Online Journal Faculty of Medicine Universitas Sriwijaya
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The Hubungan Kepadatan Sel Plasma dengan Karakteristik Klinikohistopatologi pada Diffuse Large B Cell Lymphoma
No full textDiffuse Large B Cell Lymphoma (DLBCL) is a malignancy derived from the malignant transformation of B cells from the germinal center. This type of non-Hodgkin's lymphoma is the most common and represents about 30-40% of all cases. The tumor microenvironment of B-cell lymphoma plays an important role in the regulation of tumor cell survival and proliferation. Plasma cells in the tumor microenvironment have an important role in the formation of the anti-tumor immune response, even in low numbers, these cells can produce large amounts of cytokines and antibodies. The purpose of this study was to determine the relationship between plasma cell density and clinico-histopathological characteristics of DLBCL patients. A cross-sectional study was conducted. The samples of this study were paraffin blocks of DLBCL patients referred to Anatomic Pathology Departement Faculty of Medicine Universitas Sriwijaya/RSUP Dr. Mohammad Hoesin Palembang. From 50 cases during the 2018-2020 period, 32 samples were selected. Plasma cells were morphologically identified on HE slides. Statistical analysis was performed using the chi-square test. The distribution of DLBCL cases found more in the age group <60 years (56,3%), male gender (68,8%), extranodal tumor location (56,3%). Centroblastic variants were higher (78,1%) than others, and the non-GCB subtype (78,1%) was higher than the GCB. There is no significant relationship between plasma cell density and the clinico-histopathological characteristics of DLBCL age, sex, tumor location, variant, and subtype.Diffuse Large B Cell Lymphoma (DLBCL) adalah kelompok keganasan heterogen yang berasal dari transformasi sel B dari germinal center. Jenis limfoma non-Hodgkin ini paling umum dan mewakili sekitar 30-40% dari semua kasus. Lingkungan mikro tumor pada limfoma sel B berperan penting dalam regulasi kelangsungan hidup dan proliferasi sel tumor. Sel plasma berada dalam infiltrasi tumor memiliki peran penting membentuk respon imun antitumor, bahkan dalam jumlah yang rendah, sel ini dapat menghasilkan sejumlah besar sitokin dan antibodi. Tujuan penelitian ini untuk mengetahui hubungan kepadatan sel plasma dengan karakteristik klinikohistopatologi pada DLBCL. Penelitian ini menggunakan metode cross-sectional. Sampel penelitian ini yaitu blok parafin pasien DLBCL di Departemen Patologi Anatomi RSUP Dr. Mohammad Hoesin Palembang. Dari 50 kasus DLBCL selama periode 2018-2020, dipilih 32 sampel yang memenuhi kriteria inklusi. Identifikasi sel plasma dilakukan dengan melihat morfologinya pada slide HE. Analisis statistik menggunakan uji chi-square. Sebaran kasus DLBCL lebih banyak pada kelompok usia <60 tahun (56,3%), jenis kelamin laki-laki (68,8%), lokasi tumor di ekstranodal (56,3%), varian terbanyak centroblastik (78,1%), serta subtipe non-GCB (78,1%). Tidak terdapat hubungan bermakna antara kepadatan sel plasma dengan karakteristik klinikohistopatologi yang meliputi usia, jenis kelamin, lokasi tumor, varian dan subtipe pada DLBCL
Analysis of Factors Associated with the Healing Status of Pulmonary Tuberculosis Patients at Puskesmas Perumnas 1 Pontianak in 2018
No full textFactors Related to the Healing Status of Patients with Pulmonary Tuberculosis in Puskesmas Perumnas 1 Pontianak2018. Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis that is still a global healthproblem. The healing of patients from TB is important to note because it can harm public health such as providingopportunities for TB disease transmission to family members and the surrounding community, thereby increasing thespread of disease and deaths due to TB. The recovery of TB patients is influenced by several factors such as age, sex, levelof education, knowledge, level of income, access to health services, the role of PMO and treatment compliance. Thisstudy aims to determine the factors associated with the healing status of TB sufferers. This type of research is analyticdescriptive with a cross-sectional design. The instruments used were questionnaires and patient medical records. Datawere obtained by interviewing 106 pulmonary TB patients at their home who had been treated with category 1treatment for 6 months in Perumnas 1 Health Center in Pontianak City. The results of Chi-square test showed that gender(p=0.005), level of education (p=0.002), knowledge (p=0.008), the role of PMO (p=0.001) and medication adherence(p=0.000) are related to the healing status of TB sufferers, while age (p=0.320), income level (p=0.728) and access tohealth services (p=0.141) are not related to the healing status of TB sufferers. Counseling about factors related to TBrecovery is expected to increase the cure rate of TB patients.Tuberkulosis (TB) merupakan