1,732 research outputs found
Da ideia de infância em Jean-Jacques Rousseau ou do "sono da razão"
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina. Centro de Ciencias da Educação. Programa de Pós-Graduação em EducaçãoOs pensamentos expostos no século XVIII pelo genebrino Jean-Jacques Rousseau influenciaram de maneira decisiva a forma como o Ocidente passou a perceber a infância. Este autor provocou uma verdadeira divisão de águas ao publicar Emílio ou Da Educação (1762). Com este feito, mais que balançar os alicerces educacionais da época, ele delega à criança um lugar no mundo. A infância passa a ter um valor em si mesma, e a ser vista como etapa fundamental na constituição humana. Ao destacar este período da vida, além de romper definitivamente com o que vigorava em seu tempo, no qual a criança era tida como um erro passageiro - um infante (aquele que não fala); um "adulto em miniatura"; ou mero objeto de paparicação e prazer - Jean-Jacques cria uma ótica inovadora de conceber a criança. Dizia que: "A natureza quer que as crianças sejam crianças antes de serem homens." Ao elaborar um conceito de infância, Rousseau afirma que "a infância é o sono da razão". O que nos surpreende devido este autor ter vivido em pleno "Século das Luzes", justamente quando a razão era evocada como o guia seguro para o pensamento e para ação em todas as idades. Ao contrário do que possa parecer, Rousseau não desmerece o período infantil, associando-o à escuridão ou a inferioridade primeira da humanidade. Ele é considerado o "inventor da infância". Retomar pensamentos que versam sobre essas ideias rousseaunianas, inaugurais da concepção moderna de Infância, por meio de pesquisa teórica, é o objetivo traçado aqui, com intuito de avançar nas compreensões estabelecidas em torno das contribuições de Jean-Jacques Rousseau para temática em exame.The thoughts exposed in the eighteenth century by the genevan, Jean-Jacques Rousseau, influenced in a decisive way the West has to realize his childhood. This author has caused a real division of the waters or publish Emile, or On Education (1762). With this done more than shake the foundations of educational time, it leaves the child a place in the world. The child is given a value in itself, and be seen as key step in the human constitution. By highlighting this period of life, and the final break with that which prevailed in his time, in which the child was seen as a mistake passenger - an infant (who does not speak), a "miniature adult" or mere object of pampering and pleasure - Jean-Jacques creates a new perspective to conceive a child. He said: "Nature wants children to be children before being men." In developing a concept of childhood, Rousseau says that "childhood is the sleep of reason". What surprises us because this author has lived in the middle of "Age of Enlightenment", just when the reason was mentioned as the sure guide for thought and action in all ages. Contrary to what may seem, Rousseau does not diminish the infantile period, associating him to the darkness or the inferiority of humanity first. He is considered the "inventor of childhood." Resume thoughts that talk about these ideas Rousseau, the inaugural modern conception of childhood, through theoretical research, stroke is the goal here, with the aim to advance the understandings established around the contributions of Jean-Jacques Rousseau to thematic examination
CD44 acts as a signalling platform controlling tumour progression and metastasis
No full textCD44 proteins emerge as major signal transduction controller. CD44 isoforms participate in several signalling pathways ranging from growth factor-induced signalling to Wnt-regulated pathways. The role of CD44 in tumour progression and metastasis is most likely linked to its function as a signalling hub. More and more evidence suggests as well that CD44 is not only a mere cancer stem cell marker but is directly involved in tumour and metastasis initiation. It is foreseeable that a link between the expression of CD44 on cancer stem cells and its function as a regulator of cell signalling will be drawn in a near future
Haploinsufficiency of c-met in cd44(-/-) mice identifies a collaboration of CD44 and c-met in vivo
No full textRecent evidence has shown that the activation of receptor tyrosine kinases is not only dependent on binding of their ligands but in addition requires adhesion molecules as coreceptors. We have identified CD44v6 as a coreceptor for c-Met in several tumor and primary cells. The CD44v6 ectodomain is required for c-Met activation, whereas the cytoplasmic tail recruits ERM proteins and the cytoskeleton into a signalosome complex. Here we demonstrate that c-Met (and hepatocyte growth factor and Gab1) is haploinsufficient in a cd44(-/-) background, as the cd44(-/-); met(-/-) (and cd44(-/-); hgf(+/-) and cd44(-/-); gab1(+/-)) mice die at birth. They have impaired synaptic transmission in the respiratory rhythm-generating network and alterations in the phrenic nerve. These results are the first genetic data showing that CD44 and c-Met collaborate in vivo and that they are involved in synaptogenesis and axon myelination in the central and peripheral nervous systems
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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