865 research outputs found
The ISM-based phylogenetic tree of the non-redundant SP1 proteins from SARS-CoV-2 viruses deposited in GISAID from January to October 2020.
No full textThe ISM-based phylogenetic tree of the non-redundant SP1 proteins from SARS-CoV-2 viruses deposited in GISAID from January to October 2020 in full resolution
Switzerland's role today is similar to the Cold War (Interview)
No full textNeutrality has put Switzerland in a special position between Russia and the West, similar to during the Cold War, argues Jeronim Perovic, director of the Center for Eastern European Studies at the University of Zurich. Renewed tensions between the U.S. and Europe may nonetheless bring opportunities for Switzerland. In Russian presidential elections on Sunday, Perovic sees Vladimir Putin's almost certain re-election as a sort of good news. Swiss businesses, he says, would at least know what to expect
Discovery of new therapeutic targets by the informational spectrum method
No full textThe field of bioinformatics has become a major part of the drug discovery pipeline playing a key role in improvement and acceleration of this time and money consuming process. Here we review the application of the informational spectrum method (ISM), a virtual spectroscopy method for structure/function analysis of proteins, in identification of functional protein domains representing candidate therapeutic targets for drugs against human immunodeficiency virus (HIV)-1, anthrax, highly pathogenic influenza virus H5N1 and cardiovascular diseases
Exploring the Antiviral Potential of Natural Compounds against Influenza: A Combined Computational and Experimental Approach
No full textThe influenza A virus nonstructural protein 1 (NS1), which is crucial for viral replication and immune evasion, has been identified as a significant drug target with substantial potential to contribute to the fight against influenza. The emergence of drug-resistant influenza A virus strains highlights the urgent need for novel therapeutics. This study proposes a combined theoretical criterion for the virtual screening of molecular libraries to identify candidate NS1 inhibitors. By applying the criterion to the ZINC Natural Product database, followed by ligand-based virtual screening and molecular docking, we proposed the most promising candidate as a potential NS1 inhibitor. Subsequently, the selected natural compound was experimentally evaluated, revealing measurable virus replication inhibition activity in cell culture. This approach offers a promising avenue for developing novel anti-influenza agents targeting the NS1 protei
Exploring the impact of nursing students’ program experiences on post-graduation career specialty choices
No full textThis poster won the Dean, Faculty of Health Sciences Award (2021).
Advisor: Dr. Shelley Canning, Faculty of Health Sciences
Evolution of 2014/15 H3N2 Influenza Viruses Circulating in US: Consequences for Vaccine Effectiveness and Possible New Pandemic
No full textabstract: A key factor in the effectiveness of the seasonal influenza vaccine is its immunological compatibility with the circulating viruses during the season. Here we propose a new bioinformatics approach for analysis of influenza viruses which could be used as an efficient tool for selection of vaccine viruses, assessment of the effectiveness of seasonal influenza vaccines, and prediction of the epidemic/pandemic potential of novel influenza viruses.View the article as published at http://journal.frontiersin.org/article/10.3389/fmicb.2015.01456/ful
Novel phylogenetic algorithm to monitor human tropism in Egyptian H5N1-HPAIV reveals evolution toward efficient human-to-human transmission
No full textYears of endemic infections with highly pathogenic avian influenza (HPAI) A subtype H5N1 virus in poultry and high numbers of infections in humans provide ample opportunity in Egypt for H5N1-HPAIV to develop pandemic potential. In an effort to better understand the viral determinants that facilitate human infections of the Egyptian H5N1-HPAIVvirus, we developed a new phylogenetic algorithm based on a new distance measure derived from the informational spectrum method (ISM). This new approach, which describes functional aspects of the evolution of the hemagglutinin subunit 1 (HA1), revealed a growing group G2 of H5N1-HPAIV in Egypt after 2009 that acquired new informational spectrum (IS) properties suggestive of an increased human tropism and pandemic potential. While in 2006 all viruses in Egypt belonged to the G1 group, by 2011 these viruses were virtually replaced by G2 viruses. All of the G2 viruses displayed four characteristic mutations (D43N, S120(D,N), (S,L)129Δ and I151T), three of which were previously reported to increase binding to the human receptor. Already in 2006–2008 G2 viruses were significantly (p<0.02) more often found in humans than expected from their overall prevalence and this further increased in 2009–2011 (p<0.007). Our approach also identified viruses that acquired additional mutations that we predict to further enhance their human tropism. The extensive evolution of Egyptian H5N1-HPAIV towards a preferential human tropism underlines an urgent need to closely monitor these viruses with respect to molecular determinants of virulence
Freud on Writing: Some Historicist Perspectives
No full textThe author looks at three readings of Freud by Derrida, Michel de Certeau, and Deleuze/Guattari, trying to answer the question: For Freud, how does writing produce meaning and what does this historicizing function imply about the psyche in general? The author inspects two of Freud’s analogies that are to explain and justify psychoanalysis: books avoiding political censorship and the mystic writing pad. These become doorways to the ensuing criticisms. The three commentaries trace sections of Freud’s thought as they relate to his fundamental concepts and to the work those concepts are supposed to do. Read together, the readings each supply support for the conclusion that Freud illegitimately treats the unconscious as the first cause, tied as he is to the metaphysics of presence. Freud’s psychoanalyst, in the name of nothingness, makes real his historicizing of the unconscious. Freud’s thought betrays his thought
Modern notion of time notion of history: About the basis of Heideggers' discussion with Hegel
No full textIn the text, the author analyses Heidegger's critique of Hegel's notions of time and history, reaching the conclusion that the weak points of that critique are contained in the fact that it did not take into account Hegel's idea of the phenomenology of time.</jats:p
Use of Barley and Wheat Reference Sequences: Downstream Applications in Breeding, Gene Isolation, GWAS and Evolution
No full textThis eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contac
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