Universidade Estadual da Paraíba (UEPB): Sistema Eletrônico de Editoração de Revistas
Not a member yet
2839 research outputs found
Sort by
PAULO FREIRE E A EXPERIÊNCIA DE ANGICOS/RN: DEMOCRATIZANDO O SABER/CONHECIMENTO EM 40 HORAS
Get PDFO artigo discute a experiência educacional denominada “40 Horas” de Angicos/RN”, projeto piloto originado no âmbito da política educacional estadual, que teve por lócus a cidade de Angicos/RN, em 1963. Teve por orientação pedagógica os princípios democráticos da Pedagogia Freiriana em que a “leitura da palavra estava articulada à leitura do mundo” (Freire, 2011). Tal proposta educacional tornou a alfabetização elemento democrático de acesso ao conhecimento e transformação da realidade. Nesse sentido, o objetivo deste trabalho é refletir sobre a experiência educacional “40 Horas de Angicos/RN”, no viés do direito igualitário à educação, discutindo a proposta pedagógica e as memórias da alfabetização, como subsídios do direito à memória e à democracia. A perspectiva de análise fundamentou-se na teoria da Memória, compreendendo-a como forma de resistência e rememoração. Já a metodologia contemplou a pesquisa bibliográfica e documental, em autores como Freire (1967, 2011), Lyra (1996), relatórios de pesquisa, apoiando-se nos estudos sobre a Memória, em Le Goff (2012), Halbwachs (2006), entre outros. As categorias de análise abarcaram a alfabetização como representação democrática, tutelada pelo direito à memória educacional e à resistência. Os resultados do estudo apontam a experiência “40 Horas de Angicos/RN” como marco representativo da democratização do direito de jovens e adultos à alfabetização, constituindo-se como direito de todos à educação, fazendo-se necessário, para a História da Educação Brasileira, sua rememoração
Representação das Trajetórias Feminina na Matemática: Uma Revisão Bibliográfica do Estado da Arte
Get PDFEste estudo trata-se de uma revisão bibliográfica investigativa das representações e trajetórias de mulheres na matemática, utilizando o método do Estado da Arte, conforme descrito por Ferreira (2002). O estudo busca consolidar diversas perspectivas sobre o tema, fortalecendo sua base teórica, estruturada em três partes distintas, cada uma abordando aspectos específicos e relevantes para a discussão sobre a igualdade de gênero na matemática. A pesquisa bibliográfica foi realizada no portal de periódicos da Capes, empregando palavras-chave como "trajetórias de mulheres", "relações de gênero", "mulheres", "matemática" e "alunas egressas", com foco em publicações dos últimos 5 anos para assegurar atualidade. A análise se concentrou na participação feminina na Matemática, permitindo uma visão abrangente de como tem sido discutido a participação de mulheres neste campo da ciência
Utilizando a Robótica no Ensino Médio
Get PDFO uso da robótica no Ensino Médio tem se mostrado uma poderosa ferramenta para o ensino de Física, oferecendo aos alunos uma experiência mais prática e envolvente. Através de projetos de robótica, os estudantes podem visualizar conceitos físicos abstratos, como força, movimento e eletricidade, de maneira concreta e aplicável ao mundo real. Além disso, a robótica estimula o trabalho em equipe, a resolução de problemas e o desenvolvimento de habilidades técnicas que vão além da sala de aula, preparando os jovens para os desafios do futuro. Com essa abordagem, o ensino de Física se torna mais dinâmico e acessível, favorecendo a aprendizagem ativa. O uso de robótica no currículo do Ensino Médio também promove uma maior conexão entre teoria e prática, proporcionando um ambiente de aprendizado onde o erro faz parte do processo criativo, e os alunos são motivados a explorar soluções inovadoras para problemas do dia a dia. Essa metodologia, que une tecnologia e educação, favorece um ensino mais humanizado, onde o estudante é o centro do processo de aprendizagem, e a Física é vista não apenas como uma matéria, mas como uma ferramenta para entender e transformar o mundo.
