1,357,013 research outputs found
Dave Zollo & Greg Brown
No full textGreg Brown is a Grammy nominated singer/songwriter. His most recent release Milk of the Moon is on Red House Records. Dave Zollo is a singer/songwriter, producer, and owner of Trailer Records. His most recent record is The Big Night
Inferences on the source mechanisms of the 1930 Irpinia (Southern Italy) earthquake from simulations of the kinematic rupture process
No full textWe examine here a number of parameters that define the source of the earthquake that occurred on 23rd July 1930 in Southern Italy (in the Irpinia region). Starting from the source models proposed in different studies, we have simulated the acceleration field for each hypothesized model, and compared it with the macroseismic data. We then used the hybrid stochastic-deterministic technique proposed by Zollo et al. (1997) for the simulation of the ground motion associated with the rupture of an extended fault. The accelerations simulated for several sites were associated with the intensities using the empirical relationship proposed by Trifunac and Brady (1975), before being compared with the available data from the macroseismic catalogue. A good reproduction of the macroseismic field is provided by a normal fault striking in Apenninic direction (approximately NW-SE) and dipping 55° toward the SW
Reply to comment by P. Rydelek et al. on "Earthquake magnitude estimation from peak amplitudes of very seismic signals on strong motion records"
No full textBased on the analysis of Mediterranean, near-source,
strong motion records Zollo et al. [2006] (hereinafter
referred to as ZLN) showed that peak displacement amplitudes
of initial P- and S-wave seismic signals scales with the
earthquake size in the moment magnitude range 4 < Mw <
7.4. Similar evidence have been also reported for southern
California [Wu and Zhao, 2006] and Taiwan [Wu et al.,
2006] using only P-wave arrivals up to 100 km distance on
mostly short period and broadband waveform data.PublishedL203033.1. Fisica dei terremotiJCR Journalreserve
Evaluating innovation capabilities of small software firms through a fuzzy model
No full text(Proceedings a cura di ZOLLO G., pubblicati da Edizioni Scientifiche Italiane, Napoli
Evaluating innovation capabilities of small software firms through a fuzzy model
No full text(Proceedings a cura di ZOLLO G., pubblicati da Edizioni Scientifiche Italiane, Napoli
The Author/Translator Interactional Process. A Case Study
No full textSee Naples and Kill (1988) is a lively and colourful novel by the con-temporary English writer, Gregory Dowling, translated into Italian in 2015.
Following the tradition of translation studies (Venuti 2000, Bass-nett 2002, Cronin 2006), this paper analyses the rewriting process of literary translation, considering in particular the fruitful but sometimes tense and even conflictual relationship between writer and translator.
The translation of the novel See Naples and Kill was an ongoing rewriting process entailing a constant dialogue between the writer and the translator. Therefore, the study aims at answering two main ques-tions: what happens if the rewriting process of translation is constant-ly questioned by the author? What happens if the author has a good mastery of the target language and s/he is her/himself a translator?
By exploring the relationship between translation and re-creation, the research focuses on the differences and similarities between the primary creation (source text) and the secondary creation (target text), and aims to verify in which way the dialogic encounter of two different personalities and cultures does not make them merge but, by retaining their own uniqueness, leads eventually to their mutually en-riching each other. A comparative analysis of the source text and the different drafts of the translated version accompanied by the author’s comments will shed light on the tense author-translator relationship in the specific case under investigation and how both actors handle this tension in order to create a new work resulting from the (dis)agreement of the two parties
Interaction of Immune and Cancer Cells/ Immune Cells within the tumor microenvironment
No full textAbstract A plethora of intrinsic and extrinsic factors, including communication
between tumorigenic cells and infiltrating immune cells, fibroblasts, epithelial cells,
vascular and lymphatic endothelial cells, cytokines and chemokines, constitute the
tumor microenvironment. Although cancer cells can be immunogenic, tumor progression
is associated with the evasion of immune surveillance, the promotion of
tumor tolerance, and even the production of pro-tumorigenic factors by tumorinfiltrating
immune cells. Here we will review the different types of immune cells
within the tumors, with a focus on their fundamental role in tumor growth and
immune escape, namely “cancer immunoediting.” Unraveling their roles and the
molecular mechanisms of action represents today an important issue for the development of new therapeutic approaches to fighting cancer
Fraseologia, traduzione e digital literacy nel contesto universitario: riflessioni e proposte per un percorso didattico sperimentale
No full textPRUNE1: a disease-causing gene for secondary microcephaly
No full textIn their Letter to the Editor, Karakaya et al. (2017) present
an interesting case report describing the clinical course
involving secondary microcephaly of a 3-year-old Turkish
boy found to be homozygous for a frameshift mutation in
PRUNE1 identified through whole exome sequencing. The
child presented with congenital hypotonia, contractures and
global developmental delay with respiratory insufficiency
and seizures developing in the first year of life. The authors
note that the affected child’s head circumference plotted on
the 75th centile at birth, and that by 38 months of age he
had developed microcephaly. Neuroimaging at 14 months
revealed cerebral and cerebellar atrophy consistent with
other patients described with Prune syndrome (Karaca
et al., 2015; Costain et al., 2017; Zollo et al., 2017).
