International journal of health sciences
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The effect of nonnutritive sweeteners on the antifungal activity of black and green tea aqueous extracts against salivary Candida albicans an (in-vitro study)
Get PDFOral diseases, while largely preventable, pose a major health burden for many countries and affect people throughout their lifetime, causing pain, discomfort and disfigurement. Mouth washing agents are an effective vehicle for antimicrobial compounds in reducing oral pathogens, managing dental plaque and maintaining proper oral health. Numerous plant extracts have been successfully incorporated into oral care products due to their antimicrobial properties, availability, and affordability. Tea plants and extracts are one of the most important natural compounds used in dental care products. The problem with tea extracts is their bitter taste, which could compromise their usage by people. So, it needs a kind of supplementation to be palatable, especially for the pediatric and geriatric populations. Hence a nonnutritive sweetener was added to tea extracts to suppress their bitter taste. This study aimed to determine the effect of nonnutritive sweeteners on the antifungal activity of black and green tea aqueous extracts against salivary C. albicans. The results showed that adding 1% of stevia and sucralose to the black and green tea aqueous extracts did not affect the antifungal activity against salivary C. 
A study on the effectiveness of a training program to reduce irrational thoughts among girls who failed in high school
Get PDFThis study aimed to investigate the effectiveness of a counseling program and the effectiveness of a training program in reducing irrational thoughts among a sample of girls who failed high school. The study sample consisted of (30) high school female students in Karak governorate, and a measure of irrational thoughts were used. They did not undergo the training program. The study’s results showed an average level on the scale of irrational beliefs. There were statistically significant differences between the average performance of the examinees on the scale of irrational thoughts in favor of the experimental group due to the training program. In contrast, the results indicated no differences in the scale of irrational beliefs of the experimental group on the follow-up measure. The study recommended an attempt to focus on the positive behavioral and psychological variables associated with positive psychology and assigned to this category specifically so that it contributes to raising their motivation for study and perseverance and the need to provide tools with acceptable or appropriate validity and stability coefficients that take care of this category and pertain to this phenomenon
Lasers in endodontics review
Get PDFLasers have been a significant advancement in the field of endodontics. Be it effective cleaning, root canal treatment, surgery etc. The lateral accessory canals and anatomical complexities have been a restraint in root canal procedure, for such cases lasers have been introduced to simplify the process & have good clinical results. As there has been a boon in the improvement of laser techniques, many latest lasers having a broad array of characteristics is accessible and can also be helpful in several areas related to dentistry. When compared with conventional techniques, laser treatments have been proven to be more advantageous. The purpose of this article is to summarize laser applications in endodontics, including their use in pulp diagnosis, dentinal hypersensitivity, pulp capping and pulpotomy, sterilization of root canals, root canal shaping & obturation & apicectomy. This article reviews the role of lasers in endodontics since the early 1970s & summarizes what future may hold for endodontics. With the potential availability of many new laser wavelengths and modes, much interest is developing in this promising field
The effectiveness of nano-cobalt oxide with manufactured plant extract and its properties on inhibiting the growth of some types of bacteria and fungi isolated from skin infections
Get PDFThe prepared cobalt oxide nanoparticles were manufactured in the first and second methods, and they show the properties of the nanomaterials for all solutions of plant extracts. XRD examination showed (440) 65, (622) 79, while Sem's examination showed the appearance with a size of 10-25 nm. Tem examination gave that nanoparticles with a size not exceeding 0.5-60 nm. The UV absorbance and permeability test indicated that the nanomaterial is at a value between 236-800nm, and energy gap values of 2.0-3.8 ev. Ft-ir assay shows that the bonding sites for cobalt oxide are at (±50) (505 to 694), and the Zeta Potential test indicated that all the particles of the solutions have very small values and that the material is not agglomerating. The Aleo vera plant extract with cobalt oxide nanomaterial, where the diameters of the inhibition zones were (35, 35, 45) mm, respectively, for the growth of both Ps.aeruginosa, S. aureus and E.coli bacteria. The results of the effect of cobalt oxide solutions on the inhibition of the growth of fungi were great, and that the nanomaterial was also sweeping, showing the absence of fungal growth Trichophyton mentagrophytes. 
