364 research outputs found
Alexandr Berndorf - author of my region
No full textTéma této bakalářské práce nese název Alexandr Berndorf autor mého regionu. Práce je rozdělena do několika částí. První kapitola se zabývá životem tohoto spisovatele a vychází z autorova vlastnoručně psaného životopisu a životopisné studie napsané Zdeňkem Papešem. Dále si práce všímá části beletristické tvorby Alexandra Berndorfa a jeho vztahu k rodnému kraji. Hlavním cílem práce je představit tohoto dnes již nepříliš známého autora a připomenout jeho přínos nepomuckému regionu.ObhájenoThe topic of this Bachelor thesis is Alexandr Berndorf an author from my native region. The work itself is divided into several parts. The first chapter maps the life of this writer and is based on his own autobiography as well as a biographic study written by Zdeněk Papeš. Furthermore, the thesis focuses on Berndorf's prose and his relationship with his birth land. Overall, its main goal is to introduce this almost forgotten author and to remind everybody of his contribution to the Nepomuk region
Differentiated medical-surgical tactics in primary colon neoformations: Summary of PhD Thesis of Medical Sciences: 321.13 – Surgery
No full textUrsu Alexandr „Differentiated medical-surgical tactics in primary colon neoformations”. Thesis for
obtaining the scientific title of PhD in Medical Sciences, Chișinău, 2026.
The thesis is presented on 182 pages, consists of introduction, 5 chapters, general conclusions, practical
recommendations, 25 tables, 43 figures, 184 bibliographical sources. 36 scientific papers have been
published on the thesis topic.
Key words: primary colonic neoformations, colorectal cancer, risk factors, biomarkers, colonoscopy,
endoscopic treatment, surgical treatment, histological examination, follow-up.
Field of study: 321.13 – surgery.
Research aim: To improve the results of the treatment of colonic neoplasms by identifying optimal
diagnostic methods and therapeutic procedures for structuring differentiated curative conduct.
Objectives of the research: (1) Correlational analysis of clinical and paraclinical manifestations of
colonic neoformations predictive of the malignant process. (2) Study of morphological and histological
aspects of primary colonic neoformations. (3) Argumentation and correlation of types of surgical
interventions according to clinical and morphopathological data in patients with primary colonic
neoformations. (4) Structuring a screening algorithm, which would improve early detection of colorectal
cancer and its preoperative staging. (5) Identification of genomic markers predictive of colorectal cancer.
Novelty and originality of the research: Based on the complex clinical-paraclinical examination, the
evolutionary peculiarities of colonic neoformations depending on age, the anatomical-topographic
specimen of the lesional area were determined and confirmed. The data obtained became an objective
substrate in improving the pre-, intra- and postoperative diagnostic-curative conduct in patients with
colon neoformations. The complex of criteria in the differentiated selection of patients for various
methods of surgical treatment was established. The risk factors for malignant colonic neoformations were
systematized, and some predictive markers of CRC were determined and studied, highlighting the
molecular profile of CRC. The research has created the foundation for screening programs that can ensure
periodic follow-up of individuals with positive tests or increased risk factors, diagnostic examination, and
prompt treatment of colonic neoplasms. A consensus has been developed regarding the determinants of
differentiated therapeutic approach in colonic neoplasms.
The application of these scientific results: Based on this doctoral research, new methods of diagnosis
and treatment of patients with primary colonic neoformations were implemented in the surgery and
endoscopy departments of the Institute of Emergency Medicine (Chișinău, Republic of Moldova) and in
the teaching process at the Department of Surgery No. 1 „Nicolae Anestiadi” of the IP „Nicolae
Testemițanu” State University of Medicine and Pharmacy in the Republic of Moldova
Tactica medico-chirurgicală diferențiată în neoformațiunile primare ale colonului: Rezumatul tezei de doctor în științe medicale: 321.13 – Chirurgie
No full textUrsu Alexandr „Tactica medico-chirurgicală diferențiată în neoformațiunile primare ale
colonului”, teză pentru obținerea titlului științific de doctor în științe medicale, Chişinău, 2026. Teza este
expusă pe 182 pagini, constă din introducere, 5 capitole, concluzii generale, recomandări practice, 25
tabele, 43 figuri, 184 surse bibliografice. Rezultatele obţinute sunt publicate în 36 lucrări ştiinţifice.
Cuvinte cheie: neoformațiuni colonice primare, cancer colorectal, factori de risc, biomarcheri,
colonoscopie, tratament endoscopic, tratament chirurgical, examen histologic, follow-up.
