Online Journal Faculty of Medicine Universitas Sriwijaya
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Neuropsychiatric Aspects of Congenital Heart Disease: A Review of Current Literatures
No full textCongenital heart disease (CHD) is a structural abnormality in the heart or majorintrathoracic blood vessel that is present at birth. Advances in modern medicalscience and technology have contributed to an increase in life expectancy andpopulation of CHD patients. Survivors of CHD may not only experience complexmedical problems due to sequelae or complications of the underlying CHD but mayalso experience neuropsychiatric disorders. This review article aims to provide anunderstanding of the neuropsychiatric aspects of CHD, including clinicalmanifestations, risk factors and mechanisms, detection, and management ofneuropsychiatric disorders in CHD. This review showed that CHD patients areprone to behavioral disorders, neurodevelopmental disorders, and mental healthdisorders such as anxiety, depression, and post-traumatic stress disorder whichcan cause a decrease in quality of life. The risk factors and mechanisms ofneuropsychiatric disorders in CHD are complex and multifactorial. Early detectionand referral of neuropsychiatric disorders are important. Management requires amultidisciplinary team approach
Perbandingan antara Pemberian Fraksi Daun Beluntas (Pluchea Indica Lees) dan Ketokonazol Secara Invitro Terhadap Candida Albicans
No full textDaun beluntas bermanfaat sebagai pengobatan flour albus dan discharge yang disebabkan oleh jamur. Penelitianini bertujuan untuk menemukan aktivitas anti-jamur fraksi pada ekstrak daun beluntas (Pluchea indica Lees)terhadap Candida albicans. Penelitian ini adalah penelitian eksperimental in vitro menggunakan desain studiPosttest-only Control Group Design. Ekstrak metanol diperoleh melalui proses maserasi sedangkan fraksinyamelalui fraksinasi cair-cair. Fraksi paling aktif ditentukan oleh uji aktivitas anti jamur. Fraksi paling aktif dengankonsentrasi 10%, 5%, 2,5%, 1,25%, 0,625% dan diameter zona hambat 0,3125% diukur dengan metodepengenceran cairan padat. Kesetaraan dengan obat dinilai melalui analisis regresi, kemudian golongan senyawaaktif ditentukan melalui uji bioautografi menggunakan kromatografi lapis tipis. Hasil penelitian diperoleh metanol-fraksi-air dapat menghambat pertumbuhan Candida albicans sedangkan ekstrak metanol, n-heksana dan etilasetat tidak menghambat. Fraksi metanol air yang memiliki diameter zona hambat mulai pada konsentrasi0,3125% dengan diameter rata-rata 7,34 mm dan pada konsentrasi 10% diperoleh diameter terbesar sebesar17,10 mm. Melalui cairan pengencer dan fraksi padat KHM dari fraksi metanol-air dihambat pada konsentrasi0,3125%. Uji kesetaraan menunjukkan bahwa 1 mg / ml ketokonazol setara dengan 39.561 mg / ml fraksi metanol-air daun beluntas. Senyawa yang menghambat jamur diduga adalah golongan aktif senyawa flavonoid dan alkaloid.Fraksi metanol-air daun beluntas (Pluchea indica Lees) memiliki aktivitas antijamur terhadap Candida albicanssecara in vitro
EVOLUSI KARDIOLOGI SEBAGAI ILMU PENGETAHUAN: TINJAUAN PUSTAKA
No full textIlmu pengetahuan adalah usaha-usaha sadar untuk menyelidiki, menemukan dan meningkatkan pemahaman manusiadari berbagai segi kenyataan dalam alam manusia. Jumlah ilmu spesialisasi kedokteran pun masih terus bertambahhingga membentuk cabang-cabang lebih kecil lagi yang dikenal sebagai sub-spesialisasi. Salah satu jenis spesialisasidalam ilmu kedokteran adalah spesialisasi ilmu kardiologi, yaitu ilmu yang memfokuskan diri untuk mempelajari organjantung. Perkembangan ilmu kardiologi tidak dapat dilepaskan dari sejarah yang melatarbelakanginya. Kemajuan ilmukardiologi sampai ke titik ini adalah sebuah perjalanan kontinu yang saling berkait. Setiap pelajaran di masa lalu akanmenjadi modal untuk pengalaman di masa depan, begitu pula dengan ilmu kardiologi, di mana tiap-tiap fase nyamenjadi fondasi untuk perkembangan di waktu mendatang
The Effectiveness of The Combination of Nanoparticles from Carica papaya L. Leaf and Chitosan 1% Against Fibroblasts in The Tooth Socket of Wistar Rats.
