138 research outputs found
Tepelna zatez a tvorba specifickych proteinu u hospodarskych zvirat.
No full textAvailable from STL Prague, CZ / NTK - National Technical LibrarySIGLECZCzech Republi
Extended pancreas donor program - the EXPAND study rationale and study protocol
No full textBACKGROUND:
Simultaneous pancreas kidney transplantation (SPK), pancreas transplantation alone (PTA) or pancreas transplantation after kidney (PAK) are the only curative treatment options for patients with type 1 (juvenile) diabetes mellitus with or without impaired renal function. Unfortunately, transplant waiting lists for this indication are increasing because the current organ acceptability criteria are restrictive; morbidity and mortality significantly increase with time on the waitlist. Currently, only pancreas organs from donors younger than 50 years of age and with a body mass index (BMI) less than 30 are allocated for transplantation in the Eurotransplant (ET) area. To address this issue we designed a study to increase the available donor pool for these patients.
METHODS/DESIGN:
This study is a prospective, multicenter (20 German centers), single blinded, non-randomized, two armed trial comparing outcome after SPK, PTA or PAK between organs with the currently allowed donor criteria versus selected organs from donors with extended criteria. Extended donor criteria are defined as organs procured from donors with a BMI of 30 to 34 or a donor age between 50 and 60 years. Immunosuppression is generally standardized using induction therapy with Myfortic, tacrolimus and low dose steroids. In principle, all patients on the waitlist for primary SPK, PTA or PAK are eligible for the clinical trial when they consent to possibly receiving an extended donor criteria organ. Patients receiving an organ meeting the current standard criteria for pancreas allocation (control arm) are compared to those receiving extended criteria organ (study arm); patients are blinded for a follow-up period of one year. The combined primary endpoint is survival of the pancreas allograft and pancreas allograft function after three months, as an early relevant outcome parameter for pancreas transplantation.
DISCUSSION:
The EXPAND Study has been initiated to investigate the hypothesis that locally allocated extended criteria organs can be transplanted with similar results compared to the currently allowed standard ET organ allocation. If our study shows a favorable comparison to standard organ allocation criteria, the morbidity and mortality for patients waiting for transplantation could be reduced in the future.
TRIAL REGISTRATION:
Trial registered at: NCT0138400
R.W. Fassbinder and H. Huntgeburth: Screen Versions of the "Effi Briest"
No full textBakalaura darba „Efija Brīsta” R. V. Fasbindera un H. Huntgeburtas ekranizācijās tēma ir literatūras ekranizācija. Darbā tiek pētītas divas jaunākās Teodora Fontanes romāna ekranizācijas, pirmā – 1974. gada Fontāne Efija Brīsta no režisora Rainera Vernera Fasbindera un otrā 2009. gada Efija Brīsta no režisores Hermīnes Huntgeburtas. Darba mērķis ir abās literatūras ekranizācijās atklāt atšķirību starp literāro oriģināltekstu un ekranizāciju, kā arī salīdzināt filmas savā starpā. Izpētes procesā ir izmantotas dažādas teorijas, piemēram, Vernera Faulstiša filmas analīzes pamati, Vernera Volfa intermedialitātes teorija, Sandras Popes un Stefana Horlahera vizualitātes teorijas un daudzas citas. Bakalaura darba rezultātā ir noskaidrots, ka Fasbindera filma satura ziņa ir tuvāka Fontanes romānam, nekā Huntgeburtas ekranizācija. Vizualitātes ziņā melnbaltā Fasbindera filma vairāk ataino māksliniecisko pieeju filmai, nekā Huntgeburtas krāsaina un dabiska ekranizācijas maniere.The theme of the Bachelor thesis R. W. Fassbinder and H. Huntgeburth: Screen Versions of the "Effi Briest" are screen versions of literary works. The study is concerned with the investigation of the two most recent screen versions of Theodor Fontane’s novel, the first one Fontane Effie Briest by by Rainer Werner Fassbinder (1974), and the second one Effie Briest by Hermine Huntgeburth (2009). The purpose of the study is to discover the differences between the original literary text and the screen versions as well as to compare the films to each other. In the course of the investigation various theories have been used, for instance, Werner Faulstich’s film analysis basics, Werner Wolf’s intermediality theory, Sandra Pope’s and Stefan Horlacher’s visuality theory, and many other theories. As a result of the study, it was discovered that in regard to the content the film by Fassbinder is more similar to Fontane’s novel than Huntgeburth’s screen version. In regard to the visuality, the black-and-white film by Fassbinder better conveys the artistic approach to the film than Huntgeburth’s colourful and natural approach to filming a screen version