penyakit menular yang disebabkan oleh Mycobacterium tuberculosis, dan sampai saat ini masih merupakan masalah kesehatan di dunia. Kesembuhan pasien dari penyakit TB merupakan hal yang penting untuk diperhatikan karena dapat berdampak negatif pada kesehatan masyarakat seperti memberi peluang terjadinya penularan penyakit TB kepada anggota keluarga dan masyarakat sekitar, sehingga menambah perluasan penyakit dan kematian akibat TB. Kesembuhan pasien TB dipengaruhi beberapa faktor seperti usia, jenis kelamin, tingkat pendidikan, pengetahuan, tingkat pendapatan, akses ke layanan kesehatan, peran PMO dan kepatuhan berobat. Penelitian ini bertujuan untuk mengetahui faktor-faktor yang berhubungan dengan status kesembuhan penderita TB. Jenis penelitian ini adalah deskriptif analitik dengan desain potong lintang. Instrumen yang digunakan adalah kuisioner dan rekam medis pasien. Data diperoleh dengan cara mewawancarai 106 pasien TB paru di rumah pasien yang telah berobat dengan pengobatan kategori 1 selama 6 bulan di Puskesmas Perumnas 1 Kota Pontianak. Hasil penelitian dengan uji Chi Square menunjukkan bahwa jenis kelamin (p=0,005), tingkat pendidikan (p=0,002), pengetahuan (p=0,008), peran PMO (p=0,001) dan kepatuhan berobat (p=0,000) memiliki hubungan dengan status kesembuhan penderita TB, sedangkan usia (p=0,320), tingkat pendapatan (p=0,728) dan akses ke layanan kesehatan (p=0,141) tidak memiliki hubungan dengan status kesembuhan penderita TB. Penyuluhan mengenai faktor yang berhubungan dengan kesembuhan TB diharapkan dapat meningkatkan angka kesembuhan pasien TB
The Incidence of Knee Pain Complaints in Pedicab Riders in the Kemuning District, Palembang
No full textBackground: Knee pain is a major source of disability, and the most frequently complained of disease in people aged 50years and over, this complaint is often associated with osteoarthritis. Complaints of knee pain in OA patients are stronglyassociated with decreased stability of the knee joint. As the main stabilizer in the knee joint, extensor muscle strengthplays a major role in the pain complaints that occur, so that one of the recommended physiotherapy measures for kneeosteoarthritis patients in reducing pain complaints is to exercise the knee extensor muscle strengthening in the form ofpedaling a bicycle. The pedaling movement is a work activity carried out by pedicab drivers. Therefore, this study wasconducted to determine the incidence of knee pain complaints in pedicab riders in the District of Kemuning, Palembang.Method: This type of research is descriptive with cross sectional study design. The study population was pedicab driverswho operated in the Kemuning District of Palembang. Primary data were collected by conducting interviews todetermine whether there were complaints of pain in the knee and assessed by the KOOS Score and Numeric Rating Scale(NRS), as well as measurements of body weight and height. Results: The results showed that 8 pedicab drivers (17.8%)complained of knee pain and 37 pedicab drivers (82.2%) did not complain of pain in their knees. Conclusion: Theincidence of knee pain complaints among pedicab drivers in the Kemuning sub-district of Palembang is lower than that ofpedicab drivers who do not complain of pain in their knees
Oral Discomfort And Impaired Oral Function In The Fixed Lingual Orthodontic Treatment
No full textIntroduction: Aesthetic consideration has become an important component for patients to decide the use of fixed orthodontic appliance, one of which is the fixed lingual orthodontic appliance. However, there are still many complaints about the discomfort felt by the patient that affects their compliance to the treatment. This paper aims to deliver the knowledge regarding oral discomfort and impaired oral function in the fixed lingual orthodontic treatment to be used as operator and patient education material. Materials and Methods: “lingual braces” was the sole keyword used in three journal databases (Google Scholar, ScienceDirect, and PubMed) resulted in 11 journals that was used in this paper. Results: complaints were mostly about speech disturbance (6 journals), discomfort on the tongue (5 journals), pain (1 journal), difficulty in cleaning the oral cavity (4 journals), difficulty in chewing and dietary changes (3 journals), and caries (2 journals). Discussion: discomfort arising during treatment was largely associated with the reduced space which was occupied by the tongue at rest. This resulted in the continuous contraction of the tongue muscles. The contraction increases discomfort and resulted in impaired oral functions such as speech and chewing. The use of bracket that is closer to the surface of the teeth can reduce complaints. Conclusion: the lingual orthodontic bracket position and type of the system used in the treatment affects the patient's comfort. Most of the discomfort appeared in the first 3 months of treatment and decreased with time.
