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Aortic, musculoskeletal and organ characteristics on computed tomography in knee osteoarthritis – an explorative study in the IMI-APPROACH cohort
Full text link[Abstract] The systemic associations with knee osteoarthritis (KOA) are incompletely understood. This study explores aortic disease, musculoskeletal and organ findings in patients with KOA in relation to their symptoms or radiographic abnormalities. Full body computed tomography (CT) scans of 255 IMI-APPROACH participants were investigated using an automated analysis of multislice CT (Voronoi Health Analytics) that extracts aortic size and calcifications, and volumes and densities of bones, muscles, fat compartments and thoracic and abdominal organs. The CT measurements were primarily related to KOA as measured with Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), visual scores and automated knee radiograph analysis of osteophytes, bone sclerosis and joint space width. The median age was 67 years, body mass index (BMI) 26.8 kg/m2 and 78% were female. About half had Kellgren-Lawrence grade ≥ 2. Larger knee osteophyte area was associated with a larger aortic volume (RSpearman=0.21,P = 0.001), which can be due to elongation or dilatation. We observed an association between more symptoms and increased psoas (RSpearman=-0.23,P < 0.001) and lower leg (RSpearman=-0.23,P < 0.001) muscle density, suggesting less microscopic muscle fat. Symptomatic KOA was associated with substantially lower lung volume (771 ml difference between 50% worst and 50% best WOMAC), but not with visible lung disease. Lung volume and density were significantly associated with the physical functioning WOMAC component. These associations remained significant after adjustment for age, sex and BMI. KOA is associated with significant systemic changes, including altered aortic and organ volumes. These correlations suggest that KOA's impact may extend beyond the joints. Future research should explore the causal relationships and therapeutic implications associations.The research leading to these results has received support from the Innovative Medicines Initiative Joint Undertaking under Grant Agreement n° 115770, resources of which are composed of financial contribution from the European Union’s Seventh Framework Programme (FP7/2007–2013) and EFPIA companies’ in kind contribution
50 anos despois
No full textA Iniciativa “Principia”, presentada o día 26 de febrero de 2025 no Salón de actos da ETSAC, consta de 27 rexistros audiovisuais que inclúen clases maxistrais, entrevistas, conversacións, reflexións e sesións docentes, co obxetivo de construir e compartir a historia da ETSAC e deixar un rexistro audiovisual dunha significativa mostra do profesorado que contribuíu de xeito decisivo a poñela en marcha, conformando a súa identidade ao longo do tempo como resultado da confluencia das súas moi diversas traxectorias docentes e profesionais. Idea, dirección e montaxe do arquitecto Xosé Manuel Rosales Noves.Rexistro audiovisual que recolle unha conferencia do profesor da ETSAC, Xosé Manuel Casabella López, e que forma parte da colección “Principia” que, con motivo do 50 aniversario da Escola Técnica Superior de Arquitectura da Coruña, fai un recoñecemento académico á súa labor e legado
Thermo-economic analysis of green hydrogen production onboard LNG carriers through solid oxide electrolysis powered by organic Rankine cycles
Full text link[Abstract] LNG carriers play a crucial role in the shipping industry meeting the global demand for natural gas (NG). However, the energy losses resulting from the propulsion system and the excess boil-off gas (BOG) cannot be overlooked. The present article investigates the H2 production on board LNG carriers employing both the engine's waste heat (WH) and the excess BOG. Conventional (ORC) and dual-pressure (2P-ORC) organic Rankine cycles coupled separately with a solid oxide electrolysis (SOEC) have been simulated and compared. The hydrogen (H2) produced is then compressed at 150 bar for subsequent use as required. According to the results, the 2P-ORC generates 14.79 % more power compared to ORC, allowing for an increased energy supply to the SOEC; hence, producing more H2 (34.47 kg/h compared to 31.14 kg/h). Including the 2P-ORC in the H2 production plant results in a cheaper H2 cost by 0.04 /kgH2 in this case. Onboard H2 production is a versatile process independent from the propulsion system ensuring the ship's safety and availability throughout a sea journey.Funding Research contract funded by the Ferrol Industrial Campus under the Call “Talent in Training 2023” 2022/CP/139, Spain. Funding for open access charge from University of A Coruna.
