15 research outputs found
Tracheal bronchus in children - a congenital bronchopulmonary malformation with clinical significance
No full textIntroduction. The tracheal bronchus (BT) is a rare congenital tracheal abnormality, defined as the presence
of an ectopic bronchus that comes from the lateral wall of the trachea. Most cases are asymptomatic and
occasionally diagnosed by advanced chest imaging techniques. BT is usually associated with other
congenital abnormalities, such as congenital heart disease, pulmonary vascular abnormalities, respiratory
tract abnormalities, or chromosomal abnormalities (1). There are 3 types of BT: type I originating at the
middle and lower junction of the trachea, type II - in the lower third of the trachea and type III has a BT
resulting from the tracheal wall near the level of the carina, giving the appearance of trifurcated carina (3).
During endotracheal intubation, it can lead to atelectasis, the association of an infection and poor
ventilation, which would lead to lung collapse (2).
Aim of study. Computed tomographic (CT) evaluation of the chest in children with congenital
malformation - tracheal bronchus.
Methods and materials. Computed tomographic (CT) evaluation of the chest in children with congenital
malformation - tracheal bronchus. The current study included 14 children with congenital malformation -
tracheal bronchus, confirmed by CT of the rib cage. The average age of children is 3.5 ± 4.5 / 3.6 years
with a range of 5 months to 15 years. The study included 6 boys (42.9%: 95% CI 17.7-71.1) and 8 girls
(57.1%: 95% CI 28.9-82.3). Pulmonary CT was performed using Toshiba Aguillion Prime 80 Slices. The
statistics were processed by Epi Info 7.2, Microsoft Excel.
Results. Tracheal bronchus was found in all children with an emergency on the right side. In 3 children
(21.4%: 95% CI 4.7-50.8) the malformed bronchial segment has a medium onset of trachea, in 2 children
(14.3%: 95% CI 1.8-42.8) . ) in the lower segment, and in most cases - 9 children (64.3%: 95% CI 35.1-
87.2) near the tracheal bifurcation, resulting in the trifurcated appearance of the trachea Children with this
malformation presented children with bronchopulmonary changes infiltration pneumonia at 3 (21.4%: 95%
CI 4.7-50.8), interstitial changes with the appearance of frosted glass in 2 cases (14.3%: 95% CI 1.8-42.8),
segmental infiltrations with atelectatic component - 4 children (28.6%: 95). % CI 8.4-58.1), and pulmonary
fibrosis in 3 children (21.4%: 95% CI 4.7-50.8). Other congenital malformations (azygous venous lobe,
Fallot tetralogy, common arterial trunk, doubling of the brachiocephalic vein) than tracheal bronchus were
detected in 3 children (21.4%: 95% CI 4.7-50.8).
Conclusion. The tracheal bronchus is a congenital malformation of the right side of the trachea. This
bronchial malformation is clinico-imaged by bronchopulmonary changes with pneumonic infiltration,
fibrotic changes with matte glass imaging, segmental atelectasis and fibrotic changes, and some children
are associated with other congenital malformation
Some aspects of adrenal structure and functioning in the fetus
No full textDepartment of Histology,
Cytology and Embryology,
Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of MoldovaIntroduction. In adults, the adrenal gland consists of two parts: the outer one - the adrenal
cortex and one in the inside - the medullary adrenal. The epithelial cortices of the adrenal cortex
are arranged in three areas: the glomerular area, which specializes in the production of
mineralocorticoids (the main representative being aldosterone), the fasciculating area producing
glucocorticoids (cortisol, cortisone) and crosslinked area possessing the ability to deliver sex
hormones androgens, estrogens).
Aim of the study. Description of physiological and histological changes occurring in the adrenal
glands of the fetus.
Conclusions. The adrenal glands have an important role in the prenatal period, contributing to
the development of the fetus as well as throughout life. From a histological point of view, the
adrenal glands at the fetus have a different structure from the adult, which is represented mostly
by permanent and temporary fetal cortical and a disorganization of the medullary substance
Evaluation of adiposity indices in pediatric rheumatological disorders
No full textUniversitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, Chişinău, Republica MoldovaIntroduction. The Body Mass Index (BMI) is currently the most used indicator that assesses the
nutritional status of children and adults, but it cannot fully reflect the difference between excess
adipose tissue and that of muscle mass. The Tri-Ponderal Mass Index (TPI) is used as an alternative
to calculate body weight recently, being successfully used to determine obesity, but also
cardiovascular and metabolic risk factors. Data comparing BMI and TPI in the pediatric population
with rheumatic pathology are currently not available.
