Indian Journal of Pharmaceutical and Biological Research (IJPBR)
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Preliminary study of the digestive effects of Chenopodium ambrosioides Linn. (Chenopodiaceae) leaves extracts in goats
Get PDFThe effects of the crude aqueous extract of Chenopodium ambrosioides leaves on food intake and digestibility were evaluated with twelve Sahelian goats weighing about 25 kg. Three experimental groups, each consisting of three animals, were treated respectively with the dose of 1ml, 2ml and 4ml/kg of body weight. Treatment was daily and lasted three days. One control group, receiving the same diet as the experimental groups, was involved. The experiment revealed that the herbal extract induced a highly significant variation (p 0.01) in voluntary feed intake expressed in grams of dry matter (DM) from 366.67 g ± 86 (control group) to 631.67 g ± 106.37 (4ml/kg/BW treated group). Concerning digestibility, the results indicated an increase in the absorption of ash and fibre (39.65 % ± 2.65 to 51.38 % ± 4.91). But the digestibility of protein was only slightly influenced by the herbal extract. Animals treated with 4ml/kg/BW dosage had soft and pasty faeces. The aqueous extract of C. ambrosioides leaves would own interesting digestive effects in small ruminants in the fattening stage or those suffering from indigestion due to rumen stuffing. Further specialized studies may clarify those effects
Bacteriostatic activity of con a lectin from Canavalia ensiformis
Get PDFThe aim of this work was to explore the therapeutic applications of Con A lectin from Canavalia ensiformis and to explore its antibacterial activity. Activity of lectin was quantified by their ability to agglutinate erythrocytes using Hemagglutination assay. Characterization and purity of Con A lectin was evaluated by using SDS-PAGE analysis. The reversal of hemagglutination activity of lectin was evaluated by using the sugars namely; mannose, galactose, lactose, fructose, glucose. The antibacterial activity of lectins was tested against Streptococcus mutans, Staphylococcus aureus, Bacillus subtilis, Escherichia coli using pour plate method. Amoxycillin was used as standard. At 250mg/ml concentration Con A lectin showed good bacteriostatic activity
Bioactivity, therapeutic utility and toxicological risks of Khaya senegalensis
Get PDFVegetative organs of Khaya senegalensis (Ders.) A. Juss. are widely used in African pharmacopoeia. A review of pharmacological studies, focused on this plant, was carried out, using the available scientific literature. Several studies have revealed its bioactive properties and therefore its medical efficacy. Aqueous and alcoholic extracts of the stem bark and leaves of this plant have shown efficient in the treatment of some bacterial infections. Their widely reported biochemical effects, such as _-amylase activity inhibition, decreasing in bowel motility and in some blood and serum enzyme (Aspartate transferase, Alanine transferase and Alkaline phosphatase) justify indications against diabetes, diarrhea and liver disorders. Antiparasitic properties directed against helminths and coccidian are also attributed to these herbal medicines. However, according to some results recorded in various studies, this plant has a high risk of toxicity in chronic treatment (several weeks). Histotoxic effects (in liver and kidney) resulting in increased of plasma total protein, blood urea and creatinine are reported
Ethnomedicinal Plants of Barmer District, Rajasthan Used in Herbal and Folk Remedies
Get PDFThe Barmer district a part of Thar Desert is very rich in herbal plant wealth. The herbal plants of this region have great potential to be used in drug and pharmaceutical industries. These herbal plants have been used by local people, tribal communities, vendors, native doctors such as Ojhas, Bhagats Bhopas and experts of Ayurvedic fields since long time in herbal and folk remedies. Kalbelia, Nats, Bhils, Raika, Bhopas, Banjara, Gadolia-Lohar Langa and Manganiars communities of this district have a rich knowledge of plants based traditional medicines. Ethnomedicinal plants like Aristolochia bracteolata Lamk., Calligonum polygonoides Linn., Cardiospermum halicacabum Linn., Clerodendrum phlomoidis Linn., Evolvulus alsinoides Linn., Grewia tenax (Forsk.) Fiori., Maytenus emarginata (Willd.) Ding Hau., Mollugo Cerviana (Linn.) Seringe. Neurada procumbens Linn., Ocimum americanum Linn., Peganum harmala Linn., Pergularia daemia (Forsk) Chiov., Portulaca oleracea Linn., Sarcostemma acidum (Roxb.) Voigt. and Trianthema portulacastrum Linn. have been selected for this research work.The present investigation is aimed to create awareness about the ethnomedicinal value of the plants and their uses to draw the attention of pharmacologists, phytochemists and pharmaceuticals
A Review on Pharmaceutical Validation and Its Implications
Get PDFThe process validation is establishing documented evidence which provides high degree of assurance that a specific process consistently produces a product meeting its predetermined specifications and quality characteristic. According to GMP validation studies are essential part of GMP these are required to be done as per predefined protocols. The validation study provides the accuracy, sensitivity, specificity and reproducibility of the test methods employed by the firms, shall be established and documented. Thus the validation is an essential part of the quality assurance