No full textNanoparticles size can make easier for drugs to enter and react quickly to the body.In this study, nanoparticles Carica papaya L. leaf were used and combined withchitosan 1%. The aim of this study was to measure the effectiveness of thecombination of nanoparticles from Carica papaya L. leaf and chitosan 1% againstfibroblasts in the tooth socket of Wistar rats. Carica papaya L. leaf extract wasmade by maceration method and converted into a concentration of 25%, 50%, 75%and 100%, then made into nanoparticles using the nanoemulsion method. Chitosan1% was made using Na-TPP solvent using the ionic gelation method with a ratio of2:1 and after that it was mixed with nanoparticles of Carica papaya L. leaf thenmade into a gel preparation. The ANOVA statistical test shows a significant numberof p <0.05, so it can be ignored that the increase in the number of fibroblast cellsproduced by the nano gel extract is 25%, 50%, 75% and 100%, its 138, 173, 177.4and 328. Thus, the combination of 100% Carica papaya L. leaf nanoparticle extractand 1% nanocitosan was the most effective in increasing fibroblast cells on Wistarrat tooth socket
Pengaruh Riwayat Bayi Berat Badan Lahir Rendah dan Ibu Anemia dalam Kehamilan terhadap Risiko Stunting pada Balita Usia 0-24 Bulan di Wilayah Kerja Puskesmas Tanjung Bintang Kabupaten Lampung Selatan
No full textStunting is the condition in children when their height is shorter than a child of his age because of stunted growth due to chronic malnutrition. Stunting can be caused by low birth weight in newborns and maternal anemia. The objective of the study is to know the effect of low birth weight in newborns and maternal anemia on the risk of stunting in the toddler with the age range between 0-24 months in the Tanjung Bintang Primary Health Care. This research is an observational-analytic study with a cross-sectional approach. This research was conducted in the region of Tanjung Bintang Primary Health Care. The sample was 73 toddlers with an age range between 0-24 months. Data were analyzed with a Chi-square test to know the influence of the independent variable with a value of α = 0,05. The results found a 37% risk of stunting, 12.3% history of low birth weight in newborns, and 34.2% history of maternal anemia. The results of the bivariate analysis was no influence of a history of low birth weight in newborns on the risk of stunting (p-value = 0.718) and there was an influence of maternal anemia on the risk of stunting in toddlers (p-value = 0.001). There is no influence history of low birth weight in newborns on the risk of stunting and there is an influence of maternal anemia on the risk of stunting in toddlers aged range between 0-24 months in the region of Tanjung Bintang Primary Health Care.Stunting adalah keadaan tubuh yang lebih pendek dari anak seusianya karena pertumbuhan yang terhambat akibat kekurangan gizi yang kronis. Stunting dapat disebabkan oleh bayi berat badan lahir rendah dan ibu anemia dalam kehamilan. Tujuan dari penelitian ini adalah untuk melihat pengaruh riwayat bayi berat badan lahir rendah dan riwayat ibu anemia dalam kehamilan terhadap risiko stunting pada balita usia 0-24 bulan di Wilayah Kerja Puskesmas Tanjung Bintang. Penelitian ini adalah penelitian observasional-analitik dengan pendekatan cross-sectional. Penelitian ini dilakukan di wilayah kerja Puskesmas Tanjung Bintang. Sampel dalam penelitian ini sebanyak 73 balita usia 0-24 bulan. Data dianalisis dengan uji Chi-square untuk mengetahui pengaruh setiap variabel bebas dengan nilai α = 0,05. Hasil penelitian menunjukkan bahwa 37% balita risiko stunting, 12,3% balita dengan riwayat bayi berat badan lahir rendah dan 34,2% balita dengan riwayat ibu anemia dalam kehamilan. Hasil analisis bivariat menunjukkan hasil bahwa tidak terdapat pengaruh riwayat bayi berat badan lahir rendah terhadap risiko stunting (p-value = 0,718) dan terdapat pengaruh riwayat ibu anemia dalam kehamilan terhadap risiko stunting pada balita (p-value = 0,001). Dari penelitian ini dapat disimpulkan bahwa tidak terdapat pengaruh riwayat bayi berat badan lahir rendah terhadap risiko stunting dan terdapat pengaruh riwayat ibu anemia dalam kehamilan terhadap risiko stunting pada balita usia 0-24 bulan di wilayah kerja Puskesmas Tanjung Bintang
