Online Journal Faculty of Medicine Universitas Sriwijaya
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Pengaruh Pemberian Vitamin C Terhadap Kadar Serum LDH dan Kualitas Hidup Pasien Limfoma Non–Hodgkin
No full textNon-Hodgkin's Lymphoma (NHL) is a primary malignancy of lymphocytes that can be derived from B lymphocytes, T lymphocytes. Vitamin C plays a role as an antioxidant in the body. This study was to find out the effect of vitamin C administration on LDH serum levels and quality of life in NHL patients at RSMH Palembang. This study was a pilot study with open clinical trials, conducted from February 2021 to May 2021. There were 15 research subjects (age18-60 years) given vitamin C supplementation 2 grams per day for 8 weeks. Before and after treatment was examined LDH levels, serum vitamin C, fill out the FFQ questionnaire (intake of vitamin C) and EORTC C30 questionnaire (quality of life). Obtained a decrease in LDH levels between before and after treatment in the low grade group (p =0.008) and in the high grade group (p= 0.000). Obtained improvement of quality of life between before and after treatment in the low grade group (p <0.05). A strong negative correlation was obtained in the high grade group between vitamin C levels and LDH levels before treatment (r= -0.75 p = 0.031) and after treatment (r= -0.819 p = 0.013). In the high grade group after treatment there was a strong positive correlation between vitamin C nutrisurvey with function scale (r = 0.790 p = 0.02) and strong negative correlation with symptom scale (r = -0.74 p = 0.03). Vitamin C supplementation decrease LDH serum levels in all clinical stages of NHL patients and improve quality of life and influence the correlation between vitamin C levels and the scale component of quality of life symptoms in advanced or high grade group of NHL patients in RSMH Palembang.Limfoma Non-Hodgkin (LNH) merupakan keganasan primer limfosit yang dapat berasal dari limfosit B, limfosit T. Vitamin C berperan sebagai antioksidan didalam tubuh. Penelitian ini untuk mengetahui pengaruh pemberian vitamin C terhadap kadar serum LDH dan kualitas hidup pada pasien LNH di RSMH Palembang. Penelitian ini merupakan pilot study dengan uji klinik terbuka, dilakukan mulai Februari 2021 sampai Mei 2021. Terdapat 15 subjek penelitian (usia 18-60 tahun) diberikan suplementasi Vitamin C 2 gram perhari selama 8 minggu. Sebelum dan setelah perlakuan diperiksakan kadar LDH, serum vitamin C, mengisi kuesioner FFQ (asupan vitamin C) dan kuesioner EORTC C30 (kualitas hidup). Didapatkan penurunan kadar LDH antara sebelum dan sesudah perlakuan pada kelompok low grade (p = 0.008) dan pada kelompok high grade (p= 0,000). Didapatkan perbaikan kualitas hidup antara sebelum dan sesudah perlakuan pada kelompok low grade (p< 0,05). Didapatkan korelasi negatif kuat pada kelompok high grade antara kadar vitamin C dengan kadar LDH sebelum perlakuan (r= -0,75; p= 0,031) dan sesudah perlakuan (r= -0,819; p= 0,013). Pada kelompok high grade setelah perlakuan didapatkan korelasi positif kuat antara nutrisurvey vitamin C dengan skala fungsi (r= 0,790; p= 0,02) dan korelasi negatif kuat dengan skala gejala (r= -0,74; p= 0,03). Suplementasi vitamin C mempengaruhi penurunan kadar serum LDH pada semua stadium klinis pasien LNH dan mempengaruhi perbaikan kualitas hidup serta mempengaruhi korelasi antara kadar vitamin C dengan komponen skala gejala kualitas hidup pasien LNH stadium lanjut atau high grade di RSMH Palembang
The Enamel Hypoplasia (Case Report)
No full textIntroduction: Disturbances during teeth growth and development may lead to dental abnormalities. Disruption in the process of formation of the enamel matrix may result in a surface defect known as enamel hypoplasia. Purpose: This case report aimed to show a technique of direct composite resin for esthetic resolution in anterior teeth with enamel hypoplasia. Case presentation: A 20-year-old male patient presented at the YARSI Dental Hospital (Jakarta) with a complaint of chalky white spots on the maxillary anterior teeth. The clinical examination showed wet white spots on the labial surfaces of 13, 21, and 23 (FDI), also caries on the labial and mesial surfaces of 12, 11, and 22. The treatment plan were composite resin direct veneers on After 5 months follow-up, evaluation of patients’s appearance showed that the affected teeth are maintained in good condition. Conclusion: Clinical success in the management of enamel hypoplasia depends on the severity of the lesion, the diagnosis, and the determination of a treatment plan