Aim of study. To evaluate the effectiveness of the TPI, as well as to compare the usefulness of the
TPI and BMI in assessing the growth and development of children.
Methods and materials. Our study included 881 children, hospitalized for a period of 2 years, in
the Rheumatology section of the Mother and Child Institute, between December 1, 2021 and
November 30, 2023. The value of the anthropometric indicators was calculated by age groups of
children, as well as evaluated according to gender. The data were analyzed using the Microsoft
Excel Office365 calculation program.
Results. Of the 881 children included in the study, 394 (44.72%) were boys and 487 (55.28%)
were girls. The mean age of the children included in the study was 10.73±4.54 years (95%
CI:10.43;11.03), with a ratio of girls/boys 1.23:1.0. The average values of the anthropometric
indicators evaluated in the study were for BMI 18.38 ± 3.92 (95% CI: 18.12;18.64), and for TPI it
was 12.96 ± 2.90 (95% CI :12.76;13.15). Under the age of 3 years, 85 children were registered, of
which 47 boys and 38 girls, between 4 and 10 years, 287 children (140 boys, 147 girls), and most
of the children included in the study (57.78%) were older than 14 years (509 children: 207 boys,
302 girls). BMI in children up to 3 years was 15.56 ±2.08 (95% CI:15.11; 16.01), and TPI included
a value of 17.15±3.65 (95%CI:16,36;17,94). In children aged between 4 and 10 years, BMI
included a value of 16.49±3.67 (95%CI:16.06;16.92), and TPI was 12.89±2.76 (95%CI:
12.57;13.21). Most of the children included in the study obtained a value of 19.92±3.54 (95% CI:
1.
Conclusion. TPI represents an eloquent parameter of nutritional status and can be used to assess
the growth and development of children, both in boys and girls. It can also be a predictive element
of obesity and metabolic syndrome, as well as its associated factors. The TPI estimates body fat
percentage more accurately than BMI in study children, and requires only one value for each
gender, instead of the multiple complicated age- and gender-specific values required for BMI to
be used especially in adolescents
From English to Romanian: Bob Dylan translated by Mircea Cartarescu
No full textopenQuesta tesi di laurea magistrale si concentra sull'analisi della traduzione ‒ dall'inglese al romeno ‒ del testo del brano A hard rain's a-gonna fall di Bob Dylan, tratta dal libro "Bob Dylan, Suflare în vânt: 100 de poeme traduse de Mircea Cărtărescu", che contiene una selezione di cento testi di canzoni di Dylan - o poesie, come l'autore rumeno, come molti altri, li qualifica giustamente - tradotti da Mircea Cărtărescu, egli stesso scrittore di poesia e prosa. Per quanto riguarda l'approccio, questo studio non si basa su alcuna teoria della traduzione ‒ spesso inutilmente complicata ‒ ma è condotto, piuttosto, empiricamente sulla base di principi linguistici e stilistici, seguendo minuziosamente il testo della canzone, dal primo all'ultimo verso, in quello che potrebbe essere chiamato un approccio verticale.This master dissertation focuses on analyzing the translation ‒ from English into Romanian ‒ of Bob Dylan’s lyrics of the song A hard rain’s a-gonna fall, drawn from the book titled Bob Dylan, Suflare în vânt: 100 de poeme traduse de Mircea Cărtărescu , which contains a selection of one hundred Dylan song lyrics – or poems, as the Romanian author, as many others, rightfully qualifies them – translated by Mircea Cărtărescu, himself a writer of both poetry and prose. Regarding the approach, this study does not rely on any theory of translation ‒ which are often unnecessarily complicated ‒ but it is rather conducted empirically on the basis of linguistic and stylistic principles, following the song text in minute detail, from the first to the last line of verse, in what could be called a vertical approach
Бронхолегочный врожденный порок – трахеальный бронх у детей
No full textManifestările imagistice a cutiei toracice au fost analizate prin tomografie computerizata (TC) la 14 copii (vârsta medie de 3,5±1,25 ani) cu malformație congenitală – bronh traheal. Bronhul traheal a fost depistat la toți copiii cu emergență
pe partea dreaptă. Bronhul malformativ își are pornirea diferită: din segmentul mediu al traheii, din segmentul inferior
și la majoritatea copiilor lângă bifurcația traheii. Această malformație de bronh se realizează clinico-imagistic prin modificări bronhopulmonare cu caracter de infiltrație pneumonică, modificări fibrotice cu aspect imagistic de sticlă mată,
