102,532 research outputs found
Bibliographie Hilarion G. Petzold 1958 – 2009 mit Anhang als Einführung
No full textDieses Archiv enthält die Gesamtbibliographie der Werke des Autors nebst einiger Texte „Über H. G. Petzold“ im Schlussteil der Bibliographie sowie einen Anhang mit einer Einführung in die Architektur des Werkes in seinem wissenslogischen Aufbau als Ausarbeitung seines „Tree of Science Modells“ (2007).This archive contains the complete bibliography of the author and some texts about H. G. Petzold, moreover an epilogue with an introduction to the architecture of the works in its epistemological structure and composition and as an elaborations of Petzold’s „Tree of Science Modell (2007).https://www.fpi-publikation.de/polyloge/01-2009-petzold-h-g-gesamtbibliographie-h-g-petzold-1958-2009-updating-november2009/peerReviewedpublishedVersio
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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3346: Samuel G. Freedman, author, 2013
No full textPhotograph of author Samuel G. Freedman, at NT Daily Slash meeting in the Mayborn School of Journalism at UNT
A combination of capillary and dielectrophoresis-driven assembly methods for wafer scale integration of carbon-nanotube-based nanocarpets
No full textThe wafer scale integration of carbon nanotubes (CNT) remains a challenge for electronic and electromechanical applications. We propose a novel CNT integration process relying on the combination of controlled capillary assembly and buried electrode dielectrophoresis (DEP). This process enables us to monitor the precise spatial localization of a high density of CNTs and their alignment in a pre-defined direction. Large arrays of independent and low resistivity (4.4 x 10-5 omega m) interconnections were achieved using this hybrid assembly with double-walled carbon nanotubes (DWNT). Finally, arrays of suspended individual CNT carpets are realized and we demonstrate their potential use as functional devices by monitoring their resonance frequencies (ranging between 1.7 and 10.5 MHz) using a Fabry–Perot interferometer
The Right to Strike under the United States Constitution: Theory, Practice, and Possible Implications for Canada
No full textAnswering critics of the Canadian Supreme Court's judgment in B.C. Health, the author argues that the Court laid the foundation for a principled and durable doctrine protecting constitutional labour rights, one that goes directly to the heart of the matter — the inequality of workers’ power in the employment relation. In the author’s view, two paths could lead from B.C. Health to the recognition of Charter protec- tion for a right to strike: one that treats the right as an accessory to col- lective bargaining, and one that upholds the right directly on the basis of the Charter values of equality and participation. The author supports the latter approach, contending that constitutional rights should be defined in relation to fundamental values, in a way that is not contingent on time-bound or fact-sensitive assessments about the role of strikes within a particular collective bargaining regime. Although a Charter right to strike may involve the courts in difficult choices about when to defer to legislative policy decisions, and courts may lack the institutional capac- ity to deal effectively with labour law issues, the author points out that judges can look to ILO standards for expert guidance. Noting that the U.S. experience in this area might be of considerable use to Canadians, the author concludes by providing an overview of American case law concerning a constitutional right to strike.Peer reviewe
Apolipoprotein E and cholinergic enzymes : the interface in dementia
No full textThe main confirmed genetic risk factor for sporadic form of Alzheimer’s disease (AD) is apolipoprotein E (ApoE) ε4 allele (APOE4). ApoE protein aids in receptor ligand mediated transport, distribution and metabolism of fatty acids and cholesterol. However, the molecular mechanism of its contribution to the pathological events in AD is still highly obscure. Some reports implicate ApoE in amyloid-beta (Aβ) deposition in the brain, one of the main hallmarks of AD. But there are no consensuses about how ApoE causes the accumulation of Aβ deposits. The main neuronal network that becomes severely affected in the course of AD and Lewy body dementia disorders (LBD) is the central cholinergic system, and the main available therapeutic options are cholinesterase inhibitors which prevents the degradation of cholinergic neurotransmitter, acetylcholine (ACh). However, it is unclear, why these particular neuronal populations are selectively affected in AD and LBD. In addition to the classical view of the cholinergic neurotransmission, extrasynaptic cholinergic signaling also plays a crucial role in the regulation of immune system. Although, it is not clear how ACh can reach and act on such non-neuronal cell population in the brain or in the peripheral organs.This thesis aimed to provide some insights in these unresolved issues. We found that APOE4 gene dose-dependently was associated with the highest ApoE protein expression in cerebrospinal fluid (CSF) of dementia patients (AD and DLB). This finding was observed in two independent study cohorts. Correlation analyses between the CSF ApoE protein and clinical measures (various cognitive tests), paraclinical measures (cerebral glucose metabolism and Aβ load by positron emission tomography) and AD biomarkers (CSF Aβ and tau, etc) suggested that high levels of ApoE protein may act as one of the driving forces of the pathological events in AD and DLB. This thesis also examined a postulated genetic interaction between APOE4 and a certain genetic variant of the ACh-degrading enzyme, butyrylcholinesterase (BuChE), namely BCHE-K allele. This directed genetic analysis was then to some extent scrutinized at their protein expression levels. The findings indicated that in the absence of APOE4, BCHE-K was associated with the lowest CSF ApoE