DSpace @ Recep Tayyip Erdoğan Üniversitesi Akademik Açık Arşiv
Not a member yet
12203 research outputs found
Sort by
Effects of dexmedetomidine treatment after cerebral ischemia/reperfusion on apoptosis and oxidative stress: a rat model
No full textObjectives: Cerebral ischemia/reperfusion (IR) injury is characterized by excessive oxidative stress and activation of apoptotic pathways, which play a central role in neuronal loss and poor neurological outcomes. Modulation of these mechanisms represents a clinically relevant strategy for neuroprotection. This study aimed to investigate the neuroprotective effects of dexmedetomidine (Dex) on oxidative stress, apoptotic signaling, and neuronal integrity in an experimental rat model of cerebral IR injury. Materials and Methods: Female Wistar rats were assigned to control, IR, and IR+Dex groups. Transient cerebral ischemia was induced for 45 min followed by 2 h of reperfusion. Oxidative stress was evaluated using serum antioxidant enzyme activities (superoxide dismutase [SOD], catalase [CAT], glutathione peroxidase [GSH-Px]), total oxidant and antioxidant status (TOS, TAS), and lipid peroxidation levels (malondialdehyde [MDA]). Apoptotic signaling was assessed by histopathological examination, transmission electron microscopy, and immunohistochemical analysis of B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein (Bax) and apoptotic peptidase activating factor-1 (APAF-1) expression, quantitatively evaluated using QuPath with statistical comparison between groups. Bioinformatic network analysis and molecular docking were performed to explore predicted interactions between Dex and apoptosis-related proteins. Results: Cerebral IR induced a marked oxidative imbalance, characterized by reduced antioxidant enzyme activities and increased lipid peroxidation. Dex treatment partially improved antioxidant capacity and reduced oxidative stress parameters. Histopathological and ultrastructural analyses demonstrated severe neuronal degeneration following IR, whereas Dex-treated rats exhibited attenuated neuronal damage and improved ultrastructural preservation. Immunohistochemical analysis showed increased Bax and APAF-1 expression and reduced Bcl-2 expression after IR; these alterations were significantly modulated toward control levels in the IR+Dex group. Bioinformatic analysis identified apoptosis-related pathways, including apoptosis, p53 signaling, and necroptosis, as significantly enriched, while molecular docking suggested stable predicted interactions between Dex and key apoptotic regulators. Conclusions: In this experimental rat cerebral IR model, Dex exerted partial but significant neuroprotective effects by attenuating oxidative stress, modulating apoptotic marker expression, and preserving neuronal morphology. These findings support the potential role of Dex as a neuroprotective agent in ischemia-related brain injury, warranting further translational investigation
Dünya'da ve Türkiye'de Çay Üretimi
No full textÇay tarımı Dersi 14. Hafta Ders Notu Konusu : Dünya'da ve Türkiye'de Çay Üretim
Editorial: New trends in type 2 diabetes diagnosis and management in primary care, volume II
No full textType 2 diabetes mellitus (T2DM) continues to represent one of the most substantial and persistent global health challenges, with its burden extending far beyond glycemic control to encompass cardiovascular disease, microvascular complications, healthcare utilization, and socioeconomic consequences
Adherence to the mediterranean diet and metabolic gene expression in smokers: an integrative transcriptomic approach
No full textBackground: Cigarette smoking disrupts cellular energy metabolism and remains a major global health problem. The Mediterranean diet, characterized by antioxidant and anti-inflammatory properties, has been implicated in the regulation of metabolic pathways. Objective: This study aimed to examine the association between adherence to the Mediterranean diet and the expression of energy metabolism-related genes in smokers aged 18–55 years. Methods: Smokers were classified according to their Mediterranean Diet Adherence Screener (MEDAS) scores into an adhering group (n = 24) and a non-adhering group (n = 24). Participant characteristics were recorded, blood samples were collected, and total RNA was isolated. Gene expression analysis was performed using a custom RT-qPCR array targeting energy metabolism-related genes. Pathway enrichment analysis was conducted using EnrichR Reactome 2024, and gene–metabolite relationships were explored using MetaboAnalyst 6.0 to support pathway-level interpretation. Results: Smoking was associated with coordinated upregulation of genes involved in glycolysis, glucose transport, lipid metabolism, amino acid metabolism, the pentose phosphate pathway, and redox regulation, consistent with a metabolically stressed state. In contrast, adherence to the Mediterranean diet was associated with lower expression of genes related to glycolytic flux, lipid β-oxidation, and amino acid turnover, alongside relatively higher engagement of tricarboxylic acid cycle-related pathways and reduced activation of redox-associated processes. Conclusions: Adherence to the Mediterranean diet was associated with differences in the expression of genes involved in cellular energy metabolism among smokers, suggesting a potential modulatory role of dietary patterns in smoking-related metabolic alterations
Microwave assisted synthesis of furan/triazole substituted cobalt(ii) phthalocyanine and investigation of electrochromic properties
No full textIn this study, tetra 4-(4-fluorophenyl)-5-(furan-2-yl)-4H-1,2,4-triazole-3-thio substituted Co(II) phthalocyanine was synthesized from novel, 4-((4-(4-fluorophenyl)-5-(furan-2-yl)-4H-1,2,4-triazol-3-yl)thio)phthalonitrile, compound by microwave irradiation. The novel compounds were characterized by FT-IR, 1H NMR, 13C NMR, mass spectrometric and elemental analysis methods. The electrochemical and in-situ spectroelectrochemical properties of CoPc are determined. During the reduction process, one quasi reversible metal-based and one reversible phthalocyanine-based redox couple were observed. 4-(4-fluorophenyl)-5-(furan-2-yl)-4H-1,2,4-triazole-3-thio- substituent included CoPc electropolymerized on indium tin oxide (ITO) glass electrode. Electrochromic performance of Poly(CoPc) film was recorded with in-situ spectroelectrochemical measurements. The effect on optical contrast thickness of film, solvent and supporting electrolyte was investigated. The color of Poly(CoPc) film changed from green to brown color at 1.40 V and optical contrast was recorded as 34 % at 690 nm in DCM/TBAPF6 electrolyte. In addition, coloring/bleaching time was recorded as about 10 s
Classification: Performance Evaluation and Ensemble Methods
No full textData Mining 11. Hafta Ders Notu Konusu : Classification: Performance Evaluation and
Ensemble Method
How analytic properties of functions influence their images under the limit q-stancu operator?
