1,228 research outputs found
sj-docx-1-smo-10.1177_20503121231182517 – Supplemental material for Verification of an intravenous fluid warmer: A prospective, two-center observational trial
No full textSupplemental material, sj-docx-1-smo-10.1177_20503121231182517 for Verification of an intravenous fluid warmer: A prospective, two-center observational trial by Mikko Lax, Seppo T. Mustola, Kimmo Repo, Jari Järvinen, Danielle K. Bayoro, Steven H. Cataldo, Viivi Karhinen, Edward A. Rose, Herman Groepenhoff and Andreas D. Waldmann in SAGE Open Medicine</p
Impact of positive end-expiratory pressure and recruitment maneuver on healthy lungs in dogs assessed by functional and anatomical monitoring methods
No full textIntroduction Atelectasis is a common occurrence during anesthesia, and positive end-expiratory pressure (PEEP) ventilation and recruitment maneuvers (RM) can be used to mitigate this. However, both techniques may be associated with side effects in healthy lungs, and close monitoring is indicated. This study aimed to evaluate the effects of PEEP and RM in healthy dogs and to compare functional lung monitoring methods by electrical impedance tomography (EIT), volumetric capnography (VCap), and blood gas analysis with the gold-standard anatomical monitoring provided by computed tomography (CT). Methods and materials Nine healthy Beagle dogs underwent anesthesia and mechanical ventilation three times. After 35 min using zero end-expiratory pressure (ZEEP), CT images, VCap, EIT measurements, and arterial blood gas samples were taken. Thereafter, either (1) ZEEP was continued, (2) PEEP initiated or (3) an RM was performed followed by PEEP. Ten minutes after changing the ventilation mode all measurements were repeated. Only one ventilation mode was employed during each anesthesia. Results During RM, we found a significant increase in the percentage of overaerated lung (V hyper ) ( p < 0.001), while the amount of normally aerated lung (V normal ), poorly aerated lung and non-aerated lung decreased ( p ≤ 0.001). VCap showed an increase in airway dead space (VD aw /VT) ( p = 0.002), and a decrease in alveolar dead space (VD alv /VT alv ). For PEEP, an increase in airway dead space ( p = 0.003) was found. For both groups, the amount of carbon dioxide exhaled per breath (VTCO 2,br ) decreased ( p = 0.001), and EIT showed a shift of the center of ventilation to the dependent lung areas ( p = 0.021 and p = 0.046, respectively). Oxygenation was superior in RM compared to ZEEP ( p = 0.033). The arterial partial pressure of carbon dioxide decreased in RM ( p = 0.012). Positive associations were found between V hyper and VD aw /VT ( p = 0.004), V hyper and VD aw /VT ( p = 0.004), V hyper and V normal with VTCO 2,br ( p = 0.002 for both). Negative associations were found between V hyper and VD alv /VT alv ( p = 0.004) and non-dependent silent spaces ( p = 0.050), and V normal with oxygenation ( p = 0.030). Conclusion While RM may be effective in improving gas exchange, it appears to be not benign in healthy lungs, and PEEP might be the preferable strategy to avoid lung collapse during anesthesia. Functional monitoring – EIT, VCap, blood gas analysis – does not detect changes corresponding to anatomical findings on CT
Dissertatio Politica De Nuptiis
No full textQuam ... in Celeberrima Witebergensium Academia Sub Praesidio ... Dni. M. Jacobi Rösers/ Sondershusa Schwartzburgici ... Publico & placido Eruditorum Examini submittit Author Andreas Mylius, Ileburgo Misnicus. In Audit. Minor. ad. d. 11. Iul. ...Druckvariante ohne Widmung, nicht identisch mit VD17 14:653394
Boosting joint models for longitudinal and time-to-event data
No full textJoint models for longitudinal and time-to-event data have gained a lot of attention in the last few years as they are a helpful technique clinical studies where longitudinal outcomes are recorded alongside event times. Those two processes are often linked and the two outcomes should thus be modeled jointly in order to prevent the potential bias introduced by independent modeling. Commonly, joint models are estimated in likelihood-based expectation maximization or Bayesian approaches using frameworks where variable selection is problematic and that do not immediately work for high-dimensional data. In this paper, we propose a boosting algorithm tackling these challenges by being able to simultaneously estimate predictors for joint models and automatically select the most influential variables even in high-dimensional data situations. We analyze the performance of the new algorithm in a simulation study and apply it to the Danish cystic fibrosis registry that collects longitudinal lung function data on patients with cystic fibrosis together with data regarding the onset of pulmonary infections. This is the first approach to combine state-of-the art algorithms from the field of machine-learning with the model class of joint models, providing a fully data-driven mechanism to select variables and predictor effects in a unified framework of boosting joint models
