17 research outputs found
A Survey of Stability Results for Redundancy Systems
No full textRedundancy mechanisms consist in sending several copies of a same job to a subset of servers. It constitutes one of the most promising ways to exploit diversity in multi-servers applications. However, its pros and cons are still not sufficiently understood in the context of realistic models with generic statistical properties of service-times distributions and correlation structures of copies. We aim at giving a survey of recent results concerning the stability - arguably the first benchmark of performance - of systems with cancel-on-completion redundancy. We also point out open questions and conjectures.Fil: Anton, Elene. Centre National de la Recherche Scientifique; FranciaFil: Ayesta, Urtzi. Centre National de la Recherche Scientifique; FranciaFil: Jonckheere, Matthieu Thimothy Samson. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Calculo. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Calculo; ArgentinaFil: Verloop, Ina María. Centre National de la Recherche Scientifique; Franci
La alteridad en la lengua romanesca de José María Arguedas : estudio de una poética heterolingüe
No full textCe travail tente de montrer en quoi la poétique de l’écrivain péruvien José María Arguedas peut être qualifiée d’hétérolingue dans la mesure où elle transforme l’espagnol à partir du quechua. Nous essayons également de saisir les moyens par lesquels il est possible de traduire cette poétique tout en restant fidèle à l’empreinte que dépose le quechua sur la langue espagnole. En menant une analyse comparative des traductions de trois romans, Yawar fiesta, Los ríos profundos et El zorro de arriba y el zorro de abajo, nous retraçons l’évolution de la poétique hétérolingue arguédienne et nous mettons en lumière le défi qu’elle pose à ses traducteurs qui se voient obligés de créer une « hospitalité linguistique » inédite à leur langue de travail.This research tries to prove that the poetic discourse developed in the novels by Peruvian author José María Arguedas can be considered as heterolingual, in that the Spanish language he uses is highly influenced by Quechua. The endeavour in this work is to study how it is possible to translate Arguedas's poetics while remaining faithful to the imprint left by Quechua on the Spanish language. The comparative analysis of the translations of the three novels, Yawar fiesta, Los ríos profundos and El zorro de arriba y el zorro de abajo, reveals the evolutionary process of the heterolingual poetic in José María Arguedas writings. This evolution presents a challenge to his translators who have been compelled to create a new “linguistic hospitality” in their working language.Esta tesis intenta demostrar las razones que llevan a calificar la obra poética de José María Arguedas como heterolingüe, considerando que ésta transforma el español a partir de la lengua quechua. También trata de estudiar los medios a través de los cuales se puede traducir esta poética manteniendo fielmente la impronta que deja el quechua en la lengua española. El análisis comparativo de las traducciones de tres novelas, Yawar fiesta, Los ríos profundos y El zorro de arriba y el zorro de abajo, pone en evidencia el proceso de evolución de la poética heterolingüe arguediana así como el desafío que impone a sus traductores que se ven obligados a crear una nueva “hospitalidad lingüística” en sus lenguas de trabajo
Los dibujos de Daneri para el INA-Casa en Génova
No full text[ES] En este trabajo se analiza, a través de los dibujos, qué hace diferente y transgresora la arquitectura de Daneri en Génova en la posguerra, y qué le lleva a investigar y experimentar nuevas vías, a veces contrarias al resto de intervenciones del INA-Casa en Italia. Los quartieri son singulares por su apertura a la modernidad, en ocasiones importada, que abre la puerta a la prefabricación, sinónimo de avance tecnológico. Se aporta el testimonio de Grossi Bianchi, coautor de Bernabò Brea, que confirma la influencia de Le Corbusier. Los dibujos evidencian su intención por la adaptación a la abrupta topografía genovesa, a la vegetación existente y a la introducción del paisaje como elemento proyectual. También se pone de manifiesto el papel relevante de los medios de difusión de la arquitectura: revistas, CIAM, trienal que introducen a Daneri en la arquitectura moderna y a la vez lo sitúan en el debate internacional.[EN] This paper analyses, through drawings, what makes Daneri s architecture in post-war Genoa different and transgressive, and what drives him to investigate and experiment with new approaches, sometimes contrary to the rest of INA-Casa s interventions in Italy. The quartieri are unique for their openness to modernity, sometimes imported, which paves the way to prefabrication, synonymous with technological advancement. The testimony of Grossi Bianchi, co-author with Bernabò Brea, confirms the influence of Le Corbusier. The drawings evidence his intention to adapt to Genoa s abrupt topography, existing vegetation, and the introduction of the landscape as a design element. The significant role of architectural dissemination media magazines, CIAM, triennial is also highlighted, as they introduce Daneri to modern architecture and simultaneously place him within the international debate.Guillem González-Blanch, M. (2025). Daneri s drawings for INA-Casa in Genova. EGA Expresión Gráfica Arquitectónica. 30(54):70-89. https://doi.org/10.4995/ega.2025.23573OJS7089305
Balance between sodium and calcium currents underlying chronic atrial fibrillation termination: An in silico intersubject variability study
