Online Journal Faculty of Medicine Universitas Sriwijaya
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Relationship of Lipid Profile with Wagner Severity Level in Diabetic Feet at General Hospital Dr. M. Djamil Padang
No full textA B S T R A C TIntroduction Diabetic foot is an erosion or injury to the epidermis or the distal soleof the foot and the base of the foot in people with diabetes mellitus (DM). Diabeticfoot is a major cause of limb amputation in non-traumatic cases. Per year, as manyas 2-3% of people with diabetes experience complications of diabetic foot. Theprevalence of DM sufferers with diabetic foot is 20-40% in developing countries. InIndonesia, the prevalence of DM sufferers with diabetic foot is around 15% with 32%mortality rate. One factor plays an important role in predisposing the occurrence ofdiabetic foot is the lipid profile. The aim of this study was to determine the correlationbetween lipid profile and Wagner Severity Level on diabetic foot patients at Dr. M.Djamil Central Public Hospital, Padang in the period of July 2020 to December 2020.Method: This research is an observational analytic study with cross sectionalanalytic design. The research sample of 47 cases was taken by non-probabilitysampling with the consecutive sampling method. This research is an observationalanalytic study with cross sectional analytic design. The research sample of 47 caseswas taken by non-probability sampling with the consecutive sampling method.Result: There were 47 cases that met the inclusion criteria where the 51-60 yearsage group (55.3%) was the largest group in cases of diabetic foot. Of these groups, itwas dominated by female patients, namely 31 patients (66.0%). Meanwhile, the BodyMass Index (BMI) was dominated by the group with BMI <25 kg/m2 with a total of26 patients (55.3%). Diabetic foot patient at Dr. M Djamil Central Public HospitalPadang who underwent amputation was 25 patients (53.2%) where most of them,namely 40 patients (85.1%) had suffered from Diabetes Mellitus for> 5-10 years. Thefindings obtained based on the Wagner Severity Level were that the Wagner grade 3-5 (heavy) group consisted of 24 people (51.1%) and Wagner 1-2 (mild) as many as 23people (48.9%). The results of the bivariate test between lipid profile levels withWagner Severity Level in diabetic foot patients showed a significant correlation asindicated by a p value <0.05. Conclusion: Wagner Severity Level which is gettinghigher in diabetic foot patients shows low HDL levels, high LDL levels and high levelsof triglycerides in blood plasma
Hubungan Kadar Anti Mullerian Hormon (AMH) Dan Indeks Massa Tubuh (IMT) Dengan Panjang Siklus Menstruasi Premenopause Di Bidan Praktik Mandiri Ranting Seberang Ulu I
No full textSistem reproduksi wanita merupakan sistem kompleks yang meliputi semua alat reproduksi wanita dan akanberubah sesuai dengan siklus perkembangan. Siklus perkembangan reproduksi wanita berlangsung secaraalamiah mulai dari menarche sampai menopause. Sebelum terjadi menopause ada masa transisi yang disebutpremenopause. Perubahan organ reproduksi pada masa premenopause ini ditandai dengan terjadinya gangguanpada menstruasi. Perpanjangan dan pengurangan siklus menstruasi dapat dipengaruhi oleh beberapa faktorseperti Anti Mullerian Hormon (AMH) dan Indeks Massa Tubuh (IMT). Tujuan mengetahui hubungan kadar AMHdan IMT terhadap panjang siklus menstruasi premenopause di BPM Ranting Seberang Ulu I.Penelitian inidilakukan di Laboratorium Biomolekuler Kedokteran Universitas Sriwijaya dengan desain penelitianobservasional analitik. Sebanyak 74 orang sample dipilih secara Convinience Sampling yang dibagi menjadi 2kelompok yaitu kelompok siklus mesntruasi normal dan tidak normal. Kedua kelompok diukur TB dan BB nyauntuk mengetahui IMT dan diambil darah vena untuk dialkukan pemeriksaan AMH dengan metode ELISA. Hasilanalisis data AMH dan siklus menstruasi dilakukan dengan uji Mann-Whitney. nilai p=0,004, IMT dan siklusmenstruasi dilakukan dengan uji T Independen nilai p=0,484, AMH dan IMT dilakukan dengan uji Spearman nilaip=0,789 dengan nilai alpha 0,05 (p<α). Disimpulkan bahwa ada hubungan antara AMH dan siklus mestruasi, tidakada hubungan antara IMT dan siklus mestruasi dan tidak ada hubungan antara AMH dan IMT
