1,720,963 research outputs found
Modalità di pulizia e disinfezione dei nebulizzatori in ambito domiciliare nell’area Senese e frequenza di una loro contaminazione batterica
No full textIn questo studio aperto, prospettico abbiamo verificato le modalita di manutenzione dei nebulizzatori in ambito domiciliare nell'area senese ai fini della loro igiene. Cinquantasette soggetti adulti (40 maschi, 17 femmine: eta 73,4 ± 7,9
anni; FEV 1,21 ± 0,65 L; FEV % pred 53,3 ± 23,6: VC% pred 82,5 ± 19,0) che presentavano una cronica limitazione al
flusso delle vieaeree eavevano usato domiciliarmente un nebulizzatore per patologie delle basse vie aeree furono arruolati in modo consecutivo per questo studio. I risultati sono stati ricavati dalle risposte di ciascun paziente ad un questionario auto-somministrato circa la manutenzione del proprio nebulizzatore con particolare attenzione alla loro igiene. Di ogni aerosol terapeutico fu anche eseguita una valutazione microbiologica. I medici che avevano prescritto la aerosolterapia, prevalentemente con corticosteroidi e broncodilatatori, non fornirono mai informazioni circa la necessita di una regolare sanificazione e disinfezione dei nebulizzatori domiciliari. Conseguentemente la manutenzione igienica di nebulizzatori sovente era eseguita occasionalmente, variava largamente ed era lasciata alla esperienza di ciascun paziente. Una contaminazione batterica degli aerosol fu riscontrata in 40 di 59 campioni (68%), mentre pesanti contaminazioni (100 CFU per piastra) erano presenti in almeno 19 casi (32 %) e principalmente sostenute da germi Gram negativi. Riscontrammo un ridotto rischio di contaminazione batterica dei nebulizzatori solo in quei pazienti che smontavano regolarmente le parti disassemblabili dell'apparecchio aerosolico dopo ogni nebulizzazione e ne sciacquavano ogni componente con acqua corrente. II rischio di contaminazione batterica degli aerosol, inoltre, aumentava significativa mente con l'aumentare della frequenza di utilizzo del nebulizzatore
Expression of measles virus antigens in Streptococcus gordonii
No full textThe measles virus proteins haemagglutinin (HA) and fusion protein (F), which together mediate attachment and penetration of the virus in the host cell and can elicit production of neutralising antibodies in the course of natural infection were expressed in the vaccine vector Streptococcus gordonii, a Gram-positive bacterium normally present in the human oral cavity. HA and F were expressed as fusion proteins attached to the bacterial surface, and were both found to be immunogenic when the recombinant S. gordonii were inoculated subcutaneously in mice
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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