 
Regulation of Cell Cycle
No full textThe cell cycle is a vital process in the life of every organism. Normally, the cell cycleresults in cell division. Cell division consists of 2 main processes, namely DNAreplication and chromosome division that has been duplicated into 2 daughter cells.Cyclin is expressed periodically so that the cyclin concentration varies at each phase ofthe cell cycle. Cdks are threonine or serine protein kinases which must bind to cyclinfor its activation. The concentration of Cdks is relatively constant during the cell cycle.Cyclin-dependent kinase inhibitor (CKI) is a protein that can inhibit Cdk activity bybinding to Cdk or the cyclin-Cdk comple
Neoadjuvan Chemotheraphy Responses to Local Advanced Breast Cancer Patients at Dr Moh Hoesin Hospital Palembang
No full textNeoadjuvant Chemotherapy Responses on Locally Advanced Breast Cancer Patients in General Hospital of Mohammad Hoesin Palembang. Breast cancer is a malignancy which invaded breast tissue in the form of ductal or lobular. One most therapy which given is neoadjuvant chemotherapy. Neoadjuvant Chemotherapy can reduce tumor size so that surgery can be performed with good for breast removal with Modification of Radical Mastectomy (MRM) and Breast Conservative Therapy (BCT). This purposes from this research is to find out neoadjuvant chemotherapy response in Locally Advanced Breast Cancer Patients which is received chemotherapy treatment in RSUP dr Mohammad Hoesin Palembang. This observational descriptive study was conducted at RSUP Mohammad Hoesin Palembang in period between October until November 2019. The sample of this study was locally advanced breast Cancer patients who underwent chemotherapy that met the inclusion and exclusion criteria. The data were obtained by interviews and observed medical record from the patients which were then analyzed by univariate analysis using SPSS version 25. In this study there were 34 locally advanced breast cancer patients who fulfilled the inclusion and exclusion criteria. 24 of 34 patients (70,6%) received positive response and 10 of 34 patients (29,4%) received negative response. Many factors can determine the success of chemotherapy neoadjuvant one of them is a status of molecular subtype from breast cancer patients that must be managed with hormonal therapy and the provision of appropriate chemotherapy regimens also determine the success rate of neoadjuvan therapy in local breast cancer patients.Breast cancer is a malignancy which invaded breast tissue in the form of ductal or lobular. One most therapywhich is given is neoadjuvant chemotherapy. Neoadjuvant Chemotherapy can reduce tumor size so that surgerycan be performed with good breast removal with Modification of Radical Mastectomy (MRM) and BreastConservative Therapy (BCT). This purpose from this research is to find out neoadjuvant chemotherapy response inLocally Advanced Breast Cancer Patients which has received chemotherapy treatment in RSUP dr MohammadHoesin Palembang. This observational descriptive study was conducted at RSUP Mohammad Hoesin Palembang inthe period between October until November 2019. The sample of this study was locally advanced breast Cancerpatients who underwent chemotherapy that met the inclusion and exclusion criteria. The data were obtained byinterviews and observed medical records from the patients which were then analyzed by univariate analysis usingSPSS version 25. In this study there were 34 locally advanced breast cancer patients who fulfilled the inclusion andexclusion criteria. 24 of 34 patients (70,6%) received positive response and 10 of 34 patients (29,4%) receivednegative response
UJI VALIDITAS DAN RELIABILITAS BOREDOM PRONENESS SCALE (BPS) VERSI BAHASA INDONESIA PADA MAHASISWA PROGRAM STUDI PENDIDIKAN DOKTER FAKULTAS KEDOKTERAN UNIVERSITAS SRIWIJAYA
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Abstract
Validity and Reliability Testing of Boredom Proneness Scale Indonesian Version Amongst Faculty Medicine Sriwijaya University. Boredom is defined as a state of relatively low arousal and dissatisfaction, which is attributed to an inadequately stimulating situations. Everyone has a tendency to experience boredom. Boredom Proneness Scale (Farmer and Sunberg, 1986) is one of many scale that can measures boredom proneness. BPS hasn’t been adapted from the original language (English) in Indonesia. This study uses validity and reliability approach. Process of study divided into adaptation process and psychometric analysis process. Psychometric analysis of BPS Indonesian Version consists of Item Content Validity Analysis (I-CVI) & Scale Content Validity Index (S-CVI). BPS Indonesian Version was spread twice amongst students of Medicine Program Faculty of Medicine Batch 2016─2018. Psychometric analysis of Boredom Proneness Scale Indonesian Version as Guttman Scale was done by counting the coefficient of reproducibility (CR) and coefficient of scalability (CS). BPS Indonesian Version were obtained by adaptation process. Based on 9 experts’ appraisal in experts panel, minimum I-CVI is 0,83 (minimally accepted index 0,78) on the 10th scale and S-CVI is 0,98 (minimally accepted index 0,90). CR of BPS Indonesian Version is 0,589 (first) and 0,594 (second) which defines BPS Indonesian Version is not valid and CS of BPS Indonesian Version is obtained as 0,177 (first) and 0,188 (second) which defines BPS Indonesian Version is not appropriate to be used in study. BPS Indonesian Version is not aprropriate to be used in measuring boredom proneness in students of Medicine Program Faculty of Medicine Sriwijaya University.
