226 research outputs found
Efficacy of filial therapy
No full text#nofulltext#Kafescioğlu, Nilüfer (Dogus Author) -- Özer, Serap (Dogus Author) -- Çarkoğlu, Aslı (Dogus Author) 1002 - TÜBİTAK Hızlı Destek Programı. Destek#: 111K008..
Vocal cord paralysis during the treatment of mantle cell lymphoma with vincristine
No full textCase description We present a case of a seventy-eight year-old man who developed vocal cord paralysis without any sign of peripheral neuropathy during the treatment of Mantle Cell Lymphoma. He first presented in 2008 with a few bilateral small inguinal lymph nodes. Inguinal lymph node biopsy demonstrated Mantle Cell Lymphoma. Flow cytometry studies of peripheral blood and bone marrow cells were compatible with Mantle Cell Lymphoma. R-CHOP chemotherapy triweekly (Rituximab; Cyclophosphamide; Adriamycin; Vincristine; and Methylprednisolone) was planned. At the end of the second cycle, the patient complained of hoarseness without any symptoms of dysphagia or odynophagia. Direct flexible laryngoscopy showed bilateral vocal cord paralysis. Vincristine was discontinued and the patient's voice gradually resolved in about 4 months. Conclusion Vincristine may cause peripheral, autonomic and cranial neuropathies. However cranial nerve involvement is quite uncommon
DAYA SERAP SISWA PADA MATERI MATA PELAJARAN MESIN LISTRIK DAN KONTROL MOTOR
No full textLatar belakang dilaksanakannya penelitian ini adalah berdasarkan hasil penelaahan dari kegiatan belajar mengajar selama Program Pengalaman Lapangan (PPL) yang penulis lakukan di sekolah diperoleh kenyataan bahwa banyak siswa tidak mampu menjawab pertanyaan lisan maupun tulisan yang diberikan oleh guru. Tujuan penelitian ini untuk (1) mengetahui daya serap siswa terhadap materi rangkaian kontrol motor bintang-segitiga dan (2) mengetahui konsep-konsep pada materi rangkaian kontrol motor bintang-segitiga yang belum dimengerti oleh siswa. Metode penelitian yang digunakan adalah kuantatif deskriptif. Dalam penelitian ini ditemukan bahwa rata-rata daya serap siswa sebesar 73%; data daya serap yang paling sering muncul sebesar 67%; nilai tengah dari hasil daya serap siswa sebesar 73%; daya serap terendah sebesar 58%; daya serap tertinggi sebesar 91% dan berdasarkan hasil pengelolaan data konsep dikuasai siswa, diperoleh rata-rata konsep dikuasai siswa sebesar 74%; presentase konsep dikuasai siswa yang paling sering muncul sebesar 82%; nilai tengah presentase dari konsep dikuasai siswa sebesar 76%; konsep dikuasai siswa terendah sebesar 53%; konsep dikuasai siswa tertinggi sebesar 88%.