Although the child had abnormal neurology from birth,
there was a period of early developmental regression.
Peripheral spasticity in the lower extremities and optic atrophy
were not documented until 38 months. In addition to
the PRUNE1 variant, Karakaya et al. also identified a
second homozygous variant in the CCDC14 gene in the
Turkish child’s whole exome sequencing data that, while
listed to have an allele count of 108 in the current Genome
Aggregation Database (gnomAD) release, is notably absent
in homozygous fashion (Lek et al., 2016). CCDC14 is
known to be expressed in human brain, reported to negatively
regulate centriole duplication and interact with proteins
previously associated with primary microcephaly
(Firat-Karalar et al., 2014). Thus, while it seems likely
that the homozygous PRUNE1 variant is primarily responsible
for the clinical presentation in the Turkish child, it is
impossible to determine whether there may be any phenotypical
contribution from this additional homozygous
sequence variant.
Recently, Costain et al. (2017) described a homozygous
consensus splice site variant in PRUNE1 (c.521-2A4G;
NM_021222.1) in a 2-year-old Oji-Cre male who presented
with congenital hypotonia and talipes, whose head circumference
was large at birth ( +3 standard deviations), but by
2 years and 2 months plotted on the 50th centile, with a
weight and height on the 95th and 75th centiles, respectively.
However, it should be noted that the child’s father
is macrocephalic ( +4 standard deviations), the published
clinical photographs at 2 years 5 months of age illustrate
bitemporal narrowing, a sloping forehead and large ears,
consistent with a developing microcephaly, and neuroimaging revealed cortical and cerebellar atrophy. He
developed respiratory insufficiency shortly after birth, and
infantile spasms in the first year of life (Costain et al., 2017).
It remains to be determined how the phenotypical outcomes
stemming from proposed loss-of-function mutations
defined by Karakaya et al. and Costain et al., relate to
missense mutations published by Karaca et al. and also
Zollo et al., which are likely to involve at least partial
gain-of-function outcomes in PRUNE1 activity. However,
as more cases are investigated and published, the phenotype
associated with autosomal recessive Prune neurodevelopmental
disorder, and the functional outcomes of
PRUNE1 mutation, are becoming clearer. It is now apparent
that while some patients have a small head at birth and
others a head circumference in the normal range, the key
component of the microcephaly is that it is progressive, and
associated with characteristic neuroimaging findings with a
thin or hypoplastic corpus callosum and cortical and cerebellar
atrophy developing in early childhood. Although all
patients with Prune syndrome described to date are neurologically
impaired from birth, there also appears to be a
neurodegenerative component with progression of the disorder.
In our manuscript, we described clinical overlap of
Prune syndrome with the neurodegenerative condition associated
with homozygous mutations in TBCD (Zollo et al.,
2017). TBCD encodes one of the five tubulin-specific chaperones
that are required for a/b-tubulin de novo heterodimer
formation and the disorder is characterized by
developmental regression, seizures, optic atrophy and secondary
microcephaly, cortical atrophy with delayed myelination,
cerebellar atrophy and thinned corpus callosum
(Edvardson et al., 2016; Flex et al., 2016; Miyake et al.,
2016; Pode-Shakked et al., 2017). The neurodegenerative
phenotype documented in the Turkish child by Karakaya
et al. further demonstrates the similarities with the TBCD
disorder and Prune syndrome, and confirms optic atrophy
to be a feature of Prune syndrome. Interestingly, it is also
becoming clear that respiratory insufficiency is a common
feature of Prune syndrome, having been documented by
Karakaya et al. and in the Oji-Cre child, as well as the
youngest affected Omani child described in our manuscript
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