No full textBackgroundAtrial remodeling as a result of long-standing persistent atrial fibrillation (AF) induces substrate modifications that lead to different perpetuation mechanisms than in paroxysmal AF and a reduction in the efficacy of antiarrhythmic treatments.ObjectiveThe purpose of this study was to identify the ionic current modifications that could destabilize reentries during chronic AF and serve to personalize antiarrhythmic strategies.MethodsA population of 173 mathematical models of remodeled human atrial tissue with realistic intersubject variability was developed based on action potential recordings of 149 patients diagnosed with AF. The relationship of each ionic current with AF maintenance and the dynamics of functional reentries (rotor meandering, dominant frequency) were evaluated by means of 3-dimensional simulations.ResultsSelf-sustained reentries were maintained in 126 (73%) of the simulations. AF perpetuation was associated with higher expressions of INa and ICaL (P <.01), with no significant differences in the remaining currents. ICaL blockade promoted AF extinction in 30% of these 126 models. The mechanism of AF termination was related with collisions between rotors because of an increase in rotor meandering (1.71 ± 2.01cm2) and presented an increased efficacy in models with a depressed INa (P <.01).ConclusionMathematical simulations based on a population of models representing intersubject variability allow the identification of ionic mechanisms underlying rotor dynamics and the definition of new personalized pharmacologic strategies. Our results suggest that the underlying mechanism of the diverging success of ICaL block as an antiarrhythmic strategy is dependent on the basal availability of sodium and calcium ion channel conductivities
Durability Assessment of a Plasma-Polymerized Coating with Anti-Biofilm Activity against L. monocytogenes Subjected to Repeated Sanitization
No full textCopyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).[EN] Biofilm formation on food-contact surfaces is a matter of major concern causing food safety and spoilage issues to this sector. The aim of this study was to assess the durability of the anti-biofilm capacity of a plasma-polymerized coating composed of a base coating of (3-aminopropyl) triethoxysilane (APTES) and a functional coating of acrylic acid (AcAc). Coated and uncoated AISI 316 stainless steel (SS) plates were subjected to five sanitization cycles with sodium hypochlorite (0.05%) and peracetic acid (0.5%). The effectiveness of the coating for the inhibition of multi-strain Listeria monocytogenes biofilm formation was confirmed using a three-strain cocktail, which was grown on the SS plates at 12◦ C for 6 days. Compared to the uncoated SS, relative biofilm productions of 14.6% on the non-sanitized coating, 27.9% on the coating after sanitization with sodium hypochlorite, and 82.3% on the coating after sanitization with peracetic acid were obtained. Morphological and physicochemical characterization of the coatings suggested that the greater anti-biofilm effectiveness after sanitization with sodium hypochlorite was due to the high pH of this solution, which caused a deprotonation of the carboxylic acid groups of the functional coating. This fact conferred it a strong hydrophilicity and negatively charged its surface, which was favorable for preventing bacterial attachment and biofilm formation.SIThis publication is based upon work from COST Action CA19110—PlAgri, supported by COST (European Cooperation in Science and Technology-www.cost.eu). XPS tests were conducted by the Advanced Microscopy Laboratory (LMA) of The Institute of Nanoscience of Aragón (INA), University of Zaragoza. The authors are thankful to the LMA-INA for the access to their equipment and their expertise. The AFM images were taken by the Central Research Support Service (SCAI) of the University of Málaga (UMA). The author P. Fernández-Gómez is grateful to Junta de Castilla y León and the European Social Fund (ESF) for awarding her a predoctoral grant (BOCYL-D-15122017-4). The author M. Oliveira is in receipt of a Juan de la Cierva contract IJC2018-035523-I awarded by the Spanish Ministry of Science, Innovation, and Universities MCIN/AEI/10.13039/501100011033. The author E. Sainz-García, as researcher of the University of La Rioja, is thankful to the postdoctoral training program funded by the Plan Propio of the University of La Rioja. The authors I. Muro-Fraguas and A. Sainz-García are thankful to the program of pre-doctoral contracts for the training of research staff that is funded by the University of La Rioja.This study is part of the Research, Development and Innovation projects AGL2017-82779- C2-R and PID2020-113658RB-C2, funded by MCIN/AEI/10.13039/501100011033 and by ERDF “A way to make Europe”
Development and characterization of anti-biofilm coatings applied by Non-Equilibrium Atmospheric Plasma on stainless steel
No full text[EN] Biofilm-mediated microbial persistence of pathogenic and spoilage bacteria is a serious problem in food industries. Due to the difficulty of removing mature biofilms, great efforts are being made to find new strategies to prevent bacterial adherence to surfaces, the first step for biofilm development. In this study, coatings of (3-aminopropyl)triethoxysilane (APTES), tetraethyl orthosilicate (TEOS) and acrylic acid (AA) were applied by Non-Equilibrium Atmospheric Plasma on stainless steel (SS) AISI 316, the SS most commonly used in food industry equipment. Their anti-biofilm activity was assessed against Listeria monocytogenes CECT911 and Escherichia coli CECT515 after incubation at 37 °C. The best results were obtained for L. monocytogenes, with coatings consisting of a base coating of APTES and a functional coating of TEOS (AP10 + TE6) or AA (AP10 + AA6) that reduced biofilm production by 45% and 74%, respectively, when