International journal of health sciences
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Synthesis and characterization of new 1,3-Oxazepine-4,7-dione compounds from 1,2-diaminobenzene
Get PDFIn this research, done synthesized a series of new 1,3-oxazepine-4,7-dione derivatives as D1-D3 compounds via using [2+5] cycloaddition reaction. Synthesized compounds that have been bis azo groups [B1-B3] from 1,2-diaminobenzene via coupling its diazonium salt with phenoxide anion of 4-alkoxybenzaldehyde which Alkoxy was as pentyl, hexyl, and Heptyl groups. These compounds B1-B3 are condensed with 4-Bromoaniline in Schiff bases reactions to give bisazoimine derivatives C1-C3. The compounds C1-C3 were produced by cycloaddition reaction to produce 1,3-oxazepine-4,7-dione derivatives D1-D3. The structures of the synthesized compounds are characterized by spectroscopic methods, such as FTIR, and 1HNMR spectra with the elemental composition analysis. The compounds D1-D3 that are synthesized play a big role in the inhibition of growth
The impact of regular exercise on overweight metabolic syndrome in school-aged children: A literature review
Get PDFTo review studies that can examine whether there is any effect of physical activity on obesity. Obesity is defined as an energy deficit caused by lifestyle behaviour such as poor food habits & insufficient physical activity time, both of which are significantly linked to obesity development. Journal articles published between 2011-2021 were secured by searching computerized bibliographical databases. High evidence studies such as systemic reviews and cross-sectional studies were included. A total of 30 studies were selected. After analysing the studies, it was seen that: Physical activity has been shown to reduce obesity in children. Increased physical activity (reduced inactive behaviour) in combination with healthy eating appears to be more beneficial in lowering obesity than either a good diet or increased PA alone
The efficacy of Carica papaya leaf extract against some bacteria which isolated from cow milk
Get PDFThe advent of science to the search for antibiotics principally depends on medicinal plants as raw materials. Pathogenic bacteria isolated from cow milk represent play a major role in mastitis and are not easy to treat even with the use of a wide range of antibacterial agents. Finding alternative substances that may eliminate those bacteria with fewer side effects especially if they are derived from natural sources. Here, papaya leaf was collected, air-dried, powdered and extracts (PLE) of tow solvents; ethanol (EPLE) and aqueous (EPLA) were used to evaluate their Mueller-Hinton based inhibition activities against Escherichia coli, Klebsiella pneumonia and Staphylococcus aureus (isolated from milk of local cows in the current work). The results showed that the ethanol extract of papaya leaves (EPLE) was highly effective in decreasing the growth of Klebsiella pneumoniae and Staphylococcus aureus, while did not show any activity in inhibiting of E. coli. Compared with the aqueous extract of papaya leaves (EPLA), which did not record any inhibition of the growth of bacteria isolated for the study only in its high concentration (80%) for each (E. coli and Klebsiella pneumoniae)
Association of NTproBNP in metabolic syndrome
Get PDFAim: The association between NTpro BNP values and different biochemical and anthropometric parameters of metabolic syndrome patients and non-metabolic syndrome individuals are correlated here. Methods: The research involved 200 people aged 21 to 60 years old (100 control and 100 cases). The following measurements were taken- FBS, SBP, DBP, BMI, and lipid profile. Using multiple regression, we examined the correlation between NTproBNP and metabolic syndrome and non-metabolic syndrome patients. Correlation of Metabolic syndrome parameters with NTproBNP values are done. Result: NT pro BNP values are higher in metabolic syndrome patients in comparison to non-Metabolic syndrome patients. NTproBNP values are positively correlated with SBP, TG, LDL values in metabolic syndrome patients. Conclusion: NT pro BNP values are higher in metabolic syndrome patients in comparison to non-Metabolic syndrome patients
The effect and characterizations of silver nanoparticles on biofilm formation in Pseudomonas aeruginosa isolated from UTIs patients
Get PDFBackground: Urinary tract infection (UTI) is a common health problem in both community and nosocomial settings, affecting both men and women equally.Pseudomonas aeruginosa is an opportunistic human pathogen causing devastating acuteand chronic infections in individuals with compromised immune systems. Biofilmis an architecture built mostly by autogenic extracellular polymeric substances which function asa scaffold to encase the bacteria together on surfaces, and to protect them from environmentalstresses, impedes phagocytosis and thereby conferring the capacity for colonization and long-termpersistence.The present study aim to evaluate the antibacterial activity of chemo-synthesized AgNPs onbiofilm-forming XDR Pseudomonas aeruginosaisolated from UTIs patients. Methods: These study was conducted in Al-Qadisiyah province, Iraq at five major hospitals (AL-Diwanyia Teaching Hospital,Feminine and children teaching hospital, Afak General Hospital, AL-Hamzah General Hospital and AL-Shamiya General Hospital) during the period from (November, 2020 to June, 2021). A total of 800 urine samples were collected from male and females referring to five major hospitals. The age of the patients ranged from (1 to 80) years-old. Results:Sixty isolates were showed positive and identified as P. aeruginosa by using selective media, biochemical test system and VITEK-2 compact system. Genetically, in the present study, a total DNA was extracted from all clinical P.aeruginosa isolates
Incidence of post-operative pain using three different endodontic preparation instruments: An in vivo study
