Online Journal Faculty of Medicine Universitas Sriwijaya
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Hubungan Polimorfisme Gen XRCC1 Arg399Gln terhadap Kejadian Kanker Serviks pada Wanita Ras Melayu
No full textKanker serviks merupakan kanker yang terjadi pada serviks atau leher rahim, suatu daerah yang terletak pada organreproduksi wanita yang merupakan pintu masuk ke arah rahim, letaknya antara rahim (uterus) dan liang senggamaatau vagina. Insiden terjadinya kanker serviks dipengaruhi oleh Human Papiloma Virus (HPV), usia, usia terlalu mudaberhubungan seksual, paritas, riwayat keluarga dan RAS. Gen XRCC1 sebagai perancah dalam BER yang terlibatdalam membantu memperbaiki kesalahan-kesalahan selama replikasi DNA serta menjaga integritas genom. SingleNukleotida Polymorphism (SNP) di XRCC1 telah dikaitkan dengan pengembangan yang terjadi pada kanker serviksyang dapat mengurangi aktivitas perbaikan DNA, meningkatkan terjadinya mutasi sehingga kerentanan terhadapkanker. Penelitian ini bertujuan untuk melihat adakah hubungan polimorfisme gen XRCC1 Arg399Gln dengankejadian kanker serviks. Penelitian ini merupakan penelitian observasional analitik dengan desain case-controldengan jumlah sampel sebanyak 35 orang wanita kanker serviks dan 35 orang wanita normal yang setiap sampelmemiliki RAS melayu Jambi. Identifikasi polimorfisme gen XRCC1 Arg399Gln dilakukan dengan teknik PCR-RLFPamplifikasi dengan primer spesifik yang digunakan untuk melihat mutagenesis. Hasil analisis dengan uji Chi-Squaregenotipe G/G (Wild Type), G/A (Mutant Heterozigot) dan G/A (Mutant Heterozigot) terhadap kanker serviks nilai ρ= 0,032 (OR : 10.074 ; CI : 1,186 -85,570). Kesimpulan ada hubungan polimorfisme genotip gen XRCC1 Arg399Glnterhadap kejadian kanker serviks pada wanita RAS Melayu Jambi
Hubungan Antara Anemia dan Kebiasaan Merokok pada Ibu Hamil dengan Kejadian BBLR di Rumah Sakit Umum Pusat Dr. Mohammad Hoesin Palembang Tahun 2016
No full textLow Birth Weight (LBW) is an infant born with a birth weight of less than 2500 grams regardless of gestation. Birth weight is the weight of the baby weighed in 1 hour after birth. (Depkes RI, 2009). Based on WHO and UNICEF data, in 2013 about 222 million babies were born in the world, of which 16% were born with low birth weight. The percentage of LBW in developing countries is 16.5% twice that of developed countries (7%) (Scholar Unand, 2014). The purpose of this study was to determine whether there is a relationship between anemia and Smoking Habit in Pregnant Women with LBW occurrence in General Hospital Dr. Mohammad Hoesin Palembang Year 2016. This research use analytical survey method with cross sectional approach. The population in this study were all mothers who gave birth monthly in Midwifery Installation of Dr. General Hospital Mohammad Hoesin Palembang in 2016 as many as 315 respondents. The sample of this research is some of mothers who give birth enough month in Midwifery Installation of Dr. General Hospital Mohammad Hoesin Palembang Year 2016 as many as 315 respondents. ". From the results of bivariate analysis of anemic respondents with the occurrence of LBW obtained statistical test X2 count = 23.22 which means there is a significant relationship between anemia with the incidence of BBLR. Respondents smoking with the occurrence of LBWR obtained statistical test X2 count = 41.20 which means there is a relationship Meaningful between smoking and LBW incidence. From the results of this study is expected that this research can be a reference material and is a complete information and useful for the development of knowledge about LBW
Benign Tumor in Labia Minora
No full textVulva tumors are generally a rare disease encountered in gynecological clinical practice, especially at a young age. Vulvar tumors, more common in the labia major and rarely in the labia minor, clitoris, vestibulum, and posterior comicura. The most common vulvar benign tumors are fibroma, papilloma, lipoma, angioma, and others. A 39-year-old woman, at RSCM Urogynecology Jakarta clinic with chief complain mass or swelling in right labia minor. Size of mass increases in period of one year. Mass began to grow at 8 months of pregnancy. By 2014, patients have same mass in the right and left labia minor, and tumor excision has been performed. Conclusions of the specimens sent for pathological assessment are fibroepithelial papillomas. Gynecological and palpation examinations show 2 solid papilloma masses, in right labia minor, 8x4x2 cm and 3x2x2cm, painless, and