compared with the uncoated SS. These coatings were further characterized, together with a variation of the best one that replaced the acrylic acid with succinic acid (AP10 + SA6). Their anti-biofilm activity was assessed under different incubation conditions, including two strains of L. monocytogenes isolated from processing environments of a meat industry. The coating AP10 + AA6 reduced the biofilm formation by 90% after incubation at 12 °C, a temperature more representative of those commonly found in food processing environments. The morphological and physico-chemical characterization of the selected coatings showed that the coating with the highest anti-biofilm activity (i.e., AP10 + AA6) had lower surface roughness and higher hydrophilicity. This suggests that the formation of a hydration layer prevents the adherence of L. monocytogenes, an effect that seems to be enhanced by low temperature conditions, when the wettability of the strains is increasedSIThis work was supported by Ministerio de Economía, Industria y Competitividad from Spain (MINECO) (project AGL2017-82779-C2-R “Programa Estatal de I + D + i Orientada a los Retos de la Sociedad”) and co-funded by the European Regional Development Fund (FEDER) “A way to make Europe”. XPS tests were conducted by the Advanced Microscopy Laboratory (LMA) of The Institute of Nanosciences of Aragon (INA), University of Zaragoza. The authors are thankful to the LMA-INA for the access to their equipment and their expertise. The AFM images were taken by the Central Research Support Service (SCAI) of the University of Malaga ´ (UMA). P. Fernandez-G ´ omez ´ is grateful to Junta de Castilla y Leon ´ and the European Social Fund (ESF) for awarding her a pre-doctoral grant (BOCYL-D-15122017-4). The author E. Sainz-García, as postdoctoral researcher of the University of La Rioja, thanks the postdoctoral training program that is funded by the Plan Propio of the University of La Rioja. The author I. Muro-Fraguas thanks the program of pre-doctoral con tracts for the training of research staff funded by the University of La Rioj
Reflexiones en torno a los chocho, nonoualca o popoloca: su definición
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New bacterial strains for ibuprofen biodegradation: Drug removal, transformation, and potential catabolic genes
No full textIbuprofen (IBU) is a significant contaminant frequently found in wastewatertreatment plants due to its widespread use and limited removal during treat-ment processes. This leads to its discharge into the environment, causingconsiderable environmental concerns. The use of microorganisms hasrecently been recognized as a sustainable method for mitigating IBU con-tamination in wastewater. In this study, new bacteria capable of growing ina solid medium with IBU as the only carbon source and removing IBU froma liquid medium were isolated from environmental samples, including soil,marine, mine, and olive mill wastewater. Four bacterial strains, namely Kleb-siella pneumoniae TIBU2.1, Klebsiella variicola LOIBU1.1, Pseudomonasaeruginosa LOIBU1.2, and Mycolicibacterium aubagnense HPB1.1, wereidentified through 16S rRNA gene sequencing. These strains demonstratedsignificant IBU removal efficiencies, ranging from 60 to 100% within14 days, starting from an initial IBU concentration of 5 mg per litre. Thesebacteria have not been previously reported in the literature as IBUdegraders, making this work a valuable contribution to further studies in thefield of bioremediation in environments contaminated by IBU. Based on theIBU removal results, the most promising bacteria, K. pneumoniae TIBU2.1and M. aubagnense HPB1.1, were selected for an in silico analysis to iden-tify genes potentially involved in IBU biodegradation. Interestingly, in thetests with TIBU2.1, a peak of IBU transformation product(s) was detectedby high-performance liquid chromatography, while in the tests with HPB1.1,it was not detected. The emerging peak was analysed by liquidchromatography–mass spectrometry, indicating the presence of possibleconjugates between intermediates of IBU biodegradation. The proteinsencoded on their whole-genome sequences were aligned with proteinsinvolved in an IBU-degrading pathway reported in bacteria with respectivecatabolic genes. The analysis indicated that strain HPB1.1 possessesgenes encoding proteins similar to most enzymes reported associated withthe IBU metabolic pathways used as reference bacteria, while strainTIBU2.1 has genes encoding proteins similar to enzymes involved in boththe upper and the lower part of that pathway. Notably, in the tests with thestrain having more candidate genes encoding IBU-catabolic enzymes, noIBU transformation products were detected, while in the tests with the strainhaving fewer of these genes, detection occurred.Received: 4 May 2024 Accepted: 13 July 2024DOI: 10.1111/1758-2229.13320ENVIRONMENTAL MICROBIOLOGY REPORTSThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium,provided the original work is properly cited.© 2024 The Author(s). Environmental Microbiology Reports published by John Wiley & Sons Ltd.Environmental Microbiology Reports. 2024;16:e13320. wileyonlinelibrary.com/journal/emi4 1 of 23https://doi.org/10.1111/1758-2229.13320FCT Fundação para a Ciência e a Tecnologia,Portugal PTDC/CTA-AMB/7782/2020, UIDB/04326/2020, LA/P/0101/202
Prognostic Factors of Late-onset Hearing Loss in Infants With Congenital Cytomegalovirus and Normal Audiologic Assessment at Birth
No full textChildren with congenital cytomegalovirus (cCMV) can develop late-onset sensorineural hearing loss (LO-SNHL). In this study, we aim to assess the characteristics and predictors of LO-SNHL in infants with cCMV having normal hearing at the first neonatal assessment.