Hubungan antara Higiene Perorangan dan Kejadian Koinfeksi Cacingan pada Penderita Tuberkulosis
No full textTuberculosis (TB) and intestinal worms are infectious diseases with a large number of sufferers in Indonesia. The high prevalence of intestinal worms in Indonesia allows the occurrence of STH coinfection in pulmonary TB patients which causes anti M. tuberculosis immunity to decrease so that the response to tuberculosis treatment is not optimal. One of the risk factors of STH infection is personal hygiene. The purpose of this study was to analyze the relationship between individual hygiene and the incidence of STH coinfection in TB patients in Tempurejo Sub-District, Jember District. This type of research is observational research with cross sectional analytic design. The population used was TB patients in Tempurejo Sub-District in the period September - October 2019. The data used in this study were primary data in the form of interviews and results of stool examination. Stool examination is carried out using the sedimentation and floatation methods. Data analysis was performed using Fisher's exact test. The results of this study indicate that the incidence of STH co-infection in TB patients in Tempurejo Subdistrict is 9.67% and is caused by two STH species, A. lumbricoides (66.7%) and Hookworm (33.3%). Respondents' personal hygiene consisted of good hygiene (64.5%) and bad hygiene (35.5%), where 66.7% of cases of STH coinfection occurred in respondents with poor personal hygiene. Fisher's test results showed that there was no significant relationship between personal hygiene with the incidence of STH coinfection in TB patients in Tempurejo Sub-District, Jember District (p-value of 0.281).Tuberkulosis (TB) dan cacingan merupakan penyakit infeksi dengan jumlah penderita yang banyak di Indonesia. Tingginya prevalensi cacingan di Indonesia memungkinkan terjadinya koinfeksi STH pada pasien TB paru yang menyebabkan imunitas anti M. tuberculosis menurun sehingga respon terhadap pengobatan tuberkulosis menjadi tidak maksimal. Cacingan salah satunya dipengaruhi oleh higiene perorangan. Tujuan penelitian ini adalah untuk menganalisis hubungan antara higiene perorangan dan kejadian koinfeksi cacingan pada penderita TB di Kecamatan Tempurejo Kabupaten Jember. Jenis penelitian ini adalah penelitian observasional dengan desain analitik cross sectional. Populasi yang digunakan adalah pasien TB di Kecamatan Tempurejo dalam periode waktu September – Oktober 2019. Data yang digunakan dalam penelitian ini adalah data primer berupa hasil wawancara dan hasil pemeriksaan feses. Pemeriksaan feses dilakukan menggunakan metode sedimentasi dan floatasi. Analisis data dilakukan menggunakan uji Fisher. Hasil penelitian ini menunjukkan bahwa kejadian koinfeksi cacingan pada pasien TB di Kecamatan Tempurejo Kabupaten Jember sebesar 9,67% dan disebabkan oleh dua spesies STH yaitu A. lumbricoides (66,7%) dan Hookworm (33,3%). Higiene perorangan responden terdiri atas higiene baik (64,5%) dan higiene buruk (35,5%), dimana 66,7% kejadian koinfeksi cacingan terjadi pada responden dengan higiene perorangan buruk. Hasil uji Fisher menunjukkan bahwa tidak ada hubungan yang signifikan antara higiene perorangan dengan kejadian koinfeksi cacingan pada pasien TB di Kecamatan Tempurejo Kabupaten Jember (p-value sebesar 0,281)
Hubungan Kejadian Asfiksia Neonatorum dengan Gangguan Fungsi Koklea pada Neonatus