Thermal oxidation kinetics of additive free polyamide 6-6
No full textThermal aging of an additive free PA 6-6 has been elucidated at 90, 100, 120, 140, 150 and 160 C in airventiled ovens by Fourier transform infrared spectrophotometry, viscosimetry in molten state and uniaxial tensile testing. Oxidation of methylene groups starts after a considerably shorter induction period but reaches a lower maximal rate than in additive free PE. Cleavage of CeN bonds constitutes the main source of chain scissions. It leads to the formation of aldehyde chain-ends and a catastrophic decrease in molar mass. Embrittlement occurs at a very low conversion ratio of the oxidation process, in particular when the concentration of aldehyde chain-ends reaches a critical value of [PH¼O]F z 5.6 10 3 mol l 1, corresponding to a critical value of the number average molar mass ofMnFz17 kg mol 1. At this stage, the entanglement network in the amorphous phase is deeply damaged. A non-empirical kinetic model has been derived from the oxidation mechanistic scheme previously established for PE, but improved by adding elementary reactions specific to polyamides such as the rapid decomposition of unstable hydroxylated amide groups. This model describes satisfyingly the main features of the thermal oxidation kinetics of PA 6-6, but also of other types of aliphatic polyamides studied previously in the literature such as: PA 6, PA 12 and PA 4-6, as long as it is not controlled by oxygen diffusion. At the same time, it confirms the existence of an universal character for the thermal oxidation kinetics of aliphatic polyamides whatever their origin, i.e. their initial molar mass, crystallinity ratio, concentration of impurities, structural irregularities, etc
Diffusion approximation and first–passage–time problem for a model neuron. III. A birth–and–death process approach
No full textA stochastic model for single neuron's activity is constructed as the continuous limit of a birth-and-death process in the presence of a reversal hyperpolarization potential. The resulting process is a one dimensional diffusion with linear drift and infinitesimal variance, somewhat different from that proposed by Lansky and Lanska in a previous paper. A detailed study is performed for both the discrete process and its continuous approximation. In particular, the neuronal firing time problem is discussed and the moments of the firing time are explicitly obtained. Use of a new computation method is then made to obtain the firing p.d.f.. The behaviour of mean, variance and coefficient of variation of the firing time and of its p.d.f. is analysed to pinpoint the role played by the parameters of the model. A mathematical description of the return process for this neuronal diffusion model is finally provided to obtain closed form expressions for the asymptotic moments and steady state p.d.f. of the neuron's membrane potential
Structure and twinning stress of martensites in non-stoichiometric NiMnGa single crystal
No full textLack of an Association Between Three Tagging SNPs Within The FTO gene and Smoking Behavior
No full textПОЗИЦІОНУВАННЯ УКРАЇНИ В СУЧАСНИХ МІЖНАРОДНИХ МІГРАЦІЙНИХ ПРОЦЕСАХ
No full textThe article is devoted to the actual determination of Ukraine’s actual positioning in modern migration processes. It was emphasized that due to the full-scale war, the number of Ukrainian migrants around the world is constantly increasing, which leads to a decrease in the workforce in the national labor market. It has been established that over the past 30 years there has been an increase in emigration from Ukraine to middle-income countries, with a gradual increase in the flow to high-income countries. It is summarized that high level of emigration or labor export create significant risks for the effectiveness of socio-economic and socio-political transformations. For Ukraine this is particularly relevant, because of the talents outflow, which has increased significantly during 2022-2023. This will have a significant negative impact on society and economy.
Attention is drawn to the fact that besides the fact of high rates of emigration, Ukraine is also one of the world\u27s centers of attraction for migrants: before the full-scale invasion, there was a steady increase in both labor immigrants and students, the majority of whom came to Ukraine from the post-soviet countries of Central Asia, India and China. The expediency of restoring and supporting this human flow for the post-war recovery of Ukraine has been determined.
An analysis of the employment indicators of Ukrainian refugees to the OECD countries was carried out. It was determined that due to the introduction of special schemes and political measures in most countries, Ukrainians got the opportunity to look for work at an earlier stage than other waves of refugees. This led to extremely high employment rates among Ukrainian migrants in some European countries.
