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Correlation between disease severity and quality of life index in psoriasis patients treated with Lactobacillus plantarum IS-10506
Get PDFPsoriasis is a chronic and relapsing inflammatory skin disease that affects both genders at all ages. The purpose of this study is to identify the correlation between psoriasis area severity index (PASI) and Dermatology Life Quality Index (DLQI) for patients with plaque psoriasis before and after treatment with Lactobacillus plantarum IS-10506. This was a before after cohort study. Adults with mild to moderate psoriasis were recruited into the study. All participants received the original Indonesian probiotic strain Lactobacillus plantarum IS-10506 at a dose of 2x1010 colony forming units (CFU) per day for six weeks. A total of 22 patients, with a mean age of 43 years, participated in the study. Participants had psoriasis for an average of 14 years. There was a correlation between PASI score and several quality-of-life questionnaire elements in certain condition, such as professional jobs, unemployment, obesity, and joint symptoms. The correlation between particular conditions reveals that occupations, obesity, and joint symptoms have a greater impact on psoriasis patients
A paediatric English linguistics intervention on spoken language for English-speaking parents of deaf children having hearing problems
Get PDFBackground: This research aimed to find internet information about hearing loss, hearing technology, and spoken language acquisition for Pakistani English-speaking families of deaf or hard-of-hearing children (DHH). Methods: The existence or lack of parent education material on various websites was investigated using an exploratory, descriptive methodology. The research looked at the many Internet resources available. Results: Many websites with information for parents of DHH children acquiring spoken communication were found to be international. Each website was examined in fifteen different content categories. These websites featured English content. According to the present research findings, internet resources for Pakistani English-speaking parents with DHH students struggling with spoken dialect are typically less and less and not deeply involved. Conclusion: A Paediatric English Linguistics Mediation on Spoken Language for Parents of Deaf Children with Hearing Problems in Pakistani English internet alternatives for Pakistani English-speaking parents of DHH children who are having difficulty with spoken dialect are becoming fewer and more uninvolved
TMJ & Its role in Prosthodontia: A Systematic Review
Get PDFAim The aim of this systematic review was to evaluate importance of TMJ and assessing the prevalence of temporomandibular joint disorders (TMJD) among the general population. Methodology Five main electronic databases and three grey literature were searched to identify observational studies in which TMJD was diagnosed using the research diagnostic criteria (RDC/TMD) or diagnostic criteria (DC/TMD). The studies were blindly selected by two reviewers based on eligibility criteria. Risk of bias (RoB) was assessed using the Joanna Briggs Institute Critical Appraisal Checklist, and the “R” Statistics software was used to perform meta-analyses. Results From 2741 articles, 21 were included. Ten studies were judged at low RoB, seven at moderate, and four at high. The TMJD investigated were as follows: arthralgia, disk displacement (DDs) with reduction (DDwR), DDwR with intermittent locking, DDs without reduction (DDwoR) with limited opening, DDwoR without limited opening, degenerative joint disease (DJD), osteoarthritis, osteoarthrosis, and subluxation. The main results from prevalence overall meta-analyses for adults/elderly are as follows: TMJD (31.1%), DDs (19.1%), and DJD (9.8%). Furthermore, for children/adolescents are as follows: TMJD (11.3%), DDs (8.3%), and DJD (0.4%). Considering the individual diagnosis meta-analyses, the most prevalent TMJD is DDwR for adults/elderly (25.9%) and children/adolescents (7.4%). 
Amorphous solid dispersions of ritonavir by melt-quenching: A quality by design approach
Get PDFRitonavir is crystalline solid which is very slightly soluble in water yet having high dose. This condition necessitates enhancement of solubility before developing into dosage forms. Melt-quenching is recently exploring technique for developing amorphous solid dispersions (ASDs) for crystalline drugs to with a hydrophilic carrier to enhance solubility. ASDs have a drawback of poor thermodynamic stability which needs to be considered. The current work was aimed to develop ASDs for Ritonavir with improved solubility yet thermodynamically stable. Quality by design (QbD) was employed to elucidate the effects of the carrier, plasticizer and cooling temperature on the solubility and stability of the prepared ASDs. Differential scanning calorimetry (DSC) and X-ray diffraction (X-RD) analysis were performed to investigate the physical state of Ritonavir and the stability of the ASDs upon storage. These results illustrated the effects of the factors on the solubility and stability were significant at p< 0.05. Statistical optimization was performed to identify the best combination of the factors to obtain ASDs with maximum solubility and stability. ASDs prepared with Soluplus as carrier at 50% w/w, Poloxamer 188 as plasticizer 15% w/w at6.81oC temperature were found to have desired solubility and stability
Evaluation of utilised doses of Heart Failure (HF) medications between genders and its association with clinical status among Heart Failure (HF) patients at hospital Serdang
Get PDFObjective This study aimed to evaluate the utilised doses of HF medications between genders among HF patients in local setting. Methods This study was conducted as retrospective study involving data collection from medical records of patients with documented HF in Hospital Serdang, Selangor. A total of 131 patients (74 males versus 57 females) were conveniently recruited from patients undergoing follow-ups at cardiology outpatient clinic, Hospital Serdang, Selangor with matched age, different ethnics, baseline and current EF and comorbidities. Utilised doses of HF medications were categorised as percentage of recommended doses or usual daily doses, which were 0%, <50%, ≥50% and ≥100%.Results No significant difference was observed in utilised doses of HF medications between genders in study population which proved that the utilised doses of HF medications were not influenced by gender differences. However, Malay and Indian were found to utilise higher MRA doses compared to Chinese and indigenous people (P < 0.05). This study also found that baseline (r = -0.386; P < 0.001) and current (r = -0.265; P < 0.01) ejection fraction were weakly and inversely correlated with MRA utilised doses. 
