Indian Journal of Pharmaceutical and Biological Research (IJPBR)
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Perceived Stress among Undergraduate Medical Students and its Determinants: A Cross-Sectional Study in a Teaching Hospital in West Bengal
Get PDFStress among medical students is a growing concern worldwide. The objectives were to assess the perceived stress, its sources and its pattern among undergraduate medical students and to find out determinants of stress among them. This cross sectional descriptive study was conducted among 225 undergraduate medical students of three academic years of Bankura Sammilani medical college during March-June 2015.Data were collected using a pretested, semistructured, anonymous, self-administered questionnaire which consisted of Perceived Stress Scale -10 for assessment of stress . Data were analysed using SPSS version 20.0. Binary Logistic Regression (BLR) model was adopted to find determinants of stress. Proportion of stressed students was 38.2% and mean stress score was 18.41(SD±6.22). Female students were more stressed than male students. About 80% of students perceived ‘vast syllabus’ and ‘lack of attention and time from teacher’ as stressors. Around 50% of students reported ‘Worry about future’, ‘Own expectation of becoming doctor’, ‘Inadequate quantity and quality of food in hostel’ and ‘Lack of recreation’ as stressors. ‘Disturbed in-campus political environment’ was perceived as a source of stress by 42.2% students. In BLR model, only five stressors, ‘Relationship problem with partner/love affair’, ‘Quarrel/maladjustment with friends’, ‘Living away from home’, ‘Competitive environment’, ‘Lack of attention and time from teachers’ were found statistically significant. Most of the stressors were related to academic and psychological domains. Regular review and restructuring of medical curriculum, implementing in-campus health promotional measures for students to cope with stress are needed to address the issue
Rotula aquatica. Lour-A Review on Medicinal uses Phytochemistry and Pharmacological actions
Get PDFRotula aquatic Lour is an important medicinal herb in Ayurvedic system of medicine. The plant occurs as a small branched shrub that grows characteristically among rocks and trailing over pebbles in stream beds, belonging to the family Boraginaceae and widely distributed throughout India. It is commonly called as Pasanabheda in Ayurveda. As only few studies are done on this plant, the comprehensive review presenting here will summarize regarding its Phytochemical and Pharmacological activities with the help of available and update information. Various studies indicated the antiurolithiatic, hypoglycemic, anti-inflammatory, antibacterial and anthelmintic properties of Rotula aquatica. Although the information are very encouraging and revealed some of the constituents of the plant like polyphenols and tannins as important therapeutically agents. The herb should be studied more extensively to confirm these results and reveal other potential therapeutic effects. Various traditional claims of the plant are still remain to be validated scientifically. Clinical trials for the reported preclinical studies should be performed urgently to further validate the claims on human
Synthesis, Spectral Studies and Antimicrobial Activity of imidazo[2,1-b][1,3,4]thiadiazole derivatives
Get PDFThiadiazole is a heterocyclic compound containg both two nitrogen atom and one sulfur atom as a part of the aromatic five-membered ring. The imidazo [2,1-b]-1,3,4-thiadiazole ring system is the core skeleton of well known immunomodulator levamisole. The synthesis and antimicrobial activity of nine 6-Phenyl-2- substituted imidazo [2,1-b]-1,3,4-thiadiazole derivatives were reported against Gram +ve bacteria Bacillius subtilis (MTCC 121), Staphyloccus aureus (MTCC 87), Gram –ve bacteria Pseudomonas aeruginosa (MTCC 424), Escherichia coli (MTCC 40), and fungal strains Candida albicans (MTCC 183), Fusarium solani (MTCC 2935), Fusarium oxyporium (MTCC 2840). Ciprofloxacin and Fluconazole were used as standard drug for antibacterial and antifungal activity respectively. The synthesized compound (6) and (5b) had moderate antibacterial activity especially with Gram negative Escherichia coli (MTCC 40) where (5a) and (5f) had good antibacterial activity. The structures of the synthesized compounds were established by IR, NMR and Mass spectral studies
Evaluation of Nutritional value of Mollugo cerviana Ser. growing wild in Bikaner District of Rajasthan
Get PDFPlants of arid and semiarid zones are good source of phytochemically important compounds. Mollugo cerviana is a common wild plant of Bikaner and surrounding areas and it has been evaluated for the nutritive contents from root, shoot and fruits. The results obtained by AOAC (1995) method shows that the plant is rich in nutritive contents
Development of Anti-diabetic Niosomes Formulation Containing Metformin and Gliclazide
Get PDFMetformin/Gliclazide niosomes were formulated with span 60 by ether injection method. Three batches MG1-MG3 were prepared in order to study influence of drug polymer ratio on the niosomes formation and in vitro drug release. The formulated niosomes were characterized by drug entrapment, vesicle size determination, and in vitro drug release. Optimized concentration of span 60 and cholesterol was found to be 1:1. In the in-vitro study, niosomes formulation of MG1 showed high percentage of drug release, 40.18 to 45.75% for about 8 hrs. This indicated that this batch of niosomes formulation exhibit sustained drug release pattern as the niosomes act as reservoir system for continuous delivery of drug. The quantity of Metformin/Gliclazide present in the niosomes and the release medium were estimated by a validated HPLC method. The formulated niosomes had acceptable physicochemical characters and released the drug over 6-8 h. The data obtained from in vitro release studies were fitted with various kinetic models and was found to follow Higuchi kinetics
Syzygium aromaticum L. (Clove): A vital herbal drug used in periodontal disease
