency energy with the MICROTAZE OT-110 M machine. Aim: The aim of this study is using endovenous microwave ablation as a new technique in treatment of lower limb varicose veins according to the results, advantages, disadvantages and complications. Subjects and Methods: This study was conducted on 30 patients with varicose veins of lower limbs. It was conducted in the department of vascular surgery, Al- Azhar University Hospitals – Cairo (Al-Hussein and and said-Galal Hospitals). After taking a written consent, patients were subjected to Clinical evaluation and Duplex Ultrasound. Results: over weighted and patients with 30-50 years were the most. A statistically significant improvement was observed in AVVQ at different follow-up intervals. 
Legal violations in talk shows on Iraqi satellite channels
Get PDFThis research seeks to shed light on the legal violations related to media laws and regulations that are committed in talk shows, and the extent of the commitment of the communicator and the guests in their dialogues and the audience interfering with them, in order to reveal the violators and their motives and the topics that helped commit the violations, and to identify the types of violations. The research problem is summed up in the existence of a new media reality after 2003, as well as the complexity of the political, security, social and economic scene in Iraq, which was reflected on the nature of dialogue in television talk shows. , may affect as a whole, and in one way or another, the civil peace within the society. This study derives its importance from the impact of the legal violations committed in the talk shows, from its various aspects, and the subtle overlap between freedom of opinion and criticism in the talk shows, and the legal violations of legislation that deal with violations in satellite channels, whose danger to the media and society is evident
Perceived external prestige: Meta-perception of nurses and customers’s opinion in hospital, Makassar City
Get PDFThis study aims to measure the accuracy of nursing meta-perception on the prestige of the hospital based on customers (perceived external prestige). The research was conducted at five locations; Hospitals A, B, C, D and E in Makassar City. The locations of the study were determined by the trend of the turnover rate at those five hospitals in the last three years. The population was nurses with non-permanent status (freelance, honorary, contract, and intern permanent) for all hospitals as many as 214 people. As a control on the assessment of the accuracy of nurses' meta perception, a survey was conducted on customers at each study site. In general, there is a similar perception between nurses and customers, although the nurse's perceived value is higher than customers. This means that nurses have high optimism than the actual customer's perceptions. There was no correlation between nurses’ perceived external prestige with customers' opinions. Therefore, the hospital should always be active and continuous in seeking information needs and desires of the customer in an effort to provide the best service
Preparation, spectroscopic characterization and study of biological activity as anticancer of some compounds using a new azo-Schiff base ligand (N,N,O) derived from 2-amino-5-methyl thiazol
Get PDFThe biological activity of the Co(III) complex of azo-Schiff bases derived from 2-amino-5-methylthiazole azo-Schiff bases was studied. Elementary examines, attractive instant volumes, spectroscopy (IR, electronic, 1 H NMR, and XRD), then thermogravimetric investigations described the azo-Schiff bases and their mineral complexes. For the cobalt complex, an octahedral geometry has been proposed. Thermal and infrared data of the mineral complexes confirmed the presence of the collected water. Schiff bases and mineral complexes have been tested for their anti-cancer propertie