Acknowledgements The authors would like to thank Xunta de Galicia and the Research Center for Naval and Industrial Technologies (CITENI) of the industrial campus of Ferrol – University of A Coruna, Spain for their financial support through the Convocatoria “Talento en Formacion´ ” 2022/CP/139. The authors acknowledge the Norwegian University of Science and Technology (NTNU) for their hosting during the research stay and collaboration in this article.Xunta de Galicia; 2022/CP/13
Examining the Consumer Behaviour of Ultra-Processed Food Products: Evidence from the Spanish Market
Full text linkThis version of the article has been accepted for publication, after peer review, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1108/BFJ-06-2024-0606[Abstract] Purpose: Ultra-processed food products are omnipresent in our homes and in grocery stores, and everybody consumes these food products once in a while. In this context, the present study aims to analyse what factors influence the consumption behaviour of ultra-processed food products and, more precisely, what factors drive consumer satisfaction and purchase intention of these food products in one specific market – Spain-. Design/methodology/approach: A model of consumer behaviour of ultra-processed food products is proposed and analysed through structural equation modelling on a sample of 608 consumers. Findings: Findings indicate that the effortlessness of ultra-processed food products, as well as their affordability, are the factors that exert the higher influence on consumer satisfaction and purchase intention of ultra-processed food products. On the other hand, the product quality and the ability to save time show a negative influence on both consumer satisfaction and intention to purchase. Contrary to the initial expectations, product convenience and the hedonistic nature of ultra-processed food products do not influence consumer behaviour. Practical implications: Food policymakers and public health interventions may consider possible actions to reduce the consumption of ultra-processed food products, the reduction of their affordability through taxation or the compulsory inclusion of nutritional warnings in the front of the package to confront marketing actions developed by food companies. Originality/value: This study examines the factors that drive the purchase and consumption of ultra-processed food products in one European mature market: Spain
Design, Implementation and Practical Evaluation of an Opportunistic Communications Protocol Based on Bluetooth Mesh and libp2p
Full text link[Abstract]: The increasing proliferation of Internet of Things (IoT) devices has created a growing need for more efficient communication networks, especially in areas where continuous connectivity is unstable or unavailable. Opportunistic networks have emerged as a possible solution in such scenarios, allowing for intermittent and decentralized data sharing. This article presents a novel communication protocol that uses Bluetooth 5 and the libp2p framework to enable decentralized and opportunistic communications among IoT devices. The protocol provides dynamic peer discovery and decentralized management, resulting in a more flexible and robust IoT network infrastructure. The performance of the proposed architecture was evaluated through experiments in both controlled and industrial scenarios, with a particular emphasis on latency and on the impact of the presence of obstacles. The obtained results show that the protocol has the ability to improve data transfer in environments with limited connectivity, making it adequate for both urban and rural areas, as well as for challenging environments such as shipyards. Moreover, the presented findings conclude that the protocol works well in situations with minimal signal obstruction and short distances, like homes, where average latency values of about 8 s have been achieved with no losses. Furthermore, the protocol can also be used in industrial scenarios, even when metal obstacles increase signal attenuation, and over long distances, where average latency values of about 8.5 s have been obtained together with packet losses of less than 5%.This work has been supported by Centro Mixto de Investigación UDC-NAVANTIA (IN853C 2022/01), funded by GAIN (Xunta de Galicia) and ERDF Galicia 2021–2027. In addition, this work has been supported by the grant PID2020-118857RA-100 (ORBALLO) funded by MCIN/AEI/10.13039/501100011033.Xunta de Galicia; IN853C 2022/0
Galician Theatre during Franco’s Regime: the Castelao Prize (1964-1967)
Full text link[Resumo] O Premio Castelao foi convocado en 1964 pola Agrupación Cultural O Galo, constituída por estudantado universitario compostelán, como reacción á ausencia dunha mo-dalidade en lingua galega no II Premio Nacional de Teatro Universitario convocado polo SEU. Para conseguir a dotación do premio organizouse unha colecta popular, a Campaña do Peso. O premio terá catro convocatorias e concitará a adhesión das novas xeracións mais tamén das provenientes do galeguismo republicano organizadas agora no grupo Galaxia. O certame vincularase á estratexia de institucionalización da cultura galega articulada arredor do Día das Letras Galegas, creado en 1963. A investigación sobre o Premio Castelao permite tamén descubrir obras inéditas e non representadas, e completar así a historia do teatro galego durante o franquismo.[Abstract] The Castelao Prize was organized in 1964 by the Agrupación Cultural O Galo, formed by students from the University of Santiago de Compostela, as a reaction to the absence of a Galician language category in the II National University Theatre Prize orga-nized by the SEU. In order to obtain the prize money, a popular campaign, the Campaña do Peso, was organized. The prize will be awarded four times and will attract the support of the new generations but also of those coming from the republican galeguismo now organized in the Galaxia group. The contest will be linked to the strategy of institutionalization of Ga-lician culture articulated around the Día das Letras Galegas, created in 1963. The research on the Castelao Prize also allows us to discover unpublished and unrepresented works, and thus complete the history of Galician theater during Franco’s regimeMiinsterio de Ciencia, Innovación y Universidades; PID2020-115649RB-I0
