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Observation and study of the decay J/psi -> phi eta eta '
No full textKolcu, Onur Buğra (Arel Author)We report the observation and study of the decay J/psi -> phi eta eta' phi eta eta' using 1.3 x 10(9) J/psi events collected with the BESIII detector. Its branching fraction, including all possible intermediate states, is measured to be (2.32 +/- 0.06 +/- 0.16) x 10(-4). We also report evidence for a structure, denoted as X, in the phi eta' mass spectrum in the 2.0-2.1 GeV/c(2) region. Using two decay modes of the eta' meson (gamma pi(+)pi(-) and eta pi(+)pi(-)), a simultaneous fit to the Ore mass spectra is performed. Assuming the quantum numbers of the X to be J(P) = 1(-), its significance is found to be 4.4 sigma, with a mass and width of (2002.1 +/- 27.5 +/- 21.4) MeV/c(2) and (129 +/- 17 +/- 9) MeV, respectively, and a product branching fraction B(J/psi -> eta X) x B(X -> phi eta') = (9.8 +/- 1.2 +/- 1.7) x 10(-5). Alternatively, assuming J(P) = 1(+), the significance is 3.8 sigma, with a mass and width of (2062.8 +/- 13.1 +/- 7.2) MeV/c(2) and (177 +/- 36 +/- 35) MeV, respectively, and a product branching fraction B(J/psi -> eta X)x B(X -> phi eta') = (9.6 +/- 1.4 +/- 2.0) x 10(-5). The angular distribution of J/psi -> eta X is studied and the two J(P) assumptions of the X cannot be clearly distinguished due to the limited statistics. In all measurements the first uncertainties are statistical and the second systematic
Early prediction of sepsis from clinical data using artificial intelligence
No full text2019 Scientific Meeting on Electrical-Electronics and Biomedical Engineering and Computer Science, EBBT 2019 -- 24 April 2019 through 26 April 2019 --Demirer, Oya (Arel Author)Sepsis is a major cause of death in the world. World Health Organization estimates 30 million people developing sepsis and 6 million people die from sepsis each year; an estimated 4.2 million newborns and children are affected. The mortality rate is highest in septic shock in poor and developing countries. Early prediction of sepsis is critical for improving sepsis outcomes. The late prediction of sepsis in non-sepsis patients is a challenging problem. The aim of this study is to develop an artificial intelligence-based early warning and therapeutic decision support system which reduces sepsis-associated hospital mortality. We propose two compatible Boolean switchable Partially Observable Markov Decision Processes (POMDP) under a general risk-sensitive optimization criterion with finite time horizon. It is based on Spectral analysis of unevenly sampled (missing) observations with Demographics, Vital Signs, and Laboratory values for the patient. The policy is a common mixture of sepsis and non-sepsis beliefs on own utility functions which favors to achieve Pareto Optimality from this high dimensional belief space. © 2019 IEEE
Observation of D-s(+) -> p(n)over-bar and confirmation of its large branching fraction
No full textKolcu, Onur Buğra (Arel Author)The baryonic decay D-s(+) -> p (n) over bar is observed, and the corresponding branching fraction is measured to be (1.21 +/- 0.10 +/- 0.05) x 10(-3), where the first uncertainty is statistical and second systematic. The data sample used in this analysis was collected with the BESIII detector operating at the BEPCII e(+)e(-) double-ring collider with a center-of-mass energy of 4.178 GeV and an integrated luminosity of 3.19 fb(-1). The result confirms the previous measurement by the CLEO Collaboration and is of greatly improved precision. This result will improve our understanding of the dynamical enhancement of the W-annihilation topology in the charmed meson decays
Fuzzy logic based risk assessment system giving individualized advice for metabolic syndrome and fatal cardiovascular diseases