firmly defined. In mons pubis area, skin looks coarse, thickened, hyperkeratotic. Speculum examination showed no abnormality. Patient diagnosed as a recurrent minor armored labia tumor. On December 5, 2017 an excision and reconstruction operation was conducted. Obtained pathological exam on December 20, 2017 with results stromal fibroepithelial polyps. Among all tumors in the vulva, tumors in labia minor appear less frequently. Biopsy should be performed for histologic examination to exclude malignant allegations. Furthermore, because of the location and size of the tumor, it can cause severe interference symptoms in the patient and therefore early diagnosis and treatment is essential
Placental Factors Affecting Birth Weight of Late Onset Severe Preeclampsia
No full textObjective of the study is to determine the correlation of placenta and birth weight in late onset preeclampsia. A case-control study,analysis prevalence was conducted in Moh Hoesin Hospital Palembang from August 2015 to August 2016. Samples were women who giving birth in Moh Hoesin Hospital Palembang. They were devided into two groups, severe preeclampsia as case group and normotension as control. Data were analyzed by X2, Exact Fisher’s and logistic regression test using SPSS 16.0. There were 180 subjects (90 cases and 90 controls). There was a positive correlation between placental macroscopic and late onset preeclampsia (p=0.009; OR=6.9), in contrast there was only one different placental microvascularisation of 16, between late onset preeclampsia and normotension, the mural or occlusive fibrin thrombi chorion (p=0.005; OR=9.9). Birth weight in late onset preeclampsia tended to be small but still in normal range and it was not statistictly significant (p=0.112; OR=10.4). There was a positive correlation between placental macroscopic and SGA baby on late onset preeclampsia (p=0.026; OR=16.6), but it wasnot proven microscopically. Placenta remains contributed to the pathogenesis of the late onset preeclampsia, but not as dominant as the early one
Parental Risk Factors in Children With Intellectual Disability: An Investigation.: Faktor Risiko Orang Tua Pada Penyandang Disabilitas Intelektual (DI) di Sekolah Luar Biasa (SLB) Palembang
No full textIntellectual Disability (ID) is a condition where there is a significant disturbance in one’s development including social, cognitive and adaptive function. The prevalence of ID worldwide is varied, whereas its prevalence in South East Asia including Indonesia is quite high. The exact cause of ID is yet to be known. A couple of risk factors are believed to be involved in the occurence of ID. This study aims to identify parental risk factors in children with ID in Special Need School in Palembang. This is a observational descriptive study towards children with ID in Special Need School in Palembang. Primary data were obtained from direct interview and questionnaire filled by parents. Variables being identified were Paternal risk factors (age and smoking habit), Maternal risk factors (age, parity, drug and herbs consumption history during pregnancy, smoking exposure during pregnancy) and family history. There are 68 samples who are mostly male (64.70%) with Mild ID (60.29%). Majority of the Father were <35 years old when they had their child (64.71%) with a smoking habit of 52.94%. Most Mother were age 21-35 years old when pregnant, with parity history of less than 4 (77.94%). Children with ID in Special Need School Palembang showed similar risk factors compared to previous studies. It is hoped that the prevalence of ID can be reduced by preventing the known risk factors
Hubungan Pengetahuan Akseptor Kb terhadap Pemakaian Kontrasepsi Implan di Kota Palembang Tahun 2017
No full textData of Health Office of Palembang City Year 2014, from 16 sub districts in Palembang city, there are 4 districts which proportion of new KB 0% implant participants, ie District Ilir Barat II, Plaju, Kalidoni and Sematang Borang where from 4 Subdistricts have 6 Puskesmas with each of the proportion of participants of new KB Implants also 0% Sie Makrayu Health Center, Plaju, Bukit Sangkal, Kalidoni, Sei Selincah and Sematang Borang. This study aims to know the relation of knowledge of acceptor of KB to implant contraception usage in Palembang city year 2017. This research design is analytic survey with Cross sectional approach. The population used by the researcher is the family planning acceptors who are in the working area of Makrayu Health Center, Plaju, Sarang