106 research outputs found
Israël Palestine sous les cartes
No full textColloque international antiAtlas des FrontièresNouveau Conservatoire Darius Milhaud, Aix-en-ProvenceDu 30 septembre au 2 octobre 2013« Israël Palestine sous les cartes » est un projet de visualisation dynamique des chaînes relationnelles développées par un anthropologue au cours de ses enquêtes de terrain dans l’espace israélo-palestinien (2005-2010). Ce travail exploratoire implique un anthropologue (Cédric Parizot), un sociologue (Antoine Vion) et un spécialiste de visualisation de données complexes (Wouter Van den Broeck). Le premier objectif est d’analyser sous un autre angle le niveau d’imbrication entre espaces israéliens et palestiniens. Le second est de confronter les trois chercheurs à des pratiques, des méthodologies et des données inhabituelles émanant d’autres disciplines. D’une part, en ayant recourt à un niveau beaucoup plus élevé d’abstraction, l’anthropologue opère un repositionnement radical par rapport à ses données de terrain. En dépit de la perte temporaire de la précision de l’observation anthropologique, cette visualisation dynamique lui offrira une compréhension plus globale du monde social dans lequel il a évolué. D’autre part, cette expérience permettra au sociologue et à l’anthropologue de mieux apprécier les conditions de production de leur connaissance, non seulement en tenant compte du fait que ces données sont situées dans le temps, dans l’espace et dans des interactions spécifiques, mais aussi et surtout en soulignant que l’anthropologue et le sociologue font partie intégrante du réseau-frontière qu’ils tentent de déchiffrer. En d’autres termes, ce projet implique l’anthropologue et sociologue à la fois en tant que chercheurs et en tant qu’objets de recherche. Enfin, en traitant un autre type de réseau complexe (impliquant moins d’individus, mais des couches plus complexes d’interactions), Wouter van den Broeck a l’intention d’expérimenter une nouvelle sémiologie de la cartographie de réseau applicable à l’étude des réseaux issus de la recherche qualitative
Entropy production as correlation between system and reservoir
No full textpeer reviewedWe derive an exact (classical and quantum) expression for the
entropy production of a finite system placed in contact with one or several
finite reservoirs, each of which is initially described by a canonical equilibrium
distribution. Although the total entropy of system plus reservoirs is conserved,
we show that system entropy production is always positive and is a direct
measure of system–reservoir correlations and/or entanglements. Using an
exactly solvable quantum model, we illustrate our novel interpretation of the
Second Law in a microscopically reversible finite-size setting, with strong
coupling between the system and the reservoirs. With this model, we also
explicitly show the approach of our exact formulation to the standard description
of irreversibility in the limit of a large reservoir
The making of sixty-nine days of close encounters at the science gallery
No full textThe SocioPatterns sensing platform uses wearable electronic badges to sense close-range proximity among individuals. It was used in an experiential exhibit that simulated a virtual epidemic among the visitors of the INFECTIOUS: STAY AWAY exhibition in the Science Gallery in Dublin, Ireland. The collected data was used to generate a highresolution visualization that illustrates the variation in contact activity over the course of the exhibition. © 2012 ISAST
The live social semantics application: A platform for integrating face-to-face presence with on-line social networking
No full textWe describe a novel application that integrates real-world data on the face-to-face proximity of individuals with their identities and contacts in on-line social networks. This application was successfully deployed at two conference gatherings, ESWC09 and HT2009, and actively used by hundreds of people. Personal profiles of the participants were automatically generated using several Web 2.0 systems and semantic data sources, and integrated in real-time with face-to-face proximity relations detected using RFID-enabled badges. The integration of these heterogeneous data sources enables various services that enhance the experience of conference attendees, allowing them to explore their social neighbourhood and to connect with other participants. This paper describes the architecture of the application, the services we provided, and the results we achieved in these deployments
Live Social Semantics
No full textSocial interactions are one of the key factors to the success of conferences and similar community gatherings. This paper describes a novel application that integrates data from the semantic web, online social networks, and a real-world contact sensing platform. This application was successfully deployed at ESWC09, and actively used by 139 people. Personal profiles of the participants were automatically generated using several Web~2.0 systems and semantic academic data sources, and integrated in real-time with face-to-face contact networks derived from wearable sensors. Integration of all these heterogeneous data layers made it possible to offer various services to conference attendees to enhance their social experience such as visualisation of contact data, and a site to explore and connect with other participants. This paper describes the architecture of the application, the services we provided, and the results we achieved in this deployment
Towards the development of industrially useful measurement protocols for nuclear decommissioning
No full textIndustrially useful measurement methods/protocols and reference materials are under development to support the decommissioning of nuclear installations. During nuclear decommissioning several types of measurements need to be undertaken: (1) ambient dose rate and nuclide identification measurements taken at specific places to map an unknown region, (2) surface contamination measurements, (3) atmospheric contamination measurements and (4) measurements for waste characterization, especially with the aim of improving free release measurements. Being able to work in high radiation fields or workplaces with high contamination risks and limiting the exposure of workers are strong driving factors for automation of measurement protocols. In these circumstances, characterisation methods based on light probes that can be used by robots or more portable probes for the workers are favourable.
In many cases, concrete materials need to be characterised. However, a concrete reference material, supporting the measurement procedures, is not available yet. In collaboration with the European Commission's Joint Research Centre (JRC) a new research approach is launched that focusses on the development of industrially useful radiological characterisation protocols and simultaneously works towards the development of a concrete-based reference material. In this project, the impact of heterogeneity (for example linked to radionuclide distribution over binder and aggregate phase) in the concrete-based materials on the used characterisation methods is studied. In addition, during the project several nuclear measurement methods based on light-wide probes, are tested, evaluated and optimised for characterisation of concrete during nuclear decommissioning.