Get PDFCloves are widely used in dental care, and are effective against a large number of bacteria. The main component of clove oil is eugenol, with β-caryophyllene and eugenyl acetate. The review of published results reveals a great opportunity to treat periodontal disease. The purpose of this study is to compare the bud, leaf and stem essential oil compositions from S. aromaticum and then to evaluate the correlation of the results with anatomic and geographical origins of the essential oil. Many commercial essential oils isolated from bud, leaf and stem were used in this work. The oils were analyzed by GC and then constituents were identified from the whole. The major constituent in oils was eugenol, with increasing percentages from bud (72.08 - 82.36%) to leaf (75.04 - 83.58%) and stem (87.52 - 96.65%). In the clove bud essential oil eugenyl acetate is the second major component (8.6 - 21.3%) while detected in considerably lower amount in the leaf (0 - 1.45%) and stem (0.07 - 2.53%). In leaf essential oil, the second main compounds were β-caryophyllene (11.65 - 19.53%) and α-humulene (1.38 - 2.17%), less represented in bud essential oils (2.76 - 8.64% and 0.34 - 1.04% respectively) and in stem essential oils (1.66 - 9.7% and 0.22 - 1.31% respectively). For each plant material, variation in the percentage of the main constituents was observed according to the sample geographic origin
Prescription pattern of NSAIDS and the prevalence of NSAID-induced gastrointestinal risk factors of orthopaedic patients
Get PDFBackground: Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly used medications in the world. NSAID-induced adverse reactions involve upper gastrointestinal (GI) tract complications, which can be life-threatening. Objectives: The study was conducted to explore the current prescription pattern of non-steroidal anti-inflammatory drugs (NSAIDs) and the prevalence of NSAID-induced gastrointestinal(GI) risk factors of orthopedic adult inpatient.Materials and methods: A prospective observational NSAIDs induced GI risk related study was conducted over a period of 6 months by clinical pharmacist. Study cohort included 105 orthopaedic inpatients who are taking or will be taking NSAIDs for more than a week. A self-administered questionnaire was completed by each patient. A simplified risk scoring scale (the Standardized Calculator of Risk for Events; SCORE) was used to measure patients‟ risk for GI complications. The pattern of NSAIDs prescription was identified from medical recordings.Results: The study groups were stratified into four risk groups according to GI SCORE tool, 27.6% of the patients belonged to high risk or very high risk groups for GI complications. Analysis of prescription pattern revealed that 11.4% of the patients aged over 65 yr, 19% with co morbid disease were prescribed with COX-2 selective inhibitor. Conclusion: In this study assessment of prescription pattern and GI risk factors for NSAIDs were evaluated and in conclusion, physician‟s considerate prescription of NSAIDs with well-understanding of each patient‟s GI risk factors is strongly encouraged to prevent serious GI complication
PHYSICOCHEMICAL AND HPTLC ANALYSIS OF PIPPALIMULA (ROOT OF Piper longum LINN.)
Get PDFPippalimula (root of Piper longum Linn.) is the spice of Indian cuisine having immense therapeutic properties. The study was conducted to evaluate Physicochemical, phytochemical analysis and HPTLC analysis using specific solvent system for Pippalimula. Material and Methods: Fine powder of Grade I Pippalimula (root of Piper longum Linn.) and alchoholic extract were obtained and subjected to phytochemical analysis and chromatographic study.Discussion: Physicochemical analysis of the root was carried out. HPTLC analysis of the methanolic extract of the root powder was performed with Toluene: Ethyl acitate 9:1.(v/v) Conclusion: HPTLC analysis of root of Piper longum Linn.can provide standard analysis with selected solvent system and can be used as a reference for the authentication and quality control of the drug. The study will provide referential information for the correct identification of the crude drugs
Dendrimer: a novel approach for drug delivery systems
Get PDFDendrimers are hyper-branched macromolecules having tree like structure, consisting of a core molecule and alternating layers of monomers. So they can be synthesized by divergent and convergent growth methods. During synthesis, properties of dendrimers like dendrimer size, molecular mass, surface group can be controlled and configured to the desired need. Dendrimers have the ability to encapsulate and bind the guest molecule can be used for solubility enhancement, sustained release and various drug delivery applications. The reflections on biomedical and industrial applications of dendrimers given in this report clearly demonstrate the potential the class of polymer architecture and indeed substantiate the high hopes for the future of dendrimers
A review on nanoparticles – preparation and evaluation parameters
Get PDFNanotechnology defined as a tiny science. Design characterization, production and applications of structures, devices and systems by controlling shape and size at nanometer scale is refers to nanotechnology. Nanotechnology by which we can achieve better therapeutic action, better bioavailability and better patient compliance. Several nanoformulations are successfully used for brain delivery which includes nanoparticles system (polymeric/solid lipid), liposomes, dendrimer‟s, nanoemulsions, nanosuspension and ligand mediated nanosystems.Nanoparticles are defined as particulate dispersions or solid particles drug carrier that may or may not be biodegradable. Several techniques are used for preparation of nanoparticles like Solvent Evaporation, Double Emulsification method, Emulsions - Diffusion Method, Nanoprecipitation, Coacervation method, Salting Out Method, Dialysis and Supercritical fluid technology. Nanoparticles are subjected to several evaluation parameters such as yield of nanoparticles, Drug Content / Surface entrapment / Drug entrapment, Particle Size and Zeta Potential , Surface Morphology, Polydispersity index, In-vitro release Study, Kinetic Study, Stability of nanoparticles