664 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Calamites : [On the organization of the Fossil Plants of the Coal-measures. Part I]
No full textby W.C. WilliamsonHandschriftliches Geschenkexlibris: "Professor Heer with the kind regards of the Author" 011342593_0001 Exemplar der ETH-BI
Die prediking oor die eindoordeel
No full textPreaching on the last judgement.This article deplores the fact that the theologumenon 'last judgement' has become a museum piece. It seeks to stimulate a new debate on this topic. The author is convinced that this theologumenon is a central topic of the Jewish-Christian" religion and should therefore be actualised in such a way that it again can become part of the living faith of the church. The author enters into discussion with Moltmann about God's actions in this world, with Pannenberg about the criterion of the judgement and with Kung about eternal punishment
Further Forensic Fables
No full textI had earlier found Fifty Forensic Fables, though in a republication by the original publisher in 1949. See my comments there. Again, these stories had all appeared in the Law Journal. Before the thirty fables, this volume, like the first, offers a table of cases cited and a table of statutes. Again, each story has an enjoyable newspaper-like caricature. One can get a good sense of these stories, I believe, by trying the second and third of them. In The Industrious Youth and the Stout Stranger (5), a con man looking like W.C. Fields hires the industrious youth and then borrows a sum of money from him. Of course the industrious youth never sees him again. In Mr. Whitewig and the Rash Question (9), the young Mr. Whitewig has established a very strong case when he asks one question too many of the Police Inspector, i.e., why he arrested the defendant. That question produces the records of nine previous convictions. There are twenty-six pages given to an index starting on 107. The covers are heavy boards with titles pasted on.This is a hardbound book (hard cover)By O (Theo Mathew
Proline-rich tyrosine kinase 2 mediates gonadotropin-releasing hormone signaling to a specific extracellularly regulated kinase-sensitive transcriptional locus in the luteinizing hormone beta-subunit gene
No full textG protein-coupled receptor regulation of gene transcription primarily occurs through the phosphorylation of transcription factors by MAPKs. This requires transduction of an activating signal via scaffold proteins that can ultimately determine the outcome by binding signaling kinases and adapter proteins with effects on the target transcription factor and locus of activation. By investigating these mechanisms, we have elucidated how pituitary gonadotrope cells decode an input GnRH signal into coherent transcriptional output from the LH beta-subunit gene promoter. We show that GnRH activates c-Src and multiple members of the MAPK family, c-Jun NH2-terminal kinase 1/2, p38MAPK, and ERK1/2. Using dominant-negative point mutations and chemical inhibitors, we identified that calcium-dependent proline-rich tyrosine kinase 2 specifically acts as a scaffold for a focal adhesion/cytoskeleton-dependent complex comprised of c-Src, Grb2, and mSos that translocates an ERK-activating signal to the nucleus. The locus of action of ERK was specifically mapped to early growth response-1 (Egr-1) DNA binding sites within the LH beta-subunit gene proximal promoter, which was also activated by p38MAPK, but not c-Jun NH2-terminal kinase 1/2. Egr-1 was confirmed as the transcription factor target of ERK and p38MAPK by blockade of protein expression, transcriptional activity, and DNA binding. We have identified a novel GnRH-activated proline-rich tyrosine kinase 2-dependent ERK-mediated signal transduction pathway that specifically regulates Egr-1 activation of the LH beta-subunit proximal gene promoter, and thus provide insight into the molecular mechanisms required for differential regulation of gonadotropin gene expression
Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling.