Hubungan Polimorfisme Gen CYP1A1 (Ile462Val) dengan Kejadian Karsinoma Epitel Ovarium
No full textKarsinoma epitel ovarium adalah salah satu kanker ovarium yang menyumbang 90% dari kasus kanker ovarium danselalu menjadi penyebab utama kematian di antara keganasan ginekologi. Salah satu faktor resiko yang dapatmenimbulkan kanker ovarium adalah genetik. CYP1A1 (Cytochrome P450 Family 1 Subfamily A member 1) adalahgen penyandi protein yang menyandi sejumlah enzim sitokrom P450 yang berperan dalam metabolisme obat danbahan-bahan asing (xenobiotic) yang masuk ke dalam tubuh, juga berperan penting pada karsinogenesis. Penelitianini bertujuan untuk mengetahui hubungan polimorfisme gen CYP1A1 (Ile462Val) dengan kejadian karsinoma epitelovarium. Penelitian ini merupakan penelitian analitik observasional, rancangan penelitian case control yangdilakukan di Laboratorium Biologi Molekuler Fakultas Kedokteran Universitas Sriwijaya pada bulan Maret-April 2017.Sampel adalah koleksi sampel darah pasien di Laboratorium Biologi Molekuler Fakultas Kedokteran UniversitasSriwijaya Palembang yang didiagnosis kanker ovarium yang dibuktikan dengan gambaran histopatologi sebanyak 30subjek kelompok karsinoma epitel ovarium dan 30 subjek kelompok bukan karsinoma epitel ovarium. Pemeriksaanpolimorfisme gen CYP1A1 (Ile462Val) menggunakan metode PCR-RFLP. Hasil penelitian menunjukkan ada hubunganyang bermakna antara polimorfisme gen CYP1A1 (Ile462Val) dengan kejadian kanker epitel ovarium (p=0,020)
Prevalensi Penderita Leprosy Berdasarkan Pemeriksaan Histopatologi di Bagian Patologi Anatomi RSUP DR. Mohammad Hoesin Palembang
No full textLeprosy (kusta atau Morbus Hansen) merupakan suatu infeksi granulomatosa kronis oleh M. leprae yang menyerangsaraf tepi, kulit, mukosa mulut, dan saluran nafas bagian atas. Penyakit ini menular dan menyebar di seluruh duniaterutama negara berkembang seperti Indonesia. Walaupun tidak menimbulkan kematian, leprosy dapatmenimbulkan ulserasi, mutilasi, dan deformitas. Pemeriksaan histopatologi perlu dilakukan untuk menunjangdiagnosis secara akurat. Penelitian ini bertujuan untuk mengetahui prevalensi penderita leprosy yang diperiksasecara histopatologi di RSMH Palembang. Jenis penelitian ini adalah deskriptif observasional dengan rancangan crosssectional. Dari 29.175 kasus diperoleh 35 kasus yang terdiagnosis leprosy dan memenuhi kriteria inklusi. Prevalensipenderita leprosy di Bagian Patologi Anatomi RSMH Palembang tahun 2009-2013 adalah 1,19/1000 sampel danmayoritas pasien berusia 32-41 tahun (34,3%). Mayoritas (80%) penderita leprosy adalah laki-laki. Pada pemeriksaanhistopatologi leprosy dijumpai tipe I (2,9%), TT (20%), BT (20%), BB (8,6%), BL (31,4%), dan LL (17,1%). Penelitian inimenunjukkan bahwa prevalensi leprosy di Bagian Patologi Anatomi RSMH tahun 2009-2013. Prevalensi, demografi,dan karakteristik histopatologi leprosy pada penelitian ini mungkin dapat menyediakan gambaran secara umummengenai kondisi kasus leprosy yang diperiksa secara histopatologi di Sumatera Selatan khususnya Palembang
Relationship of The Degree of Head Injury Based on Glasgow Coma Scale (GCS) with the Arrival of Acute Post Concussion Syndrome (PCS) Onset in Post-Head Injury Patients in General Hospital Dr.M.Djamil Padang