No full textHearing impairment on infants cause delayed development of speech, language, cognitive skills, and also social and emotional problems. The Joint Committee of Infants Hearing (JCIH) in 2007 stated perinatal asphyxia as one of the risk factors of infants hearing impairment. Hypoxia on asphyxiated neonates lead to the damage of outer hair cells (OHC) and edematous changes in stria vascularis in cochlea. The damage of OHC can be seen in the result of Otoacoustic Emission (OAE). The aim of this study was to analyze the correlation between neonatal asphyxia and cochlear dysfunction. This study was an observational analytic with cross sectional study design. Sampling was performed at dr. Soebandi and Kaliwates Jember Hospital November 29th 2019 – January 8th 2020 period in perinatology room. The sample is obtained by consecutive sampling. The data obtained were analyzed using Chi-square test with p-value < .,05. Out of 16 neonates, 8 neonates were with moderate asphyxia and other 8 neonates were not having any history of asphyxia. Cochlear dysfunction was noted in 3 (37.5%) neonates of moderate asphyxia and 6 (75%) neonates without history of asphyxia. The result of the study showed no significant correlation between moderate neonatal asphyxia and cochlear dysfunction (p=0.142).Gangguan pendengaran pada masa bayi dapat menyebabkan gangguan bicara, berbahasa, kognitif, masalah sosial, dan emosional sehingga dapat menurunkan kualitas hidup seseorang. The Joint Committee of Infants Hearing (JCIH) tahun 2007 menyatakan asfiksia neonatorum sebagai salah satu faktor risiko gangguan pendengaran pada neonatus. Hipoksia pada bayi dengan kondisi asfiksia dapat menyebabkan kerusakan pada outer hair cell (OHC) dan edema stria vaskularis sehingga mengganggu fungsi koklea. Kerusakan outer hair cell dapat dinilai dengan pemeriksaan Otoacoustic Emission (OAE). Tujuan penelitian ini untuk menganalisis hubungan kejadian asfiksia neonatorum terhadap gangguan fungsi koklea pada neonatus. Penelitian ini merupakan penelitian analitik observasional dengan metode cross sectional. Penelitian ini dilakukan di RSD dr. Soebandi dan RSU Kaliwates Jember pada 29 November 2019 - 8 Januari 2020 di Ruang Perinatologi. Pengambilan data menggunakan consecutive sampling. Analisis data dilakukan menggunakan Chi-square test dengan p-value < 0,05. Dari 16 neonatus, 8 neonatus memiliki riwayat asfiksia derajat sedang dan 8 neonatus lainnya tidak memiliki riwayat asfiksia. Gangguan fungsi koklea ditemukan pada 3 (37,5%) neonatus dengan asfiksia derajat sedang dan 6 (75%) neonatus tanpa riwayat asfiksia. Hasil penelitian menunjukkan tidak terdapat hubungan antara asfiksia neonatorum derajat sedang dengan gangguan fungsi koklea (p=0,142)
CRISPR-Cas9 Potential in Eradicating HIV Latent Reservoir as The Up-to-date Therapy For HIV-1
No full textAccording to the Ministry of Health in Indonesia, in 2018, there are about 640 thousand cases of people with HIV within the death rate of 38 thousand people. This number grows annually, in fact, according to WHO, there are approximately 38 million people who are diagnosed with HIV in the world in 2019. Thus, HIV-AIDS is a dangerous health problem and needs to be taken care of as soon as possible. HIV (Human Immunodeficiency Virus) is a retrovirus that got its name from the infecting immune cells in the human body. There are two types of HIV, named HIV-1 and HIV-2. Both have the same basic gene arrangement, transmission process, intracellular replication lane, and both cause AIDS. The differences between them are the HIV-1 spreads globally, while HIV-2 locally happens in West Africa. Currently, ART (Antiretroviral Therapy) is the most commonly used method of treatment for HIV-1. Treatment for HIV-1 with ART is effective in controlling HIV-1 virus replication but has not been able to completely eradicate the latent viral reservoir. In the past few years, it is known that there is a CRISPR (Clustered Regularly Interspaced Short Palindromic Repeat) method that can modify genes (DNA) in the body of an organism. However, apart from its potential in handling HIV-1, there are still obstacles in the mechanism
Effect of Artemisia vulgaris Extract on P53 Expression and Caspase-8 Expression (Study on Adenocarcinoma Mammae C3H Mice Given Adriamycin- Cyclophosphamide Chemotherapy Regimen)
No full textBackground: The incidence of breast cancer worldwide is still high. Surgery remains the top choice with other modalities of chemotherapy. radiation. and immunotherapy such as Artemisia vulgaris (AV). Purpose : The study was aimed to demonstrate that administration of AV extract increased the levels of p53 and Caspase-8 in adenocarcinoma mammae.