Bioethical Principles of Use of Experimental Animals in Biomedical Research
No full textA B S T R A C TResearch is an activity carried out based on scientific principles and methodssystematically to obtain information, data, and information from related subjects, withunderstanding the theory and proving assumptions and / or hypotheses. The resultsobtained are conclusions that can be applied or become additional knowledge for theadvancement of science. However, research activities must still respect the rights anddignity of research subjects. Health research includes biomedical, epidemiological,social, and behavioral research. Some health research can be done in vitro, usingmathematical models, or computer simulations
Hubungan Akreditasi Sekolah, Asal Sekolah, Jalur Penerimaan Mahasiswa dan Tempat Tinggal dengan Indeks Prestasi Kumulatif Mahasiswa
No full textProses pembelajaran merupakan kegiatan utama dalam dunia pendidikan, termasuk di Perguruan Tinggi (PT).Keberhasilan proses pembelajaran dipengaruhi oleh faktor internal dan faktor eksternal. Untuk mengukurkeberhasilan dalam pembelajaran di universitas menggunakan Indeks Prestasi Kumulatif. Tujuan objektif daripenelitian ini adalah menentukan hubungan akreditasi sekolah, asal sekolah, jalur penerimaan, dan tempattinggal dengan IPK mahasiswa PSPD angkatan 2014 FK Unsri. Jenis penelitian ini adalah observasi analitik dengandesain potong lintang. Responden dalam penelitian ini adalah seluruh mahasiswa PSPD Angkatan 2014 FK Unsriyang memenuhi kriteria inklusi sebanyak 216 mahasiswa. Data diambil dari Sub-bagian Akademik berupa data IPKdan jalur penerimaan dan Unit Bimbingan Konseling Mahasiswa (UBKM) berupa data asal sekolah dan tempattinggal sedangkan data akreditasi sekolah diperoleh dari web resmi Kementrian Pendidikan dan Kebudayaan.Analisis data bivariat menggunakan uji Chi-Square bila memenuhi syarat. Bila tidak memenuhi syarat makadigunakan uji alternatif yaitu kolmogorov-smirnov. Berdasarkan analisis bivariat, tidak terdapat hubunganakreditasi sekolah (A dan B) dan asal sekolah (kota dan kabupaten) dengan IPK dengan nilai p= 1,000, tidakterdapat hubungan asal sekolah (Palembang dan luar Palembang) dengan IPK dengan nilai p= 0,843, dan tidakterdapat hubungan tempat tinggal (bersama orang tua dan kos) dengan IPK dengan nilai p=0,730 sedangkanberdasarkan analisis bivariat terdapat hubungan jalur penerimaan (SNMPTN, SBMPTN, dan USM) dengan IPKdengan nilai p= 0,000. Terdapat hubungan jalur penerimaan dengan IPK Mahasiswa PSPD Angkatan 2014 FK Unsri.Namun, tidak terdapat hubungan akreditasi sekolah, asal sekolah dan tempat tinggal dengan IPK Mahasiswa PSPDAngkatan 2014 FK Unsr
Nurse Index Satisfaction at Hospital with Nurse Profession, Training, Nurse Assessment and Ethic Implementation in Pandemic Situation
No full textIntroduction. Pandemic Covid-19 situation in Indonesia since March 2021, make hospitals to have adaption with condition. Therefore, there is un satisfaction for nurse profession, training, nurse assessment and ethical in emergency, this is known by pre survei in emergency. This research was aimed to study about nurse satisfaction in pandemic area, and see pandemic effect to nurse satisfaction, topic research is satisfaction for nurse profesion, training, nurse assesment and ethical nurse.
Methods. Research method for this research is descriptive quantitative, where research use fact, situation and variable happen when the research on going. instrument used in this research is quisoner, sample used is nurse which work in Hospital X, Tangerang district with total sample 151 nurses.
