Online Journal Faculty of Medicine Universitas Sriwijaya
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Perubahan Berat dan Histologi Testis Tikus Putih Jantan (Rattus Norvegicus) Akibat Pemberian Fraksi Daun Jambu Biji Merah (Psidium Guajava L.)
No full textDaun Jambu Biji Merah (Psidium guajava L.) merupakan tanaman yang banyak tumbuh di Indonesia. Kandungankimia yang terdapat dalam daun jambu biji merah adalah alkaloid, flavonoid, tanin, minyak atsiri dan beta-sitosterol yang diduga bersifat antifertilitas. Terrjadinya peningkatan jumlah penduduk yang sangat tinggi yaitu1,49% per tahun maka perlu dikembangkan metode kontrasepsi pada pria yang aman, efektif dan reversibelitastinggi. Penelitian ini bertujuan untuk menganalisis perubahan berat dan histologi testis tikus putih jantan (Rattusnorvegicus) akibat pemberian fraksi daun jambu biji merah. Metode penelitian yang digunakan adalah trueexperiment dengan rancangan post test control group design menggunakan 24 ekor tikus jantan yang dibagimenjadi 4 kelompok perlakuan yang masing-masing kelompok terdiri atas 6 tikus jantan. Setiap kelompok diberiperlakuan fraksi n-heksan, etil asetat, metanol air sebanyak 80 mg/ekor/hari selama 48 hari dan untuk kelompokkontrol diberi CMC 1% 2 ml, pemberian dilakukan dengan cara sonde oral. Hasil penelitian menunjukkan adanyapenurunan rata-rata berat testis, diameter tubulus seminiferus, tebal epitel tubulus seminiferus serta penurunanjumlah sel Leydig antara kelompok kontrol dengan kelompok perlakuan. Berat testis dan diameter tubulusseminiferus pada hasil uji pos hoct tes antara kelompok kontrol dan kelompok perlakuan didapatkan nilai p<0,05artinya ada perbedaan yang sangat signifikan tebal epitel tubulus seminiferus antara kelompok kontrol dankelompok perlakuan. Begitu juga pada tebal epitel tubulus seminiferus dan jumlah sel Leydig, pada hasil uji poshoct test didapatkan nilai p<0,05. Dari hasil penelitian dapat disimpulkan bahwa fraksi daun jambu biji merahdapat menurunkan berat testis, diameter tubulus seminiferus, tebel epitel tubulus seminiferus dan jumlah selLeydig
Efek Ekstrak Daun Jati Belanda terhadap Kadar Myeloperoxidase Jaringan Paru Tikus Putih Wistar Model Kontusio Pulmonum
No full textKontusio pulmonum adalah cedera pada parenkim paru yang sering terjadi akibat trauma tumpul pada dinding dada.Cedera ini akan mengaktivasi respon inflamasi yang dapat menghasilkan efek stres oksidatif sehingga akhirnya terjadikerusakan jaringan paru. Beberapa studi mengindentifikasi efek ekstrak daun jati belanda terkait proses inflamasi danefeknya sebagai antioksidan. Penelitian ini merupakan studi eksperimental secara in vivo dengan pendekatan prepost-test with control group design yang bertujuan mengetahui efektivitas ekstrak daun jati belanda (Guazuma ulmifolia)dalam proteksinya terhadap sel alveolar paru dengan praperlakuan kontusio pulmonum. Subyek penelitian ini ialah tikusputih (Rattus norvegicus) galur Wistar yang terbagi menjadi 5 kelompok yaitu kontrol positif, kontrol negatif, ekstrakdaun jati belanda 125 mg/kgBB, 250 mg/kgBB dan 500 mg/kgBB. Tikus diinduksi dengan menjatuhkan beban seberat400 gram setinggi 50 cm. Hasil penelitian Ekstrak Daun jati belanda (EDJB) semua dosis dan kontrol positif dapatmenurunkan kadar ekspresi myeloperoksidase secara signifikan (p<0.05). Oleh karena itu, dapat disimpulkan ekstrakdaun jati belanda (Guazuma ulmifolia) semua dosis efektif dalam menurunkan ekspresi myeloperoxidase pada jaringanpulmo tikus putih Wistar yang diinduksi kontusio pulmonum
Effectiveness of Tamarillo Skin Extract (Solanum betaceum Cav.) with Sealer Combination in Inhibiting Growth of Enterococcus faecalis
No full textIntroduction : Caries is a growth medium for pathogenic micro-organisms an inflammatory process can occur which can cause damage to the tooth pulp. Enterococcus faecalis one of the Gram-positive facultative anaerobes which causes failure after endodontic treatment. In the field of dentistry, herbal ingredients can be used as alternative medicinal ingredients because the ingredients is tamarillo skin which contains flavonoids, terpenoids, saponins and phenol compounds. In addition to herbal alternatives, endodontic filling also uses ingredients that have antibacterial potential that can kill and prevent reproduction in the root canals, one of which is the zinc oxide eugenol sealer which is usually applied together with gutta percha.
