International journal of health sciences
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Comparative synthetic study, in silico screening and biological evaluation of some substituted tetrahydropyrimidine-2-one derivatives as potential DHFR inhibitors
Get PDFIn present study we have selected pyrimidine scaffold to design and develop some DHFR inhibitors as potential antibacterial and antifungal agents. The designed derivatives were first screened through ADMET property calculations and then those possess drug-likeness properties were subjected for the molecular docking studies. The derivatives which were found to be significant DHFR inhibition potential were subjected for the synthesis followed by spectral analysis and biological evaluation. From this virtual screening, it was concluded that all the compounds possess drug-like properties and hence were subjected to molecular docking studies. The selected derivatives were synthesized and subjected for in vitro biological evaluation. The comparative study for synthesis of the derivatives such as conventional, ultrasonic, microwave synthesis was carried out. It was also observed that yield of the compound was very good in microwave assisted synthesis i.e. 73.24% which is almost 30-40% more than that of the conventional and ultrasonic method. In mass spectrum it was observed that, product obtained through microwave method was completely pure and did not displayed any peak of starting material, whereas product obtained through conventional and ultrasonic method showed presence of starting material
Carbon trading: A tool to control global warming
Get PDFIn current scenario Global Warming has given rise to a new form of commerce i.e. the carbon trade. Carbon trading is advance format where firms or countries buy and sell carbon permits as part of a program to trim out carbon emission. It is a widespread method countries utilize in order to meet their obligations specified by international Kyoto Protocol (1997) of United Nations Framework Convention on Climate Change; namely the reduction of carbon emissions in order to mitigate future climate changes. It specifically targets carbon dioxide calculated in terms of CO2 equivalent or CO2. India signed and ratified the Kyoto Protocol in August 2002. Since India is exempted from framework of the treaty, it is expected to gain from the protocol in terms of transfer of technology and related foreign investments. India was an early player in the market and was doing well, but after the entry of China in 2005, it gradually out performed Indian the carbon market. The objective of the paper is to discuss the regulatory mechanism of carbon trading in international market with special reference to opportunities for the emissions market in Indian context. 
An imperical analysis of various extracts of Bacopa Monnieri towards antibacterial and antifungal activities
Get PDFBacopa monnieri was also known as “Brahmi.” Theses plant has been considered as medicinal plants in Ayurvedic systems for centuries. This present study was carried out to evaluate the antibacterial and antifungal properties of ethanolic, diethyl ether, ethyl acetate, and aqueous extracts of B. monnieri. Agar disc diffusion tests were carried out to determine the antimicrobial effects of ethanolic, diethyl ether, ethyl acetate and aqueous extracts of B. monnieri against Gram-positive (Staphylococcus aureus), Gram-negative (Escherichia coli) bacterial strains and antifungal strains (Aspergillus flavus, and Candida albicans). Among the various extracts, diethyl ether extracts of B. monnieri has an antibacterial potency against Staphylococcus aureus (gram positive), and ethyl acetate extract showed effects on E. coli (gram negative) at higher concentrations of 300 μg mL-1. The ethanolic extract has potent antifungal activity against the fungus (Aspergillus flavus, and Candida albicans) compared to diethyl ether and ethyl acetate-ether. Both extracts (diethyl ether and ethyl acetate) has a minimum antifungal effect while these extracts showed more inhibitory effects on tested bacteria. 
Degree coprime domination and degree non-coprime domination in graphs
Get PDFLet G(V,E) be a finite, undirected, simple graph without isolated vertices. A dominating set D of V(G) is called a degree coprime dominating set of G if for every v∈V-D, there exist a vertex u∈D such that uv∈E(G) and (deg u,deg v)=1. The minimum cardinality of a degree coprime dominating set is called the degree coprime domination number of G and is denoted by γ_cp (G). A dominating set D of V(G) is called a degree non-coprime dominating set of G if for every v∈V-D, there exist a vertex u∈D such that uv∈E(G) and (deg u,deg v)≠1. The minimum cardinality of a degree non-coprime dominating set is called the degree non-coprime domination number and is denoted by γ_ncp (G). We obtain the degree coprime domination number for some graphs
Trait emotional intelligence can predict the health behaviour of employees: An empirical study in Indian pharmaceutical industry
Get PDFEmotional Intelligence can be measured either as an ability, based on maximum performance tests or as a trait, based on self-perception tests. A lot of academic, professional and behavioural attributes have been studied in relation to EI and research has shown that trait EI is better correlated with health outcomes than ability EI. Health behaviour is an understudied subject that has been shown to be linked with EI. The present study evaluated the correlation of EI, measured both by an ability and a trait measure among one hundred nineteen employees of the Indian pharmaceutical industry with health behaviour, as measured by Vickers health behavioural checklist, and to assess the role of age in association with these parameters. Trait EI, as measured by Schutte self-report test, was found to be better correlated with health behaviour than ability EI, as measured by an Indian scale by Chadha and Singh. Further, trait EI was found to be predictive of health behaviour. Age was positively correlated with both ability and trait EI, but not with health behaviour. The potential implication of the results for the organization and the future direction of research in this field has been discussed in the Indian scenario
Comparative analysis of the lipid profile before and after application of the nursing strategy