Hill, Kalidoni, Sei Selincah and Sematang Borang City of Palembang in 2017 and the sample number is 30 respondents. Sampling technique using Simple Random Sampling approach. Bivariate analysis using chi square statistical test (α = 0,05). The instrument used for data collection is a questionnaire conducted at 6 health centers in Palembang city. The results obtained p value 0.002 <α (0.05), it shows that there is a relationship between the knowledge of respondents with the use of contraceptive implants in Palembang City Year 2017. Test results also obtained OR = 3,143. The conclusion of this research is that there is a correlation between the knowledge of respondents with the use of contraceptive implants in Palembang City in 2017. It is expected to build positive information about KB Implant by involving the role of health cadres through extension activities and dissemination of information about the success of Implant use
Relationship of Scabies With Pioderma: As a Risk Factor
No full textScabies is a parasitic infestation of the skin, that is affecting on the low income and crowded community in many tropical countries, especially developing countries such as Indonesia. Scabies infestation increases the incidence of secondary pyoderma include impetigo, folliculitis, cellulitis, ecthyma, abscess. Secondary pyoderma is a skin infection disease mainly caused by group A Streptococcus (GAS) and Staphylococcus aureus (SA). Pyoderma is a risk factor for the glomerulonephritis infection, rheumatic diseases, which significantly increases morbidity and mortality, causing the government burden. The aim of this study is determining the etiology and correlation of pyoderma infection in scabies patient. To determine sosio-demographic included sex, age in pediatric patients in primary schools (SD) in the district of Kertapati Palembang. The study design was cross sectional, and study samples were new scabies patients in the elementary school (age 6-14-year-old) with or without pyoderma. Clinical findings included history, physical examination and diagnostic procedure, which was investigation of skin scraping specimen material (SSB = skin surface biopsy) in confirmation with dermoscopic polar examination (DS) to show Sarcoptes scabiei mites. Microbiological examination with Gram stain identified the etiology of pyoderma. Results of this study shows that there was a significance relationship between scabies infestation and pyoderma in children in elementary school. Staphylococcus aureus dan GAS are the most common caused of pyoderma in pediatric patients with scabies. Conclusion is there is a significant correlation between scabies and pyoderma. There is a need to provide scabies and pyoderma medication at primary care health center as well as counseling for prevention in Palembang area with crowded population periodically.
 
Maternal Knowledge Factor, Maternal Age and Maternal Parity Associated with Genesis of Normal Delivery at Palembang Hospital of Bari Year 2017: Faktor Pengetahuan Ibu, Umur Ibu dan Paritas Ibu yang Berhubungan dengan Kejadian Persalinan Normal di RSUD Palembang Bari Tahun 2017
No full textChildbirthis a processLabor of opening and depleting the cervix and the fetus down into the birth canal. Birth is a process in which the fetus and amniotic are pushed out through the birth canal. (Sarwono, 2008). According to the World Health Organization (WHO) estimates more than 585,000 mothers annually die during pregnancy or childbirth. Indonesia Health Demographic Survey (SDKI) Survey in 2012, Maternal Mortality Rate in Indonesia is still high at 359 per 100,000 live births. The purpose of this study is the knowledge of maternal knowledge, maternal age, and maternal parity associated with normal birth events at Palembang Bari Hospital 2017. This study used analytical survey method with cross sectional approach. The population in this study were all maternal mothers at the Palembang Bari Hospital in 2017. Sampling in the study was conducted non-randomly with the technique of "Accidental Sampling". Data analysis was done univariat and bivariate with Chi-Square statistical test with significance level α = 0,05. The result of this research shows that there is correlation between mother's knowledge with normal delivery incidence with p value 0,001, there is correlation between mother age with normal delivery incidence with p value 0,009, there is relation between mother parity with normal delivery incidence with p value 0,001. From result of this research hopes healthcare workers can improve normal delivery care services and more often to carry out maternal safety counseling