atelectazii segmentare și modificări fibrotice, iar la unii copii se asociază și alte malformații congenitale.Imaging of the rib cage was analyzed by computed tomography (CT) in 14 children (mean age 3,5±1,25 years) with
congenital malformation – tracheal bronchus. Tracheal bronchus was found in all children with an emergency on the right
side. The malformed bronchus has a different origin: from the middle segment of the trachea, from the lower segment and
in most children near the bifurcation of the trachea. This bronchial malformation is clinico-imaged by bronchopulmonary
changes with pneumonic infiltration, fibrotic changes with matte glass imaging, segmental atelectasis and fibrotic changes, and some children are associated with other birth defects.Изображении грудной клетки были проанализированы с помощью компьютерной томографии (КТ) у 14 детей
(средний возраст 3,5±1,25 года) с врожденными пороками развития – трахеальный бронх. Выход трахеального
бронха был обнаружен у всех детей с справа. Деформированный бронх имеет различное начало: от среднего
сегмента трахеи, от нижнего сегмента и у большинства детей вблизи бифуркации трахеи. Бронхолегочные изменения при этой бронхиальной мальформации характеризуются пневмонической инфильтрацией, фиброзными
изменениями с матовым изображением стекла, сегментарными ателектазами и фиброзными изменениями, а у
некоторых детей сочетаются с другими врожденными дефектами
FAMILY RISK FACTORS AND THEIR IMPACT ON DEVELOPMENTAL DISORDERS IN CHILDREN 0-3 YEARS
No full textUniversitatea de Stat de Medicină și Farmacie „Nicolae Testemițanu”, Chișinău, Republica MoldovaIntroducere. Perioada copilăriei timpurii oferă o experienţă critică pentru a modela traiectoria dezvoltării holisti-ce a copiilor. Statutul economic scăzut al familiei şi nivelul de educaţie scăzut al părinţilor au fost asociate cu o dezvoltare intelectuală deficitară şi abilităţi lingvistice mai slabe în rândul copiilor. Scop. Scopul acestui studiu a fost de a analiza factorii de risc familiali şi sociali asupra dezvoltării copiilor de vârstă mică prin prisma unui studiu analitic obser-vaţional. Material şi metode. Analiza retrospectivă a 53 de copii internaţi în Institutul Mamei şi al Copilului, în intervalul octombrie-noiembrie 2024.Tulburările de dezvoltare au fost evaluate conform criteriilor prevăzute în Ghidul de Monitorizare a Dezvoltării Copilului.Analiza statistică a datelor a fost efectuată cu ajutorul programelor statistice Microsoft Excel. Rezultate. În studiu au fost incluşi 53 copii, 34 băieţi şi 19 fete; vârsta medie a copiilor a fost de 25,92. Studiul a notat că 47% din copii locuiesc în case supraaglomerate; 66% dintre mame şi 69,81% dintre taţi deţin studii medii de specialitate; Analiza statutului familial relevă că 88,67% dintre mame sunt căsătorite; 9,43% aparţin unor familii monoparentale; 35,84% dintre copii provin din familii cu condiţii economice precare; 50,94% din familii cu venituri medii; Majoritatea copiilor (62,27%) au fost diagnosticaţi cu tulburare globală de dezvoltare; 26,41% tulburare de dezvoltare izolată; 11,32% dintre copii-dezvoltare adecvată vârstei. Concluzii. Datele obţinute subliniază complexitatea tulburărilor de dezvoltare a copiilor de vârstă mică şi evidenţiază importanţa evaluării multidimensionale şi a intervenţiilor timpurii, adaptate nevoilor individuale ale copilului şi contextului socio-economic şi educaţional al familiei.Introduction. Low socioeconomic status of the family is associated with a negative impact on children's development. The role of parents in raising children includes economic resources and quality time spent with them. Low parental education has been associated with poor intellectual development and poorer language skills. Objective. The purpose of this study was to analyze family and social risk factors on the development of young children through an observational analytical study. Material and methods. The study involved a retrospective analysis of 53 children hospitalized at the Mother and Child Institute, between October and November 2024. Developmental disorders were assessed according to the criteria provided in the Child Development Monitoring Guide. Statistical analysis of the data was performed using Microsoft Excel statistical programs. Results. The study included 53 children, 34 boys and 19 girls; the average