1,375,299 research outputs found
Oral History Interview, Jeanne Witte (1170)
No full textIn these interviews, Jeanne Witte discusses growing up on a farm and attending a one-room schoolhouse near Marshfield, WI. She also discusses her thoughts and memories as a UW-Madison Libraries staffer. To learn more about this oral history, download & review the index first (or transcript if available). It will help determine which audio file(s) to download & listen to.In her two July 2011 interview with Troy Reeves, Jeanne Witte detailed her thoughts and memories as a UW-Madison Libraries staffer. Witte spoke of the time period between the 1950s and 1980s and on the following topics: UW-Madison, UW-Madison Libraries, UW-Stevens Point, gay/lesbian activism. Witte grew up near Marshfield, WI, so she described growing up on the farm and attending a one-room schoolhouse. This interview was conducted for inclusion into the UW-Madison Oral History Program
Edwin E. Witte
No full textEdwin E. Witte was a Professor of Economics at the University of Wisconsin and Chairman of the Committee on Economic Security, which oversaw the drafting of the original Social Security Act. Witte is generally acknowledged as the principal author of the Social Security legislation as it went to Congress. In later years, he consulted on the National Labor Relations Act and continued to teach and supervise Ph.D. students
John T. Witte Interview
No full textJohn (Jack) Turner Witte was born on April 1, 1924, in Toledo, Ohio. He was a graduate of Scott High School. His attendance at Dartmouth College was interrupted by his enrollment in Naval officer training; he served during World War ll in the Pacific, and also the Korean War. His grandfather began the Moreton Storage Company in 1878, and Jack eventually bought the business. His interview includes a brief family history. He was preceded in death by his wife Ann, and died in Toledo on February 14, 2014
The role of microtubules in initial neuronal polarization
No full textNeurons are highly polarized cells with two structurally and functionally distinct compartments, axons and dendrites. This dichotomy is the basis for unidirectional signal propagation, the quintessential function of neurons. During neuronal development, the formation of the axon is the initial step in breaking cellular symmetry and the establishment of neuronal polarity. Although a number of polarity regulators involved in this process have been identified, our understanding of the intracellular mechanisms underlying neuronal polarization still remains fragmentary.
In my studies, I addressed the role of microtubule dynamics in initial neuronal polarization. To this end I aimed to investigate the following issues: 1) How do microtubule dynamics and stability change during initial neuronal development? 2) Do microtubules play an instructive role in axon formation? 3) What are possible regulators mediating changes in microtubule dynamics during axon formation?
Using hippocampal neurons in culture as a model system for neuronal polarization I first addressed the dynamics of microtubules in early developmental stages of neurons. Assessing posttranslational modifications of tubulin which serve as markers of microtubule turnover I found that microtubule stability is increased in a single neurite already before axon formation and in the axon of morphologically polarized cells. This polarized distribution of microtubule stability was confirmed by testing the resistance of neuronal microtubules to pharmacologically induced depolymerization. The axon of polarized neurons and a single neurite in morphologically unpolarized cells showed increased microtubule stability. Thus, I established a correlation between the identity of a process and its microtubule stability.
By manipulating specific regulators of neuronal polarity, SAD kinases and GSK-3beta, I analyzed a possible relation between a polarization of microtubule stability and neuronal polarity. I found that a loss of polarity correlated with a loss of polarized microtubule stability in neurons defective for SAD A and SAD B kinases. In marked contrast, the formation of multiple axons, induced by the inhibition of GSK-3beta, was associated with increased microtubule stability in these supernumerary axons. These results suggested that SAD kinases and GSK-3beta regulate neuronal polarization –at least in part– by modulating microtubule dynamics.
To establish a possible causal relation between microtubule dynamics and axon formation I assessed the effects of specific pharmacological alterations of microtubule dynamics on neuronal polarization. I found that application of low doses of the microtubule destabilizing drug nocodazole selectively reduced the formation of future dendrites. Conversely, low doses of the microtubule stabilizing drug taxol led to the formation of multiple axons. I also studied microtubule dynamics in living neurons transfected with GFP-tagged EB3, a protein binding specifically to polymerizing microtubule plus ends. In line with my previous observations I found that microtubules are stabilized along the shaft of the growing axons while dynamic microtubules enrich at the tip of the growing process, suggesting that a well- balanced shift of microtubule dynamics towards more stable microtubules is necessary to induce axon formation. By uncaging a photoactivatable analog of taxol I induced a local stabilization of microtubules at the neurite tip of an unpolarized neuron which was sufficient to favor the site of axon formation. This indicates that a transient stabilization of microtubules is sufficient to trigger axon formation.
In summary, my data allow the following conclusions:
1) Microtubule stability correlates with the identity of a neuronal process.
2) Microtubule stabilization causes axon formation.
3) Microtubule stabilization precedes axon formation.