Research objective: to determine the effectiveness of the extract of tamarillo (Solanum betaccum Cav.) skin sealer combination in inhibiting the growth of Enterococcus faecalis.
Method: The research was conducted in an experimental laboratory post test only control group design.
Results : a sealer made from zinc oxide-eugenol had the largest diameter compared to the combination group of 100%, 75%, 50%, 25% tamarillo skin extract with sealer, and aquadest. Based on the One Way Anova test, there was a significant difference in the mean diameter of the inhibition zone (p <0.05) and the Post Hoc LSD analysis test showed that the sealer was the best group to kill the Enterococcus faecalis bacteria.
Conclusion : sealers have a good effect on inhibiting Enterococcus faecalis bacteria as a cause of failure in endodontic treatment
Malignant Brain Lymphoma Based on Age, Gender, Symptoms, Imaging Modality, Hiv Examination, And Histopathology at Dr. Kariadi Central General Hospital Semarang From January 2016 to December 2018
No full textBackground: Primary CNS Lymphoma (PCNSL) is rare cancer from the brain or spinal cord lymphatic tissue. The incidence increased in patients over 60 years, with an incidence rate of 0.5/100,000 per year. PCNSL associated with poor survival. The aim of the study was to determine the incidence of Brain Malignant Lymphoma based on age, gender, symptoms, imaging modalities, HIV examination, and histopathological results at dr. Kariadi Semarang.
Methods: This is a retrospective descriptive study. We collected brain malignant lymphoma patient’s medical records who came to the ER and the Neurosurgery Polyclinic of Dr. Kariadi Semarang from period January 2016-December 2018.
Results: There were 1,012 brain tumor patients, 6 patients were brain malignant lymphoma with the highest prevalence in the age range of 45-65 years (5 patients) and 66.67% male. The most common symptom was blurred vision 23.07%. The imaging modalities showed lesions on: right parietal lobe 14.29%, sella region 14.29%, parasella region 14.29%, cerebellum 14.29%, IV ventricle 14.29%, vertebrae sacrum 2-5 14.29 %, and the fronto-temporo-parietal region 14.29%. No HIV test data were obtained. According to histopathology, Diffuse large B cell Lymphoma Malignant non Germinal Center (DLBCL) and High grade, B cell Non Hodgkin Lymphoma (small type) each were 33.33%.
Conclusions: The prevalence of malignant brain lymphoma cases was highest in the 45–65 year age group and male, with blurred vision. Most of the results of imaging modalities show an even distribution of brain malignant lymphomas and generally do not do HIV testing. The most common histopathological diagnosis was DLBCL
Use of 99m Tc in The Field of Radiofarmation: A Review
No full textA B S T R A C TTechnetium-99m ( 99m Tc) has been applied in nuclear medicine as a radiopharmacyfor both diagnosis and therapy. 99m Tc is obtained from a 99 Mo/ 99m Tc (half-life 66 h)generator in the form of sodium pertechnetate (Na[ 99m TcO 4 ]) by decaying to 99 Tc for 6hours and emitting gamma energy rays (Eɤ = 140 keV). This radionuclide has anelectron configuration of 4d 5 5s 2 , which will form complexes with different ligandsand have oxidation rates from +1 to +7. The coordinated complex of technetium-99mhas been utilized in nuclear medicine in tissues and organs (thyroid, red and whiteblood cells, kidneys, brain, myocardial, and bone). The resulting kit production musthave based on Good Manufacturing Practice, which consists of batch planning,washing, sterilization of glassware and stopper, starting material, preparation oflarge quantities of the solution, sterile filtration, dispensing, crimping, a summary ofprocess control, quarantine, packaging and leaving the production premises
Molahidatidosa from Pathophysiology to Clinical: Literature Review
No full textA B S T R A C THydatidiform is a gestational trophoblast disease which is histopathologicallycharacterized by the proliferation of avascular trophoblast cells and corial villi andundergoing hydrophic degeneration. The proliferation of trophoblast cells inhydatidiform moles can be in the form of cytotrophoblast, syncytiotrophoblast orintermediate trophoblast proliferation
Characteristics and Patterns of Deep Neck Infection in Dr. Mohammad Hoesin General Hospital Palembang 2020
No full textIntoduction: Deep neck infection is the accumulation of pus in the potential space and facial area in the deep neck. The incidence of deep neck space infections is 1/100.000 in adults and 2/100.000 in children. Risk factors such as age, oral hygiene, and comorbidities such as DM are predisposed factors in deep neck infection. Effective pus collection of specimens is essential, to obtain the organisms and determine the effective antibiotics.