No full text7th International Conference on Biomedical Engineering and Biotechnology (iCBEB) --OCT 17-20, 2018 -- Nanjing, PEOPLES R CHINABirtane, Sibel (Arel Author) --- WOS: 000472616700007PubMed ID: 31045527In 2005, global cardiovascular diseases caused 30% of deaths in Europe, which is 46% of total deaths for all death groups. Today, according to the International Adult Diabetes Federation, 20% to 25% of the adult population in the world has Metabolic Syndrome. Turkish Statistical Institute claims that in Turkey 408782 people died of circulatory system diseases in 2016 and it is expected that numbers will dramatically increase. In 2003, total worldwide healthcare budget of Diabetes Mellitus was up to 64.9 billion International Dollars with the continuing rise in prevalence, it is expected that total costs will increase to 396 billion International Dollars by 2025. The main purpose of this study was to present a clinical decision support system that calculates Metabolic Syndrome existence and evaluate HeartScore risk level for Turkish population. The second objective was to create a detailed personal report about individual's risk level of Metabolic Syndrome and HeartScore and give advice to him/her to reduce it. The fuzzy logic risk assessment system (FLRAS) was formed in LabVIEW graphical development platform according to International Diabetes Federation and European Heart Journal's criteria. Mamdani type fuzzy logic sets were identified for each input variable and membership functions were assigned depending on the magnitude of the input limits. System's performance was tested on 96 (72 females, 24 males) patient data. Results show that the proposed system was able to evaluate the Metabolic Syndrome risk with 0.9285 specificity, 0.92708 accuracy and 0.925 sensitivity
Observation of psi(3686) -> p(p)over-bar phi
No full textUsing a data sample of 4.48×108 ?(3686) events collected with the BESIII detector, we present a first observation of ?(3686)?pp ?, and we measure its branching fraction to be [6.06±0.38(stat)±0.48(syst)]×10-6. In contrast to the earlier discovery of a threshold enhancement in the pp-mass spectrum of the channel J/???pp, denoted as X(pp), we do not find a similar enhancement in ?(3686)?pp?. An upper limit of 1.82×10-7 at the 90% confidence level on the branching fraction of ?(3686)?X(pp)??pp? is obtained. © 2019 authors. Published by the American Physical Society
Computational investigation of influenza A virus M2 protein inhibition mechanism by ion channel blockers
No full textThe M2 protein of the influenza A virus, responsible for flu, is a homotetramer transmembrane protein, forming a transmembrane ion channel, where His 37s act as pH sensors and Trp 41s and Asp 44s act as channel gates. Opening of this channel leads to transfer of virus RNA into the human host. Thus, blocking this transfer is an important pharmaceutical strategy to stop infection. As a result of viral drug resistance, commercially available channel inhibitors, rimantadine (RIM) and amantadine (AMA), are not as effective as they used to be. Understanding binding sites and outcomes of binding will lead to new inhibitor design studies. Here, utilizing molecular docking with classical and constant pH molecular dynamics simulations, two novel binding sites for RIM and AMA molecules were revealed. Both structural and chemical effects of inhibitors on M2 protein on the closed, inactive M2 channel structure were investigated. Upon binding of the inhibitor molecules, decrease in ion channel cross-distances was observed. Meanwhile, RIM binding did not alter protonation of His 37s and Asp 44s, whereas AMA binding drastically increased the protonation population of two residues from different monomers, creating a more basic channel at physiological pH
Observation of e(+)e(-) -> pi(+) pi(-)psi(3770) and D-1(2420)(0)(D)over-bar(0) + c.c
No full textSeveral intermediate states of the reaction channels e+e-??+?-D0D?0 and e+e-??+?-D+D- are studied using the data samples collected with the BESIII detector at center-of-mass energies above 4.08 GeV. For the first time in this final state, a ?(3770) signal is seen in the DD? invariant mass spectrum, with a statistical significance of 5.2? at s=4.42 GeV. There is also evidence for this resonance at s=4.26 and 4.36 GeV with statistical significance of 3.2? and 3.3?, respectively. In addition, the Born cross section of e+e-??+?-?(3770) is measured. The proposed heavy-quark-spin-symmetry partner of the X(3872), the state X2(4013), is also searched for in the DD? invariant mass spectra. No obvious signal is found. The upper limit of the Born cross section of the process e+e-??0X2(4013) combined with the branching fraction is measured. Also, the processes e+e-?D1(2420)D?+c.c. are investigated. The neutral mode with D1(2420)0?D0?+?- is reported with statistical significance of 7.4? at s=4.42 GeV for the first time, and evidence with statistical significance of 3.2? and 3.3? at s=4.36 and 4.60 GeV is seen, respectively. No evident signal for the process e+e-?D1(2420)0D?0+c.c.,D1(2420)0?D?+?- is reported. Evidence for e+e-?D1(2420)+D-+c.c.,D1(2420)+?D+?+?- is reported with statistical significance of 3.1? and 3.0? at s=4.36 and 4.42 GeV, respectively. © 2019 authors. Published by the American Physical Society. Published by the American Physical Society under the terms of the https://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International license. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI. Funded by SCOAP3