No full textIn the study of various q-versions of the Bernstein polynomials, a significant attention is paid to their limit operators. The present work focuses on the impact of the limit q-Stancu operator S∞q,α on the analytic properties of functions when 00. It is shown that for every f∈C[0,1], the function S∞q,αf admits an analytic continuation into the disk {z:|z+α/(1-q)|<1+α/(1-q)}. In addition, it is proved that the more derivatives f has at x=1, the wider this disk becomes. Further, if f is infinitely differentiable at x=1, then the function S∞q,αf is entire. Finally, some growth estimates for (S∞q,αf)(z) are obtained
Navigating microplastic-induced stress in plants: adaptations from physiology to gene regulation
No full textThe growing concern about microplastic (MP) pollution and its impact on plant systems is reaching alarming levels due to the increase in plastic production and the resulting environmental degradation. Therefore, we explored bibliometric trends of physiological and molecular responses of plants to MP-induced stress, covering sources, interactions, and inconsistencies in research findings. We used bibliometric analysis (n = 84) from 2017–2025 to identify global research trends in plant–MP interactions, integrating mechanistic insights into physiological and molecular responses across species. Data reveals a high scientific publication growth rate (19.84%) in plant-MP studies between 2017 and 2025, culminating in 2024, driven by global pollution awareness. Research priorities primarily focus on understanding impacts on growth, stress responses, and toxicity, as indicated by the most frequent keywords, while critical areas like cellular interactions does not get enough attention. The dominance of environmental journals in the area and strong international co-authorship (29.59%) confirms the topic’s interdisciplinary nature and global research effort. The literature provides a holistic understanding showing that the MP exposure triggers upregulation of the phenylpropanoid pathway (up to 60% increase in phenolic compounds), disrupts nutrient uptake and water transport reduces seed germination (20% decrease at 200 mg/kg), and elevates ABA levels (up to 40% increase) and, often exhibit increased ROS production indicating a clear stress response varying based on plant species and MP characteristics. This review dissects the bibliometric data to identify key research gaps, propose potential solutions, and suggest avenues for improving plant MP stress tolerance. Further research into the long-term ecological consequences of plant-MP interactions might pave the way for sustainable strategies to mitigate the detrimental effects of prolonged MP pollution on plant ecosystems and ensure food security
Wireless power transfer in offshore renewable energy: A review of technologies, challenges, and future directions
No full textThe growing demand for sustainable and reliable energy solutions in remote coastal regions has sparked significant interest in offshore renewable energy systems, including floating solar arrays, wind turbines, wave energy, and hybrid energy systems. Wireless Power Transfer (WPT) technologies have emerged as a promising approach that enhances safety and efficiency in power generation, transmission, and storage, particularly in challenging underwater and oceanic environments. The primary objective of this study is to evaluate the effectiveness of various WPT methods for offshore energy transmission, including near-field techniques (inductive and capacitive coupling) and far-field approaches (microwave and laser-based systems), while addressing the challenges presented by long-distance energy transportation and undersea infrastructure. Additionally, this study highlights innovations in energy storage technologies, such as underwater pumped storage hydropower (UPSH), underwater compressed air energy storage (UWCAES), and electrochemical storage systems, which help to mitigate the instability of renewable energy generation. Through a comprehensive analysis of existing literature and case studies, this study highlights the technical, economic, and environmental challenges associated with offshore wireless energy systems. Key findings suggest that while WPT offers significant advantages in safety and flexibility, further research is needed to optimise efficiency, reduce costs, and minimise ecological impacts