International journal of health sciences
Not a member yet
9988 research outputs found
Sort by
Correction of the degree of endogenic intoxication and lipoproxidation processes by the infusion drug (rheoambrasol) with experimental hypoxia, induced by sodium nitrite
Get PDFRationale (relevance): Almost all known diseases, as a rule, are accompanied by a hypoxic state associated primarily with oxygen deficiency and impaired energy metabolism, which cause damage to the structure and functioning of organs and cells. Using a complex of a polysaccharide with a bioenergetic substrate, a blood-substituting infusion drug"Rheoambrasol" has been developed, which is able to protect cells from free radical oxidation and restore disturbed energy metabolism in cells during hypoxia. Purpose: to evaluate the effectiveness of correction of the hypoxia-inducible factor - HIF-1α, endogenous intoxication, the intensity of lipid peroxidation processes in the liver during experimental nitrite hypoxia with the new blood-substituting infusion drug "Rheoambrasol". Material and methods. The setting of the experimental hypoxia model was carried out in outbred male rats weighing 185 ± 10.2 g by administering sodium nitrite at a dose of 90 mg / kg. In the blood plasma of experimental animals, the content of hypoxia-inducible factor (HIF-1α), indicators of endogenous intoxication, the intensity of lipid peroxidation (LPO) and the activity of antioxidant enzymes systems (AOS) were determined in the liver. 
Perception of B. Ed trainees towards internship: A study on construction and validation of the tool
Get PDFTo determine the level of perception of B.Ed. trainees toward the internship, which is a required component of their educational experiences at a teacher training institution, the current research set out to determine the level of perception of B.Ed trainees toward the internship. In order to achieve the goal, a quantitative descriptive research was conducted. There were 94 B.Ed Trainees from a teacher education institution in the Tamilnadu district of Tiruchirappalli who took part in the study. The descriptive research made use of a tool that had been created by the investigator. The instrument was originally comprised of 50 statements in the pilot phase, which were then verified using a "t" test to determine their validity. The tool's dependability and validity have been proven, and it is now in use. During the final tool's development, 24 items were rejected and 26 items were retained. According to the findings, B.Ed students have generally an average perception regarding internships in general
Automated medical image classification using deep learning
Get PDFMedical imaging is extremely important in the domain of medicine. Image classification is now utilized to distinguish aberrant tissues from healthy tissue in brain imaging. The brain tumor is identified from MRI images by using some classification techniques, where the area of the tumor as well as the tumor size is detected. Automatic tumor detection using brain MRI is efficient and time- saving, assisting the neurologists in diagnosis. Tumors can increase the risk of cancer, which is the most common cause of death or major cause of mortality worldwide. To detect brain tumors at the moment, effective automation of tumor detection is essential. Marker based Watershed algorithm is a typical segmentation technique which is used for identifying brain tumors. For brain tumor detection, we performed marker based watershed classification on MRI images with the use of gray scale images, then by noise removal and morphological operations. The steps in the methodology are as follows: Gray-level and sharpening was used in the pre-processing, and the image was segmented using thresholding as well as the marker based watershed algorithm, and the CNN was used for classifying the images. Finally, the tumor's location and size were determined
Assessment of plasmin and inducible nitric oxide synthase in the patients with COVID-19
Get PDFAims of study: The purpose of this study is to compare the levels of plasmin, inducible nitric oxide, and nitric oxide in COVID-19 infection patients to a healthy control group, with a scientific interpretation of the predicted results. Methods: Data was collected from ninety people, divided into two groups: patients and controls, and a demographic study was conducted, which included age, gender, oxygen saturation, and BMI, with diabetes and asthma eliminated. The plasmin and inducible nitric oxide levels are estimated using the enzyme-linked immune sorbent assay (ELISA) technique, and nitric oxide is measured using a spectrophotometer. Results: Patients with COVID-19 showed a substantial rise in the values of plasmin and inducible nitric oxide synthase enzyme, as well as a decrease in the value of nitric oxide, when compared to healthy controls
Corrosion inhibitor of carbon steel in 3.5%NaCl solution with Schiff base compounds
Get PDFIn this work, synthesized N4,N4`-bis(2, 3, 4 nitro benzylidene) biphenyi-4-4`-diamine(B1-B3) , was tested as an inhibitors in controlling the corrosion of carbon steel in NaCl 3.5% solution by using open circuit potential (OCP),at four different temperatures (293, 303, 313 and 323 K). Furthermore, the surface morphology was investigated using the Atomic force microscopy (AFM). The effect of using different Schiff bases and temperature was also investigated. Schiff bases was synthesized and characterized via using. Fourier Transform Infrared Spectroscopy (FT-IR)and Atomic Force Microscope (AFM) characterized . The experimental results shown that Schiff bases can consider as an excellent corrosion inhibitors for carbon steel in NaCl 3.5% solution, by presence of Schiff bases the corrosion of carbon steel was significantly suppressed. The inhibition efficiency is decreased with the increases of temperature. Kinetic and thermodynamic activation parameters (Ea, A, ΔH*, ΔS* and ΔG*) were calculated
