1,721,302 research outputs found
Activation of the Notch pathway in Down syndrome: cross-talk of Notch and APP.
No full textABSTRACT Down syndrome (DS) patients suffer
from mental retardation, but also display enhanced
-APP production and develop cortical amyloid
plaques at an early age. As -APP and Notch are both
processed by -secretase, we analyzed expression of the
Notch signaling pathway in the adult DS brain and in a
model system for DS, human trisomy 21 fibroblasts by
quantitative PCR. In adult DS cortex we found that
Notch1, Dll1 and Hes1 expression is up-regulated.
Moreover, DS fibroblasts and Alzheimer disease cortex
also show overexpression of Notch1 and Dll1, indicating
that enhanced -APP processing found in both DS
and AD could be instrumental in these changes. Using
pull-down studies we could demonstrate interaction of
APP with Notch1, suggesting that these transmembrane
proteins form heterodimers, but independent of
-secretase. We could demonstrate binding of the intracellular
domain of Notch1 to the APP adaptor
protein Fe65. Furthermore, activated Notch1 can transactivate
an APP target gene, Kai1, and vice versa,
activated APP can trans-activate the classical Notch
target gene Hes1. These data suggest that Notch expression
is activated in Down syndrome, possibly
through cross-talk with APP signaling. This interaction
might affect brain development, since the Notch pathway
plays a pivotal role in neuron-glia differentiation.—
Activation of the Notch pathway in Down syndrome:
cross-talk of Notch and APP. Fischer, D. F., van Dijk,
R., Sluijs, J. A., Nair, S. M., Racchi, M., Levelt, C. N.,
van Leeuwen, F. W., Hol, E. M. FASEB J. 19, 1451–1458
(2005
Introduction. Beyond the confinement of affliction: a discursive field of experience
Get PDFNgoma, a southern African ritual of healing, dance, rhythm and rhyme, is at the heart of social effort to change the fortunes of individuals and communities so that well-being is restored. This collective volume investigates ngoma in its many and culturally diverse manifestations. Contributions: Rijk van Dijk, Ria Reis and Marja Spierenburg (introduction); Henny Blokland (the use of drums in weddings in Unyamwezi, Tanzania, as the key to their use in healing cults and politics); Annette Drews (gender and ngoma among the Kunda of eastern Zambia); Ria Reis (therapeutic ngoma in Swaziland); Marja Spierenburg (the influence of healers' clientele in the Mhondoro territorial cult in Dande, Zimbabwe); Matthew Schoffeleers (rain cults as therapeutic ngoma in the Mbona cult of rural Malawi); Cor Jonker (the politics of therapeutic ngoma as exemplified in the Zionist churches in urban Zambia); Rijk van Dijk (ngoma and born-again fundamentalism in urban Malawi). In the afterword, John M. Janzen takes up critically the challenges to his own work (1992) presented by the contributions in this volume.ASC – Publicaties niet-programma gebonde
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Shaping the International Relations of the Netherlands, 1815-2000: A small country on the global scene
Get PDFThis book seeks to launch a new research agenda for the historiography of Dutch foreign relations during the nineteenth and twentieth centuries. It does so in two important ways. First, it broadens the analytical perspective to include a variety of non-state actors beyond politicians and diplomats. Second, it focuses on the transnational connections that shaped the foreign relations of the Netherlands, emphasizing the effects of (post-) colonialism and internationalism. Furthermore, this essay collection highlights not only the key roles played by Dutch actors on the international scene, but also serves as an important point of comparison for the activities of their counterparts in other small states
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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