Disease-associated signatures persist in extracellular vesicles from reprogrammed cells of osteoarthritis patients
Full text link[Abstract] Osteoarthritis (OA) is a prevalent joint disorder that lacks effective therapies to halt cartilage degeneration. Mesenchymal stromal cell (MSC)-derived small extracellular vesicles (sEVs) are being investigated as promising chondroprotective agents. Compared to primary MSCs, induced pluripotent stem cell (iPSC)-derived MSCs (MLCs) offer superior scalability and enhanced paracrine activity. The aim of this study was to explore the feasibility of using autologous MLC-derived sEVs as a potential therapeutic strategy for OA through the analysis of their protein cargo. iPSCs from an OA patient and a healthy donor were differentiated into MLCs. sEVs were isolated from these MLCs and characterized, with a particular focus on their protein cargo. Both iPSC lines were successfully differentiated into MLCs, which secreted sEVs with comparable size distributions and yields. The analysis of differentially expressed proteins revealed a high abundance of proteins associated with OA pathology and cartilage degradation in sEVs from OA MLCs compared to those from healthy MLCs. The persistence of OA-associated protein signatures in autologous MLC-derived sEVs may limit their therapeutic efficacy. These findings underscore the importance of carefully evaluating disease-specific protein profiles in sEVs for regenerative applications.info:eu-repo/grantAgreement/ISCIII/Programa Estatal de Generación de Conocimiento y Fortalecimiento del Sistema Español de I+D+I/PI20%2F00933/ES/VESICULAS EXTRACELULARES PEQUEÑAS (SEVS): UNA NUEVA HERRAMIENTA TERAPEUTICA PARA EL TRATAMIENTO DE LA ARTROSISinfo:eu-repo/grantAgreement/ISCIII/Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia/PI17%2F02197/ES/CELULAS MADRE PLURIPOTENTES INDUCIDAS (IPS) COMO MODELO DE ARTROSIS DE MANOSXunta de Galicia; ED431B 2023/58Xunta de Galicia; ED431B 2020/5
Adaptive incremental transfer learning for efficient performance modeling of big data workloads
No full textThis manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/bync-nd/4.0/. This version of the article has been accepted for publication in Future Generation Computer Systems. The Version of Record is available online at https://doi.org/10.1016/j.future.2025.107730The algorithms, evaluation metrics, cross-validation methods, and resources used in this study are openly available at https://github.com/mgarralda/garralda-performance-model. Further details can be obtained from the corresponding author on reasonable request.[Abstract]: The rise of data-intensive scalable computing systems, such as Apache Spark, has transformed data processing by enabling the efficient manipulation of large datasets across machine clusters. However, system configuration to optimize performance remains a challenge. This paper introduces an adaptive incremental transfer learning approach to predicting workload execution times. By integrating both unsupervised and supervised learning, we develop models that adapt incrementally to new workloads and configurations. To guide the optimal selection of relevant workloads, the model employs the coefficient of distance variation (CdV) and the coefficient of quality correlation (CqC), combined in the exploration–exploitation balance coefficient (EEBC). Comprehensive evaluations demonstrate the robustness and reliability of our model for performance modeling in Spark applications, with average improvements of up to 31% over state-of-the-art methods. This research contributes to efficient performance tuning systems by enabling transfer learning from historical workloads to new, previously unseen workloads. The full source code is openly available.This work has been supported by the National Plan for Scientific and Technical Research and Innovation of the Spanish Government, Spain (Grant PID2019-109238GB-C22 and PID2023-147404OB-I00), and by the Xunta de Galicia (Grant ED431C 2022/44) with the European Union ERDF funds, Spain. CITIC, as Research Center accredited by Galician University System, is funded by “Consellería de Cultura, Educación e Universidade from Xunta de Galicia, Spain ”, supported in an 80% through ERDF Operational Programme Galicia 2014–2020, and the remaining 20% by “Secretaría Xeral de Universidades” (Grant ED431G 2023/01).Xunta de Galicia; ED431C 2022/44Xunta de Galicia; ED431G 2023/0
Adaptation and validation of an abbreviated version of the SIPAT integrated psychosocial risk scale in patients with liver cirrhosis candidates for liver transplantation (SIPAT-11)
No full textObservational study[Resumen] Introducción. Los pacientes con cirrosis hepática candidatos a trasplante hepático deben ser evaluados tanto en la esfera clínica, como en la sociofamiliar para obtener buenos resultados y evitar medidas terapéuticas fútiles. Para la evaluación de la esfera social no disponemos de una escala validada en español en este perfil de paciente. La escala Stanford Integrated Psychosocial Assessment for Transplantation (SIPAT) es un instrumento de medida de las esferas sociales, familiares y psicológicas en candidatos a trasplante de órgano sólido. El objetivo de este estudio es adaptar y validar una versión abreviada de la escala SIPAT en español para pacientes con cirrosis hepática.
