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ANALISIS KADAR GROWTH DIFFERENTIATION FACTOR-15, GALEKTIN-3, SOLUBLE SUPPRESSION OF TUMORIGENICITY-2 SERUM DENGAN KEJADIAN DISFUNGSI SISTOLIK DINI VENTRIKEL KANAN PADA PENDERITA HIPERTENSI ARTERI PULMONAL
No full textABSTRAK
Analisis Kadar Growth Differentiation Factor-15, Galektin-3, Soluble
Suppression Of Tumorigenicity-2 Serum Dengan Kejadian Disfungsi
Sistolik Dini Ventrikel Kanan Pada Penderita
Hipertensi Arteri Pulmonal
Mefri Yanni
Hipertensi arteri pulmonal (HAP) merupakan bagian dari hipertensi pulmonal, yang
didefinisikan berdasarkan pemeriksaan kateterisasi jantung kanan dengan mPAP > 20
mmHg, tekanan baji arteri pulmonal (pulmonary arterial wedge pressure/PAWP) £ 15
mmHg, dan resistensi vaskular paru (pulmonary vascular resistance, PVR) ≥ 2 WU.
Keadaan kompleks pada penyakit ini menyebabkan vasokonstriksi dan remodelling
vaskular yang progresif pada arteri pulmonalis bagian distal, sehingga akhirnya
mengakibatkan gagal jantung kanan sampai kematian. Penelitian ini bertujuan untuk
menganalisis kadar growth differentiation factor-15, galektin-3, soluble suppression of
tumorigenicity-2 serum dengan kejadian disfungsi sistolik dini ventrikel kanan (VKa) pada
penderita HAP.
Penelitian ini merupakan penelitian analitik dengan desain potong lintang yang
dilakukan pada pasien HAP dengan dan tanpa disfungsi sistolik dini ventrikel kanan
berdasarkan pemeriksaan ekokardiografi speckle tracking menggunakan global
longitudinal strain ventrikel kanan. Sampel penelitian terdiri dari 28 orang kelompok HAP
tanpa disfungsi VKa dan 37 orang kelompok HAP dengan disfungsi VKa. Data diperoleh
melalui rekam medis, pemeriksaan ekokardiografi transtorakal, dan pemeriksaan darah
serum dengan ELISA. Data yang diperoleh kemudian dianalisis menggunakan program
SPSS.
Karakteristik subjek pada penelitian ini didominasi oleh wanita dengan usia rerata
41.52±15.36 tahun, mayoritas berada pada WHO kelas fungsional II dengan etiologi HAP
terbanyak disebabkan oleh penyakit jantung bawaan dengan pirau yang belum dikoreksi.
Ekspresi kadar ketiga biomarka ditemukan lebih tinggi pada kelompok disfungsi dini VKa
dibandingkan kelompok normal. Analisis perbedaan kadar biomarka berdasarkan kejadian
disfungsi dini VKa pada penderita HAP di penelitian ini menemukan bahwa hanya kadar
konsentrasi GDF-15 memiliki perbedaan yang bermakna secara statistik (p = 0.01).
Berdasarkan analisis ROC, didapatkan nilai AUC untuk GDF-15 sebesar 0.67 (rentang
kepercayaan 95% 0.54-0.80) dan nilai titik potong untuk menentukan disfungsi sistolik dini
ventrikel kanan pada nilai 706,93 pg/ml dengan sensitifitas 54,1% dan spesifisitas 89,3%.
Penelitian ini menyimpulkan bahwa terdapat perbedaan kadar ekspresi GDF-15
dengan nilai yang lebih tinggi pada kelompok disfungsi dini VKa, namun tidak ditemukan
perbedaan yang signifikan pada kadar ekspresi Gal-3 dan sST2 serum
PERAN LEMAK EPIKARDIAL PADA PENYAKIT JANTUNG KORONER STABIL
No full textVisceral fat tissue widely known have endocrine function by secreting Cytokines that provide it function in metabolism of visceral organ such as heart. It function have pivotal role under physiology and patology condition by secreting antiinflamatory cytokines in physiology condition, otherwise proinflammatory cytokines in patology condition. Epicardial fat tissue as regard this function, have more important role to the heart, because it have two advantage than other visceral depots. First, this tissue have same microcirculation provided by small branch of coronary arteries, and second it were not boundary by any structure. Recent studies found that there were correlation between increased epicardial fat depot and coronary artery disease. It seems correlate with this unique structure and function. This literature review focuse on how is the role of epicardial fat tissue in atheroschlerotic process especially in coronary artery
PEMERIKSAAN FUNGSI ENDOTEL PADA PENYAKIT KARDIOVASKULAR
No full textCardiovascular risk factors have been known to play a role in vascular endothelial damage. Endothelial damage can cause a condition called endothelial dysfunction. Endothelial dysfunction is the initial process of various cardiovascular problems such as coronary heart disease, stroke, peripheral artery disease, and others. Early stage endothelial damage can actually be detected, but often patients present at the stage of cardiovascular problems. Various examinations of endothelial function start from invasive, non invasive, until biomarkers marking the occurrence of dysfunction can be done. So that we can prevent or reduce the occurrence of further damag
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
PERUBAHAN MORFOLOGI KATUP MITRAL PADA DEMAM REMATIK AKUT DAN PENYAKIT JANTUNG REMATIK
No full textRheumatic fever and rheumatic heart disease remains a significant cause of cardiovascular disease in the world, especially in industrial countries and developing countries. Rheumatic heart disease is the most serious complication of rheumatic fever which is characterized by the occurrence of heart valve defects are most of the mitral valve, aortic and tricuspid followed. Valvulitis or inflammatory process in the tissue of the mitral valve causing edema of the valve leaflets and chordae tendineae, causing disruption valve closure is causing mitral regurgitation. Eventually fibrosis and calcification of the valve that causes stiffness and the valve leaflets into mitral valve stenosis. The earliest possible introduction of cardiac involvement in rheumatic heart disease is an important part in the prevention of further heart damage
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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