100,876 research outputs found
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
T-MAE : Temporal Masked Autoencoders for Point Cloud Representation Learning
No full textThe scarcity of annotated data in LiDAR point cloud understanding hinders effective representation learning. Consequently, scholars have been actively investigating efficacious self-supervised pre-training paradigms. Nevertheless, temporal information, which is inherent in the LiDAR point cloud sequence, is consistently disregarded. To better utilize this property, we propose an effective pre-training strategy, namely Temporal Masked Auto-Encoders (T-MAE), which takes as input temporally adjacent frames and learns temporal dependency. A SiamWCA backbone, containing a Siamese encoder and a windowed cross-attention (WCA) module, is established for the two-frame input. Considering that the movement of an ego-vehicle alters the view of the same instance, temporal modeling also serves as a robust and natural data augmentation, enhancing the comprehension of target objects. SiamWCA is a powerful architecture but heavily relies on annotated data. Our T-MAE pre-training strategy alleviates its demand for annotated data. Comprehensive experiments demonstrate that T-MAE achieves the best performance on both Waymo and ONCE datasets among competitive self-supervised approaches
Anti-breast cancer and anti-angiogenic potential of a lichen-derived small-molecule: barbatolic acid
No full textWOS: 000451760200008PubMed ID: 30155608Natural products have been used for centuries as the most potent remedies to cure many diseases including cancer diseases. Angiogenesis is defined as the formation of new capillaries from existing vessels and plays a key role in the tumorigenesis process. Barbatolic acid is a little known lichen-derived small-molecule. In the present study, barbatolic acid was isolated from the acetone extract of Bryoria capillaris, and its anti-breast cancer and anti-angiogenic potential was investigated using human umbilical vein endothelial cells (HUVECs), human breast ductal carcinoma (T-47D) and cisplatin-resistant BRCA2-mutated human breast TNM stage IV adenocarcinoma (HCC1428) cells. AlamarBlue cell viability, lactate dehydrogenase cellular membrane degradation and PicoGreen dsDNA quantitation assays were performed to determine the cytotoxic potential of barbatolic acid. Anti-angiogenic and anti-migratory activities were investigated using endothelial tube formation assay and scratch wound healing assay, respectively. Half maximal inhibitory concentration of barbatolic acid was found to be higher than 100 mu M for HUVEC, HCC1428 and T-47D cells. The sub-cytotoxic concentrations such as 25 mu M, 50 mu M and 100 mu M were applied to determine anti-angiogenic and anti-migratory activities. Although the sub-cytotoxic concentrations inhibited endothelial tube formation and cellular migration in a concentration depended manner, barbatolic acid was more effective on the migration of HCC1428 and T-47D breast cancer cells than the migration of HUVECs. Consequently, the findings suggest that barbatolic acid is a promising anti-angiogenic and anti-migratory agent and the underlying activity mechanisms should be investigated by further in vitro and in vivo experiments.Commission of Scientific Research Projects of Anadolu University [1502F068]I thank, Prof. Aysen Turk, Prof. Ayse Tansu Koparal, Assoc. Prof. Mehmet Candan, Assoc. Prof. Ilker Avan and Aysegul Varol from Anadolu University, Eskisehir, Turkey for their contributions and supports, and the Commission of Scientific Research Projects of Anadolu University for the financial supports of the related project (Grant Number 1502F068)
Handwritten biographical information on Paulina T. McClung Merritt
No full textA handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Pelevin’s Trinity in the novel “t”: author – protagonist – reader
No full textThe article attempts to interpret Pelevin's artistic strategy in the novel "T" by exploring its subject organization and addressing the key problems of the author, the protagonist, and the reader as they are seen by the researcher. The article analyzes the peculiarities of constructing the narrative reality in the novel "T", and goes on to discuss Pelevin's philosophic models of the development of the humankind, and the emergence of his new anthropology
Investigation of some lichen-derived substances' cosmetic potential for skin protection against ultraviolet B
No full text41st FEBS Congress on Molecular and Systems Biology for a Better Life - SEP 03-08, 2016 - Kusadasi, TURKEYWOS: 000383616901668FEB
Electrical characterization of two analogous Schottky contacts produced from N-substituted 1,8-naphthalimide
No full textSayin, Serkan/0000-0003-0518-3208WOS: 000453231100040PubMed: 30511079The aim of this study was to analyze the interface states (N-ss) in pure Al//p-Si/Al, Al/N-F Nft/p-Si/Al and Al/N-T Nft/p-Si/Al Schottky barrier diodes (SBDs). N-Substituted 1,8-naphthalimide thin films were deposited on a p-Si substrate by spin coating and annealed at approximate to 200 degrees C for 60 s under an air atmosphere. Al contacts were obtained via reactive magnetron sputtering. The current voltage (I-V) characteristics of the SBDs were measured at room temperature. From the I-V characteristics, the SBDs ideality factor (n) and zero-bias barrier height values (phi(b)) of 1.27, 1.00, and 1.05 and 0.66 eV, 0.70 eV, and 0.64 eV were observed for the Al//p-Si/Al, Al/N-F Nft/p-Si/Al and Al/N-T Nft/p-Si/Al Schottky barrier diodes, respectively. The interface state density distribution profile (N-ss) as a function of (E-ss-E-v) was extracted from the forward-bias I-V measurements by considering the effective barrier height and (phi(e)) and series resistance (R-s) of the Schottky diode. The obtained N-ss plot tendency showed that the existence of interface states has no significant effect on the rectifying and capacitance characteristics. The N-ss values with the 1,8-naphthalimide layer were lower than that without it. This shows that naphthalimide exhibits a strong contribution by blocking the unwanted states and some traps in the conduction mechanism, which may cause possible cracks or deep paths for carriers to travel along the junction.Gazi University Scientific Research Project (BAP)Gazi University [05/2017-02]The authors wish to express sincere appreciation and gratitude to Professor Suleyman oZCELK and Assoc. Prof. Tark Aar from Gazi University (Faculty of Arts and Sciences, Physics Department) for their assistance and guidance in the preparation of this work, also this work is supported by Gazi University Scientific Research Project (BAP) with the Grand Contract No. 05/2017-02
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