Physical activity and pregnancy related health outcomes in overweight and obese pregnant women: A systematic review and meta-analysis
Get PDF---Background Maternal overweight and obesity are considered as one of the obstetric risk factors of many health problems, and physical activity is viewed as one of the strategies in promoting a healthier pregnancy. Hence, the aim of this systematic review is to study the effects of physical activity on various pregnancy-related outcomes in overweight and obese pregnant women. Methodology Three online databases were searched for randomized controlled trials published between the years 2010 and 2021. The articles that reported the effect of physical activity on maternal and/or fetal outcomes were retrieved. The study characteristics and the data on health outcomes were extracted. Effect estimates were calculated using relative risk (RR), mean difference (MD), and standardized mean difference (SMD) with a random-effect model and 95% confidence interval (CI). Results Eleven studies were included for the statistical meta-analysis study. Physical activity was observed to significantly reduced GWG by 0.89 kg (95% CI = -1.63 to -0.14, P=0.02) and no significant results were found for other maternal and fetal outcomes measured. Conclusion Physical activity-only intervention shown to be beneficial in improving gestational weight gain, and appear to have promising results towards promoting good pregnancy-related health outcomes in overweight and obese pregnant women overall.
 
Community Pharmacy Health Screenings: Aiding in assessing occurrence of obesity and associated factors amongst the community population
Get PDFThe increase of obesity among Malaysians is recognized as a health concern on par with hypertension and diabetes. Early detection such as health screenings and prevention via education, can reduce morbidity and mortality. Conducting health screenings through community pharmacies may be a good choice considering the easy access to the community. This study aimed to investigate the possible factors such as demographic (age, gender, family history of obesity) and lifestyle (exercise habit, frequency of eating outside, smoking behaviour) that are associated with occurrence of obesity. This was a cross-sectional study in an area of Johor, utilising a guided data collection form. Body Mass Index (BMI) was used as the parameter for obesity status. According to Clinical Practice Guideline on Management of Obesity 2004, Body Mass Index (BMI) of 27.5 kg/m² and more is considered obese. A total of 183 respondents revealed 62 (33.9%) were obese and 121 (66.1%) were not obese. Both family history of having obesity and exercise habit were significantly associated with BMI values that could be related to risk in obesity, while age and frequency of eating outside had no significant correlation and association respectively. 
Qualitative study on processes, issues and challenges in implementation of islamic obligatory cleansing (Sertu) in halal pharmaceutical industry
Get PDFIslamic obligatory cleansing known as sertu in Malay language is one of the essential elements to ensure the halal integrity of products including in pharmaceuticals [1], [2]. It is an islamic cleansing required to be conducted when tools and equipment in the production facility are contaminated with severe najs (Naj Mughallazah) which are of pork or dog-based contaminant. Islamic law has prescribed the way to cleanse Naj Mughallazah by using one time of clay and clean water suspension followed by six times of rinsing with pure water (mutlaq) [3]. The study on the implementation of sertu cleansing especially in halal pharmaceutical industry is very limited if any [4]. Hence this study was conducted to explore the process, issues, and challenges as well as to discover the success factors in the implementation of sertu cleansing in pharmaceutical facilities from the perspective of sertu providers. This study used the qualitative in-depth interview and purposive sampling technique where participants were selected among sertu providers who have the experience of conducting sertu cleansing in pharmaceutical facilities. Data were analysed using thematic analysis and validated through triangulation with data from a few sources. 
Port terminal safety: A conceptual paper on factors that affects occupational stress risk assessment in container terminal
Get PDFA part of the supply chain that is very important to Malaysia is the port sector. A high-risk work environment is leading to a rise in occupational stress among port terminal workers. It is necessary for an organisation to correctly diagnose the aspects of the working lifestyle conditions that are perceived as risks by workers and to investigate the consequences of these risks in order for the organisation to be successful in the prevention of occupational stress problems. The aim of this conceptual paper is to investigate the factors that influence the safety practitioner's perception of safety and health risk assessment at port terminal. Data on safety and health that were collected in the past were analysed. Misunderstanding over the definition of a hazard and how to interpret a risk assessment matrix were both factors. This paper will scrutinize those factors and accomplish suggestions for how research should be done in Malaysia in the future
An extensive work on comparing sentiment patterns in twitter archives between two persons
Get PDFIn social media starting from 2006 Twitter gets Major attention because of the text shared via Twitter causes positive or negative impacts. Hence comparing two persons twitter archives is important to analyse the similarity of words they use semantics of the reviews and finding the Trends of words. This study evaluates how the characteristics of tweets are changing over years. This study finds which words used in tweets cause a number of retweets and also returns the sentiments of tweets