Purpose: The aim of this study was to describe the characteristics and bacterial patterns of abscess in Dr. Mohammad Hoesin General Hospital Palembang.
Methods: This study was conducted retrospectively using medical records of patients who diagnosed deep neck infection in Dr. Mohammad Hoesin General Hospital Palembang during January to December 2020 who took pus collection and been checked in microbiology laboratory. Data recorded include gender, age, site, onset, risk factors, comorbidities, bacteria culture, antibiotic sensitivity, and complications.
Results: Of the 36 patients, 23 (63.8%) were males, followed by 13 (36.1%) were female, and the age of 31-45 years old group were found in 13 subjects (36.1%). The onset was mostly found at 0-1 week as many as 19 subjects (52.7%). The highest complaints of dysphagia and odynophagia were found in 22 cases (26,2%), odontogenic factors were found in 35 cases (97,2%). Abscess location in multiple space were found in 17 cases (47,2%), while in single space there were 19 cases (52.7%), where the most location was in submandibular space in 7 cases. Diabetes was the most comorbid factors found in 6 subjects (50%). The most bacterial were Klebsiella pneumoniae in 4 cases (11.1%) and sensitive antibiotics including ciprofloxacin, meropenem, and tigecycline, in 6 cases (20%) respectively. And the most complication was mediastinitis in 6 cases (75%).
Conclusion: Klebsiella pneumoniae is the most common found in deep neck infection with sensitive antibiotics including ciprofloxacin, meropenem, and tigecycline
Effect of Non-Coding Region RNA Gene XIST (X-Inactive Specific Transcript) on Human Breast Cancer
No full textX chromosome is a sex chromosome found in both women and men. The inactivation of the X chromosome is linked to a non-coding region of RNA known as the XIST gene (X-inactive specific transcript). This gene is located in the X inactivation center (XIC X-inactive center). The XIST gene is a region that belongs to the RNA group, non-coding transcripts (NCT), also known as microRNA. Breast cancer (Breast Cancer) is a type of cancer that commonly affects women, but men can develop breast cancer, but the chances are small, about 1 in 1000. Breast cancer is a cancerous neoplasm that is malignant, and occurs in the mammary gland. The presence of a specific XIST gene on the X chromosome and the prevalence of breast cancer, which is mostly in women, raises the idea that there is an influence of this gene on breast cancer (breast cancer) in the epigenetic process. The XIST gene related to microRNA has an opportunity to be looked at because certain microRNAs have a greater or lesser level (concentration) in cancer cells than normal cells. This is a new opportunity to continue to be developed as a consideration for a new treatment method involving gene therapy
Korelasi Antara Kadar Feritin Serum dan Status Gizi Pasien Talasemia-β Mayor
No full textTalasemia adalah penyakit kronik yang membutuhkan transfusi darah berulang, karena adanya gangguan sintesishemoglobin akibat mutasi dari satu atau lebih gen globin. Transfusi secara terus menerus dapat menyebabkanterjadinya penimbunan besi dalam tubuh khususnya jantung, hati, dan organ endokrin, serta dapat menyebabkanpertumbuhan yang terhambat dan gizi kurang atau gizi buruk. Penelitian ini bertujuan untuk mengetahui korelasiantara kadar feritin serum dan status gizi pasien talasemia-β mayor di RSUP Dr. Moh. Hoesin Palembang.Penelitian ini merupakan penelitian observasional analitik dengan desain cross sectional. Sampel penelitian iniadalah pasien talasemia-β mayor yang menjalani rawat inap di Departemen Ilmu Kesehatan Anak RSUP Dr.Mohammad Hoesin pada bulan Oktober hingga November 2016 yang memenuhi kriteria keikutsertaan. Dari 43pasien, sebagian besar (60.5%) pasien memiliki badan kurus sesuai dengan indeks berat badan menurut usia(BB/U) dan berperawakan pendek sesuai indeks tinggi badan menurut usia (TB/U), namun hanya 14.0% pasienmemiliki gizi kurang menurut indeks BB/TB. Didapatkan nilai rata-rata kadar feritin serum 2837.69 μg/L, denganrentang 278.7-13867 μg/L. Hasil uji korelasi antara kadar feritin serum dan status gizi menunjukkan nilai p=0.326dan nilai r=0.153. Terdapat korelasi yang tidak bermakna antara kadar feritin serum dan status gizi pasientalasemia-β mayor
Immunology Aspects in Tension-Type Headache Chronicity
No full textTension-Type Headache (TTH) headache is a type of primary headache which mostlycomplained by patients. The pain often ignored due to low mortality rates. Inadequatemanagement makes the pain becoming chronic and causing a high disability rate. Many factorsinvolved in transforming infrequent tension-type headache to chronic tension-type headache.A deeper understanding of the immune system's role in the pathophysiological process andmodulation of chronic pain could be a potential target for developing therapies in managingchronic pain