The reason for conducting this research is based on the results of a review of teaching and learning activities during the Field Experience Program (PPL) that the author did in school, it was found that many students were unable to answer the oral and written questions given by the teacher. The purpose of this research is (1) to know the absorption of students to the star-triangular motor control circuit material and (2) to analyze the concepts in the star-triangular motor control circuit material that have not been understood by students. The research method used is descriptive quantitative. In this research it was found that the average absorption of students was 73%; the absorption data that most often appears is 67%; the median value of student absorption is 73%; lowest absorption capacity of 58%; highest absorption capacity of 91% and based on the results of data management the concept is mastered by students, the average concept is mastered by students is 74%; the percentage of concepts mastered by students which most often appears is 82%; the median percentage of the concept is mastered by students is 76%; the concept is mastered by students as low as 53%; the concept is mastered by the highest student at 88%
An investigation of localised surface plasmon resonance (LSPR) of Ag nanoparticles produced by pulsed laser deposition (PLD) technique
No full text32nd International Physics Congress of Turkish-Physical-Society (TPS) -- SEP 06-09, 2016 -- Bodrum, TURKEYNoble metal nano-structures such as Ag, Cu, Au are used commonly to increase power conversion efficiency of the solar cell by using their surface plasmons. The plasmonic metal nanoparticles of Ag among others that have strong LSPR in near-UV range. They increase photon absorbance via embedding in the active semiconductor of the solar cell. Thin films of Ag are grown in the desired particle size and interparticle distance easily and at low cost by PLD technique. Ag nanoparticle thin films were grown on micro slide glass at 25-36 mJ laser pulse energies under by PLD using nsNd:YAG laser. The result of this work have been presented by carrying out UV-VIS and AFM analysis. It was concluded that a laser energy increases, the density and size of Ag-NPs arriving on the substrate increases, and the interparticle distance was decreases. Therefore, LSPR wavelength shifts towards to longer wavelength region.Turkish Phys SocScientific and Technical Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [1649B031503748]; Scientific Research Projects Coordination Unit of Selcuk UniversitySelcuk University [15201070, 15301020]This work was supported by the; Scientific and Technical Research Council of Turkey (TUBITAK) under Grant No. 1649B031503748 and Scientific Research Projects Coordination Unit of Selcuk University, Project No. 15201070 and 15301020. The data presented in this work will be as a part of Ph.D. thesis of Serap YIGIT GEZGI
Scanning electron microscopic study of cold-stored small bowel: comparison of Euro-Collins and Lactated Ringer solutions
No full textA study was carried out to investigate time-related morphological changes of the rat small bowel during preservation of the organ in hypothermic Euro-Collins and Lactated Ringer solutions. Small bowels were perfused via the ascending aorta. After flushing of the intestinal lumen with cold saline solution, perfused grafts were placed in respective preservation solutions at 4°C for 0, 3, 6 and 12 hours. Perfusion and storage in saline solution at 4°C was performed for controls. Biopsy samples were prepared for examination at the light and scanning electron microscopic levels. The results indicate that both preservation solutions are suitable for short term preservation of the small bowel
Stress-induced transcriptional changes and DNA damage associated with bis(2-ethylhexyl) adipate exposure in Zebrafish (Danio rerio) larvae
No full textThe present study evaluates potential toxic effects of bis(2-ethylhexyl) adipate (DEHA) plasticizer to larval (72 h post fertilization) zebrafish (Danio rerio) by analyzing changes in expression levels of stress-related genes (p53, rad51 and xrcc5) and assessing possible DNA damage of DEHA in larvae. the lethal concentration for 50% mortality (LC50) in larval zebrafish exposed for 96 h to 0-200 mg L-1 DEHA was 89.9 +/- 8.03 mg L-1. A concentration-dependent increase in DNA strand breaks was detected in cells from larvae exposed for 96 h to DEHA. There were some significant differences in induction of stress-related genes in larvae exposed to DEHA relative to control.Recep Tayyip Erdogan UniversityRecep Tayyip Erdogan University [2015.53001.103.01.02]This project was funded by Recep Tayyip Erdogan University, Scientific Research Projects Fund (Project No. 2015.53001.103.01.02). the information contained in this article was extracted from a master's thesis by the author, Serap Terzi
Understanding an Introverted Child: A Narrative Study