Methods: This study used "Post test only control group design" on 24 females C3H mice that were randomly selected and divided into four groups : group K (control). P1 (chemotherapy). P2 (extract). and P3 (combination). Adenocarcinoma mammae comes from the inoculation of donor mice. Chemotherapy of Adriamycin 0.18 mg and Cyclophosphamide 1.8 mg were given in 2 cycles. AV 13 mg (0.2 ml) was given once daily orally. P53 and Caspase-8 levels were evaluated by imunohistochemical staining.
Results: Mean of p53 and Caspase-8 levels were found in groups K. P1. P2. P3 were 22.06+1.73. 37.16+1.20. 24.60+1.08. 39.78+1.19 dan 17.16+1.28. 26.20+1.11. 24.60+1.08. 39.78+1.19. The statistical analysis showed that there were significant differences in the levels of p53 between groups of K vs P1. P3 (p=0.001). K vs P2 (p=0.048). P1 vs P2 (p=0.001). P1 vs P3 (p=0.039). P2 vs P3 (p=0.001). and in Caspase-8 between groups of K vs P1. P3 (p=0.001). K vs P2 (p=0.048). P1 vs P2 (p=0.001). P1 vs P3 (p=0.039). P2 vs P3 (p=0.001). Correlation analysis between p53 and Caspase-8 showed significant correlation (p=0.047 dan r=0.883).
Conclusion: Artemisia vulgaris can improve the effectivity of Adriamycin- Cyclophosphamide chemotherapy on C3H mice with adenocarcinoma mammae in terms of elevated levels of P53 and Caspase-8
Chitosan Menurunkan Kadar Ferritin Serum dan Deposit Besi Jantung pada Tikus Putih Wistar (Rattus norvegicus) Jantan Model Iron Overload
No full textKemampuan chitosan untuk mengikat besi dapat diketahui dengan cara mengukur kadar ferritin serum dan depositbesi jantung pada tikus putih wistar (Rattus norvegicus) jantan model iron overload. Metode yang digunakan padapenelitian ini adalah eksperimen laboratorium in vivo. Tiga puluh (30) ekor tikus wistar jantan dibagi menjadi 6kelompok, yaitu kelompok normal (N) diberi makanan standar dan tanpa perlakuan tertentu, kelompok controlnegative (K-) diberi makanan standar dan diinjeksikan iron sucrose 75 mg/KgBB selama lima minggu (3x seminggu)secara intraperitoneal. Kelompok perlakuan terdiri dari P1, P2, P3 diinjeksikan iron sucrose 75mg/kgBB selama limaminggu (3x seminggu) serta diberikan tambahan perlakuan yang berbeda. Selain diberikan makanan standar,kelompok P1 diberikan chitosan secara oral 16 mg/KgBB/hari, kelompok P2 diberikan chitosan secara oral 32mg/KgBB/hari, sedangkan kelompok P3 diberikan chitosan oral 64 mg/KgBB/hari. Kelompok control positif (K+) padapenelitian ini diinjeksi iron sucrose dan diberikan deferiprone 75mg/KgBB/hari secara oral. Hasilnya menunjukkanbahwa pemberian chitosan 16mg/KgBB/hari yang diberikan secara oral tidak memiliki perbedaan secara signifikan(p>0,05) dari pemberian deferiprone oral dalam menurunkan kadar ferritin serum dan deposit besi jantung
Hubungan SNP (Rs867500) Gen STX1A Exon 10 dengan Tingkat Kecerdasan Intelektual
