International journal of health sciences
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To study an elderly people's abnormal electrocardiographic changes at government hospital
Get PDFPopulation aging is one of the demographic characteristics of the 21st century. This process is necessarily accompanied by an increase in the prevalence of cardiovascular diseases that may have expression on the electrocardiogram (ECG). Aim: to study an elderly people's abnormal electrocardiograph at government hospital. Material and Methods:All the Patients were admitted in the department of Medicine at Government medical college, Kadapa, Andhra Pradesh, India. Study period January 2021 to june 2021These participants were then clinically examined and studied in accordance with the study's guidelines to generate the necessary data, which was then categorised, tabulated, and classed before being subjected to analysis. Total 300 persons should taken in the study.150 were healthy one and 150 were patients. The age of the persons should be 65 years and above, both the sex were included. Conclusion: Atrial fibril-lation was the most prevalent rhythm abnormality. With no association to sex or skin tone, ventricular repolarization changes outweighed ventricular depolarization changes. There were a sizable number of instances with extended QT, left ventricular hypertrophy, and anomalous left atrium
The relationship of emotional plans to the position of control for players in the first-class basketball league
Get PDFThe importance of the research was to know the relationship between emotional plans and the position of control for basketball players for the purpose of a balanced and integrated building based on scientific foundations in explaining the failures and fluctuations of levels for sports teams in order to improve the reality of the basketball game in our country. The results and recommendations of this research are within the reach of coaches, administrators, and those interested in sports. As for the research problem, it was represented in cases of fluctuation in the levels of players in performance during the training process, which is reflected in the fluctuation of the performance of their teams through their results in the league matches, and this was confirmed by some experienced club coaches who noticed that there are cases of fluctuation in the levels of teams and players of first-class clubs. While the objectives of the research were to identify the relationship between emotional plans and the position of control for the players of the first-class basketball league. The researchers concluded that there is a relationship between emotional plans and the position of control for first-class basketball players
Understanding cell to cell communication in tumor microenvironment: Translating the present knowledge to therapeutics
Get PDFThe tumor microenvironment is an atmosphere that covers a tumor withinside the body. It consists of the extracellular matrix, immune cells, blood vessels, and different cells, like fibroblasts. Cell-to-cell communication is a vital procedure that continues the organic features and hemostasis of cells in microenvironmental, organs, and intact systems. The cell-to-cell communication complexity has been studied for many years and is now well-known because a part of the molecular mechanisms of complexity, organ disorder, and developmental biology. A tissue microenvironment of a growing tumor is constituted of the tumor stroma, proliferating tumor cells, infiltrating inflammatory cells, blood vessels, and quite a few related tissue cells. The tumor microenvironment offers all the vitamins, it desires to the tumor and also makes an area for the tumor to expand. Researchers are running to recognize its position in most cancer risk, improvement, and treatment. While therapeutically focused on the tumor microenvironment is an appealing method for the remedy of most cancers, current FDA-permitted remedies have restrained efficacy. Immune checkpoint blockade remedy changed into the primary era of antibody-primarily based cures to target immune cells withinside the microenvironment of tumor (PD1 and CTLA4). 
Screening of AmpC-Family genes among Pseudomonas aeruginosa isolated from burn patients in Najaf City, Iraq
Get PDFBurn patients are at risk of severe infections caused by pseudomonas aeruginosa due to their immunosuppressive conditions. A one mechanism of resistance in this pathogen by AmpC beta-lactamases, therefore this study included molecular screening AmpC family genes among isolates of P. aeruginosa. The present work was conducted in Al-Sadr Medical City, and burns unit center as well as some chief clinical laboratories in Al-Najaf City period December 2021 to March 2022. An entirety of 68 patients were checked to recognize P. aeruginosa isolates. Bacterial growth were 59 (86.76%), as following 12(17.64%), 47 (69.11%) and 9 (13.23%) for gram-positive bacteria, gram-negative and non- growth respectively .Results recorded 32(54.23%) of P. aeruginosa isolates. At same respect, the percentage of P. aeruginosa isolates in women were 20(33.89%) compared with 12(20.33%) in male. Results showed 20(62.5%) of isolates were resistance to piperacillin-tazobactam, , with a MIC of 128 µg/ml, Also data in table (2) showed that 32(100%) resistance to cefazoline antibiotic at MIC of 64 µg/ml. Whereas, the bacterial isolates showed less resistance to ceftazidime and cefepime, as the resistance ratios reached 21(65.62%) and 19(59.37%) respectively.the results showed that 20(62.5%) were resistant to imipenem while 19(59.37) and 18(56.25) were resistance gentamycin and amikacin respectively. 
Comparison of biochemical/haematological parameters in healthy vs preeclamptic females
Get PDFObjectives: To evaluate and compare the Biochemical/Haematological parameters in healthy (pregnant subjects) vs preeclamptic females. Methodology: This descriptive cross-sectional study was planned/conducted at IBMS KMU Peshawar and the data was collected from the Dept. of Gynaecology & Obstetrics-Lady Reading Hospital Peshawar, from June 2019 to July 2020. One hundred thirty-eight pregnant subjects between the gestational ages of 26-30 weeks were included in the study. The subjects were divided into two cohorts; Patients with preeclampsia (Group I N=92) and a Normotensive Control Group; women with normal pregnancy (Control group N=46). Blood from the subjects was checked for Haemoglobin (Hb) and Platelet (PLT) levels and Body Mass Index (BMI) among other parameters. Blood was taken and analysed at the Hospital Lab via Cobas 6000 analyser. Data was analysed using SPSS version 26.0 for MacBook Pro. Results: Body mass index of PE group was significantly higher compared to normal group (p<0.001). Similarly, mean platelet counts and hemoglobin in PE group was lower as compared to normo-tensive group and the differences were statistically significant (p<0.05). There was no significant difference in mean gestational age (weeks) between the two groups (27.83 ± 0.95 vs 27.78 ± 1.07, p= 0.33) was observed. 