Targeting PRMT5 protein-protein interactions with peptidic modulators
No full textProtein arginine methyltransferase 5 (PRMT5) is an important enzyme, methylating arginine residues of its substrates. PRMT5 is involved in a very large number of various cellular process, and has strong ties to a plethora of health disorders. PRMT5 mediates a number of protein-protein interactions (PPIs) with diverse adaptor proteins, such as the obligate binding partner MEP50, and adaptor proteins RioK1, pICln and COPR5. Modulation of PRMT5 PPIs appears as an attractive alternative to the inhibition of the active methylation site, giving an opportunity for significantly more precise targeting of the PRMT5 functionality in cells. This thesis describes pathways for development of peptidomimetics intended for the inhibition of various PPIs formed by PRMT5 or its adaptor protein MEP50. PPI between PRMT5 and MEP50 was investigated using available structural data to design inhibitory peptides. The compounds were synthesised and evaluated using biophysical and enzymatic assays. None of the synthesised compounds showed any activity in the employed assays. In the second part, the thesis describes the analysis of a potential PPI between SUZ12 and MEP50. A number of SUZ12 fragments spanning different protein regions were synthesised and tested for the direct interaction with the PRMT5-MEP50 complex. The analysis indicated that the short SUZ12 sequence CPWCTL is responsible for the interaction with the methyltransferase complex. Further analysis with the binding sequence and control proteins showed very strong non-specific interactions. In light of the obtained results any further peptidomimetic development based on the SUZ12 sequence was not pursued. The final chapters of the thesis focus on the PPIs between PRMT5 and adaptor proteins RioK1, pICln and COPR5. A consensus sequence GQF[D/E]DA[D/E], identified in the terminal regions of the adaptor proteins, was determined to be responsible for mediating the interactions with PRMT5. Biophysical assays and X-ray crystallography allowed to characterise the binding interface and revealed that the consensus sequence binds to the non-catalytic TIM barrel domain of PRMT5. The biophysical data were then used for the design of highly stable macrocyclic PRMT5 adaptor protein interaction inhibitors. Optimisation of the molecular structure resulted in a potent cyclic PRMT5 binder (KD = 89 nM). The developed molecule could inhibit the PPI between PRMT5 and full length pICln when tested in vitro (IC50 = 654 nM). Examination of the compound activity in cellular lysates revealed a surprising selectivity towards the inhibition of the PRMT5 interactions with RioK1 over the interactions with pICln. The developed compound did not supress the enzymatic activity of the methyltransferase and did not inhibit the interaction with MEP50
Calculation of Transpulmonary Pressure From Regional Ventilation Displayed by Electrical Impedance Tomography in Acute Respiratory Distress Syndrome
No full textTranspulmonary driving pressure (DPL) corresponds to the cyclical stress imposed on the lung parenchyma during tidal breathing and, therefore, can be used to assess the risk of ventilator-induced lung injury (VILI). Its measurement at the bedside requires the use of esophageal pressure (Peso), which is sometimes technically challenging. Recently, it has been demonstrated how in an animal model of ARDS, the transpulmonary pressure (PL) measured with Peso calculated with the absolute values method (PL = Paw—Peso) is equivalent to the transpulmonary pressure directly measured using pleural sensors in the central-dependent part of the lung. We hypothesized that, since the PL derived from Peso reflects the regional behavior of the lung, it could exist a relationship between regional parameters measured by electrical impedance tomography (EIT) and