Keywords: Boredom Proneness Scale, Boredom, Validity, ReliabilityKejenuhan merupakan keadaan gairah dan ketidakpuasan yang relatif rendah akibat situasi yang tidak menstimulasi secara memadai. Setiap orang memiliki kecenderungan untuk mengalami kejenuhan. Boredom Proneness Scale (Farmer dan Sunberg, 1986) merupakan salah satu alat ukur yang dapat digunakan untuk menilai tingkat kecenderungan kejenuhan. Belum dilakukan adaptasi BPS dari Bahasa Inggris (orisinal) di Indonesia. Penelitian ini menggunakan desain penelitian uji validitas dan reliabilitas. Proses penelitian dibagi menjadi proses adaptasi dan proses analisis psikometrik. Proses analisis psikometrik meliputi analisis Item Content Validity Index (I-CVI) & Scale Content Validity Index (S-CVI). Dilakukan penyebaran BPS Versi Bahasa Indonesia sebanyak dua kali pada mahasiswa PSPD FK Universitas Sriwijaya Angkatan 2016─2018. Tahap analisis BPS Versi Bahasa Indonesia sebagai skala Guttman dilakukan dengan menilai koefisien reprodusibilitas (Kr) dan koefisien skalabilitas (Ks). BPS Versi Bahasa Indonesia didapatkan melalui proses adaptasi. Berdasarkan penilaian 9 ahli pada panel ahli, nilai minimum I-CVI didapatkan sebesar 0,83 (nilai kesepakatan minimum 0,78) pada butir 10 serta S-CVI sebesar 0,98 (nilai kesepakatan minimum 0,90). BPS Versi Bahasa Indonesia memiliki Kr sebesar 0,589 pada penyebaran pertama dan Kr sebesar 0,594 pada penyebaran kedua yang menyatakan bahwa BPS Versi Bahasa Indonesia tidak valid serta didapatkan Ks sebesar 0,177 pada penyebaran pertama dan Ks sebesar 0,188 pada penyebaran kedua yang menyatakan BPS Versi Bahasa Indonesia tidak layak untuk disebarkan dalam penelitian. BPS Versi Bahasa Indonesia tidak layak digunakan dalam menilai kerentanan terhadap kejenuhan di mahasiswa/i Program Studi Pendidikan Dokter Universitas Sriwijaya.