A second research project, the “Archer” project, is a collaboration with industrial partners, Transnubel and Magics Instruments, and academic partner KU Leuven. The project is an energy transition project, supported by the Belgian federal authority, that aims at optimising the use of these lightweight probes in a robotics platform capable of characterizing hotspots in high radiation environments such as pipelines and storage tanks for nuclear effluents. In the presentation, the measurement approaches used in the two different projects will be presented
Towards the development of industrially useful measurement protocols for nuclear decommissioning
No full textIndustrially useful measurement methods/protocols and reference materials are under development to support the decommissioning of nuclear installations. During nuclear decommissioning several types of measurements need to be undertaken: (1) ambient dose rate and nuclide identification measurements taken at specific places to map an unknown region, (2) surface contamination measurements, (3) atmospheric contamination measurements and (4) measurements for waste characterization, especially with the aim of improving free release measurements. Being able to work in high radiation fields or workplaces with high contamination risks and limiting the exposure of workers are strong driving factors for automation of measurement protocols. In these circumstances, characterisation methods based on light probes that can be used by robots or more portable probes for the workers are favourable.
In many cases, concrete materials need to be characterised. However, a concrete reference material, supporting the measurement procedures, is not available yet. In collaboration with the European Commission's Joint Research Centre (JRC) a new research approach is launched that focusses on the development of industrially useful radiological characterisation protocols and simultaneously works towards the development of a concrete-based reference material. In this project, the impact of heterogeneity (for example linked to radionuclide distribution over binder and aggregate phase) in the concrete-based materials on the used characterisation methods is studied. In addition, during the project several nuclear measurement methods based on light-wide probes, are tested, evaluated and optimised for characterisation of concrete during nuclear decommissioning.
A second research project, the “Archer” project, is a collaboration with industrial partners, Transnubel and Magics Instruments, and academic partner KU Leuven. The project is an energy transition project, supported by the Belgian federal authority, that aims at optimising the use of these lightweight probes in a robotics platform capable of characterizing hotspots in high radiation environments such as pipelines and storage tanks for nuclear effluents. In the presentation, the measurement approaches used in the two different projects will be presented
TRPM4 inhibition by meclofenamate suppresses Ca<SUP>2+</SUP>-dependent triggered arrhythmias
No full textAIMS: Cardiac arrhythmias are a major factor in the occurrence of morbidity and sudden death in patients with cardiovascular disease. Disturbances of Ca2+ homeostasis in the heart contribute to the initiation and maintenance of cardiac arrhythmias. Extrasystolic increases in intracellular Ca2+ lead to delayed afterdepolarizations and triggered activity, which can result in heart rhythm abnormalities. It is being suggested that the Ca2+-activated nonselective cation channel TRPM4 is involved in the aetiology of triggered activity, but the exact contribution and in vivo significance are still unclear. METHODS AND RESULTS: In vitro electrophysiological and calcium imaging technique as well as in vivo intracardiac and telemetric electrocardiogram measurements in physiological and pathophysiological conditions were performed. In two distinct Ca2+-dependent proarrhythmic models, freely moving Trpm4-/- mice displayed a reduced burden of cardiac arrhythmias. Looking further into the specific contribution of TRPM4 to the cellular mechanism of arrhythmias, TRPM4 was found to contribute to a long-lasting Ca2+ overload-induced background current, thereby regulating cell excitability in Ca2+ overload conditions. To expand these results, a compound screening revealed meclofenamate as a potent antagonist of TRPM4. In line with the findings from Trpm4-/- mice, 10 µM meclofenamate inhibited the Ca2+ overload-induced background current in ventricular cardiomyocytes and 15 mg/kg meclofenamate suppressed catecholaminergic polymorphic ventricular tachycardia-associated arrhythmias in a TRPM4-dependent manner. CONCLUSION: The presented data establish that TRPM4 represents a novel target in the prevention and treatment of Ca2+-dependent triggered arrhythmias.sponsorship: This work was supported by the Fonds Wetenschappelijk Onderzoek Vlaanderen [ASP/11-Griet Jacobs, ASP/08-Wouter, G.0761.10N, G.0596.12, G.0565.07, G.0966.11, and G0E0317N]; the IUAP programme [P7/13]; and the KU Leuven Bijzonder Onderzoeksfonds [PF10/017IMIR, STRT1/09/046, GOA2009/07, EF/95/010, and TRPLe]. (Fonds Wetenschappelijk Onderzoek Vlaanderen|ASP/11-Griet Jacobs, Fonds Wetenschappelijk Onderzoek Vlaanderen|ASP/08-Wouter, Fonds Wetenschappelijk Onderzoek Vlaanderen|G.0761.10N, Fonds Wetenschappelijk Onderzoek Vlaanderen|G.0596.12, Fonds Wetenschappelijk Onderzoek Vlaanderen|G.0565.07, Fonds Wetenschappelijk Onderzoek Vlaanderen|G.0966.11, Fonds Wetenschappelijk Onderzoek Vlaanderen|G0E0317N, IUAP programme|P7/13, KU Leuven Bijzonder Onderzoeksfonds|PF10/017IMIR, KU Leuven Bijzonder Onderzoeksfonds|STRT1/09/046, KU Leuven Bijzonder Onderzoeksfonds|GOA2009/07, KU Leuven Bijzonder Onderzoeksfonds|EF/95/010, KU Leuven Bijzonder Onderzoeksfonds [TRPLe])status: Publishe
Tumor Volume and Clinical Failure in High‐Risk Prostate Cancer Patients Treated With Radical Prostatectomy
No full textTo identify the most significant cut-off of tumor volume (TV) for prediction of clinical failure (CF) among high-risk prostate cancer (hPCa) patients.status: Publishe
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