A retrospective study within the European Registry of Children with cCMV ( www.ccmvnet.org ) was performed. Included children had cCMV and a normal first audiological assessment by Auditory Brainstem Response (ABR). Late-onset hearing loss (LO-SNHL) is defined as the presence of sensorineural hearing loss after an initial normal hearing test. Hearing evaluation was performed at birth, at 6 months of age, and at least annually up to 6 years of age.
Seven hundred twenty-one children with normal audiological tests at birth were included, and 47/721 (6.5%) developed LO-SNHL. LO-SNHL was diagnosed at a range of 4-65 months of age [median (IQR) age: 34.3 (15.1-48.7) months]. Children with LO-SNHL had a higher proportion of abnormalities on physical examination at birth (45.7% vs. 20.8%; P < 0.001): petechiae (17.4% vs. 6.0%; P = 0.008), splenomegaly (8.7% vs. 2.3%; P = 0.031), hepatomegaly (13% vs. 2.9%; P = 0.001), microcephaly (15.2% vs. 4.5%; P = 0.005) and small for gestational age (21.7% vs. 8.3% P = 0.005). Children with LO-SNHL showed lower platelet count at birth [177500.0 (88750.0-261250.0)/μL vs. 243500.0 (173000.0-304000.0)/μL; P = 0.012], and higher blood viral load at birth [3.7 log (3.3-4.4) vs. 3.4 log (2.7-3.9) IU/mL; P = 0.013] and had more frequent white matter involvement (27.7% vs. 14.7%; P = 0.03) and ventriculomegaly (20.7% vs. 4.6%; P = 0.001) on birth magnetic resonance imaging. Overall, symptomatic children at birth showed a higher risk of developing LO-SNHL than asymptomatic children (32/317, 10.1%, vs. 15/404, 3.7%; P < 0.0001). Among asymptomatic children, only 0.3% developed severe or profound LO-SNHL in the best ear.In multivariate logistic regression analysis, ventriculomegaly [odds ratio (OR): 7.503 (1.78-27.9)], white matter abnormalities [OR: 3.19 (1.010-9.01)], and splenomegaly [OR: 3.679 (1.56-8.506)] at birth were associated with the development of LO-SNHL ( Fig. 1 ).
Among this large cohort of children with cCMV and a first normal audiological assessment, the risk of LO-SNHL was 6.5%. Asymptomatic children developed LO-SNHL in 3.7% of the cases versus 10.1% in symptomatic cases. In multivariate logistic regression analysis, ventriculomegaly, white matter abnormality, and splenomegaly at birth were associated with LO-SNHL.
Copyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc
EARLINET instrument intercomparison campaigns: overview on strategy and results
No full textThis paper introduces the recent European Aerosol Research Lidar Network (EARLINET) quality-assurance efforts at instrument level. Within two dedicated campaigns and five single-site intercomparison activities, 21 EARLINET systems from 18 EARLINET stations were intercompared between 2009 and 2013. A comprehensive strategy for campaign setup and data evaluation has been established. Eleven systems from nine EARLINET stations participated in the EARLINET Lidar Intercomparison 2009 (EARLI09). In this campaign, three reference systems were qualified which served as traveling standards thereafter. EARLINET systems from nine other stations have been compared against these reference systems since 2009. We present and discuss comparisons at signal and at product level from all campaigns for more than 100 individual measurement channels at the wavelengths of 355, 387, 532, and 607 nm. It is shown that in most cases, a very good agreement of the compared systems with the respective reference is obtained