Analisis Gen Blavim, Blandm dan Blaimp Carbapenemase dengan Alat Otomatis Vitek-2 dan Metode Polymerase Chain Reaction (PCR) pada Isolat Bakteri Enterobacteriaceae di RSUP Dr. Moh. Hoesin Palembang
No full textEnterobacteriaceae is a normal flora in human intestinal tract which the most frequently caused the disease in human. Carbapenem is the last lines of antibiotic which used to treat severe infection that caused by gram-negative bacili bacteria, for example Enterobacteriaceae, but there is an increase prevalency of infection which caused by Carbapenem Resistant Enterobacteriaceae (CRE). The gene that encoding CRE is blaVIM, blaNDM, and blaIMP gene. The detection of these genes are very important to prevent spreading the nosocomial infection at hospital. The samples are from the speciment which has detected as isolate of Extended Spectrum Beta Lactamase (ESBL) Enterobacteriaceae bacteria and has occurred resistant to carbapenem group (meropenem and ertapenem) which detected by automatic equipment, VITEK 2 compact system. These samples will be processed by PCR with multiplex PCR technique to indentify blaVIM, blaNDM, and blaIMP gene. There are 43 samples consist of 33 samples (76,7%) ESBL bacteria isolate and 10 samples (23,3%) Carbapenemase bacteria isolate, 29 samples (67,4%) are Klebsiella pneumonia and 14 samples (32,6%) E. coli. These samples were from blood (5 samples/ 11,6%), sputum (16 samples/ 37,2%), peritoneal fluid (1 sample/ 2,3%), pus (4 samples/ 9,3%), urine (12 samples/ 28%), swab (3 samples/ 7%), tissue (1 sample/ 2,3%), and feces (1 sample/ 2,3%). From the PCR result, the gene was indentified from Enterobacteriaceae bacteria isolate was 28 samples (65,11%) from 43 samples. The indentified samples consist of 9 samples (32,1%) Carbapenemase bacteria isolate and 19 samples (67,9%) ESBL bacteria isolate. The identified of Enterobacteriaceae bacteria isolate consist of 15 samples blaNDM gene, 17 samples blaVIM gene, and 4 sample blaIMP gene
Prevalence of CYP2C19 Gene Polymorphism and Its Influence In Omeprazole Metabolism As Predictors Of Drug Inoxification In Malay Ethnic In South Sumatra: Prevalensi Polimorfisme Gen CYP2C19 dan Pengaruhnya Dalam Metabolisme Omeprazole Sebagai Prediktor Intoksikasi Obat Pada Etnis Melayu Di Sumatera Selatan
No full textCytochrome P450 2C19 (CYP2C19) is an enzyme complex that plays a role in the metabolism of several drugs and is part of the super family of cytochrome P450. Genetic polymorphisms in these enzymes are associated with the emergence of poor metabolic phenotypes (poor metabolizers / PMs and intermediate metabolizers / IMs) that have a poor ability to metabolize the drugs that become substrates. Genotypes and phenotypes were analyzed using PCR-RFLP and bio-analysis of omeprazole levels in 30 subjects from ethnic Malay living in South Sumatra. Markers used to assess the presence of polymorphisms in the CYP2C19 gene are two polymorphic sites of exon 5 (CYP2C19 * 2) and exon 4 (CYP2C19 * 3). 321 bp DNA bands for exon 5 and 271 bp for exon 4 will be produced after DNA amplification by PCR method under denaturation for 5 min at 95oC; followed by 60 seconds at 95oC, 60sec at 53oC and 60sec at 72oC for 30 cycles; as well as the final polymerization for 5 minutes at 72 ° C. Furthermore, DNA cutting was done using the restriction enzyme endonuclease SmaI (CYP2C19 * 2) at 30oC and BamHI (CYP2C19 * 3) with incubation at 37oC for 3 hours. Bioanalysis of omeprazole levels in the blood with LC-MS. The results of this study indicate the presence of polymorphisms on both sites will eliminate the enzyme sites SmaI and BamHI. The results showed that 46.7% of South Sumatran Malay populations were classified as PM consisting of 13.3% homozygous mutandan mutant 33.4% heterozygotes. The high phenotype of PM enzyme CYP2C19 in ethnic Malays in South Sumatra predicted to influence metabolism of drugs become substrates. However, based on spearman correlation analysis, the correlation value was 0.035 with p = 0.875. This means that between the CYP2C19 gene polymorphism and the omeprazole levels in the blood there is a weak and meaningless correlation. The results of this study provide an overview of the high genetic polymorphisms of dyspepsia syndrome patients from the Malay population, ie almost half of the study subjects (46.7%). There is a weak and insignificant correlation between polymorphism and omeprazole levels