Material y métodos. Estudio prospectivo observacional realizado en la Unidad de Hepatología del Hospital Universitario y Politécnico La Fe de Valencia, con metodología de validación de cuestionarios. Para el análisis de la fiabilidad del cuestionario se calculó la consistencia interna de todas las variables, para la variabilidad un análisis factorial exploratorio, y para la estabilidad se realizó la prueba de test-retest.
Resultados. Se seleccionó a 96 pacientes que ingresaron por cirrosis descompensada en la Unidad de Hepatología del hospital La Fe de Valencia entre el 1 de noviembre del 2017 y el 31 de enero del 2017. El 84% fueron hombres, la edad media fue de 60,01 (DE 10,12) años. En el 73,2% de los ingresados la etiología de la cirrosis era alcohólica. Estaban en estadio A de Child el 14,4%, en el B un 57,7% y un 27,8% en el estadio C. La consistencia interna de todas las variables alcanzó una alfa de Cronbach de 0,766. En el análisis factorial exploratorio se identificaron 6 dimensiones del cuestionario que explican el 84,27% de la variabilidad total. Para ver la estabilidad del instrumento se repitió la medición a los 2 y 6 meses de seguimiento obteniéndose en la prueba del test-retest una concordancia kappa de 0,612 y de 0,565, respectivamente.
Conclusión. El cuestionario SIPAT-11 presenta unas buenas características psicométricas en pacientes cirróticos candidatos a trasplante hepático. Es de fácil cumplimentación y puede ser administrado por profesionales no especialistas en el área de Salud Mental.[Abstract]
Introduction: Patients with liver cirrhosis who are candidates for liver transplantation must be evaluated both clinically and socially in order to obtain the optimal outcomes and avoid futile therapeutic measures. For the evaluation of the social aspects in these patients, no validated scale in Spanish is available. The SIPAT (Stanford Integrated Psychosocial Assessment for Transplantation) scale is an instrument that measures the social, family and psychological aspects in candidates for solid organ transplantation. The objective of this study is to adapt and validate an abbreviated version of the SIPAT scale in Spanish for patients with liver cirrhosis.
Material and methods: Prospective observational study carried out in the Hepatology Unit of the La Fe Unversity Hospital in Valencia, by questionnaire validation methodology. To analyze the reliability of the questionnaire, the internal consistency of all variables was calculated, for variability an exploratory factor analysis, and for stability the test-retest test was carried out.
Results: 96 patients who were admitted for decompensated cirrhosis to the Hepatology Unit of the La Fe Hospital in Valencia between November 1, 2017 and January 31, 2017 were selected. 84% were men, the mean age was 60.01 (SD 10.12) years. In 73.2% of those admitted, the etiology of cirrhosis was alcoholic. 14.4% had a Child's stage A, 57.7% B and 27.8% C. The internal consistency of all variables reached a Cronbach's Alpha of 0.766. In the exploratory factor analysis, 6 dimensions of the questionnaire were identified that explain 84.27% of the total variability. To see the stability of the instrument, the measurement was repeated at 2 and 6 months of follow-up, obtaining in the test-retest a kappa agreement of 0.612 and 0.565 respectively.
Conclusion: The SIPAT-11 questionnaire has good psychometric characteristics in cirrhotic patients who are candidates for liver transplantation. It is easy to complete and can be administered by professionals who are not specialists in the area of Mental Health
Caso Industrias del Mar SL.
Full text link[Resumen] SUPUESTO DE HECHO
Industrias del Mar SL, es propiedad por partes iguales de los hermanos don Juan Fernández y doña María López y tiene una planta de envasado de conservas del mar en Boiro, A Coruña.
Con las pérdidas incurridas por la sociedad conservera INDUSTRIAS DEL MAR SL en el presente ejercicio, su patrimonio esto ha quedado formado por las cuatro partidas siguientes (datos en miles de euros -k€-): Capital social 100; Reservas 45; Rendimientos de ejercicios anteriores menos 45; Rendimientos del ejercicio menos 60.
Son administradores solidarios don Juan Fernández y doña María López, quienes para lograr la continuidad de la empresa que tiene 7 trabajadores están buscando un comprador que adquiera las participaciones.Traballo fin de grao. (UDC.FDER). Dereito. Curso 2023/202