Get PDFThe lipid profile is a laboratory test that determines the levels of cholesterol and triglycerides in the body. The objective of the research is to compare the current lipid profile in relation to the initial result of the participants in the implemented nursing strategy, through laboratory tests to discover the differences and propose improvements in nursing care. It is a qualitative-quantitative, descriptive, and longitudinal study. The sample taken from 87 people; 39 rural and 48 urban patients. The result was that the self-care of people makes it possible to improve health, due to the complications of triglycerides, and nursing interventions focused on health promotion and prevention are relevant by motivating and encouraging patients to carry a healthy lifestyle. healthy life, which promotes balanced diets in fats, carbohydrates, proteins, and sugars, performing physical activity adapted to their daily life rhythms; as well as to carry out routine check-ups to rule out any alteration in the organism that causes the lipid profile to rise
Effect of changes in some beneficial elements and dangerous heavy metals in cow and sheep manure on human and animal health and the environment
Get PDFCow and sheep manure contains beneficial nutrients nitrogen (N) carbohydrates (CHO) and Organic matter (OM), and is therefore used as an organic fertilizer. However, the excessive use of manure can cause environmental problems and negatively affect human and animal health because these materials also contain large amounts of heavy metals, especially selenium (Se), nickel(Ni), cobalt(Co), tin(Sn), lead(Pb), and cadmium(Cd) To assess the potential risks due to increased concentrations of heavy metals in sheep and cow manure.The compost was collected from three different regions in Kirkuk, Diyala and Sulaymaniyah governorates in Iraq and Kurdistan Region where the results showed The content of cow and sheep manure of organic matter (OM), carbohydrates (CHO) and nitrogen (N) levels were normal, which are beneficial nutrients for soil and plants and used as organic fertilizer. The level of selenium, nickel and cobalt was higher in cow manure compared to sheep manure in all governorates. The level of lead and cadmiumwas higher in sheep manure in Diyala governorates compared to cow manure
Relationship of anti-thyroid peroxidase antibody enzyme to antioxidant and lipid level in women with thyroid diseases
Get PDFThe research involved study the relation between thyroid peroixdase (TPO) and some of the measured biochemical parameters reduced glutathione (GSH), arylesterase (ARE), ceruloplasmin, malondialdehyde, cholesterol, triglyceride, LDL, VLDL, HDL, atherogenic index)in serum blood patients compared with control group, the result demonstration is a significant increase in the activity of TPO enzyme(112.63± 69.5 Iu/ml), (273.9±235.1 Iu/ml) in hyperthyroidisum and hypothyroidisum patient respectively compared with activity in control group was( 33.9 ±18.99 Iu/ml), also the results showed the significant increase in the concentration of (HDL), significant decrease in (GSH, ARE enzymes, cholestero, LDL, atherogenic index) and while a non significant increase in (ceruloplasmin,malondialdehyde), non significant decrease in(triglyceride, VLDL) in hyperthyroidism, also the results had been shown a significant increase in (malondialdehyde, triglyceride, VLDL), and a significant decrease in (GSH, ARE enzymes) while a non significant increase in (ceruloplasmin, cholesterol, LDL, atherogenic index) and a non significant decrease in (HDL) in hypothyroidism, Correlation coefficient of TPO enzyme with these clinical parameters showed a positive significant correlation with (GSH enzyme)in control group and with (HDL) in hyperthyroidism while the results showed that there is no significant correlation between TPO enzyme with the rest of boichemical parameters (GSH enzyme)
Cooperative and antagonistic reactions of heavy metallic elements and its impact on health that are supplemented with selenium and zinc in Kurdi sheep
Get PDFThe purpose of present study was to determine the variations in the levels of Selenium, Zinc, Iron, Copper, Molybdenum and Manganese in the serum of Kurdi sheep and to compare the age difference in the levels of minerals between lambs and rams that are supplemented with Selenium and Zinc individually or their combination.It was on two experiences.The males of the Kurdi sheep from lambs and rams for four coefficients each as follows; First Treatment: (control) without adding, Second Treatment: added Selenium with a dose of 0.5 mg /kg fed,Third Treatment: added Zinc with a dose of 100 mg /kg fed, Fourth Treatment: added Selenium with Zinc with a dose of 0.5 + 100 mg/kg fed, then they were given gelatinous capsules daily for 60 days.Selenium and Zinc supplementation and their combination led to significant increase in the Selenium and Zinc concentration in the blood serum of lambs and Rams. Selenium, Zinc and their combinationsignificantly contributed to changes in the analysed minerals (Selenium, Zinc, Iron, Copper Molybdenum and Manganese)
Genetic analysis of Acenitobacter bumannii associated with viral respiratory infections
Get PDFIn this study, samples were collected from Corona patients who were in isolation units for Corona virus patients, where samples were taken (from the nasal passage, mouth and sputum) and the samples were transferred by a liquid nutrient medium to the laboratory and kept at -2 temperature until they were cultivated on the medium of the Maconkey and saved In the incubator for 24 hours to observe the types of bacteria present , The samples were also cultured on Chrom agar Base Acinetobacter bacteria (which is a selective medium).It is difficult to distinguish it phenotypically from other bacteria, The phenotypic detection of A. bumannii bacteria, biochemical tests, and then molecular detection using ITS-specific primer were also performed and molecular detection using SP4-specific primer were also performed . A molecular assay for the CipA gene that encodes for the production of an enzyme complementary-inhibitor and Plg-binding protein of A. baumannii (Cip A) was also performed and The molecular assay for the Peptidase M10, metallopeptidase-specific primer gene was also performe. As the most important virulence factors in A. bumannii , Because the two enzymes played an important role in the pathogenesis of these bacteria .