protein, and the slowest annual cognitive decline, suggestive of some protective effects by BCHE-K. In the presence of APOE4, this protective effect of BCHE-K was either insufficient or rather increased the negative impact of APOE4 on both CSF ApoE levels and the rate of annual cognitive decline in patients. Given that astrocytes, one of the key players of the immune system in the central nervous system are the main sources of ApoE and BuChE, this thesis also aimed at providing a 7 mechanistic understanding of the interplays between extrasynaptic cholinergic immune-regulatory signaling, Aβ, ApoE and BuChE.In this context, our previous studies have provided evidence for APOE4 dependent molecular interaction between ApoE protein, Aβ and BuChE leading to formation of hyperactive BuChE-Aβ-ApoE complexes (BAβACs), which then accumulates in the brain, causing abnormal extrasynaptic ACh levels, astroglial dysfunction, altered Aβ clearance and aggregation in AD and DLB patients. Nonetheless, this hypothesis and the well-established cholinergic anti-inflammatory hypothesis faced a major dilemma, since ACh is a highly instable signaling molecule to be able to diffuse and act on cholinoceptive cells located far from the cholinergic synapses. This thesis provided a solution to this dilemma by providing for the first time, compelling evidence for the presence of ACh-synthesizing enzyme, choline acetyltransferase (ChAT) in human extracellular fluids, such as CSF and plasma. We showed that both lymphocytes and astrocytes might be the sources of soluble ChAT, as they were capable of acquiring cholinergic phenotype (expressing ChAT) on demand, and releasing ChAT into extracellular fluids. We showed that soluble ChAT was fully functional, and could maintain steady state ACh equilibrium in the presence of highly active ACh-degrading enzymes in CSF. Thus this thesis also provided for the first time evidence that astrocytes are cholinergic cells and hence might be an active part of the non-neuronal cholinergic network in the brain. In addition, the undertaking of this thesis led to development of a novel, sensitive integrated assay for sequential quantitative measurements of ChAT activity and protein levels in practically any biological fluid deemed to contain this enzyme.Conclusions and future perspectives: This thesis provided important insights into the complex interplays that are ongoing in vivo in the course of two major dementia disorders (AD and DLB) between several key genetic and/or molecular factors and cellular networks. This thesis also provided a novel research tool, facilitating future studies for reviewing the above hypothesis in the field of dementia as well as other neuroinflammatory disease such as multiple sclerosis, which this thesis has pointed out.List of scientific papersI. S. Vijayaraghavan, W. Maetzler, M. Reimold, C. U. Lithner, I. Liepelt-Scarfone, D. Berg and T. Darreh-Shori. (2014). High apolipoprotein E in cerebrospinal fluid of patients with Lewy body disorders is associated with dementia. Alzheimer's & Dementia. 10(5): 530-540.e1. https://doi.org/10.1016/j.jalz.2013.03.010 II. S. Vijayaraghavan, A. Karami, S. Aeinehband, H. Behbahani, A. Grandien, B. Nilsson, K. N. Ekdahl, R. Lindblom, F. Piehl and T. Darreh-Shori. (2013). Regulated extracellular choline acetyltransferase activity-the plausible missing link of the distant action of acetylcholine in the cholinergic anti-inflammatory pathway. PloS one. 8(6): e65936. https://doi.org/10.1371/journal.pone.0065936 III. S. Vijayaraghavan, T. Darreh-Shori, A. Rongve, G. Berge, S. B. Sando, L. R. White, B. H. Auestad, A. Witoelar, O. A. Andreassen, I. D. Ulstein and D. Aarsland. (2016). Association of Butyrylcholinesterase-K Allele and Apolipoprotein E varepsilon4 Allele with Cognitive Decline in Dementia with Lewy Bodies and Alzheimer's Disease. J Alzheimers Dis. 50(2): 567-576. https://doi.org/10.3233/JAD-150750 IV. S. Vijayaraghavan, D. Aarsland, T. Darreh-Shori. Interplay of genetic and phenotypic variations of Apolipoprotein E and Butyrylcholinesterase in patients with Alzheimer’s disease and Lewy body dementia. [Manuscript]</p
G-Rank: Unsupervised Continuous Learn-to-Rank for Edge Devices in a P2P Network
No full textRanking algorithms in traditional search engines are powered by enormous training data sets that are meticulously engineered and curated by a centralized entity. Decentralized peer-to-peer (p2p) networks such as torrenting applications and Web3 protocols deliberately eschew centralized databases and computational architectures when designing services and features. As such, robust search-and-rank algorithms designed for such domains must be engineered specifically for decentralized networks, and must be lightweight enough to operate on consumer-grade personal devices such as a smartphone or laptop computer. We introduce G-Rank, an unsupervised ranking algorithm designed exclusively for decentralized networks. We demonstrate that accurate, relevant ranking results can be achieved in fully decentralized networks without any centralized data aggregation, feature engineering, or model training. Furthermore, we show that such results are obtainable with minimal data preprocessing and computational overhead, and can still return highly relevant results even when a user’s device is disconnected from the network. G-Rank is highly modular in design, is not limited to categorical data, and can be implemented in a variety of domains with minimal modification. The results herein show that unsupervised ranking models designed for decentralized p2p networks are not only viable, but worthy of further research.https://github.com/awrgold/G-RankComputer Scienc
Author inscription in The Chinese slave-girl: a story of woman's life in China
No full textThis edition includes a gift inscription by author Rev. J.A. Davis, "To Rev. A. G. Russell with the warmest regards of the author J.A. Davis."Davis, John Agnell, 1839-1897
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