Domeniul de studiu: 321.13 – Chirurgie.
Scopul cercetării: Ameliorarea rezultatelor tratamentului neoformațiunilor colonice prin identificarea
metodelor diagnostice și a procedeelor terapeutice optimale pentru structurarea conduitei curative
diferențiate.
Obiectivele lucrării: (1) Analiza corelațională a manifestărilor clinico-paraclinice a neoformațiunilor
colonice predictoare ale procesului malign. (2) Studierea aspectelor morfologice și histologice ale
neoformațiunilor primare ale colonului. (3) Argumentarea și corelarea tipurilor de intervenții chirurgicale
în funcție de datele clinico-morfopatologice la pacienții cu neoformațiuni primare ale colonului. (4)
Structurarea unui algoritm de screening, care ar îmbunătăți depistarea precoce a cancerului colorectal și
stadializarea preoperatorie a acestuia. (5) Identificarea marcherilor genomici predictori ai cancerului
colorectal.
Noutatea si originalitatea ştiinţifică: În baza examenului clinico-paraclinic complex au fost determinate
si confirmate particularitățile evolutive ale neoformațiunilor colonice în funcție de vârstă, specimenul
anatomo-topografic al zonei lezionale. Datele obținute au devenit un substrat obiectiv în ameliorarea
conduitei diagnostico-curative pre, intra- și postoperatorie la bolnavii cu neoformațiuni ale colonului. S-a
stabilit complexul de criterii în selectarea diferențiată a pacienților pentru diverse metode de tratament
chirurgical. S-au sistematizați factorii de risc pentru neoformațiunile colonice maligne, și au fost
determinați și studiați unii marcheri predictori ai CCR, fiind evidențiat profilul molecular al CCR.
Problema ştiinţifică aplicativă soluţionată: Cercetarea a creat fundamentul unor programe de screening
care să poată asigura urmărirea periodică a persoanelor depistate cu teste pozitive sau cu factori de risc
sporit, examinarea diagnostică și tratamentul prompt al neoformațiunilor colonice. A fost elaborat un
consens în privința factorilor determinanți ai atitudinii terapeutice diferențiate în neoformațiunile de
colon.
Implementarea rezultatelor ştiinţifice: În baza acestei cercetări doctorale au fost implementate noi
metode de diagnostic și tratament pacienților cu neoformațiuni colonice primare în secțiile de chirurgie și
endoscopie din cadrul Institutului de Medicină Urgentă (or. Chișinău, Republica Moldova) și în procesul
didactic la catedra de Chirurgie nr.1 ,,Nicolae Anestiadi” a IP Universitatea de Stat de Medicină și
Farmacie ,,Nicolae Testemițanu” din Republica Moldova
Differentiated medical-surgical tactics in primary colon neoformations
No full textUrsu Alexandr „Tactica medico-chirurgicală diferențiată în neoformațiunile primare ale
colonului”, teză pentru obținerea titlului științific de doctor în științe medicale, Chişinău, 2026. Teza este
expusă pe 182 pagini, constă din introducere, 5 capitole, concluzii generale, recomandări practice, 25
tabele, 43 figuri, 184 surse bibliografice. Rezultatele obţinute sunt publicate în 36 lucrări ştiinţifice.
Cuvinte cheie: neoformațiuni colonice primare, cancer colorectal, factori de risc, biomarcheri,
colonoscopie, tratament endoscopic, tratament chirurgical, examen histologic, follow-up.
Domeniul de studiu: 321.13 – Chirurgie.
Scopul cercetării: Ameliorarea rezultatelor tratamentului neoformațiunilor colonice prin identificarea
metodelor diagnostice și a procedeelor terapeutice optimale pentru structurarea conduitei curative
diferențiate.
Obiectivele lucrării: (1) Analiza corelațională a manifestărilor clinico-paraclinice a neoformațiunilor
colonice predictoare ale procesului malign. (2) Studierea aspectelor morfologice și histologice ale
neoformațiunilor primare ale colonului. (3) Argumentarea și corelarea tipurilor de intervenții chirurgicale
în funcție de datele clinico-morfopatologice la pacienții cu neoformațiuni primare ale colonului. (4)
Structurarea unui algoritm de screening, care ar îmbunătăți depistarea precoce a cancerului colorectal și
stadializarea preoperatorie a acestuia. (5) Identificarea marcherilor genomici predictori ai cancerului
colorectal.