No full textA B S T R A C TBackground: Traumatic brain injury is the main cause of death in the populationunder the age of 45 years, and the fourth leading cause of death in the entire ofpopulation. Based on the degree of traumatic brain injury, it is commonly categorizedbased on the Glasgow Coma Scale (GCS). Post-Concussion Syndrome (PCS) is theset of somatic, emotional / behavioral and cognitive symptoms that occur after atraumatic brain injury. The aim of this study was to find out the prevalence andcorrelation of the degree of traumatic brain injury based on the Glasgow Coma Scale(GCS) and the emersion of Post-Concussion Syndrome (PCS) acute onset in patientswith head injuries Method: This study was a cross-sectional analytic study ofpatients who experienced Post-Concussion Syndrome (PCS) after traumatic braininjury at DR. M. Djamil Hospital Padang in 2020 from June to November 2020. Datawere collected by filling in a questionnaire (The Rivermead Post ConcussionSymptoms Questionnaire) and medical record data of neurosurgical patients thatmet the inclusion and exclusion criteria. Result: : It indicated that 70 patients wereincluded in the inclusion criteria of this study. A total of 38 (54.3) respondents didnot undergo the acute onset of PCS, meanwhile respondents who experienced acuteonset of PCS were 32 (45.7) respondents. The results showed that 25 (67.6%)respondents with mild traumatic brain injury had PCS acute onset, while 4 (17.4%)respondents with moderate degree of traumatic brain injury had PCS acute onset,and 4 (17.4%) respondents had PCS acute onset PCS 3 (30%) respondentsexperienced severe traumatic brain injury with acute onset PCS and statistically thedifference in the proportion of data from each of these variables was significant witha p-value of 0.0001. The results of statistical tests showed that p value> 0.05 on thecorrelation between PCS and GCS, thus, it can be concluded that there was nocorrelation between the direction of the relationship between PCS and GCS.Conclusion There was no correlation between the degree of traumatic brain injurybased on GCS and the incidence of PCS acute onset, either it was unidirectional orvice versa in patients with head injuries at RSUP M. Djamil Padang
Effectiveness of Artemisia Vulgaris as Supplementation Against Chemotherapy of Mammae Adenocarcinoma to Reduce Expression of NF-κB and CD 34 (Study in C3H Mice Given Chemotherapy Adriamycin - Cyclophosphamide)
No full textIntoduction: Breast cancer is a significant healthcare problem worldwide. Surgery remains the treatment of choice combined with other modalities such as chemotherapy, radiation, and immunotherapy such as Artemisia vulgaris (AV). Selective cytotoxicity of AV is intended as a supplementation to Adriamycin-Cyclophosphamide, improving the response rate of chemotherapy in adenocarcinoma mammae.
Method: This study used a "Post-test only control group design" on 24 females C3H mice that were randomly selected and divided into four groups: group K (control), P1 (chemotherapy), P2 (extract), and P3 (combination). Adenocarcinoma mammae come from the inoculation of donor mice. Chemotherapy of Adriamycin 60 mg / m 2 and Cyclophosphamide 600 mg / m 2 were given in two cycles. AV 13 mg (0.2 ml) was given once daily orally. NF-κB expression and CD34were evaluated using imunohistochemical staining.
Result: The expression of NF-κB and microvascular density of CD 34 were obtained in groups of K, P1, P2, P3 Statistical analysis showed significant decrease in the expression of NF-κB between groups K and P1, P2, P3. Correlation analysis between NF-κB expression with CD 34 was found to have significant correlation (p = 0,039 and r = 0,897).