 
FÍSICA APLICADA AOS JOGOS
Get PDFEste artigo surge a partir de pesquisas, observações e construções feitas pelos residentes de física do Programa Institucional de Bolsas e Iniciação à Docência (PIBiD) ,que ocorreu entre os anos de 2023 e 2024, desenvolvido Escola Cidadã Integral Auzanir Lacerda. Esse artigo descreve a abordagem do projeto "Física Aplicada aos Jogos", que foi uma aula eletiva que ocorria uma vez por semana e era liderada pelos residentes de física na escola, com o apoio do professor e do coordenador do Pibid. O foco principal do projeto era enfrentar a falta de interesse dos estudantes do ensino médio da Escola Auzanir durante as aulas de física. O projeto baseou-se principalmente na aprendizagem significativa, utilizando os jogos como sua principal ferramenta de ensino, que simultaneamente cativava os alunos ao longo de toda a aula. Esse texto busca transmitir como a iniciativa abordou essas questões, destacando a importância do projeto realizado , e como ele pode ser uma boa solução para resolução de alguns desafios educacionais muito comuns
O problema da participação e transparência NA Agência Nacional De Mineração (ANM) após o caso Brumadinho
Get PDFA partir da análise do desastre ambiental de Brumadinho (2019), o problema da participação e transparência na Agência Nacional de Mineração (ANM) evidencia a contradição entre a prática regulatória e os desafios que esse órgão enfrena desde o desastre para incrementar a governança regulatória contra novos desastres envolvendo rejeitos de barragens de mineração. Este artigo objetiva explicar esse problema regulatório entre o incremento dos processos decisórios dentro da ANM (com maior transparência, participação social e accountability) e o sucateamento da própria agência, explorando as lições aprendidas e as melhorias na prática regulatória do setor
In silico analysis of the ADMET profile of the chemical constituents present in a hydroethanolic extract of the leaves of Embaúba (Cecropia pachystachya Trécul)
Get PDFEmbaúba (Cecropia pachystachya Trécul) is a tree native to Brazil, whose leaves have traditionally been used to treat respiratory, inflammatory, and gastrointestinal disorders. These biological activities are attributed to phenolic acids and flavonoids, including chlorogenic acid, epicatechin, isoorientin/orientin, and rutin. This study aimed to identify these compounds in the hydroethanolic extract (HE) of Embaúba and perform an in silico analysis of their pharmacokinetic parameters using the PreADMET® (Prediction of Absorption, Distribution, Metabolization, Excretion, and Toxicity) software. The chromatographic analysis confirmed the presence of the five compounds, as evidenced by co-elution with reference substances. The compounds exhibited weak interactions with plasma proteins and limited penetration across the blood-brain barrier, except for epicatechin. They demonstrated good permeability through the skin, facilitating their passage from the stratum corneum to deeper tissues. Additionally, these compounds showed low to moderate absorption and permeability in CaCo-2 cells, indicating their potential for human intestinal absorption. Although they did not inhibit P-glycoprotein, they were found to inhibit the isoenzymes CYP2C19 and CYP2C9. Additionally, chlorogenic acid, epicatechin, and isoorientin exhibited mutagenic effects in the Ames test. In conclusion, given the significant therapeutic potential of Embaúba, in silico assays should be employed to predict the pharmacokinetic profiles of its compounds, thereby facilitating and expediting the development of new drugs and reducing costs, time, and failures in the process.Embaúba (Cecropia pachystachya Trécul) is a tree native to Brazil, whose leaves have traditionally been used to treat respiratory, inflammatory, and gastrointestinal disorders. These biological activities are attributed to phenolic acids and flavonoids, including chlorogenic acid, epicatechin, isoorientin/orientin, and rutin. This study aimed to identify these compounds in the hydroethanolic extract (HE) of Embaúba and perform an in silico analysis of their pharmacokinetic parameters using the PreADMET® (Prediction of Absorption, Distribution, Metabolization, Excretion, and Toxicity) software. The chromatographic analysis confirmed the presence of the five compounds, as evidenced by co-elution with reference substances. The compounds exhibited weak interactions with plasma proteins and limited penetration across the blood-brain barrier, except for epicatechin. They demonstrated good permeability through the skin, facilitating their passage from the stratum corneum to deeper tissues. Additionally, these compounds showed low to moderate absorption and permeability in CaCo-2 cells, indicating their potential for human intestinal absorption. Although they did not inhibit P-glycoprotein, they were found to inhibit the isoenzymes CYP2C19 and CYP2C9. Additionally, chlorogenic acid, epicatechin, and isoorientin exhibited mutagenic effects in the Ames test. In conclusion, given the significant therapeutic potential of Embaúba, in silico assays should be employed to predict the pharmacokinetic profiles of its compounds, thereby facilitating and expediting the development of new drugs and reducing costs, time, and failures in the process
Baclofen: development and characterization of modified release tablets: DEVELOPMENT AND CHARACTERIZATION OF MODIFIED RELEASE TABLETS