Lipoprotein abnormalities in diabetic patients
Get PDFObjectives: To evaluate and compare blood glucose levels and lipid profile in diabetic vs healthy adults. Methodology: This descriptive cross sectional study was conducted from January 2021 to April 2021. The study samples were collected from Northwest General Hospital Peshawar. Sixty patients with diagnosed type 2 diabetes and an equal number of control subjects were included in this study. After the recruitment of subjects according to the inclusion criteria, subjects were divided into two cohorts; Patients with Diabetes (Group I N=60) and a Non-Diabetic Control Group (Control group N=60). Blood from the subjects was checked for glucose levels and lipid profile. Blood was taken and analysed at the Hospital Lab via Cobas 6000 analyser. Data was analysed using SPSS version 26.0 for MacBook Pro. T test was applied to the data and p value was kept at 0.05 for significance. Results: Fasting Blood Glucose (FBS) rise was statistically significant (p=0.03) with a mean and standard deviation (SD) of 161.21±46.31* for Group I and 79.29±18.56 for Group II with a Mean Difference (MD) of 81.92. 
Morphometric analysis of cervical canal stenosis using computerized tomography (CT) scan in a North Indian Community
Get PDFIntroduction: Cervical spinal stenosis is a frequent condition that causes a lot of pain and disability. To avoid long-term disability as a result of irreversible spinal cord injury, quick diagnosis and treatment are required. Cervical vertebrae have smaller bodies than other vertebrae, and their purpose is to support the head, protect the spinal cord, and permit head movement. Material and Methods: A case control study has been undertaken at a tertiary care setting of Uttar Pradesh for a period of 1 year from June 2020 to May 2021. Patients with either cervical spine stenosis or facet joint arthrosis or both aged between 20 to 80 years of either gender who attended Out-patient departments of the hospitals were involved. Results: A sum of 83 individuals were made part of the Case group and 50 patients were included as the Controls. Around 50% of the case population were females (n=42) and 56% of the controls were males (n=28). The Mean±SD Torg ratio of C3 cervical vertebra among the case group was 0.78±0.05, where as it was 0.84±0.06 in the control group. Mean±SD Torg ratio of C4 cervical vertebra among the case group was 0.76±0.05, whereas it was 0.83±0.08 in the control group
The role of NF-κB p65 and hsp70 in colorectal adenocarcinomA
Get PDFFree radicals and inflammation in tumor microenvironment are important aspects of tumor biological activity. They activated NF-κB p65 transcription factor pathway. HSP70 is chaperone protein that regulated host of imune response to cancer cells. NF-κB p65 and HSP70 expression is associated with poor prognosis and new targeted therapy in colorectal adenocarcinoma. This study aims to analyze correlation between NF-κB p65 expression in macrophages and HSP70 in tumor cells with various T stages of colorectal adenocarcinoma. This cross-sectional study was performed on 48 paraffin blocks from colorectal adenocarcinoma at the Anatomical Pathology Laboratory of Dr. Soetomo General Academic Hospital Surabaya from January 2015 to December 2019. The samples were divided into four groups based on T stages of colorectal adenocarcinoma. Immunohistochemical staining was performed to detect NF-κB p65 expression in nucleus or cytoplasm of macrophages and HSP70 in cytoplasm of tumor cells. There was no significant difference of NF-κB p65 expression percentage in macrophages at four groups (p=0.31). There was significant differences of HSP70 expression percentage in tumor cells at four groups (p=0.014). There was no correlation between NF-κB p65 expression in macrophages and HSP70 expression in tumor cells with various T stages of colorectal adenocarcinoma (rs=0.05, p=0.97)
Hematological changes of diabetes and non-diabetes patients in ministry of science and technology
Get PDFType 2 diabetes mellitus (DM) is a chronic condition marked by hyperglycemia. In order to ascertain the linkage in individuals with diabetes and non-diabetes of various ages, hyperglycemia in DM is closely related to Hba1c and hematological tests. Samples and data from the ministry of science and technology's lab were gathered utilizing questionnaires and biochemical data. The difference in the means of fasting blood sugar (FSB), white blood cells (WBC), hemoglobin (Hb), and packed cell volume (PCV), between the patients and the control group is shown by the hemoglobin a1c (Hba1c), which is statistically significant (P 0.01)
Mechanical and thermal (Poly methyl methacrylate' / Poly Vinyl Pyrrolidone) blend use in denture material
Get PDFIn the main search, efforts are made to develop the properties of the PMMA resin that is used: To create a blend polymer for the upper and lower prosthesis of a complete denture, several weight ratios of poly vinyl pyrrolidone (pvp) (0,2%, 6%, 10%, 14%, 18%, 22%, 26%) were added to cold-cured poly methyl methacrylate (PMMA). The effects of external polyvinylpyrrolidone (PVP) concentrations on mechanical features such as hardness, impact resistance, wear resistance, and thermal conductivity are studied. The results indicate that as concentrations were elevated, hardness, strength, impact resistance, and wear resistance increased, along with a decrease in thermal conductivity. The positive findings seem to have been (22% PVP and 78% PMMA)