Indian Journal of Pharmaceutical and Biological Research (IJPBR)
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Effect of Melia azedarach and Dodonaea viscosa aqueous leaf extracts on fertility in male albino rats
Get PDFMedicinal plants play a key role in human life as they are helpful in curing several diseases. They not only support health by the pharmacological nature but also utilizable as contraceptive options. The present study reveals that the medicinal plants Melia azedarach and Dodonaea viscosa leaf extracts showing antifertility activity. The decreased sperm count and reproductive organ weights including the necrotic changes in the seminiferous tubules of testis suggesting the antifertility activity of the plants. Serum glutamic oxaloacetic transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and other serological studies were also carried out to know whether side-effects of the extracts
Formulation and Dissolution Study of Valsartan Immediate Release Tablets
Get PDFIn the present study, design of oral immediate release tablets of Valsartan by direct compression technique was carried out. The main aim and objective of the work is to formulate immediate release tablets using different direct compression vehicles (DCV’S) in different ratios. The main motive is to compare the dissolution profile of these formulations and conclude the best formulation which release drug at a faster rate. To determine the best fit dissolution profile for the dosage forms. Valsartan tablets were formulated by using microcrystalline cellulose (diluents), potato starch, acacia (binder) and magnesium stearate (lubricant). The granules were compressed into tablets and were subjected to dissolution studies. The dissolution profile of the formulation F2 was found to have better dissolution rate compared to others. The In-vitro dissolution studies of all the formulations were conducted and the results were obtained, it was concluded that formulation F2 was the best with fast release of drug compared to others
Antimicrobial Screening of Some capparidaceous Medicinal Plants of North-West Rajasthan
Get PDFAntimicrobial screening of ethyl ether and alcoholic extracts of leaves of three selected medicinal plant species of capparidaceae family growing in North–Western Rajasthan was carried out. Capparis decidua, Cleome gynandra and Cleome viscosa showed positive reactions against bacterial pathogens i.e. Staphylococcus aureus, Escherichia coli and a fungal pathogen Candida albicans
Nutritional Assessment of Leaves of Wild Edible Plant Urtica ardence
No full textConsidering the growing need to identify alternative bio-nutritional sources, wild edible leaves consumed in forest zone of Uttarakhand, India were evaluated for their nutritive value in order to prioritize edible wild plant suitable for domestication. The result showed significance of wild plant species as important source of nutrient for rural poor people. The nutritional value of leaves of wild plant Urtica ardence were evaluated in terms of protein, carbohydrate, fat, fiber content, vitamin content, reducing sugars and minerals. Urtica ardence had a significant level of above nutrients and therefore was identified as promising specie for promotion as backyard planting especially farming systems suffering from crop loss, food shortage and chronic malnutrition
A Randomised Controlled Trial Comparing Intravaginal Misoprostol and Intracervical Dinoprostone in Pre Induction Cervical Ripening
Get PDFObjective: To compare the efficacy and safety of intravaginal misoprostol with intracervical dinoprostone for preinduction cervical ripening. Material andMethods: It was a randomized controlled trial conducted at department of obstetrics and gynecology, JIPMER, Puducherry. Three hundred women with Bishop score of 6, were assigned randomly to receive either intravaginal misoprostol 25 μg every four hours for four doses, and intracervical dinoprostone gel 0.5 mg every eight hours for two doses. (one hundred women in each group). Oxytocin was initiated as per standardized protocol, if the cervix was favourable. If the cervical ripening was unsuccessful (Bishop score 6) after the maximum doses of drugs in both the groups, then further treatment was individualized. Efficacy and cost of the drugs were compared in both groups. Results: Primary outcome measure was change in Bishop score. Mean Bishop score change at the end of 16 hours was significantly higher in the misoprostol group, (2.57±0.59) compared to dinoprostone group (2.17±0.10, p=0.016). This finding was inspite of the fact that the dinoprostone group had higher Bishop score prior to the ripening.(3.55±0.56 vs 3.28±0.77, p=0.006). Secondary outcome measures such as mean intervention-delivery interval, oxytocin requirement, mode of delivery, maternal and neonatal outcomes were similar in both the groups. Overall mean cost of ripening agent per patient was significantly less in the misoprostol group, (22.56±93.16 rupees) compared to dinoprostone group (493.89±173.99 rupees, p0.0001).Conclusion: Low dose misoprostol is as effective as dinoprostone in cervical ripening and demonstrates similar fetal and maternal safety profile