age of the children was 25.92. The study noted that 47% of the children live in overcrowded homes; 66% of the mothers and 69.81% of the fathers have secondary specialized education. Analysis of family status reveals that 88.67% of the mothers are married; 9.43% belong to single-parent families;35.84% of the children come from families with precarious economic conditions;50.94% from families with average income. Most of the children (62.27%) were diagnosed with global developmental disorder; 26.41% isolated developmental disorder; 11.32% of the children-age-appro-priate development. Conclusion. The data obtained underline the complexity of developmental disorders in children 0-3 years and highlight the importance of multidimensional assessment and early interventions, adapted to the individual needs of the child and the socio-economic and educational context of the family
Bardet-Biedl syndrome – clinical perspectives and case presentation
No full textUniversitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, Chişinău, Republica MoldovaIntroducere. Sindromul Bardet-Biedl (SBB) este o maladie pleiotropă rară, caracterizată printr-o eterogenitate genetică și fenotipică. Caracteristicile clinice primare includ retinita pigmentară, polidactilia, obezitate centrală, hipogonadism și retard intelectual, cu abilități de învățare scăzute. Din cele secundare se enumeră întârzierea dezvoltării, deficit de vor bire, brahidactilie / sindactilie, defecte dentare, ataxie, defi cit olfactiv, diabet zaharat și boli cardiace congenitale. Scop ul lucrării. Prezentarea unui caz clinic rar cu sindrom Bardet- Biedl. Material și metode. Date anamnestice, clinice și paraclinice din fișa medicală. Pacientul a fost investigat prin ultrasonografia organelor abdominale, electroencefalografie, radiografia pumnului, tomografie computerizată (CT) cerebrală. A fost revizuită literatura privind această entitate genetică. Rezultate. Fetiță, 14 ani, manifesta următoarele acuze : reducerea progresivă a vederii, obezitate, amenoree, infantilism psihic, abilități de învățare scăzute, slăbiciune musculară distală, enurezis, encoprezis. Din date obiective relatăm: brahidactilie, hipogonadism, hirsutism, inserție joasă a părului, keratoză foliculară, telangiectazii multiple pe corp, strii violacee pe abdomen și membre. Pentru diagnostic diferențial a fost efectuată tomografia computerizată cerebrală, s-a exclus patologie la nivel de șeaua turcească. Concluzii. Abordarea multidisciplinară este cheia diagnosticării precoce a cazurilor pediatrice cu SBB, așa cum unele manifestări sunt comune și altor patologii și datele de corelare genotip-fenotip sunt limitate .Background. Bardet-Biedl syndrome (BBS) is a rare pleiotropic disease characterized by genetic and phenotypic het erogeneity. Primary clinical features include retinitis pigmentosa, polydactyly, central obesity, hypogonadism, and intellectual retardation with poor learning skills. The secondary ones include developmental delay, speech deficiency, brachydactyly/syndactyly, dental defect, ataxia, olfactory deficiency, diabetes and congenital heart disease. Objective of the study. Presentation of a rare clinical case with Bardet-Biedl syndrome. Material and methods. Anamnestic, clinical and paraclinical data from the medical record. The patient was investigated by ultrasonography of the abdomi nal organs, electroencephalography, radiography of the fist, computed tomography (CT) of the brain. The literature on this genetic entity was reviewed. Results. A 14-year-old girl presented the following complaints: progressive reduc tion of vision, obesity, amenorrhea, mental infantilism, low learning abilities, distal muscle weakness, enuresis, encopresis. From objective data we report: brachydactyly, hypogonadism, hirsutism, low insertion of hair, follicular keratosis, multiple telangiectasias on the body, purple streaks on the abdomen and limbs. For differential diagnosis, was performed cerebral computed tomography, and pathology at the level of the sella turcica was excluded. Conclusions. The multidisciplinary approach is the key to the early diagnosis of pediatric cases of BBS, as some manifestations are common to other pathologies and genotype-phenotype correlation data are limited
Medicină socială, management și științe socio-umane
No full textModeratori: Grejdean Fiodor, dr. hab. şt. med., profesor universitar
Spinei Larisa, dr. hab. şt. med., profesor universitar