Conclusion:Artemisia vulgaris can reduce angiogenesis by decreasing NF-κB expression and the microvascular density CD34 of adenocarcinoma mammae of C3H mice treated with Adriamycin-Cyclophosphamide chemotherapy and can improve the effectivity
The Effectiveness of Giving Growth Hormone to Children with Chronic Kidney Disease: Systematic Literature Review
No full textChronic Kidney Disease (CKD) can cause growth problems in children. This condition will affect children’s social life and increase morbidity and mortality. Growth hormone (GH) is one of medication that has been used for treatment of impaired growth in children with chronic kidney disease. In Indonesia, this management has not been provided, because it is expensive and its effectiveness is uncertain. This research was conducted to determine the effectiveness of growth hormone in increasing linear growth in children with CKD. This study is a systematic review of the Randomized Controlled Trial (RCT) study to determine the effectiveness of growth hormone as a treatment for children with CKD. Literature search was conducted using five databases, namely Pubmed, Google Scholar, DOAJ, BMC and CENTRAL that matched the inclusion and exclusion criteria. The guide used in the literature selection was the PRISMA flow chart. A Total of 10 studies were included in the systematic review. Growth hormone is effective in increasing linear growth in children with CKD. Generally there was a significant increase in height (standard deviation (SD)), high velocity (SD or cm) in the therapy group compared to the control group. The dose of growth hormone that is given varies, but the most is 4 IU / m2 / day, once a day, by subcutaneous injection. The duration of growth hormone administration varied from 6 months to 5 years with an average of 1.7 years. Growth hormone did not aggravate kidney problems in children with CKD and can increase important factors in bone formation, namely alkaline phosphatase and osteocalcin
Management of Jakarta Metropolitan Medical Center Hospital in Preventing Burnout in Nurses during the Covid-19 Pandemic
No full textIntroduction. The COVID-19 pandemic has caused considerable losses to the health care system in Indonesia. The Indonesian Doctors Association (IDI) noted that as of October 3, 2020, 130 doctors, nine dentists, and 92 nurses died due to COVID-19. The problems that caused the death of health workers during the COVID-19 pandemics included the lack of PPE, inadequate patient screening in health facilities, and fatigue of medical personnel due to the increasing number of COVID-19 patients as long working hours and psychological pressure. Of course, this condition can disrupt the quality of life and work productivity in the health series. Therefore, the hospital needs to make various efforts to prevent burnout in health workers during the COVID-19 pandemic.
Methods. This research was a descriptive method with quantitative and qualitative approaches. The researcher revealed the facts that occurred when the study was running and presented them as they were. The research respondents were nurses who were in the isolation room and ICU COVID-19 at MMC Hospital Jakarta. Researchers used the Maslach Bach Inventory (MBI) questionnaire instrument to 43 respondents via the Google form. Researchers also conducted interviews with the Head of Nursing and several COVID-19 nurses who had filled out questionnaires.
Results: The majority of COVID-19 nurses at MMC Hospital had moderate burnout levels. MMC Hospital Jakarta has made various efforts to prevent burnout in nurses.
Conclusion: Management of MMC Hospital in preventing burnout in nurses was good enough, but several points can be improved to make it better
Korelasi Jumlah Limfosit Absolut dan Nilai CRP Kuantitatif Terhadap Derajat Keparahan Penyakit pada Pasien Covid-19 di RSUP Dr. Mohammad Hoesin Palembang
No full textCOVID-19 is a contagious acute respiratory disease caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus. Changes in some laboratory markers such as absolute lymphocyte count and quantitative CRP in COVID-19 can be associated with the course and clinical phases of the patient whose results can be useful in grading and predicting the severity of COVID-19 disease. This study aims to determine the correlation between absolute lymphocyte count and quantitative CRP on the severity of COVID-19. This study was an observational correlative analytic study with a cross sectional design. The research was conducted in all COVID-19 treatment isolation wards at RSMH Palembang from March 2021 to April 2021 with the research subjects being patients with confirmed cases of COVID-19 with various degrees of disease. Routine blood tests of absolute lymphocyte counts and quantitative CRP were performed at the Clinical Pathology Laboratory of RSMH Palembang. The statistical analysis of the correlation test with Spearman for numerical data was not normally distributed, and Gamma for categorical ordinal data was followed by a regression test to determine the prognostic value of the two parameters. Samples obtained were 83 patients, namely 24 patients (28.9%) mild degree, 40 patients (48.2%) moderate degree, 10 patients (12%) severe