driving PL (DPL). Moreover, we explored if, by integrating airways pressure data and EIT data, it could be possible to estimate non-invasively DPL and consequently lung elastance (EL) and elastance-derived inspiratory PL (PI). We analyzed 59 measurements from 20 patients with ARDS. There was a significant intra-patient correlation between EIT derived regional compliance in regions of interest (ROI1) (r = 0.5, p = 0.001), ROI2 (r = −0.68, p < 0.001), and ROI3 (r = −0.4, p = 0.002), and DPL. A multiple linear regression successfully predicted DPL based on respiratory system elastance (Ers), ideal body weight (IBW), roi1%, roi2%, and roi3% (R2 = 0.84, p < 0.001). The corresponding Bland-Altmann analysis showed a bias of −1.4e-007 cmH2O and limits of agreement (LoA) of −2.4–2.4 cmH2O. EL and PI calculated using EIT showed good agreement (R2 = 0.89, p < 0.001 and R2 = 0.75, p < 0.001) with the esophageal derived correspondent variables. In conclusion, DPL has a good correlation with EIT-derived parameters in the central lung. DPL, PI, and EL can be estimated with good accuracy non-invasively combining information coming from EIT and airway pressure
Anselm Feuerbach's criminal novel "Andreas Bichel, Der Mädchenschlächter"
No full textAnzelm [Paul Johann Anselm] Feuerbach (1775–1833), the founder of the theory of psychological compulsion (Theorie des psychologischen Zwanges), was also famous as an author of criminal stories. In 1827 he published a book titled Aktenmäßige Darstellung merwürdigen Verbrechen, which contained more than 30 stories based on criminal cases involving manslaughter. One of these stories, with the original title Andreas Bichel, der Mädchenschlächter (Andreas Bichel, the slaughterer of girls), presents the history of a notorious murderer of young women. The motive of his acts was basically robbery. Law, especially legal proceedings, plays an important role in this [email protected] JagiellońskiE. Krzymuski, Wykład prawa karnego ze stanowiska nauki i prawa austriackiego, t. I, Kraków 1911.D. Janicka, Nauka o winie i karze w dziejach klasycznej szkoły prawa karnego w Niemczech w I połowie XIX wieku, Toruń 1998.P. J. A. Feuerbach, Aktenmäßige Darstellung merw¨urdigen Verbrechen, Frankfurt am Main 1849.S. Salmonowicz, Z wieku Oświecenia. Studia z dziejów prawa i polityki XVIII wieku, Toruń 2001.319-32514231932
Wittgenstein Reading
No full textWittgenstein's thought is reflected in his reading and reception of other authors. "Wittgenstein Reading" approaches the moment of literature as a vehicle of self-reflection for Wittgenstein. What sounds, on the surface, like criticism (e.g. of Shakespeare) can equally be understood as a simple registration of Wittgenstein's own reaction, hence a piece of self-diagnosis or self-analysis.
The book brings a representative sample of authors, from Shakespeare, Goethe, or Dostoyevsky to some that have received far less attention in Wittgenstein scholarship like Kleist, Lessing, Lewis Carroll, or Wilhelm Busch and Johann Nepomuk Nestroy. Furthermore, the volume offers means for the cultural contextualization of Wittgenstein's thoughts.
Unique to this book is its internal design. The editors' Introduction sets the scene with regards to both biography and theory, while each of the subsequent chapters takes a quotation from Wittgenstein on a particular author as its point of departure for developing a more specific theme relating to the writer in question. This format serves to avoid the well-trodden paths of discussions on the relationship between philosophy and literature, allowing for unconventional observations to be made. Furthermore, the volume offers means for the cultural contextualization of Wittgenstein's thoughts
Arithmetica Oder Rechen-Buch Von allerhand Bürgerlicher Ampts- un[d] Hauß-Rechnung : Uff der weitberühmten Stadt Braunschweig Müntz Maas und Gewicht / Vor angehende Rechenschüler mit fleiß gestellet Durch Gebhard Overheyden ... Buchhalter daselbst im Hagen
No full textHomo politicus, hoc est, Consiliarus novus, officiarus et aulicus, secundum hodiernam praxin /
No full textSignatures: A-G⁴.Author and possible place from VD17. Work also attributed to Philipp Andreas Oldenburger.Bibliographic side notes.VD17Mode of access: Internet.Bound with: Libri tres de origine urbium, excellentia earum, et augendi ratione / Giovanni Botero. Helmstedt : Johann Heitmüller, 1665 (SPECIAL 93-B15936)
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