Tintiuc Dumitru, dr. hab. şt. med., profesor universitar
Ojovanu Vitalie, dr. hab. şt. med., conferenţiar universitar
Raevschi Elena, dr. hab. şt. med., conferenţiar universitar
Dumitraș Vasile, dr. şt. med., conferenţiar universitarCOMUNICĂRI ORALE
1. Zarbailov Natalia. Performanța echipei medicului de familie în viziunea
beneficiarilor
2. Cernițanu Mariana. Particularitățile activității de învățare a studentilor
USMF „Nicolae Testemițanu” în condiții de studii la distanță
3. Banari Ion, Federiuc Victoria. Conceptul de vulnerabilitate în activitatea
medicală. Sinteze bioetice
4. Gîncotă Ecaterina, Spinei Larisa, Calac Marina, Potîng Lilia. Aspecte
sociale, medicale și legale în prevenirea și combaterea violenței asupra
copiilor și femeilor în perioada pandemiei COVID-19
5. Globa Nina, Cernei Violeta. Analiza comparativă a elementelor culturii organizaționale în spitale și centrele medicilor de familie din Republica Moldova
6. Gușilă Ilenuța, Țopa Alexandra, Zarbailov Natalia. Utilizarea soluțiilor
digitale în autogestionarea bolilor cardiovasculare și a diabetului zaharat
7. Ashwin Kanchivakkam Balaji. Mortalitatea infantilă în India: dinamica,
factorii de risc și politici de sănătate
8. Gamureac Daniela, Ferdohleb Alina. Particularități ale calității vieții
copiilor cu maladii onco-hematologice
9. Cepraga Pavel. Secretul medical în legislația Republicii Moldova
10. Ulinici Mariana, Vorojbit Valentina. COVID-19 – teste de neutralizar
Evaluarea indicatorilor ecocardiografici în hipertensiunea pulmonară la copiii cu bronșiectazii
No full textPaediatrics Department, Nicolae Testemitanu SUMPh,
Institute of Mother and ChildBackground. Arterial hypoxemia is the leading cause of secondary pulmonary hypertension (HP) in
patients with bronchopulmonary disease, especially in those with cystic fibrosis (CF). Objective of the
study. Evaluation of secondary pulmonary hypertension in children with bronchiectasis from chronic
bronchopulmonary diseases Material and Methods. The study included 37 children with chronic
bronchopulmonary disease:22 children (59.5%:95%CI 42.1-75.2) with CF and 15(40.5%: 95% CI 24.8-
57.9 ) with other bronchopulmonarydiseases.Patients were evaluated by M 2D color Doppler EcoCG with
assessment of pulmonary arterial systolic pressure (PSAP), tricuspid valve insufficiency (IVT) and chest
computed tomography (CT). Results. The average age of children with CF-7.72±0.92 years(variations
0.5–15.5 years) and 9.69±1.42 years (1.5–17 years)-control group; F state 1.57,P>0.05. The PSAP value
is increased in children with FC-33.5±1.6 mmHg(minimum-22 mmHg, maximum-50 mmHg), compared
to children in the control group-28.8±1.7 mmHg(variations 22–47 mmHg);F state 3.9,P>0.05.IVT in CF
was found in 19 children(95%:95%CI 75.1-99.9) and in all children of the control group, χ2=0.6,
p>0.05.Children with CF had varicose(36.4%) and cylindrical(40.9%) bronchiectasis, compared to those
in the control group in which traction(46.7%), cylindrical(33.3%) and more rarely predominated varicose
bronchiectasis. Conclusion. PSAP is increased in children with CF, who have more severe lung damage
due to the presence of extensive bronchiectasis compared to patients with non-CF bronchiectasis.Introducere. Hipoxemia arterială reprezintă cauza principală de apariție a hipertensiunii pulmonare
secundare (HP) la pacienții cu maladii bronho-pulmonare, în special la cei cu fibroză chistică (FC). Scopul
lucrării. Evaluarea hipertensiunii pulmonare secundare la copiii cu bronșiectazii din maladiile
bronhopulmonare cronice. Material și metode. Studiul a inclus 37 de copii cu maladii cronice
bronhopulmonare: 22 copii (59,5%:95%CI 42,1-75,2) cu FC și 15 copii (40,5%:95%CI 24,8-57,9) cu alte
afecțiuni bronhopulmonare. Pacienții au fost evaluați prin EcoCG Doppler color regim M, 2D cu
aprecierea presiunii sistolice în artera pulmonară (PSAP), a insuficienței valvei tricuspidiene (IVT) și
computer tomografia (CT) toracelui. Rezultate. Vârsta medie a copiilor cu FC a constituit 7,72±0,92 ani
(variații 0,5–15,5 ani) și 9,69±1,42 ani (1,5–17 ani) pentru lotul martor; F stat 1,57, P>0,05. Valoarea
PSAP este majorată la copii cu FC – 33,5±1,6 mmHg (minim ‒ 22 mmHg, maxim – 50 mmHg),
comparativ cu copiii din lotul martor – 28,8±1,7 mmHg (variații 22–47 mmHg); F stat 3,9, P>0,05. IVT
în FC a fost constatată la 19 copii (95%: 95%CI 75,1-99,9) și la toți copiii lotului martor, χ2=0,6, P>0,05.