Get PDFAim: The aim of this study was to evaluate the incidence of post-operative pain after cleaning and shaping with three file system using Hand, Rotary and Reciprocating motion in maxillary and mandibular molars. Materials and Method: A total 60 patients were randomly divided into 3 groups: in group 1 (n=20) teeth were prepared with hand protaper file system till F2 size. In group 2 (n=20) teeth were prepared with primary wave one gold and in group 3(n= 20) teeth were prepared with protaper gold file system till F2 size. The pre and post-operative pain score was noted using visual analog scale at 12, 24, 48 and 72 hours after preparation. Results: all the pre instrumentation pain values were higher than post-instrumentation. There was significant difference among the groups with highest post-operative incidence in wave one gold followed by hand protaper and protaper gold files after 12 hours. Conclusion: Post- operative pain was significantly lower in patients treated with rotary protaper gold as compared to wave one gold and hand protaper file systems
Synthesis, biological activity and molecular docking study of some new chalcones, pyrazolines and isoxazolines derivatives bearing 1,2,3- triazoline
Get PDFIn this work a variety of new compounds such as chalcones, pyridine and isooxazoline derivatives has been synthesized. 2-((1-(4-acetylphenyl)-4,5-dihydro-1H-1,2,3-triazol-4-yl)methyl)benzo[d]isothiazol-3(2H)-one 1,1-dioxide(1) have been chosen as a starting material. Condensation of compound(1) with aromatic aldehydes namely benzaldehyde, p-chloro benzaldehyde, p-bromo benzaldehyde, p-nitro benzaldehyde, p-hydroxy benzaldehyde, m-hydroxy benzaldehyde, p-N,N-dimethyl benzaldehyde and 2,4-dimethoxy benzaldehyde in the presence of 40% KOH gave chalcone derivatives (2a-h). The cyclization of prepared chalcone derivatives semicarbazide in the presence acetic acid product pyrazoline derivatives(3a-f). Reaction of chalcone derivatives(2a-h) with hydroxylamine hydrochloride in the presence of sodium acetate afforded corresponding isooxazoline derivatives (4a-d). FT-IR, 1HNMR, and 13CNMR were used to characterize the target compounds. The results showed that the target compounds have a good biological activity such as antibacterial and antioxidant. The molecular docking studies of the target 6ul7 with the newly synthesized compounds showed good docking scores with acceptable binding interactions. The present results reveal that the newly synthesized compounds exhibit promising inhibition activity against Escherichia Coli.  
Entacapone microsponges in the treatment of acute Parkinson’s disease: Design, development and evaluation
Get PDFObjective: The current study was based on the many different dose frequencies of entacapone, an anti-Parkinson's drug that was loaded with microsponges to change the dose frequency of the drug administration. Methods: Microsponges were made utilizing polymethacrylate polymers such as eudragit L100, eudragit S 100, and eudragit RS 100 in various ratios using a quasi-emulsion solvent diffusion, ratios such as (1:0.5, 1:1, 1:1.5 and 1:2). These polymers release the drug in a controlled manner. The polymer used for the preparation of microsponges was useful in forming sponges in which the drug was entrapped. By using the 3 polymers,12 formulations were prepared. Results: FT-IR and DSC tests were carried out and it was clear from the FT-IR and DSC spectra that there were no interactions between the entacapone and the polymer. out of 12 formulations 3 formulations were selected as optimized formulations based on the production yield (%), encapsulating efficiency, drug loading (%), and SEM analysis says that the produced microsponges formulation was extremely porous, indicating their potential for increased drug loading. 
Mobile health app to facilitate the adoption of digital health in India: A correlation study (a utaut2 based approach)
Get PDFBackground: Health care providers have begun to move their services from traditional clinical consultations to online apps as a result of the growing popularity of mobile health. Although health apps are becoming more popular and have a greater user base, there is a vacuum in the literature regarding why people want to use Healthcare apps. Objective: The primary goal of this study is to identify the factors that influence consumers' willingness to adopt and use healthcare apps for personal medical services such as consulting a doctor, ordering medications, and scheduling appointments with a doctor, as well as to investigate the willingness to use them among the tech-savvy young generation. Methods: We used random sampling to perform a quantitative study on UTAUT2 Variables for app users. SPSS and Excel were used to statistically analyze, valid data, samples were collected from 386 app users. Results: The findings revealed that Performance Expectancy, Effort Expectancy, Social Influence, Hedonic Motivation, Hedonic Motivation, Price Value, Habit, Facilitating condition, Self-efficiency, Trust, Behavioural intention, shows the higher level of significance and tends to the adoption of NDHM mobile app for healthcare needs. 
Adoption under Hindu law: Outbursting the myths about adoption in context of Hindu adoptions & maintenance act, 1956
Get PDFThe relationship of a child and parents is beyond the definition of love and piousness. This unreal bond has always been a constant source of origination of rights, liabilities and co- dependency of the former towards the latter and vice versa. The concept of adoption in India is prevalent since antiquity and the depth goes stronger in case of Hindu Law, it being the only major personal law that permits adoption even before its codification. For the following article, the authors attempted to go through how the practice of adoption has changed over the years, what are the myths associated with this concept, how Hindu Adoptions and Maintenance Act, 1956 has been able to setup equality between women and menin terms of their rights to adoption and how customs and practices are kept in harmony with the codified law. The authors have attempted to establish a link between the myths prevalent in our society on adoptions and simultaneously tried to outburst and explain them with the help of provisions of Act of 1955