9,075 research outputs found
Analysis of the test condition of a shock-expansion tube: JF-16
No full textA shock-expansion tube (SET, named JF-16) has been built at the State Key Laboratory of High Temperature Gas
Dynamics (LHD) in order to generate relatively steady and clean test gas of really high enthalpy. However, the test time of a
SET is extremely shorter as compared to a reflected-shock tunnel (RST) of the same scale which results in difficulties in the
measurements and diagnostics. An applicable means to the flow diagnostics is the integrated computation-experiment
techniques. In this paper, some numerical issues occurring in our computational investigation for the test flow of JF-16 are
discussed. The dispersion-controlled dissipative scheme (DCD) is used to setup our SET simulation code. However, spurious
oscillation at the contact surface occurs when the original scheme is applied to the simulation of JF-16 test flow. A new flux
splitting algorithm based on local characteristics is worked out for the DCD scheme. Preliminary computations indicate that
the updated algorithm is more robust to suppress the aforementioned oscillation as compared to the original algorithm.
Several experiments with the typical hypervelocity test flow of JP-16 are computed and compared to validate the algorithms.
The computations of double-wedge flows indicate that the experimental visualization is mainly the self-illumination of
nitrogen atoms instead of the schlieren image
Comparison of aging and hypercholesterolemic effects on the sodium inward currents in cardiac myocytes.
No full textElectrochemical characterizations on MnO2 supercapacitors with potassium polyacrylate and potassium polyacrylate-co-polyacrylamide gel polymer electrolytes
No full textA multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.
Full text linkWe conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 × 10⁻¹²) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 × 10⁻¹¹) on 19q12 maps to CCNE1 and rs11892031 (P = 1 × 10⁻⁷) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide associations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate associations for the GSTM1 deletion (P = 4 × 10⁻¹¹) and a tag SNP for NAT2 acetylation status (P = 4 × 10⁻¹¹), and found interactions with smoking in both regions. Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis
Business Model Innovation of JF Logistics Company
Full text link摘要 随着全球化经济的发展，市场竞争变得越来越复杂。信息时代使得物流供应链管理已上升到企业的战略管理高度。在这样的背景下，本文应用翁君奕老师的介观商务模式创新观点，对JF物流公司所处行业现状进行剖析，重新审视了外部客户市场以及内部自身情况，找出了JF物流公司自身的优势，并结合外部市场客户的需求，提出了“为客户提供个性化的集物流、资金流、信息流于一体的供应链物流服务”这一价值主张，并在此基础上，重新定位客户市场，创新服务产品，理顺内部管理架构和业务流程以支撑和保持这一价值主张。文中同时以例证来说明依据新价值主张所创新的服务产品给JF物流公司所带来的变化，以此说明通过商务模式创新来实行自身的战略...Abstract With the development of the global economy, the competition in market becomes more complicated. In the era of information, logistics and supply chain management is regarded as important as part of the company strategy. Under such background , the author of this essay uses the concept of “JieGuan Business Model Innovation” proposed by Professor Weng Junyi of Xiamen University, and analy...学位：管理学硕士院系专业：管理学院高级经理教育中心（EMBA项目）_管理经济学学号：X200615614
Temporal and spatial variability in speakers with Parkinson's Disease and Friedreich's Ataxia
No full textSpeech variability in groups of speakers with Parkinson's disease (PD) and with Friedreich's ataxia was compared with healthy controls. Speakers repeated the same phrase 20 times at one of two rates (fast or habitual). A non-linear analysis of variability was performed which used some of the principles behind the spatio-temporal index (STI). The STI usually employs variation in lip displacement over repetitions of the same utterance and a linear analysis of such signals is conducted to represent the combined variation in spatial and temporal control. When working with patients, audio measures (here we used speech energy) are preferred over kinematics ones as they are minimally disruptive to speech. Non-linear methods allow spatial variability to be estimated separately from temporal variability. The results are tentatively interpreted as showing that PD speakers were distinguished from healthy control speakers in spatial variability and ataxic speakers were distinguished from controls in temporal variability. These findings are consistent with the speech symptoms reported for these disorders. We conclude that the non-linear analysis using the speech energy measure is worth investigating further as it is potentially revealing of the differences underlying these two pathologies
Impaired T-lymphocyte proliferation function in biliary atresia patients with chronic cholestatic jaundice after Kasai operation.
No full textElectrophysiological mechanisms for the antiarrhythmic activities of naloxone on cardiac tissues.
No full textSAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.
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