Copiii cu FC imagistic prezentau bronșiectazii varicoase (36,4%) și cilindrice (40,9%), comparativ cu cei
din lotul martor, la care predominau cele tracționale (46,7%), cilindrice (33,3%) și mai rar bronșiectazii
varicoase. Concluzii. PSAP este majorată la copiii cu FC, care prezintă o afectare pulmonară mai severă,
determinată de prezența bronșiectaziilor extinse, comparativ cu pacienții cu bronșiectazii non-FC
Infecțiile mixte pulmonare la copiii cu fibroză chistică
No full textDepartamentul Pediatrie, USMF „Nicolae Testemiţanu”Background. The association of mixed pulmonary infections represents an aggravating factor of the
natural course of Cystic Fibrosis (CF) thus the appearance of chronic bronchopulmonary processes
induces antibiotic resistance, rapid health deterioration and significant decrease in quality of life.
Objective of the study. Presentation of a case of CF in a child with chronical mixed pulmonary infection
determined by Pseudomonas aeruginosa, Staphylococcus aureus, Aspergillus. Material and Methods.
The patient was completely investigated by CT, lung scintigraphy, ECHO, laboratory examinations,
bacteriological analysis of sputum, serological tests for Aspergilusfumigatus. Clinical cases of CF
without mixed infections and other scientific data were studied. Results. A 12 years old girl with CF
diagnosed at 5 years was hospitalized in a critical condition caused by bronchiectasis and pleurisy. The
dynamics of CT and lung scintigraphy revealed the total loss of left lung function and an important
alteration of the right one in last 5 years when there were multiple episodes of lung infections without
professional care. Repeated sputum bacteriologies found antibiotic resistant strains of Ps. aeruginosa
and S. Aureus, in serological test - Aspergilusfumigatus. Dispite the complex treatment with
carbapenems, aminoglycosides, antifungal and Colistin the prognosis remained reserved because of long
time inefficient control of chronic lung infections. Conclusion. Patients with CF require systematic
medical supervision with regular treatment adjustment in order to control the chronic pulmonary
infection that can lead to antibiotic resistance, clinical complications, organic and functional loss and
rapid induction of the terminal phase of disease.Introducere. Asocierea infecțiilor pulmonare mixte reprezintă un factor agravant al parcursului natural
al fibrozei chistice (FC), iar instalarea proceselor cronice bronhopulmonare induc antibiorezistența
germenilor, decompensarea rapidă a pacienților și diminuarea evidentă a calității vieții. Scopul lucrării.
Prezentarea unui caz de FC la un copil cu infecție pulmonară cronică mixtă cu Pseudomonas aeruginosa,
Staphylococcus aureus, Aspergillus. Material și metode. Pacientul cu FC a fost complet investigat prin
spirometrie, tomografie computerizată (TC), scintigrafie pulmonară, EcoCG, examene de laborator,
analize bacteriologice ale sputei şi teste serologice pentru Aspergillus fumigatus. Au fost analizate cazuri
de FC fără infecție cronică mixtă în mai multe surse științifice. Rezultate. Fetiță de 12 ani, cu FC
stabilită la 5 luni, internată în stare gravă cu exacerbarea infecțioasă pulmonară (bronșiectazii) şi
pleurezie. Dinamica TC și a scintigrafiei pulmonare denotă pierderea totală a funcției pulmonului stâng
și reducerea importantă morfo-funcțională a celui drept, în ultimii 5 ani, determinată de multiple
episoade infecțioase pulmonare fără tratamente etiopatogenice. Bacteriologiile repetate ale sputei au
indicat Ps. aeruginosa și S. aureus polirezistenți, serologic depistându-se Aspergillus fumigatus. În
pofida tratamentul cu carbapeneme, aminoglicozide, Colistin și antifungice prognosticul a rămas
rezervat, din cauza lipsei de intervenție în timp oportun. Concluzii. Pacienții cu FC necesită o
supraveghere medicală sistematică, cu ajustarea tratamentului pentru controlul infecțiilor cronice
pulmonare, cu germeni care pot dezvolta antibiorezistență, iar clinic induc modificări funcționale
ireversibile și trecerea rapidă în faza terminală a bolii