Results. Nurse satisfaction preview in hospitals X, Tangerang district is more than 90% nurses satisfied with profession of nurses, training more than, nurse assessment and ethical of nurse.
Conclusion. All the nurse satisfied with their profession, training, assesment and ethical implementation, there is improvement room to reduce blame culture in nurse division and implement just culture in nurse division
Effect of Artemisia vulgaris Extract for Increasing IL-12 and Granzyme Expression (Study on Mammary Adenocarcinoma C3H Mice Given Adriamycin- Cyclophosphamide Chemotherapy Regimen)
No full textBackground: The incidence of breast cancer worldwide is still high. Surgery remains the top choice with other modalities of chemotherapy, radiation, and immunotherapy such as Artemisia vulgaris (AV). The study was aimed to demonstrate that administration of AV extract increased p53 expression and the apoptotic index in mammary adenocarcinoma.
Methods: This study used a "Post-test only control group design" on 24 females C3H mice that were randomly selected and divided into four groups: group K (control), P1 (chemotherapy), P2 (extract), and P3 (combination). Mammary adenocarcinoma comes from the inoculation of donor mice. Chemotherapy of Adriamycin 0,18 mg and Cyclophosphamide 1,8 mg were given in 2 cycles. AV 13 mg (0.2 ml) was given once daily orally. IL-12 and granzyme expression were evaluated by immunohistochemical staining.
Results : Mean of IL-12 and Granzyme expression were found in groups K, P1, P2, P3 were 50,40 ± 1,56, 60,28 ± 1,54, 53,48 ± 1,35, 75,40 ± 1,46 dan 14,96 ± 0,61, 24,86 ± 1,21, 17,14 ± 1,02, 26,62 ± 0,70. The statistical analysis showed that there were significant differences in the IL-12 between groups of K vs P1 (0,001), P1 vs P2 (0,001), K vs P2 (0,028), P1 vs P3 (0,001), K vs P3 (0,001), P2 vs P3 (0,001) and in granzyme expression between groups of K vs P1 (0,001), P1 vs P2 (0,001), K vs P2 (0,010), P1 vs P3 (0,047), K vs P3 (0,001), P2 vs P3 (0,001). Correlation analysis between IL-12 and Granzyme expression were found significant correlation (p = 0,001 and r = -0,911).
Conclusion: Artemisia vulgaris can improve the effectivity of Adriamycin-Cyclophosphamide chemotherapy on C3H mice with mammary adenocarcinoma in terms of elevated IL-12 and Granzyme expression
Factors Related to Patient Satisfaction Level of Thyroid Tumor on Post- Operative Thyroidectomy Scar Based on Patient Scar Assessment Scale (PSAS) in General Hospital Dr. M. Djamil Padang
No full textA B S T R A C TIntroduction : Dr. M. Djamil Padang General Hospital (RSUP) still appliesconventional methods as thyroidectomy treatment. Satisfaction and comfort to thescar is one of the issues because conventional thyroidectomy surgery scars arelocated in the neck area that will affect the confidence of patients, especially women.Method: This research was a quantitative research using cross sectional studydesign. The research was conducted at The Oncology Surgery Polyclinic of RSUPDr.M. Djamil Padang with a sample of 50 respondents. Result: More than half ofthyroid tumor patients found were women (56%), most patients had totalthyroidectomy surgery (70%) with malignan tumor type (72%), and the most tumorsize in the T4 group (52%). The average age of patients during surgery was 54.26years. The average patient satisfaction score for post-thyroidectomy scars was 14.72with a total score of 16, the lowest score was 6 and the highest score was 22.Significant relationships were found in variable tumor size (p= 0.000), type of surgery(p= 0.005), tumor type (p=0.004) and gender (p = 0.028), while there was nostatistically significant relationship between age and patient satisfaction with post-thyroidectomy scars (p=0,176). Conclusion: There were significant relationshipsbetween gender, type of surgery, type of tumor, tumor size to patient satisfactionwith post-thyroidectomy scars, while age has no signifacnt relationship to patientsatisfaction with post-thyroidectomy scars. A small number of PSAS score showedthat the average patient was satisfied with post-thyroidectomy scar