I therefore deduce that microtubules are actively involved in the process of axon formation and that local microtubule stabilization in one neuronal process is a physiological signal specifying neuronal polarization
Faith Terry Witte, October 10, 1957 - January 15, 2018
No full textFaith Terry Witte passed away January 15, 2018, from complications of a stroke
The Lectures, Witte de With, 1991
No full textThis annual publication of lectures and debates contains an abridged lecture on the relation of cinema and painting (Bellour); a discussion concerning the future of public sculpture (Brouwer, Gerdes and König); an examination of Greenberg's, Poggioli's, and Bürger's views of the avant-garde; an essay on the contemporary art world (Guidieri); a discussion of the "centre and periphery" in the art world today, proposing the non-central model of Portugal (Melo), and an account of death masks, the body and the "monumental face" (Verschaffel). Includes a list of exhibitions held at Witte de With in 1991. 28 bibl. ref
Scotland and the EU : comment by Bruno De Witte
No full textPublished online: 10 September 2014This article belongs to the debate 'Schottland als EU-Mitglied'. In wenigen Tagen wird sich herausstellen, ob Schottland Teil des Vereinigten Königreichs bleiben wird oder nicht. Es könnte wirklich passieren, was es bisher noch nie gab: Aus einem EU-Mitgliedsstaat werden zwei. Oder, werden sie? Während EU-Kommission und viele nationale Regierungen sich bemühen, die Perspektiven Schottlands auf eine fortbestehende EU-Mitgliedschaft düster zu malen, stellen sich viele Europarechts-Expert_innen auf den gegenteiligen Standpunkt – darunter Sionaidh Douglas-Scott, EU-Rechts-Professorin aus Oxford. Wir stellen ihre Position in einem Online-Symposium zur Debatte.Two main options have been put on the table for (re-)accommodating an independent Scotland in the European Union: accession of an independent Scotland to the European Union by means of the procedure of accession of new member states set out in Article 49 TEU; or accommodation of Scotland as a new member state at the same time as it achieves independence, by means of a revision of the European Treaties according to Article 48 TEU. The latter option is supported by the Scottish government in its Scotland’s Future White Paper of November 2013. The Treaty revision would enter into force at the same time as Scotland would become independent (and the government suggested a date for this to happen, namely 24 March 2016). In this way, there would be a seamless transition. Scotland would not first drop out of the EU by separating from the UK, and later climb in again through an accession treaty; it would simply stay inside the EU all the time
An Uncertain Future - Anticipating Oil in Uganda
No full textSoftcover, 17x24The discovery of oil in Uganda in 2006 ushered in an oil-age era with new prospects of unforeseen riches. However, after an initial exploration boom developments stalled. Unlike other countries with major oil discoveries, Uganda has been slow in developing its oil. In fact, over ten years after the first discoveries, there is still no oil. During the time of the research for this book between 2012 and 2015, Uganda’s oil had not yet fully materialised but was becoming. The overarching characteristic of this research project was waiting for the big changes to come: a waiting characterised by indeterminacy. There is a timeline but every year it gets expanded and in 2018 having oil still seems to belong to an uncertain future. This book looks at the waiting period as a time of not-yet-ness and describes the practices of future- and resource-making in Uganda. How did Ugandans handle the new resource wealth and how did they imagine their future with oil to be? This ethnography is concerned with Uganda’s oil and the way Ugandans anticipated different futures with it: promising futures of wealth and development and disturbing futures of destruction and suffering. The book works out how uncertainty was an underlying feature of these anticipations and how risks and risk discourses shaped the imaginations of possible futures. Much of the talk around the oil involved the dichotomy of blessing or curse and it was not clear, which one the oil would be. Rather than adding another assessment of what the future with oil will be like, this book describes the predictions and prophesies as an essential part of how resources are being made. This ethnography shows how various actors in Uganda, from the state, the oil industry, the civil society, and the extractive communities, have tried to negotiate their position in the oil arena. Annika Witte argues in this book that by establishing their risks and using them as power resources actors can influence the becoming of oil as a resource and their own place in a petro-future. The book offers one of the first ethnographic accounts of Uganda’s oil and the negotiations that took place in an oil state to be
Herald Witte
No full textThe Oklahoma A&M College World War I Veterans collection captures the memories and experiences of the men and women of Oklahoma Agricultural and Mechanical College who served in World War I. In 1919, a project headed by Maude Cass, the editor of the 1919 Redskin; Professor Maroney of the Department of History; Margaret Walters, Librarian; and J.W. Cantwell, the College President, was undertaken to survey these veterans. The surveys were returned along with photographs, letters, and newspaper clippings documenting these veterans’ experiences during World War I
Witte de With jaarverslag 1990.
No full textBevat een verslag van een debat 'Monocultuur in Rotterdam?', met Geert Bekaert, Luc Leleu, Joop Linthorst e.a
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