degree and 9 patients (10.8%) critical degree. The correlation between the absolute lymphocyte count and quantitative CRP obtained the correlation coefficient value r = – 0.525. The correlation between the absolute lymphocyte count and the degree of COVID-19 disease obtained a correlation coefficient of r = – 0.605, while the correlation between the quantitative CRP value and the degree of disease was obtained r = 0.875. Based on the prognostic test, the absolute lymphocyte count (cutoff point of 1,157 cells / mm3) was obtained with a sensitivity of 68.4% and a specificity of 68.75%. Meanwhile, quantitative CRP with a cutoff point of 77.5 mg/L obtained a sensitivity of 89.4% and a specificity of 89%. The absolute lymphocyte count has a strong negative correlation with the quantitative CRP value and the disease degree in COVID-19, while the quantitative CRP value has a positive correlation with a very strong degree. Thus these two parameters can be used as predictors of disease severity, however, the quantitative CRP value can be an independent prognostic marker or a single predictor of the severity of COVID-19 disease.COVID-19 adalah sebuah penyakit pernapasan akut menular yang disebabkan oleh virus severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Perubahan beberapa penanda laboratorium seperti jumlah limfosit absolut dan CRP kuantitatif pada COVID-19 dapat dikaitkan dengan fase perjalanan penyakit dan klinis pasien yang hasilnya dapat bermanfaat dalam penentuan derajat dan memprediksi tingkat keparahan penyakit COVID-19. Penelitian ini bertujuan untuk mengetahui korelasi jumlah limfosit absolut dan CRP kuantitatif terhadap derajat keparahan penyakit COVID-19. Penelitian ini merupakan penelitian observasional analitik korelatif dengan rancangan potong lintang. Penelitian dilakukan di seluruh bangsal isolasi perawatan COVID-19 RSMH Palembang dari Maret 2021 hingga April 2021 dengan subjek penelitian adalah pasien kasus konfirmasi COVID-19 dengan berbagai derajat penyakit. Pemeriksaan darah rutin jumlah limfosit absolut dan CRP kuantitatif dilakukan di laboratorium Patologi Klinis RSMH Palembang. Analisis statistik uji korelasi dengan Spearman untuk data numerik tidak berdistribusi normal, dan Gamma untuk data ordinal kategorik dilanjutkan dengan uji regresi untuk menentukan nilai prognostik dari kedua parameter.
Sampel yang diperoleh sebanyak 83 pasien yaitu 24 pasien (28,9%) derajat ringan, 40 pasien (48,2%) derajat sedang, 10 pasien (12%) derajat berat dan ]=9 pasien (10,8%) derajat kritis. Korelasi antara jumlah limfosit absolut dengan CRP kuantitatif diperoleh nilai koefisien korelasi r = – 0,525. Korelasi antara jumlah limfosit absolut dengan derajat penyakit COVID-19 diperoleh nilai koefisien korelasi r = – 0,605, sedangkan korelasi antara nilai CRP kuantitatif dengan derajat penyakit diperoleh r = 0,875. Berdasarkan uji prognostik didapatkan hasil pada jumlah limfosit absolut (titik potong 1.157 sel/mm3) dengan sensitivitas 68,4% dan spesifisitas 68,75%. Sedangkan CRP kuantitatif dengan titik potong 77,5 mg/L didapatkan sensitivitasnya 89,4% dan spesifisitasnya 89%. Jumlah limfosit absolut memiliki korelasi negatif berderajat kuat dengan nilai CRP kuantitatif dan dengan derajat penyakit pada COVID-19, sedangkan nilai CRP kuantitatif memiliki korelasi positif dengan derajat sangat kuat. Dengan demikian kedua parameter ini dapat dijadikan prediktor keparahan penyakit, namun nilai CRP kuantitatif dapat menjadi penanda prognostik independen atau prediktor tunggal terhadap keparahan penyakit COVID-19
Antibacterial Effect Of Ethanolic Extract Of Duku Seed (Lansium Domesticum) Against Streptococcus Mutans
No full textIntroduction: Caries is a major oral health disease in Indonesia. Streptococcus mutans (S. mutans) is the main microorganism causes caries. Caries prevention can be done by mechanical or chemical methods. Plants can be used as an alternative for antibacterial chemical agent, one of which is duku seed. Ethanolic extract of duku seed showed the presence of alkaloids, flavonoids, saponins, and tannins that have antibacterial effect. Purpose: The purpose of this study was to evaluate the antibacterial effect of ethanolic extract of duku seed against S. mutans. Method: Present study was an in vitro laboratory study using post-test only control group design. Duku seed extracted by maceration with ethanol 96%. Antibacterial effect was carried out using microdilution method for MIC and MBC90 by ethanolic extract of duku seed with concentration of 0,19-100%. Inhibition zone was evaluated using disc diffusion method by ethanolic extract of duku seed with concentration of 1,56-12,5%, chlorhexidine gluconate 0,2% (positive control), and aquadest (negative control). Results were analyzed using one way ANOVA and Tukey’s LSD post-hoc. Result: The results showed that MIC and MBC90 were 0,19% and 3,12%, respectively. Ethanolic extract of duku seed at concentration of 3,12% showed the maximum inhibition zone of 4,50 mm, but still lower than chlorhexidine gluconate 0,2%. Conclusion: Ethanolic extract of duku seed has antibacterial effect against S. mutans, so it can be used as an alternative plant for dental caries prevention