Effect of pollution with crude oil and used motor oils on the concentration of protein and carbohydrates in safflower and flax plants
Get PDFThis study was conducted to clarify the effect of soil pollution with crude oil, car, and generator used oil on the concentration of protein and carbohydrates in Carthamus tinctorius and Linum usitatissimum plants as the soil was treated with crude oil and used oils for car engines and generators at three concentration for each , which are(1, 2, 3)%. The results showed that the treatment of safflower and flax plants with used motor oil and crude oil at concentrations (3)%, respectively, led to a significant decrease in protein concentration in the shoots of the two plants, reaching (0.503, 0.175) mg/g dry weight, respectively. Then, treating the two plants with crude oil at the concentration (3)% led to a significant decrease in the carbohydrate concentration in the shoots of the two plants, reaching (1.110) and (1.100) mg/g dry weight, respectively, compared to the comparison treatment, which amounted to (3.805, 3.860) mg/g. Dry weight, while we note that crude oil was significantly more effective, as it led to a decrease in the protein concentration in the two plants, reaching (0.565) mg/g dry weight, and no significant differences were observed between the effect of oil and oils for engines of generators and cars
A review on fuzzy multi-criteria decision-making methods in medical diagnosis
Get PDFIn a real-world computing environment, the information is not complete, precise, and certain, making it very difficult to derive an actual decision. Uncertainty is a factor that makes the decision-making process more difficult in medical diagnosis. Everyone is different from the other at the physical level as well as mental level, symptoms of a disease expressed by patients are linguistic in nature and vary from person to person. That is why Decision making in medical diagnosis is becoming a vast research field in medical science. In medical diagnosis, generally, uncertainty (vagueness or imprecision) arises due to patients’ vague linguistic expression of their problems to medical experts. The field of medicine and decision-making are the most fruitful and interesting areas of applications of fuzzy set theory. In the present paper, we study the importance of different fuzzy sets and fuzzy multi-criteria decision-making methods in the field of medical diagnosis
In silico molecular docking studies of di hydro pyrimidinones as MTB thymidylate kinase inhibitors
Get PDFTuberculosis is the one of the leading cause of death. Efforts are needed to develop new anti-tuberculosis medicines with alternative scaffolds because the current antibiotics are increasingly becoming ineffective against M. tuberculosis. In this study, 21 novel di hydro pyrimidinone derivatives were designed and synthesized to arrive at potentially effective anti-tubercular agents. Molecular docking studies were conducted on Mtb thymidylate kinase of Mycobacterium tuberculosis H37Rv (PDB ID 5NQ5). The enzyme active sites were docked with the title compounds after they were energy-minimized. According to their docking scores and binding energies, the ligands were ordered. The molecular docking results for the title compounds with Mycobacterium TB thymidylate kinase are very promising. Thymidylate kinase appears to be inhibited by 17c and 20c, according to the study
Serum osteocalcin levels compared with cervical maturational stages as growth indicators: An in-vivo study
Get PDFOBJECTIVE: To determine whether serum osteocalcin levels can be used as a marker for assessing skeletal maturity. MATERIALS AND METHODS: The sample consisted of 60 patients aged 08-20 years (30 males, 30 females) reporting to Department of Orthodontics and dentofacial orthopedics, and Department of Pedodontics ,Faculty of dental sciences , Ramaiah university of Applied sciences , Bangalore. Lateral cephalometric radiographs were obtained from all the subjects. Cervical staging of orthodontic patients satisfying the inclusion criteria were evaluated on their respective lateral cephalograms by using the Hassel and Farman method. After cervical vertebral maturation evaluation, 60 subjects selected for the study from the screened patients were grouped into 6 cervical stage (CS) groups of 10 per group (5 males, 5 females). 1ml blood sample was collected from each patient after taking informed consent. The collected blood was centrifuged for 20 min at room temperature and then stored at -20°C until analysis. The serum samples were subjected to ELISA test for determining levels of Osteocalcin. 
Bacteriological profile of osteomyelitis patients in government hospital, Ambikapur
Get PDFOsteomyelitis is an infection and inflammation of the bone. Bacteria are the primary cause of osteomyelitis. Infections with fungi and viruses can also cause it.It usually affects children and others who are immunocompromised. Although bacteria cannot colonise bone ordinarily, events such as trauma, ischemia, surgery, the presence of foreign particles, or the insertion of prostheses can disrupt bone integration, eventually leading to infection.AIM : To study Bacteriological profile of osteomyelitis patients in Government Hospital, Ambikapur. Material And Material: During the study period of April2021 to Oct 2021 for this study 30 patients who were diagnosed clinically and radiologically as a case of Chronic Osteomyelitis are participating in this study. The risk factors for Chronic Osteomyelitis were obtained from patient case sheets with the help of orthopedic surgeons in the department of orthopedic RSDKSGMC and Hospital.In this study, the total number of cases Chronic Osteomyelitis considered was 30.with age group of 1-60 years and both the sexs. Conclusion: Chronic osteomyelitis is a chronic disease that affects the long bones, particularly the femur and tibia, and is most common in adults. Haematogenous Osteomyelitis is becoming less common as antibiotics become more widely available and children's growing bones have a higher vascular metaphysis.