Noutatea si originalitatea ştiinţifică: În baza examenului clinico-paraclinic complex au fost determinate
si confirmate particularitățile evolutive ale neoformațiunilor colonice în funcție de vârstă, specimenul
anatomo-topografic al zonei lezionale. Datele obținute au devenit un substrat obiectiv în ameliorarea
conduitei diagnostico-curative pre, intra- și postoperatorie la bolnavii cu neoformațiuni ale colonului. S-a
stabilit complexul de criterii în selectarea diferențiată a pacienților pentru diverse metode de tratament
chirurgical. S-au sistematizați factorii de risc pentru neoformațiunile colonice maligne, și au fost
determinați și studiați unii marcheri predictori ai CCR, fiind evidențiat profilul molecular al CCR.
Problema ştiinţifică aplicativă soluţionată: Cercetarea a creat fundamentul unor programe de screening
care să poată asigura urmărirea periodică a persoanelor depistate cu teste pozitive sau cu factori de risc
sporit, examinarea diagnostică și tratamentul prompt al neoformațiunilor colonice. A fost elaborat un
consens în privința factorilor determinanți ai atitudinii terapeutice diferențiate în neoformațiunile de
colon.
Implementarea rezultatelor ştiinţifice: În baza acestei cercetări doctorale au fost implementate noi
metode de diagnostic și tratament pacienților cu neoformațiuni colonice primare în secțiile de chirurgie și
endoscopie din cadrul Institutului de Medicină Urgentă (or. Chișinău, Republica Moldova) și în procesul
didactic la catedra de Chirurgie nr.1 ,,Nicolae Anestiadi” a IP Universitatea de Stat de Medicină și
Farmacie ,,Nicolae Testemițanu” din Republica Moldova.Ursu Alexandr „Differentiated medical-surgical tactics in primary colon neoformations”. Thesis for
obtaining the scientific title of PhD in Medical Sciences, Chișinău, 2026.
The thesis is presented on 182 pages, consists of introduction, 5 chapters, general conclusions, practical
recommendations, 25 tables, 43 figures, 184 bibliographical sources. 36 scientific papers have been
published on the thesis topic.
Key words: primary colonic neoformations, colorectal cancer, risk factors, biomarkers, colonoscopy,
endoscopic treatment, surgical treatment, histological examination, follow-up.
Field of study: 321.13 – surgery.
Research aim: To improve the results of the treatment of colonic neoplasms by identifying optimal
diagnostic methods and therapeutic procedures for structuring differentiated curative conduct.
Objectives of the research: (1) Correlational analysis of clinical and paraclinical manifestations of
colonic neoformations predictive of the malignant process. (2) Study of morphological and histological
aspects of primary colonic neoformations. (3) Argumentation and correlation of types of surgical
interventions according to clinical and morphopathological data in patients with primary colonic
neoformations. (4) Structuring a screening algorithm, which would improve early detection of colorectal
cancer and its preoperative staging. (5) Identification of genomic markers predictive of colorectal cancer.
Novelty and originality of the research: Based on the complex clinical-paraclinical examination, the
evolutionary peculiarities of colonic neoformations depending on age, the anatomical-topographic
specimen of the lesional area were determined and confirmed. The data obtained became an objective
substrate in improving the pre-, intra- and postoperative diagnostic-curative conduct in patients with
colon neoformations. The complex of criteria in the differentiated selection of patients for various
methods of surgical treatment was established. The risk factors for malignant colonic neoformations were
systematized, and some predictive markers of CRC were determined and studied, highlighting the
molecular profile of CRC. The research has created the foundation for screening programs that can ensure
periodic follow-up of individuals with positive tests or increased risk factors, diagnostic examination, and
prompt treatment of colonic neoplasms. A consensus has been developed regarding the determinants of
differentiated therapeutic approach in colonic neoplasms.