Search for heavy Majorana neutrino in lepton number violating decays of D -> K pi e(+)e(+)
No full textKolcu, Onur Buğra (Arel Author)Using a data sample with an integrated luminosity of 2.93 fb(-1) taken at the center-of-mass energy of 3.773 GeV, we search for the Majorana neutrino (nu(m)) in the lepton number violating decays D -> K pi e(+)e(+). No significant signal is observed, and the upper limits on the branching fraction at the 90% confidence level are set to be B(D degrees -> K-pi(-)e(+)e(+)) K-S(0)pi(-) e(+)) K-pi(0)e(+)e(+)) K(-)e(+)nu(m),nu(m )-> pi(-)e(+) and D+ -> K(S)(0)e(+)nu(m),nu(m )->( )pi(-)e(+),and the upper limits on the branching fraction at the 90% confidence level are at the level of 10(-7) similar to 10(-6), depending on the mass of the Majorana neutrino. The constraints on the mixing matrix element vertical bar V-e nu m vertical bar(2) are also evaluated
Measurement of B(J/psi -> eta ' e(+)e(-)) and search for a dark photon
No full textKolcu, Onur Buğra (Arel Author)Using a data sample of (1310.6 +/- 7.0) x 10(6) J/psi decay events collected with the BESIII detector at BEPCII, we study the electromagnetic Dalitz decay J/psi -> eta ' e(+)e(-) with two dominant eta' decay modes, eta' -> gamma pi(+)pi(-) and eta' -> pi(+)pi(-)eta . The branching fraction is determined to be B(J/psi -> eta ' e(+)e(-)) = (6.59 +/- 0.07 +/- 0.17) x 10(-5), which improves in precision by a factor of 2 over the previous BESIII measurement. A search for the dark photon (gamma') is performed via J/psi -> eta'gamma',gamma' -> e(+)e(-). Excluding the w and phi mass regions, no significant signal is observed in the mass range from 0.1 to 2.1 GeV/e2. We set upper limits at the 90% confidence level on B(J/psi -> eta 'gamma') x B(gamma' -> e(+)e(-)), B(J/psi -> eta 'gamma') and the mixing strength as a function of dark photon mass. This is among the first searches for dark photons in charmonium decays
DLGBD: A directional local gradient based descriptor for face recognition
No full textÇevik, Nazife (Arel Author)This paper proposes a novel high-performance gradient-based local descriptor that handles the prominent challenges of face recognition such as resistance against rotational, illuminative changes as well as noise effects. One of the novelties this study poses is that, while processing the gradient for each direction, an analysis is done by considering the predecessors of the corresponding pixel as well as the successors at that direction. Furthermore, earlier studies represent these local relationships by encoding them in binary because they consider only the positive and negative intensity changes. However, we propose an alternative way of representation that encodes the relationships between each pixel and its neighbors in a multi-valued logic manner called Directional Local Gradient Based Descriptor (DLGBD). Our method not only considers the variations but also uniformity. A threshold value is defined to identify whether an intensity variation is present in the specified direction. If the intensity change exceeds the threshold value, then it is evaluated as a variation either in positively or negatively depending on the direction of the change. Three states of the relationship between multiple pixels at each direction yield a more discriminative descriptor for face retrieval. Ternary logic is applied to express three states. Ternary values that are calculated at each direction are concatenated and the resulting compound ternary value is replaced with the reference pixel. By this way, a more discriminative face descriptor is achieved which is resistant to noise and challenges in unconstrained environments. Extensive simulations are conducted over benchmark datasets and the performance of DLGBD is compared to the other state-of-the-art methods. As presented by the simulation results, the DLGBD achieves very high discriminating performance as well as providing resistance against rotation and illumination variations