Synthesis, characterization, and some pharmacological evaluation of 5-Thiocyanatouracil compound
Get PDF5-Thiocyanotouracil (5-TCU) was prepared in convenient method involved direct reaction of Potassium thiocyanate with 5-Iodouracil in refluxing aqueous solvent to give white crystalline in very good yield and high purity. This compound is important because it is similar in structure to 5-Flourouracil, which is of great importance as anti-cancer drug that is still used today. FT-IR, 1H- NMR, 13C- NMR, and CHN elemental analyses were used to describe the product. Median lethal dose LD50, in vitro antiradical activity and antibacterial effects were done. The results indicated that 5-TCU has relatively high LD50, non-significate antioxidant effect compare with ascorbic acid, and some antibacterial activity
Role of RASSF1-A gene in early detection of colorectal carcinogenesis
Get PDFBackground: Colorectal cancer (CRC) is a malignant neoplasm originating from the un-controlled cell proliferations in epithelial cells lining of rectum, colon, or appendix. RASSFs wereconcerned in tumourigenesis and numerous members of family are presently supposed to be tumour suppressor, Aim and objectives: Estimate- function of RASSF1-A methylated gene in theCRC pathogenesis, detect RASSF1-A methylated gene cutoff value for diagnosis and using RASSF1-A gene as abio-marker to detect recurrence after surgery, Subjects and methods: This is a prospective observational case-control researchperformed on 50 cases diagnosed as CRC by endoscopy and histopathology and 50 control persons at Aswan university hospital and internal medicine department., Results: there is high significant relation between RASSF 1A and development of colorectal-cancer, Conclusion: Genetical mutations in the Kras genes and epigenetic modifications in RASSF1-A, FHIT and MGMT genes in sporadic CRC are accompanying with the generalprogress of the disorder and can be utilized as diagnostical or prognostically biomarkers in this collection of tumours
Analysis of the ZNT8, GAD65, HLA-DQA1, HLA-DQB1, and C-peptides in Indonesian children with type 1 diabetes mellitus
Get PDFAutoimmune reaction in Type 1 Diabetes Mellitus (T1DM) is caused by genetic and environmental factors. The genes HLA-DQA1 and HLA-DQB1 are strongly associated with T1DM. Other established markers of T1DM were Zinc Transporter 8 Antibody (ZnT8), Glutamic Acid Decarboxylase Antibody-65 (GAD65), and C-peptide. This study aims to analyze ZnT8, GAD65, HLA-DQA1, HLA-DQB1, and C-peptide in Indonesian children with T1DM. A cross-sectional study of T1DM children was conducted in Dr. Soetomo Hospital, Indonesia. ZnT8, GAD65, HLA-DQA1, HLA-DQB1, and C-peptide were examined with an ELISA kit. Mann-Whitney test was performed with a significant value of p<0.05. A total of 62 participants consisting of 31 children for each group were enrolled. The prevalence of ZnT8, GAD65, and C-peptide in T1DM patients was 77.4%, 90.3%, and 87.1%. There are 74% of T1DM children had two positive antibodies and 55% had two positive HLA peptides. There was no difference in HLA-DQA1 and HLA-DQB1 peptides between T1DM and control groups (p=0.12; p=0.19). Meanwhile, the comparison between ZnT8, GAD65, and C-Peptide values between T1DM and control groups shows a significant difference (p<0.05). HLA-DQA1 peptide value was higher in T1DM children and HLA-DQB1 peptide value was higher in non-T1DM children
The role maternal toxoplasmosis in the development of autism disease in Al-Diwaniyah governorate, Iraq
Get PDFThe study aimed to investigate the role of Toxoplasma gondii in causing autism and included 100 autistic patients from different governorates for the period from January to June of the year 2022. The results of the serological analysis showed that 8 of them were infected with toxoplasmosis by 8%, The results of the statistical analysis showed that there were no clear significant differences between the number of autistic patients with toxoplasmosis and their areas of residence at the level of probability (P > 0.05). Genetic variation (mutation analysis) was found in human mitochondrial CoxI gene among autistic patients, NCBI reference samples from one or two mutations, and the total percentage of genetic variation ranged from 2.08-1.04% , while genetic variation (mutation analysis) was found in The human mitochondrial gene Nad1 between autistic patients, healthy subjects and NCBI-Genbank reference samples had from one to two mutations in a proportion of total genetic variance that ranged 1.3-2%
Investigation of community based hepatitis a outbreak in a district in Northern Kerala
Get PDFBackground: Hepatitis A is the most common form of acute viral hepatitis worldwide. The disease is closely associated with unsafe water or food, inadequate sanitation and poor personal hygiene. Objectives: An epidemiological investigation was carried out to investigate the outbreak, describe epidemiological features and recommend measures for control. An epidemiological case sheet was prepared, case definition formulated. Result: 82 cases of hepatitis A was confirmed. According to investigation, twenty students and one religious teacher staying at nearby mosque were infected and majority was belonging to the age group 15 -25 years. There was clustering of cases in two wards of this panchayath mostly which was around the mosque. Attack rate was found to be more in the age group 15–25 years(13.31%). Males (3.37%) had an attack rate almost 3.5 times higher than that of females (0.96%). One death was reported. The case fatality rate was 1.21. Conclusion: The provision for safe drinking water and proper sanitation needs to be considered high priority by Panchayath. There should be attempts for health awareness of handwashing, proper chlorination and adequate distance between septic tank and water source at households
Medium optimization for extracellular urate oxidase production by a newly isolated Aspergillus Niger
Get PDFUrate oxidase is a peroxisomal enzyme with four equal subunits that convert uric acid to allantoin, a more soluble metabolite for excretion. The usage of uricase as a drug in medicine is to treat hyperuricemia. Many microorganisms have been used for uricase production such as Streptomyces exfoliates, Pseudomonas aeruginosa, and Aspergillus flavus. In this study, soil samples were collected and then cultured in a screening medium including uric acid as the sole carbon source. Samples with the higher ability of uricase production were selected for enzyme assay. Enzyme activity was measured by spectrophotometry and the sample with the maximal uricase activity was identified as Aspergillus niger and selected for further studies. According to the results of experiments, the optimized temperature for enzyme production by Aspergillus niger was determined to be 35±2°C. The best carbon and nitrogen source was glucose and NH4NO3, and the highest enzyme activity was observed in the presence of Cu2+ ion