No full textBaclofen (BAC) is used to treat spasticity but has a short half-life of 2 to 4 hours, requiring multiple administrations per day. The study aimed to develop modified-release tablets to overcome this problem. 3 batches of tablets containing BAC were produced: F1 containing hydroxyethyl cellulose (HEC), F2 containing poloxamer (PF127) and F3 containing the polymeric mixture of HEC and PF127. The compatibility study was carried out using thermal analysis and infrared spectroscopy with Fourier transform. Powder quality control was obtained by averaging the weight, hardness, friability, disintegration, and in vitro release of the tablets. Compatibility studies by differential thermal analysis showed that the disappearance of the second BAC event by starch was observed, and the incompatibility was confirmed by the decrease in the intensity of the 3250 cm-1 band, which suggests O-H bonding. Colloidal silicon presented dioxide in the 1:1 binary mixture, suppression of all events, which may correspond to the suppression of band 2863 cm-1, referring to N-H stretching, and 2683 cm-1, which suggests an O-H bond of the carboxylic acid. The powder flow was unsatisfactory, so granulation was produced by the wet method. The hardness of the batches varied from 9.90 N to 29.70 N. Furthermore, the uniformity of content followed the Acceptance Values. The in vitro release study demonstrated that F2 was able to modify BAC release. However, it is necessary to change the development conditions.Baclofen (BAC) is used to treat spasticity but has a short half-life of 2 to 4 hours, requiring multiple administrations per day. The study aimed to develop modified-release tablets to overcome this problem. 3 batches of tablets containing BAC were produced: F1 containing hydroxyethyl cellulose (HEC), F2 containing poloxamer (PF127) and F3 containing the polymeric mixture of HEC and PF127. The compatibility study was carried out using thermal analysis and infrared spectroscopy with Fourier transform. Powder quality control was obtained by averaging the weight, hardness, friability, disintegration, and in vitro release of the tablets. Compatibility studies by differential thermal analysis showed that the disappearance of the second BAC event by starch was observed, and the incompatibility was confirmed by the decrease in the intensity of the 3250 cm-1 band, which suggests O-H bonding. Colloidal silicon presented dioxide in the 1:1 binary mixture, suppression of all events, which may correspond to the suppression of band 2863 cm-1, referring to N-H stretching, and 2683 cm-1, which suggests an O-H bond of the carboxylic acid. The powder flow was unsatisfactory, so granulation was produced by the wet method. The hardness of the batches varied from 9.90 N to 29.70 N. Furthermore, the uniformity of content followed the Acceptance Values. The in vitro release study demonstrated that F2 was able to modify BAC release. However, it is necessary to change the development conditions
BRAF V600E Mutation in Odontogenic Keratocyst: A Systematic Review and Meta-Analysis
Get PDFObjective: To assess the frequency of the BRAF V600E mutation in odontogenic keratocyst, correlating the methods of evaluation and detection of the mutated protein. Material and Methods: This systematic review was conducted following the PRISMA guidelines and registered in PROSPERO (CRD 42022379570). An electronic search was performed up to January 20th, 2024, in the databases of Medline, Scopus, Embase, and gray literature (Google Scholar, BDTD). One hundred and sixty-six cases in seven studies were included. The methodological quality of the studies was performed according to the Joanna Briggs Institute. Results:
Only two of the seven studies reported positivity for the BRAF V600E mutation, both by molecular methods. In the remaining five studies, the BRAF V600E mutation was not present, one evaluated by RT-PCR, three by DNA sequencing, and one by IHC. Conclusion: Through analysis of the articles, the BRAF V600E gene mutation alone does not play a significant role in the pathogenesis of OKC. Further research and new studies are necessary
Dental Anxiety and Self-Esteem in Pediatric Patients Undergoing Maxillofacial Orthopedics
Get PDFObjective: To investigate the correlation between dental anxiety and self-esteem in pediatric patients undergoing six months of maxillofacial orthopedic treatment in Portoviejo, Ecuador. Material and Methods: A quasi-experimental study was conducted on 92 children aged 7 to 11 with malocclusions. Participants completed a dental anxiety scale questionnaire and the House-Tree-Person (HTP) psychological graphic test before and after the installation of maxillofacial orthopedics. Confidence interval analyses were performed for qualitative variables, while mean values with standard deviations were calculated for quantitative variables. The relationship between self-esteem and dental anxiety was assessed using a chi-square test. Results: The mean age of participants was 9 years, with 86.96% residing in urban areas. Sociodemographic variables showed statistically significant differences (p<0.05). There were statistically significant differences in dental anxiety between the initial and final periods (p<0.05), with a decrease in anxiety observed after six months of treatment. As measured by the House drawing, self-esteem was significantly higher in the first period evaluated (p<0.05). Conclusion: The study found a decrease in anxiety after six months of maxillofacial orthopedic treatment. Higher self-esteem was associated with better oral health practices, highlighting the importance of the orthodontist\u27s role in evaluating behavior to enhance treatment success and the mental health of pediatric patients
Evaluation of Staining Reduction of Teeth Endodontically Treated with CTZ Paste through the Use of Polytetrafluoroethylene Isolation Tape
Get PDFObjective: To evaluate the level of staining in teeth endodontically treated with CTZ paste with/without the use of polytetrafluoroethylene (PTFE) insulating tape and to identify the restorative material which is the most stable to pigmentation under different rhizolysis conditions. Material and Methods: 50 human deciduous incisors were selected. The teeth received CTZ filling and were divided according to whether or not PTFE was used, as well as by the length of the remaining root (1/3 or 2/3 of the root) and by the restorative material (Modified Resin Glass Ionomer Cement or Opus Bulk Resin Fill Flow). Coloration was assessed once a week for six weeks through follow-up photographs. Pearson\u27s chi-square or Fisher\u27s Exact tests were used for intergroup and intragroup comparisons after six follow-up examinations (p < 0.05). Results: After six weeks of evaluation, it was possible to notice that 100% of the teeth without PTFE had their crowns stained by CTZ. Only 33.33% with PTFE showed staining (p<0.01). There was no statistical difference regarding the type of filling material (p=0.695) or the residual length of the roots (p=1.00). Conclusion: Using PTFE is an effective resource in preventing coronal staining in primary teeth endodontically treated with CTZ paste, regardless of the restorative material used to close the endodontic access or even the length of the root remnant