No full textTujuan dari penelitian ini adalah untuk mengetahui hubungan SNP (rs867500) pada gen STX1A Exon 10 dengantingkat kecerdasan intelektual. Penelitian ini merupakan penelitian observasional analitik dengan desain penelitiancross sectional dengan populasi sebesar 368 dan sampel sebesar 36 yang dibagi menjadi dua kelompok, yaitukelompok IQ diatas rata-rata dan kelompok IQ rata-rata. Untuk mengetahui hubungan SNP (rs867500) gen STX1AExon 10 dengan tingkat kecerdasan digunakan uji X 2 (Chi-square). Hasil menunjukkan tidak ditemukan SNPs padagen STX1A exon 10. Gen STX1A dapat dikatakan berkontribusi pada kecerdasan bersama gen lainnya, yaitu GenIGFR2 dan Gen FNBPL1 meskipun tidak terdapat polimorfisme pada gen STX1A exon 10
Efek Ekstrak Buah Ciplukan (Physallis peruvenia) Pada Kadar T4 Tikus Putih
No full textHipertiroid adalah suatu kondisi dimana terjadi peningkatan sintesis dan sekresi hormon tiroid sehingga kadar hormontiroid dalam darah meningkat. Pada tahun 2013 didapatkan data 0,4% penduduk Indonesia mengalami hipertiroid. Buahciplukan (Physalis peruviana) merupakan herba Indonesia yang diduga memiliki efek terhadap hormon tiroid. Jenispenelitian adalah eksperimental in vivo dengan subyek penelitian berupa tikus putih galur Wistar berjumlah 30 ekoryang dibagi menjadi 5 kelompok yaitu kontrol negatif (Akuades), kontrol positif (PTU 100 mg/kgBB), kelompok 3, 4,dan 5 ekstrak buah Ciplukan dengan dosis 250 mg, 500 mg, dan 1000 mg per kilogram berat badan. Hasil pemeriksaanmenunjukkan terjadi penurunan kadar T4 pada perlakuan dengan kontrol positif dan pemberian eksrak buah ciplukan.Terdapat perbedaan penurunan kadar T4 untuk kelompok pemberian ekstrak buah ciplukan dosis 1, 2, dan 3 (p<0,05).Dapat disimpulkan bahwa ekstrak buah Ciplukan dengan dosis 250 mg/kgBB, 500 mg/kgBB, dan 1000 mg/kgBBmemiliki potensi sebagai anti hipertiroid
Severe Anemia in Non Suicide Self Injury as a Complication of Major Depression Disorder
No full textNon suicide self injury (NSSI) is a rare case in adults. Non suicide self injury is an act of hurting himself such as cutting, burning, punching without intending to commit suicide. NSSI itself is a complication of major depression that is not treated properly from the onset of symptoms. Severe depression that lasts for a long time, can aggravate illnesses such as the appearance of symptoms of psychosis and have an impact on various complications such as NSSI and somatic complications that can reduce the patient's health condition. Reported a case of a 22 year old woman with severe anemia due to chronic bleeding. It is known that chronic bleeding in the patient is the result of habitual cutting, in which the patient slashes her left forearm. Cutting habitualis is part of the action of NSSI where the management must be holistic and sustainable, the management of patients consists of psychotherapy as starting from dialectical behavior therapy is a form of cognitive therapy that can help a person adapt to activities that can pass through distress. Psychodynamic therapy is to help someone form new habits that previously could cause pleasure to the patient. Psychotherapy accompanied by psychopharmaceuticals can accelerate improvement in patient