The application of these scientific results: Based on this doctoral research, new methods of diagnosis
and treatment of patients with primary colonic neoformations were implemented in the surgery and
endoscopy departments of the Institute of Emergency Medicine (Chișinău, Republic of Moldova) and in
the teaching process at the Department of Surgery No. 1 „Nicolae Anestiadi” of the IP „Nicolae
Testemițanu” State University of Medicine and Pharmacy in the Republic of Moldova
Alexandr Sukorov’s passıng world
No full textThe author of this article concentrates his attention on the films directed by Alexandr Sokurov, a distinguished contemporary Russian filmmaker. Syska describes the political and aesthetical background of Sokurov’s works, underlying their key motifs: melancholy, nostalgia, reminiscences, decay of physical world, memories and time. The author mentions autobiographical components of Sokurov’s screenplays, describes his childhood defined by eternal displacement of his family, as well as the adultness - with political troubles caused by anti-communism attitude and close friendship with Tarkovsky. Syska analyzes the literary context of Sokurov’s films, cultural paradigm, religious character of film narration and theme of carnal sacrifice. All of them allow him to describe the human as someone who is deeply devoted to the internal world of memories, nostalgia, passing time and intimate relationship with dying parents
Los "Suvenires del meldar" de Alexandr Ben-Guiat
No full textThe present paper offers the edition of a Judeo-Spanish text describing certain aspects of the meldar -the Jewish religious elementary school- in late nineteenth-century Smyrne. The author of the text presents in an ironic fashion a number of amusing situations and anecdotes which he himself had experienced as a boy during his schooldays. The work provides us with important data of a socio-historical interest that broadens our knowledge of education within Sephardic communities in the Eastern Mediterranean world
Lyrical elements in Lorca's theatre - (Bodas de sangre - Bloody wedding)
No full textHerman, Alexandr. Lirical elements in Lorca´s theatre - Bloody wedding. České Budějovice: Pedagogická fakulta Jihočeské univerzity v Českých Budějovicích, 2011, 103 s., Diploma thesis. This diploma thesis presents lyrical elements in teatral work of Federico García Lorca. Author himself belogs among top members of an avantgarde movement in Spain. His dramas are up to now very often shown at the most prestigious theatre house in the world, his poetry, very often explained in new interpretation, absorbing an echoe of the folk lyric. The author was bor in the year 1898, year that ment withdrawal from its ancient position. This new situation is reflected at a new actitude towards an art and Spain. This work is divided into three parts
Alexandr Solzhenitsyn - Man and Author in Time
No full textBanchelor study deals with basic moments of life and production by Russian writer Alexander Solzhenitsyn. He won the Nobel prize for literature and also he is author of famous publications such as One Day in the Life of Ivan Denisovich and The Gulag Archipelago. This work is focusing on his publicists and also how his publication impress the readers. Work describing fate of human, who gone thru siberian forced labour camp and who truly testified about crucial events of 20th century. This work including documenty enclosure
International arbitration and the effects of foreign arbitral awards
No full textFişierul ataşat conţine: Rezumat, Abstract, Cuprins, Introducere, Bibliografie.Problemаticа studiului Crizа sistemului jurisdicționаl, mаnifestаtă prin creștereа continuă а volumului cаuzelor аflаte pe rolul instаnțelor, costurile exаgerаte аle proceselor, lentoаreа judecății și, nu în ultimul rând, lipsа de eficаcitаte а hotărârilor judecătorești, а determinаt utilizаreа unei căi rаpide, funcționаle pentru rezolvаreа disputelor intervenite între pаrticipаnții lа circuitul generаl аl schimburilor de bunuri și servicii. În аcest context s-а cristаlizаt аrbitrаjul, o jurisdicție convenționаlă de drept privаt, pentru rezolvаreа аnumitor litigii, de către unа sаu mаi multe persoаne, în cаdrul unei proceduri bаzаte pe аutonomiа de voință а părților și cu respectаreа ordinii publice, а bunelor morаvuri și а dispozițiilor imperаtive аle legii. Litigiile internаționаle soluționаte pe cаleа аrbitrаjului izvorăsc fie din rаporturi comerciаle privind vânzаreа, cumpărаreа sаu schimburile de mărfuri, prestаțiile de servicii, trаnsporturile și expe-dițiile internаționаle, fie din rаporturile privind proiectările, prospectările, executările de lucrări de аntrepriză, construcții sаu montаj, operаțiuni finаnciаre vаlutаre și orice аlte аctivități lucrаtive.
Obiectivele: cercetаreа și аnаlizа doctrinei și аctelor normаtive în domeniul аle аrbitrаjului internаționаl și efectelor hotărârilor аrbitrаle străine; determinаreа noțiunii și nаturii juridice а аrbitrаjului internаționаl; аnаlizа convenției de аrbitrаj, condițiilor de fond și formă аle convenției аrbitrаle; аnаlizа procesului аrbitrаl internаtionаl; аnаlizа efectelor hotărârilor аrbitrаle străine formulаreа concluziilor și recomаndărilor și propunerilor de legeа ferendа. Metode аplicаte lа reаlizаreа cercetării: Metodologiа cеrcеtării prezente cоnstă din mаi multe metode și аnume: metodа logică, metodа istоrică, metodа sistеmаtică, mеtоdа cоmpаrаtivă și mеtоdа аnаlizеi sistеmicе, mеtоdа fоrmаl-juridică, mеtоdа cоmpаrаtă.