A general conclusion was made that at the current stage, Ukraine\u27s participation in international migration processes mainly increases the labor shortage in the national labor market due to the high rate of emigration. The level of employment of Ukrainian migrants in Europe indicates a high degree of their integration in a new place, which actualizes the issue of non-return. Attention was drawn to the fact that for the effective functioning of the national labor market, Ukraine needs an up-to-date, effective and professionally oriented migration policy that can ensure the effective post-war recovery of the country\u27s economy.Статтю присвячено актуалізації позиціонування України в системі сучасних міграційних процесів. Наголошено, що через повномасштабну агресію чисельність українських мігрантів у всьому світі безперервно збільшується, що призводить до зменшення обсягів працездатної робочої сили на національному ринку праці. Встановлено, що протягом останніх 30 років спостерігається збільшення еміграції з України до країн з середнім рівнем доходу, з поступовим збільшенням потоку мігрантів до країн з високим рівнем доходу. Констатовано, що масштабна еміграція населення, експорт робочої сили формують значні ризики для результативності соціально-економічних трансформацій, Зокрема, для України особливо актуальною є проблема відтоку талантів, обсяги якого значно збільшились протягом 2022-2023 рр., що може мати значний негативний вплив на суспільство та економіку.
Акцентовано увагу, що водночас із високими показниками еміграції, Україна також є одним із світових центрів тяжіння для мігрантів: до повномасштабного вторгнення спостерігалось стабільне зростання припливу як трудових іммігрантів, так і студентів, переважна кількість яких приїздила до України з Індії, Китаю та пострадянських країн Середньої Азії. Підкреслено важливість відновлення та підтримки цього людино-потоку для повоєнного відновлення України.
Здійснено аналіз показників зайнятості українських біженців у країнах ОЕСР, на основі чого визначено, що завдяки запровадженню у більшості країн спеціальних схем та політичних заходів для допомоги мігрантам з України через війну, українці отримали можливість шукати роботу на більш ранньому етапі, ніж інші хвилі біженців. Це призвело до надзвичайно високих показників зайнятості серед українських мігрантів в окремих країнах Європи.
Зроблено загальний висновок, що на сучасному етапі участь України у міжнародних міграційних процесах переважно збільшує трудоресурсний дефіцит на національному ринку праці через високі темпи еміграції. Рівень зайнятості українських мігрантів в Європі свідчить про високий ступінь їх інтеграції на ринку праці приймаючих країн, що актуалізує проблему неповернення. Акцентовано увагу, що для дієвого функціонування національного ринку праці, Україні потрібна дієва та професійно-орієнтована міграційна політика, яка зможе забезпечити якнайшвидше повоєнне відновлення економіки країни
Lack of Association Between Variants within the AHSG, HCRT and NPY2R Genes and Anthropometrical Parameters in Czech Post-Monica Study
No full textThe aim of this study was to examine single nucleotide polymorphisms (SNPs) of candidate genes α2-Heremans-Schmid glycoprotein (AHSG, rs4917), Hypocretin (HCRT, rs760282) and Neuropetide Y2 receptor (NPY2R, rs 1047214), which are known to have a potential effect on body mass index (BMI) and other indicators of obesity. A population study was performed in 2007/2008 on 2559 adults (1191 males and 1368 females) from the Czech post-MONICA project. The SNPs were examined using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. We did not find any significant association between the examined SNPs and BMI across the whole population. A significantly lower triglyceride level was found in the AHSG gene CC homozygotes compared to T allele carriers in the entire population (p = 0.009). In conclusion, we are not able to confirm the hypothesis that polymorphisms within the AHSG, HCRT and NPY2R genes are major genetic determinants of BMI and plasma lipids in the Czech-Slavonic population
Study of austenite-martensite transformation in Ni-Mn-Ga magnetic shape memory alloy
No full textNiMn Ga magnetic shape memory sample showing magnetic-field-induced strain of 5.7 % in the magnetic field 0.5 T was studied at different conditions during austenite-martensite and martensite-austenite transformations. Transformation temperatures K, K were determined by AC susceptibility measurement. Structure parameters obtained from X-ray measurement are nm for austenite and nm, nm for martensite which has fivelayered modulated structure. Mechanical stress up to 4 MPa and magnetic field up to 1 T were applied in order to study their influence on the transformations. Totally 39 transformation cycles were measured. The thermoelastic strains during transformations vary from -3.6 % to +1.8 %. Simultaneous change of magnetization and strain has been observed. Thermomechanical and magnetic history of the sample seems to have no or only very weak influence on the character of austenite-martensite transformation and no clear trend emerges in our experiments
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