No full textBu çalışmada, Serap Öğretmenin (çalışmanın ikinci yazarının) kendi deneyimlerinden yolaçıkarak sınıfındaki içedönük bir öğrencisinin farkına varma ve ona ulaşma gayreti incelenmiştir.Çalışma, nitel araştırma desenlerinden biri olan “anlatı araştırması” deseni kapsamında yürütülmüştür.Anlatı araştırmalarında temel amaç, bireylerin dünyayı deneyimleme biçimlerini kendi ürettiklerihikâyeler aracılığıyla incelemektir. Bu bakış açısıyla gerçekleştirilen bu çalışmada da SerapÖğretmenin aktardığı hikâyeler aracılığıyla sınıfındaki içedönük öğrencisiyle ilgili deneyimleri ve budeneyimlerinden yola çıkarak hem içedönük öğrencisinde neden olduğu değişim hem de mesleğindeyaşadığı dönüşüm incelenmiştir. Çalışmanın verileri, bir dizi yarı-yapılandırılmış görüşmeler yoluylaelde edilmiştir. Her görüşmenin deşifre edilmesinden sonra elde edilen veriler hakkında SerapÖğretmenden e-posta aracılığıyla yazılı olarak geri bildirim alınmış ve yeterince açık veya netolmayan hususlarla ilgili yeni görüşmelerle yeni veriler sorgulanmıştır. Ayrıca, araştırma raporununyazılmasından sonra Serap Öğretmenle işbirliğine gidilerek raporun tamamına ilişkin görüşüalınmıştır. Görüşmelerden elde edilen veriler belli bir kronolojik yapı içinde yeniden organize edilerekve araştırmanın alt-soruları çerçevesinde temalandırılarak beş tema altında sunulmuştur. Bu temalarşunlardır: (1) içedönük öğrencinin farkına varma, (2) içedönük öğrenciyi tanıma, (3) içedönüköğrenciye ulaşma, (4) içedönük öğrencideki değişimi/gelişimi izleme ve (5) mesleki açıdankazanımı/gelişimi değerlendirme. Çalışmanın bulgularına göre, Serap Öğretmen içedönük öğrencisiyleilgili istediği hedeflere ulaşmış olduğunu ve zor çocuk olgusuna ilişkin olarak da mesleki açıdanönemli bir anlayış geliştirdiğini düşünmektedir. Çalışmanın sonuçlarına göre, diğer zor çocuk tiplerineilişkin olarak da gerçekleştirilecek kapsamlı anlatı araştırmalarına ihtiyaç vardır.This study examined Teacher Serap’s (the second author of this study) effort to recognizeand reach an introverted student in her classroom based on her own experiences. The study wasconducted within the scope of the “narrative research” methodology, one of the qualitative researchdesigns. The main purpose of narrative studies is to examine the ways through which individualsexperience the world and reality by analyzing their own personal stories. From this point of view, thisstudy examined Teacher Serap’s experiences with an introverted student in her classroom through herown personal stories and the changes that these experiences caused both in the introverted student andher profession. Data were collected through a series of semi-structured interviews. After eachinterview was transcribed, written feedback from the teacher was obtained through e-mails and newinterviews were conducted with her about the issues that were not clear enough. In addition, afterfinishing the writing of the research report, Teacher Serap was invited to indicate her opinions on theentire report. Data were reorganized around the sub-questions of the study and presented in achronological framework under five themes. They include: (1) recognizing the introverted student, (2)getting to know the introverted student, (3) reaching the introverted student, (4) tracing the changes inthe introverted student, and (5) evaluating the professional attainments. According to the findings,Teacher Serap believes that she has achieved her desired goals for her introverted student anddeveloped an invaluable understanding about the phenomenon of difficult children. The studyconcludes that there is a need for comprehensive narrative research studies to be carried out on othertypes of difficult children
Generalized injectivity and approximation
No full textTitle: Generalized injectivity and approximations Author: Serap S¸ahinkaya Department:Algebra Faculty of Mathematics and Physics, Charles University Supervisor: Prof. RNDr. Jan Trlifaj, DSc, Faculty of Mathematics and Physics, Charles University Abstract: Injective modules form a basic class studied in contemporary module theory. One of their generalizations, inspired by tilting theory, is the notion of a cotilting module. While tilting modules behave well with respect to localization, we show that colocalization is the correct approach when comparing the struc- ture of cotilting modules over commutative noetherian rings R with the structure of cotilting modules over their localizations Rm where m runs over the maximal spectrum of R. This is done in Chapter 2 of this Dissertation whose main results were published in the paper [33]. In Chapter 3, we investigate approximation properties of other classic generalizations of injective modules, the Ci- and quasi- injective modules, introduced by Harada et al. Suprisingly, we prove that these classes provide for approximations only in exceptional cases (when all Ci mod- ules are injective, or pure-injective). The Dissertation ends with a set of open problems. Keywords: Commutative noetherian ring, (co)tilting module, (generalized) injec- tive module.