Rezultаtul concret obţinut: constă în cercetаreа multidimensionаlă а аrbitrаjului internаționаl, nаturа juridică а аrbitrаjului, procesul аrbitrаl internаționаl și nu în ultimul rând efectele hotărârilor аrbitrаle și condițiile de regulаritаte internаționаlă а sentințelor аrbitrаle străine în sistemul Convenției de lа New York din 1958, pentru elаborаreа unor principii directorii privind regimul juridic propriu eficаcității internаționаle а sentințelor аrbitrаle străine, în vedereа vаlorificării, perenizării și dezvoltării аcquis-ului de eficаcitаte instituit de Convențiа de lа New York.The problem of the study. The crisis of the jurisdictional system, manifested by the continuous increase in the volume of cases before the courts, the exaggerated costs of the trials, the slowness of the trial and, last but not least, the lack of effectiveness of the court decisions, determined the use of a fast, functional way to resolve disputes between participants in the general circuit of exchanges of goods and services. In this context, arbitration was crystallized, a conventional jurisdiction of private law, for the resolution of certain disputes, by one or more persons, within a procedure based on the autonomy of the will of the parties and respecting public order, good morals and provisions imperatives of the law.
Objectives: research and analysis of doctrine and normative acts in the field of international arbitration and the effects of foreign arbitral awards;determining the notion and legal nature of international arbitration; analysis of the arbitration agreement, substantive and formal conditions of the arbitration agreement; analysis of the international arbitration process; analysis of the effects of foreign arbitral awards, formulation of conclusions and recommendations and proposals for the law of ferenda.
Methods applied to the realization of the research: The methodology of the present research consists of several methods, namely: the logical method, the historical method, the systematic method, the comparative method and the method of systemic analysis, the formal-legal method, the comparative method.
The concrete result obtained:consists in the multidimensional research of international arbitration, the legal nature of arbitration, the international arbitration process and last but not least the effects of arbitral awards and the conditions of international regularity of foreign arbitral awards in the system of the New York Convention of 1958, for the elaboration of some guiding principles regarding the regime legal proper to the international effectiveness of foreign arbitration awards, in order to capitalize, perpetuate and develop the acquis of effectiveness established by the New York Convention
Fecal microbial markers–the role in colorectal cancer screening: a review of literature
No full textDepartment of Surgery no.1 Nicolae Anestiadi; Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova, The 8th International Medical Congress for Students and Young Doctors, September 24-26, 2020Introduction. Colorectal cancer (CRC) is the third most common cancer worldwide,
accounting for about 10% of all cancer cases diagnosed annually. Due to the high prevalence
of CRC, implementation of a screening program, especially non-invasive would reduce the
incidence by eradicating precancerous lesions, as well as mortality by treating the early stages
of the disease.
Aim of the study. Presentation of recent information on the role of fecal microbial markers as
a non-invasive method in the early detection of CRC.
Materials and methods.. 47 literary sources were analyzed, using Medline, PubMed, Google
Scholar, Hindawi databases over a 5 year period. Keywords used in the search: microbial
markers, screening, colorectal cancer.
Results. Of the 47 articles selected: 16–dedicated to clinical diagnostic methods, 10–regarding
the fecal immunochemical test (FIT), 11–regarding the role of fecal microbial markers in
combination with FIT, as predictors of CRC and 10–regarding the specificity and sensitivity
of the markers fecal microbes in symptomatic and asymptomatic patients. Thus, it was
determined that certain bacterial species, such as Parvimonas micra, Solobacterium moorei,
and Clostridium hathewayi, are significantly enriched in stool samples from CRC patients,
whereas the presence of other bacterial species, such as Bacteroides clarus and Roseburia
intestinalis, is significantly reduced in CRC patient stool. Also, Fusobacterium nucleatum is
thought to potentiate intestinal tumorigenesis through recruitment of infiltrating immune cells
and via activation of beta-catenin signaling. Such increased or decreased presence of these
bacterial species results in higher or lower levels of signature DNA, RNA and protein species
unique to these species, witch in turn can be used for detection, both qualitatively and
quantitatively.
Conclusions. This review highlights the effectiveness of non-invasive methods in the early
diagnosis of CRC, in estimating the risk of relapse and neoplastic dissemination, as well as the
rate of response to adjuvant treatment. Implementing an effective screening program would
reduce mortality in CRC, save a significant portion of the resources that would be spent on
treating patients in advanced stages of the disease
- …
