1,722,904 research outputs found
Nicolas WANLIN
No full textNicolas WANLIN, ancien boursier de la Fondation Thiers 2006-2007, est maître de conférences en littérature française (XIXe-XXe siècles), spécialiste de la poésie scientifique du XIXe siècle, des rapports entre littérature et sciences, et de la réception de Darwin et Haeckel dans la littérature française. Publications en rapport avec le programme Biolographes: « La poétique évolutionniste, de Darwin et Haeckel à Sully Prudhomme et René Ghil », Romantisme, n°154, 2011: « Le vivant », Gisèle Sé..
Dario Gamboni, Potential Images. Ambiguity and Indeterminacy in Modem Art, 2002
No full textWanlin Nicolas. Dario Gamboni, Potential Images. Ambiguity and Indeterminacy in Modem Art, 2002. In: Genesis (Manuscrits-Recherche-Invention), numéro 24, 2004. Formes. pp. 193-194
Aloysius Bertrand, Gaspard de la Nuit
No full textWanlin Nicolas. Aloysius Bertrand, Gaspard de la Nuit. In: Romantisme, 2004, n°125. Juifs, judéité à Paris au début du XIXe siècle. pp. 143-144
TROUVER UNE LANGUE: Poésie et poétique
No full textPrésenté par Adrian Grafe et Nicolas Wanlin / Essays in French and EnglishInternational audienc
Vascular Injury Induces Epigenetic Mechanisms to Promote Restenosis After Angioplasty
No full textDue to the injury to the artery from PCI or surgical stenting, neointimal hyperplasia and restenosis are induced by the secreted growth factors and cytokines. These growth factors and cytokines promote phenotype switch in VSMCs which results in inhibition of VSMC differentiation, induction of cell proliferation and migration. Restenosis, which has an incidence rate of about 10% in using DES, leads to ischemia and myocardial infarction. Recently, different epigenetic mechanisms have been identified which regulate different cellular pathways and enhance the pathological progression of the disease.
To identify different molecular mechanisms and the effector proteins involved in promoting vascular restenosis and intimal hyperplasia, we carried out pre-clinical studies using Yucatan microswine as large mammals that were fed with atherogenic diet. Angioplasty was performed in the LCX. After completion of the study, tissues were harvested for immunofluorescence and immunohistochemical staining to check for in vivo expression of epigenetic and downstream mediators. To identify the underlying molecular mechanisms, primary VSMCs were isolated from the coronary arteries and cultured for in vitro studies. After transfecting the cultured VSMCs with siRNA specific for HDAC2, HDAC10, and SOCS3, the cells were stimulated with IGF-1 and TNF-α together, or with PDGF-BB. The primary VSMCs were also transfected with the microRNA miR-490-3p. The transfected cells were treated with DNMT1 inhibitor (5-Aza-Cytidine) and HDAC2 inhibitor (Romidepsin). MTT and scratch wound assays were used to measure VSMCs proliferation and migration. Finally, the expression of epigenetic markers and downstream regulatory proteins were detected by western blot analysis.
Results show increased expression of HDAC2 during intimal hyperplasia. Subsequent inhibition of HDAC2 expression was found to result in DNMT1 inhibition, which presumably was involved in promoting VSMC proliferation, migration and phenotype switch. HDAC10 and HDAC2 were found to co-express during intimal hyperplasia, and inhibition of HDAC10 was found to represses the expression of HDAC2 and DNMT1in VSMCs. Further, SOCS3 expression was found to inhibit the cell proliferation enhancer, Galectin-3, through HDAC10 and DNMT1 inhibition.
Future studies using HDAC10 and HDAC2 double knockout mice with carotid artery ligation will be helpful in unraveling the molecular mechanisms that regulate HDAC10-HDAC2-DNMT1 pathway associated with the development of neointimal hyperplasia. Moreover, co-localization studies and protein immunoprecipitation assays would prove possible molecular interactions between HDAC10 and HDAC2. Development of HDAC10 specific inhibitor would help in identifying the role of HDAC10 in neointimal hyperplasia and restenosis.ProQuest Traditional Publishing Optio
Gaspard de la Nuit. Le Grand Œuvre d’un petit romantique, sous la direction de Nicolas Wanlin
Full text linkNicolas Wanlin présente dans son Liminaire (pp. 7-13) le colloque de 2007 tenu en Sorbonne pour l’anniversaire de la naissance de Bertrand, qui s’organise en trois temps: «Postures d’Aloysius Bertrand» (pp. 15-58), «Poétique de Gaspard de la Nuit» (pp. 59-173) et «Interprétation de Gaspard de la Nuit» (p. 173-240). Dans la première partie, trois articles étudient la question de l’auteur, de ses référents et de sa représentation. Énumération à effet de cumul, dialogue mis en abyme ou monologiq..
Group-theoretic Johnson classes and a non-hyperelliptic curve with torsion Ceresa class
Full text linkLet l be a prime and G a pro-l group with torsion-free abelianization. We
produce group-theoretic analogues of the Johnson/Morita cocycle for G -- in the
case of surface groups, these cocycles appear to refine existing constructions
when l=2. We apply this to the pro-l etale fundamental groups of smooth curves
to obtain Galois-cohomological analogues, and discuss their relationship to
work of Hain and Matsumoto in the case the curve is proper. We analyze many of
the fundamental properties of these classes and use them to give an example of
a non-hyperelliptic curve whose Ceresa class has torsion image under the l-adic
Abel-Jacobi map.Comment: 18 pages, final versio
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
- …