Kata Kunci: Boredom Proneness Scale, Kejenuhan, Validitas, Reliabilita
Study of Social Support and Factors Affecting Efforts Improving The Quality of Life of Patients with Pulmonary Tuberculosis
No full textStudy of Social Support and Factors Affecting EffortsImproving the Quality of Life for Patients with LungTuberculosis.Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis. Decreasein the quality of life of tuberculosis patients can have a negative impact on the continuity of therapy which causes failureof therapy. The quality of life of pulmonary TB patients is important to be assessed in various aspects ranging from theaspects of physical well-being, psychology, social and environmental relations. The purpose of this study was to examinesocial support and influencing factors influencing efforts to improve the quality of life of pulmonary TB patients. This typeof research is observational research using cross sectional design. The study population was all pulmonary tuberculosispatients in Palembang City. This study received a total sample of 111 people. The quality of life was measured by theIndonesian WHOQOL-BREFF questionare instrument and the results were obtained by univariate, bivariate, andmultivariate analysis using the SPSS 22 program. Of the 111 study respondents, a good percentage of the quality of lifeof tuberculosis patients in Palembang City Health Center was 71.17% and the not good at 28.83%. There was nosignificant relationship between demographic characteristics (age, sex, body mass index, education level, employmentstatus, and marital status), blood pressure, history of diabetes, and history of smoking with quality of life. There is asignificant relationship between treatment duration. family support. friend support. and community support with thequality of life of tuberculosis patients (p value <0.05). Patients with tuberculosis with poor family support have theopportunity to have a poor quality of life of 86.18%
The Effect Of Giving Red Dragon Fruit (Hylocereus polyrhizus) Extract On Spermatozo Motility In White Rats (Rattus norvegicus) Wistar Line With High Fat Induction
No full textHyperlipidemia is a condition when high level of blood lipids and causes morphologicalchanges in spermatozoa. Red dragon fruit (Hylocereus Polyrhizus) is one of the plantsas a source of antioxidants and has unsaturated fat content that is needed in thespermatozoa maturation process. The aims of this the study is to determine the benefitsof red dragon fruit extract on the motility of white rat spermatozoa (Rattus norvegius)induced by high-fat diet. The study is design by true experimental research andresearch only testing group design. This research conducted in the Pharmacology andTherapy Laboratory, Padjajaran University Education Hospital, in January 2020 usingwhite rats, male . ± 8 weeks wistar strains weighing ± 200-250. The study sample wasdivided into several groups such group I as a control, group II as a negative control,group III as positive group with simvastatin dose 0.72 mg / day, group IV as researchgroup 1 using red dragon fruit extract dose of 60 mg / 200 grBB / day for 52 days, andgroup V as group 2 therapy using dragon fruit extract dose of 60 mg / 200grBB / dayfor 104 days. The results showed that the mean percentage of motility of ratspermatozoa increased in the relief group with the supplement of red dragon fruitextract by dosing of 60 mg / 200 grBB / day for 104 days, or 51, 2%. This studyconclude that red dragon fruit has a superior effectivity better than simvastatin inincreasing the motility of spermatozoa
Fleksibilitas Lumbal pada Pengrajin Tenun di Palembang
No full textFlexibility in the human body is the range of abilities of certain joints or groups of joints in functional unity to move optimally ,smoothly and pain-free. Lumbar flexibility is one of the most important factors that support daily human movement activities, such as walking and bending. Decreased lumbar flexibility occurs as human ages, this is also influenced by other related musculoskeletal complaints such as low back pain. Songket craftsmen generally have complaints of low back pain, due to the position and duration of work. This study was conducted to determine the relationn of low back pain complaints with lumbar flexibility among weaving craftsmen in Palembang.
This research is an observational analytic study with cross sectional design using total sampling technique. Subjects were 31 weaving craftsmen in the city of Palembang. Lower back flexibility is measured using the Sit and Reach Test method. Data were analyzed using the Gamma Correlation test.
There is a significant moderate relation with a negative direction between lower back pain and lumbar flexibility in songket craftsmen (p = 0.022). The study shows that below normal lumbar flexibility scores were found in 11 people consisting of 9 male subjects (29.03%) and 8 subjects age 18-27 years old subjects (25.80%).Fleksibilitas pada tubuh manusia merupakan rentang kemampuan sendi atau sekelompok sendi tertentu dalam kesatuan fungsional untuk bergerak maksimal secara lancar dan bebas rasa sakit. Fleksibilitas lumbal merupakan salah satu faktor terpenting yang menunjang aktivitas gerak manusia sehari – hari, seperti berjalan dan membungkuk. Penurunan fleksibilitas lumbal terjadi seiring dengan bertambahnya usia manusia, hal ini juga dipengaruhi oleh keluhan musculoskeletal lainnya yang berkaitan seperti nyeri punggung bawah. Pengrajin tenun umumnya memiliki keluhan nyeri punggung bawah, dikarenakan faktor posisi dan durasi kerjanya. Penelitian ini dilakukan untuk mengetahui hubungan keluhan nyeri punggung bawah dengan fleksbilitas lumbal pada pengrajin songket di Kota Palembang. Penelitian ini merupakan penelitian analitik observasional dengan desain cross sectional menggunakan teknik total sampling. Subjek penelitian adalah 31 pengrajin tenun di Kota Palembang. Fleksibilitas punggung bawah diukur menggunakan metode Sit and Reach Test. Data dianalisis menggunakan uji Korelasi Gamma.
Penelitian ini menunjukan terdapat hubungan bermakna antara nyeri punggung bawah dengan fleksbilitas lumbal pada pengrajin songket (p=0.022). Pada penelitian didapatkan nilai fleksibilitas lumbal dibawah normal sejumlah 11 orang yang terdiri atas subjek berjenis kelamin laki-laki sebanyak 9 orang (29.03%) dan subjek berusia 18-27 tahun sebanyak 8 orang (25.80%)