66,519 research outputs found
Mémoire de M. Fernand de Visscher sur la justice romaine en Cyrénaïque, l'Édit IV de Cyrène
No full textOlivier-Martin François. Mémoire de M. Fernand de Visscher sur la justice romaine en Cyrénaïque, l'Édit IV de Cyrène. In: Comptes rendus des séances de l'Académie des Inscriptions et Belles-Lettres, 85ᵉ année, N. 4, 1941. p. 304
Association of overweight with increased risk of coronary heart disease partly independent of blood pressure and cholesterol levels: A meta-analysis of 21 cohort studies including more than 300 000 persons
No full textRik P. Bogers, Wanda J. E. Bemelmans, Rudolf T. Hoogenveen, Hendriek C. Boshuizen, Mark Woodward, Paul Knekt, Rob M. van Dam, Frank B. Hu, Tommy L. S. Visscher, Alessandro Menotti, Roland J. Thorpe Jr, Konrad Jamrozik, Susanna Calling, Bjørn Heine Strand, Martin J. Shipley for the BMI-CHD Collaboration Investigator
Charles de Visscher. Le contrat collectif de travail, théories juridiques et projets législatifs, avec une préface de M. Raymond Saleilles. Paris, Rousseau 1911
No full textBlondel Georges. Charles de Visscher. Le contrat collectif de travail, théories juridiques et projets législatifs, avec une préface de M. Raymond Saleilles. Paris, Rousseau 1911. In: Revue internationale de l'enseignement, tome 64, Juillet-Décembre 1912. p. 570
[map] Niewe kaerte van t landt van Waes ende Hulster ambacht, vertoonende oock de stroomen van de ooster ende Wester Schelde /
No full text2 schalen : Schale van een Vlaemsche myle, 15 macken een graedt, ende houden in 2000 Rynlaendtsche roeden ; een ure gaens, in houdende 1600 rynlantsche roedenGeen legendeKoeman, Atlantes Neerlandici, dl. 2, p. 66 (C & M 10 (72))T. Campbell, Claes Jansz. Visscher (1968), p. 21, nr. 77 (Map Collector's Series, nr. 46);Bijzondere collectiesGodts, Henr
Hundreds of variants clustered in genomic loci and biological pathways affect human height
No full textMost common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have identified more than 600 variants associated with human traits(1), but these typically explain small fractions of phenotypic variation, raising questions about the use of further studies. Here, using 183,727 individuals, we show that hundreds of genetic variants, in at least 180 loci, influence adult height, a highly heritable and classic polygenic trait(2,3). The large number of loci reveals patterns with important implications for genetic studies of common human diseases and traits. First, the 180 loci are not random, but instead are enriched for genes that are connected in biological pathways (P = 0.016) and that underlie skeletal growth defects (P<0.001). Second, the likely causal gene is often located near the most strongly associated variant: in 13 of 21 loci containing a known skeletal growth gene, that gene was closest to the associated variant. Third, at least 19 loci have multiple independently associated variants, suggesting that allelic heterogeneity is a frequent feature of polygenic traits, that comprehensive explorations of already-discovered loci should discover additional variants and that an appreciable fraction of associated loci may have been identified. Fourth, associated variants are enriched for likely functional effects on genes, being over-represented among variants that alter amino-acid structure of proteins and expression levels of nearby genes. Our data explain approximately 10% of the phenotypic variation in height, and we estimate that unidentified common variants of similar effect sizes would increase this figure to approximately 16% of phenotypic variation (approximately 20% of heritable variation). Although additional approaches are needed to dissect the genetic architecture of polygenic human traits fully, our findings indicate that GWA studies can identify large numbers of loci that implicate biologically relevant genes and pathways
A 2 h periodic variation in the low-mass X-ray binary Ser X-1
No full textSpectroscopy of the low-mass X-ray binary Ser X-1 using the Gran Telescopio Canarias have revealed a ?2 h periodic variability that is present in the three strongest emission lines. We tentatively interpret this variability as due to orbital motion, making it the first indication of the orbital period of Ser X-1. Together with the fact that the emission lines are remarkably narrow, but still resolved, we show that a main-sequence K dwarf together with a canonical 1.4 M? neutron star gives a good description of the system. In this scenario, the most likely place for the emission lines to arise is the accretion disc, instead of a localized region in the binary (such as the irradiated surface or the stream-impact point), and their narrowness is due instead to the low inclination (?10°) of Ser X-1
Stable voters in an unstable party environment : continuity and change in Italian electoral behaviour
No full textM.24981-1999 Paolo Segatti, Paolo Bellucci and Marco Maraffi. 30 cm. A previous version of this paper was presented at a symposium on Political Parties : Changing Roles in Contemporary Democracies, held at the Center for Advanced Study in the Social Sciences of the Juan March Institute, Madrid, December 15-17, 1994. -- P.1. Includes bibliographical references (p. 56-59
The genetics of infectious disease susceptibility: has the evidence for epistasis been overestimated?
No full textInteractions amongst genes, known as epistasis, are assumed to make a substantial contribution to the genetic variation in infectious disease susceptibility, but this claim is controversial. Here, we focus on the debate surrounding the evolutionary importance of interactions between resistance loci and argue that its role in explaining overall variance in disease outcomes may have been overestimated
Supplemental Material2 - Supplemental material for The diagnostic accuracy of headache measurement instruments: A systematic review and meta-analysis focusing on headaches associated with musculoskeletal symptoms
No full textSupplemental material, Supplemental Material2 for The diagnostic accuracy of headache measurement instruments: A systematic review and meta-analysis focusing on headaches associated with musculoskeletal symptoms by Hedwig A van der Meer, Corine M Visscher, Tom Vredeveld, Maria WG Nijhuis van der Sanden, Raoul HH Engelbert and Caroline M Speksnijder in Cephalalgia</p
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