No full textContains fulltext :
70806.pdf (Publisher’s version ) (Closed access)Large brain size is one of the defining characteristics of modern humans. Seckel syndrome (MIM 210600), a disorder of markedly reduced brain and body size, is associated with defective ATR-dependent DNA damage signaling. Only a single hypomorphic mutation of ATR has been identified in this genetically heterogeneous condition. We now report that mutations in the gene encoding pericentrin (PCNT)--resulting in the loss of pericentrin from the centrosome, where it has key functions anchoring both structural and regulatory proteins--also cause Seckel syndrome. Furthermore, we find that cells of individuals with Seckel syndrome due to mutations in PCNT (PCNT-Seckel) have defects in ATR-dependent checkpoint signaling, providing the first evidence linking a structural centrosomal protein with DNA damage signaling. These findings also suggest that other known microcephaly genes implicated in either DNA repair responses or centrosomal function may act in common developmental pathways determining human brain and body size
Proceedings of the 9th Dutch-Belgian Information Retrieval Workshop
No full textWelcome to the 9th Dutch-Belgian Information Retrieval Workshop (DIR). I very well remember the DIR workshop in 2001 that was also organized in Twente. It took place exactly one day before my PhD defense, to give us the opportunity to have one of the PhD committee members, Stephen Robertson, as the keynote speaker. I am proud to see that DIR does not need PhD defenses any more to attract excellent keynotes. This year, DIR presents Rene van Erk, Director of Product- and Business Development Europe at Wolters Kluwer as the industry keynote; we present professor Gerhard Weikum, Scientific Director at the Max-Planck Institute for Informatics, as the academic keynote. We also present comedian Daniel van Veen as the "cultural keynote" to let our participants taste a bit of our university's unique campus activities. We have tried this year to especially encourage PhD students and researchers from industry to submit their research. Each submission was reviewed by at least two and often three or four program committee members. We thank the program committee members for their high quality reviews. Of 15 submissions to DIR, 12 were accepted. Another 5 submissions were accepted as poster presentations. Four papers were written with participation from industry and most other papers have a PhD student as the first author. Special thanks to the Netherlands Research School for Information and Knowledge Systems (SIKS) for sponsoring the participation of Dutch SIKS members, to the Werkgemeenschap Informatiewetenschap (WGI) for providing a solid financial basis for organizing DIR now and in the future, to the Netherlands Organization of Scientific Research (NWO) for sponsoring the travel and hotel costs of our international keynote speaker Gerhard Weikum, to the Centre for Telematics and Information Technology (CTIT) for sponsoring the proceedings, to the University of Twente and to Cultural Center the Vrijhof for sponsoring our cultural activity on Monday
Comparing Performance of Biomass Gasifier Stoves: Influence of a Multi-Context Approach
No full textMillions of people worldwide die prematurely or suffer from severe health ailments due to cooking equipment that causes unhealthy doses of (household) air pollution. Many attempts to address this have fallen short because technology was not improved sufficiently or the way it was introduced constituted an ill fit with the broader “cooking eco-system”. In terms of technology, (biomass) gasifier stoves look promising on all three sustainability dimensions (people, planet, profit) but have not been adopted on a substantial scale across cultures and regions either. We therefore used a design approach that takes multiple contexts (target groups) into account and compared the performance of a gasifier stove that was developed following this multi-context approach with four previous gasifier versions. With the comparative assessment using criteria well beyond mere technological performance we found that it performed better than these versions as well as than what could be expected based on historical learning, while providing additional systemic advantages. These results encourage verification of the value of the multi-context approach in more settings while providing clues for refinement of the assessment method
Author Profiling in Social Media: The Impact of Emotions on Discourse Analysis
No full text[EN] In this paper we summarise the content of the keynote that will be given at the 5th International Conference on Statistical Language and Speech Processing (SLSP) in Le Mans, France in October 23¿25, 2017. In the keynote we will address the importance of inferring demographic information for marketing and security reasons. The aim is to model how language is shared in gender and age groups taking into account its statistical usage. We will see how a shallow discourse analysis can be done on the basis of a graph-based representation in order to extract information such as how complicated the discourse is (i.e., how connected the graph is), how much interconnected grammatical categories are, how far a grammatical category is from others, how different grammatical categories are related to each other, how the discourse is modelled in different structural or stylistic units, what are the grammatical categories with the most central use in the discourse of a demographic group, what are the most common connectors in the linguistic structures used, etc. Moreover, we will see also the importance to consider emotions in the shallow discourse analysis and the impact that this has. We carried out some experiments for identifying gender and age, both in Spanish and in English, using PAN-AP-13 and PAN-PC-14 corpora, obtaining comparable results to the best performing systems of the PAN Lab at CLEF.The research work described in this paper was partially carried out in the framework of the SomEMBED project (TIN2015-71147-C2-1-P), funded by the Spanish Ministry of Economy, Industry and Competitiveness (MINECO).Rosso, P.; Rangel-Pardo, FM. (2017). Author Profiling in Social Media: The Impact of Emotions on Discourse Analysis. Lecture Notes in Computer Science. 10583:3-18. https://doi.org/10.1007/978-3-319-68456-7_1S31810583Blondel, V.D., Guillaume, J.L., Lambiotte, R., Lefebvre, E.: Fast unfolding of communities in large networks. J. Stat. Mech.: Theory Exp. 2008(10), 10008 (2008)Bonacich, P.: Factoring and weighting approaches to clique identification. J. Math. Soc. 2(1), 113–120 (1972)Brandes, U.: A faster algorithm for betweenness centrality. J. Math. 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