Mineral contents from some fabaceous plant species of Rajasthan desert
Get PDFEvaluation of mineral contents from three selected plant species of Fabaceae family growing in arid region of Rajasthan Desert was carried out. The roots, shoots and fruits of Clitoria ternatea, Sesbania bispinosa and Tephrosia purpurea collected from two different areas Chhatargarh area (Bikaner district) and Ratangarh area (Churu district) were analysed for mineral contents. The maximum Calcium (3.86%), Phosphorus (0.48%), Potassium (0.92%) and Sodium (1.08%) contents were found in roots and shoots of Grewia tenax collected from study area
Isolation and Quantification of Aflatoxin from Aspergillus flavus Infected Stored Peanuts
Get PDFIsolates of Aspergillus infected Peanuts were separately grown on modified Czapek’s medium at 280 C and the metabolites were tested for aflatoxin by HPLC. Naturally infected peanuts collected from trader’s godown were tested for aflatoxins. Aflatoxins are considered to be one of the most dangerous contaminants in food and feeds. Aflatoxins are a special group of naturally occurring metabolites produced by the fungi aflatoxins B1, B2, G1 and G2 which contaminate a variety of agricultural food and feed products .Naturally infected peanuts from Aspergillus flavus stored at trader’s godown, after several months’ storage, were found to be contaminated with aflatoxin B1
Ulcerative colitis in 17 yr old girl masquerading as severe anemia: A case report
Get PDFUlcerative colitis is a chronic inflammatory disease of unknown etiology. It is localized to the colon and spares the upper gastrointestinal tract. Ulcerative colitis can occur at any age, the peak incidence is among the age group 15-25 years and in 55-65 years. The first pediatric case was reported by Helmholz. The purpose of reporting this case of 17 year old girl with ulcerative colitis who presented with severe anemia is, to not only create awareness of ulcerative colitis among pediatric age group but also to discuss the challenges facing the diagnosis and management of the disease in a developing country like India
Preliminary morphological and anatomical study of Orthosiphon stamineus
Get PDFThis study focuses on the characterization of morphological and anatomical traits of Orthosiphon stamineus which belongs to the Lamiaceae family. Orthosiphon stamineus, better known as “Misai Kucing” or “cats whiskers” by the locals, contained active phenolics compounds such as flavanoids. Despite its wide usage as a medicinal plant, information regarding Orthosiphon stamineus specific developmental stages is relatively scarce. Furthermore, to date, no anatomical data of this plant is available. Therefore, this study aims to systematically identify the developmental stages and its anatomy which may provide more insight to its medical application. The result showed some distinct morphological and anatomical characteristics. In the morphological study, it was observed that Orthosiphon stamineus is a herbal shrub with well-developed creeping rootstock. The leaves are simple, green, and arranged in opposite pairs. The stem is approximately 28 cm in height at the stage (12 days). The flowers have long wispy stamens shaped with pale purple color. In anatomical study, the cross sections of the stem for tow stage (32) and (62) days of this plant were examined. All the detailed systematic study of this plant has not worked earlier
Evaluation of Serum Adenosine Deaminase and Retinol in patients with Laryngeal Cancer
Get PDFLaryngeal cancers account for 4% of all head and neck cancers in India. The disease process has better prognosis if it is diagnosed early. In view of this the objective of the study was to assess the reliability of serum enzyme marker adenosine deaminase and non-enzymatic antioxidant retinol in laryngeal cancer patients as supportive parameters for diagnostic purpose. Materials and methods:-25 clinically and histopathologically confirmed patients of laryngeal cancer in age group of 45-65 years were included in the study and 25 healthy subjects with in the same age group served as controls. Results:-The level of serum ADA was significantly elevated in laryngeal cancer patients in comparison to controls whereas retinol levels were significantly decreased. Conclusion: - Lipid per-oxidation as a result of cancer leads to membrane damage and an increase in cytoplasmic ADA. It is also associated with a decrease in levels of non-enzymatic antioxidant retinol. These biochemical parameters may be used as supportive parameters for diagnostic purpose and may add further for prognostic information. Further studies are required on a larger sample size to explore strategies by which normal levels of anti-oxidant can be maintained by a retinol rich diet which may play a role in reducing the morbidity and mortality due to cancer