Zobecněná injektivita a aproximace
No full textTitle: Generalized injectivity and approximations Author: Serap S¸ahinkaya Department:Algebra Faculty of Mathematics and Physics, Charles University Supervisor: Prof. RNDr. Jan Trlifaj, DSc, Faculty of Mathematics and Physics, Charles University Abstract: Injective modules form a basic class studied in contemporary module theory. One of their generalizations, inspired by tilting theory, is the notion of a cotilting module. While tilting modules behave well with respect to localization, we show that colocalization is the correct approach when comparing the struc- ture of cotilting modules over commutative noetherian rings R with the structure of cotilting modules over their localizations Rm where m runs over the maximal spectrum of R. This is done in Chapter 2 of this Dissertation whose main results were published in the paper [33]. In Chapter 3, we investigate approximation properties of other classic generalizations of injective modules, the Ci- and quasi- injective modules, introduced by Harada et al. Suprisingly, we prove that these classes provide for approximations only in exceptional cases (when all Ci mod- ules are injective, or pure-injective). The Dissertation ends with a set of open problems. Keywords: Commutative noetherian ring, (co)tilting module, (generalized) injec- tive module. 1Název práce: Zobecněná injektivita a aproximace Autor: Serap S¸ahinkaya Katedra: Katedra algebry, Matematicko-fyzikální fakulta, Univerzita Karlova v Praze. Vedoucí dizertační práce: Prof. RNDr. Jan Trlifaj, DSc, Matematicko-fyzikální fakulta, Univerzita Karlova v Praze. Abstrakt: Injektivní moduly tvoří jednu ze základních tříd studovaných v mo- derní teorii modulů. Jejich zobecněním, inspirovaným vychylující teorií, jsou kovychylující moduly. Zatímco vlastnost být vychylujícím modulem se zachovává lokalizací, analogické tvrzení pro kovychylující moduly neplatí. V dizertaci je ukázáno, že účinným nástrojem pro porovnání struktury kovychylujících modulů nad komutativním noetherovským okruhem R se strukturou kovychylujících modu- lů nad jeho lokalizacemi Rm, kde m probíhá maximální spektrum R, je kolokalizace. Tyto výsledky jsou prezentovány v kapitole 2 dizertace a byly již publikovány v článku [33]. V kapitole 3 zkoumáme aproximační vlastnosti jiných klasických zobecnění injektivních modul, Ci- a kvazi-injektivních modulů, zavedených Hara- dou a dalšími. Dokazujeme, že tyto třídy poskytují aproximace pouze ve výjimeč- ných případech (když všechny Ci-moduly jsou injektivní nebo čistě injektivní). Klíčov slova:...Katedra algebryDepartment of AlgebraFaculty of Mathematics and PhysicsMatematicko-fyzikální fakult
Determination of Potential Drug Candidate Molecules of the Hypericum perforatum for COVID-19 Treatment
No full textThe novel human coronavirus was firstly emerged in December 2019 in Wuhan, China, and has spread rapidly around the world. There is no known specific effective treatment of COVID-19. The most commonly used agents against this disease both in Turkey and around the world include chloroquine, hydroxychloroquine, lopinavir/ritonavir, favipiravir, and remdesivir. In the study, we investigated the drug potential of molecules that the components of an important medicinal plant Hypericum perforatum by using molecular docking and drug possibility properties of these molecules. The molecular docking results showed that the most stable complex was obtained with COVID-19 main protease and hypericin/isohypericin ligands with − 11 kcal/mol binding energy. Furthermore, ADMET, drug-likeness features of compounds of H. perforatum were investigated using the rules of Lipinski, Veber, and Ghose. According to the results obtained, it has been shown that H. perforatum has the potential to be an effective drug in the COVID-19 pandemic. In the next stage, it is necessary to carry out the clinically necessary reliability studies of these components. It is thought that it can be used for the treatment of COVID-19 if our molecular docking results are found to be in high correlation with clinical studies. © 2021, The Author(s), under exclusive licence to Springer Nature Switzerland AG part of Springer Nature
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