117,606 research outputs found
Expression and cellular localization of MANS::EGFP and UMANS::EGFP fusion proteins.
No full text<p>(A) Transfection of EGFP, MANS::EGFP and UMANS::EGFP results in similar expression of EGFP in NIH-3T3 fibroblasts as determined by Western blot 24 hours post transfection, with no expression of EGFP in non-transfected cells. Total MARCKS and beta-actin (loading control) expression in transfected and non-transfected NIH-3T3 fibroblasts was also determined 24 hours post transfection. (B) Analysis of membrane and cytosolic fractions for the expression of EGFP, MANS::EGFP and UMANS::EGFP as determined by Western blot analysis for EGFP expression. Cytosolic fraction purity was determined by p38 MAPK expression and beta-actin served as a loading control. Figures are representative of three independent experiments.</p
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Square Dancing with the Stars to Enhance Dynamic Hirschman Linkages?
No full textIn this Presidential Address, the author takes the reader on a reconnaissance of his life and time as a regional scientist. He points out scenery he found scintillating along the way, hoping that some may pick up the banner and chew on a few of the ideas for a while. He suggests a revisit to Albert O. Hirschman’s notion of key sectors and more empirical analysis related to Marcus Berliant’s and Masahisa Fujita’s notion of knowledge creation and transfer.Presidential Address, San Antonio, Texas, March 29, 2014 (53rd Meetings of the Southern Regional Science Association
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Letter from unknown writer to Jesse L. Boyce
No full textLetter to Jesse L. Boyce from unknown author (possibly Jack) about the investigation into the powder magazine located in the Grand Canyon. Some personal news is included in the letter such as the writer's marriage to the daughter of C.A. Taylor, former Supervisor of Cochise County
On Multidimensional and Monotone k-SUM
No full textThe well-known k-SUM conjecture is that integer k-SUM requires time Omega(n^{\ceil{k/2}-o(1)}). Recent work has studied multidimensional k-SUM in F_p^d, where the best known algorithm takes time \tilde O(n^{\ceil{k/2}}). Bhattacharyya et al. [ICS 2011] proved a min(2^{\Omega(d)},n^{\Omega(k)}) lower bound for k-SUM in F_p^d under the Exponential Time Hypothesis. We give a more refined lower bound under the standard k-SUM conjecture: for sufficiently large p, k-SUM in F_p^d requires time Omega(n^{k/2-o(1)}) if k is even, and Omega(n^{\ceil{k/2}-2k(log k)/(log p)-o(1)}) if k is odd.
For a special case of the multidimensional problem, bounded monotone d-dimensional 3SUM, Chan and Lewenstein [STOC 2015] gave a surprising \tilde O(n^{2-2/(d+13)}) algorithm using additive combinatorics. We show this algorithm is essentially optimal. To be more precise, bounded monotone d-dimensional 3SUM requires time Omega(n^{2-\frac{4}{d}-o(1)}) under the standard 3SUM conjecture, and time Omega(n^{2-\frac{2}{d}-o(1)}) under the so-called strong 3SUM conjecture. Thus, even though one might hope to further exploit the structural advantage of monotonicity, no substantial improvements beyond those obtained by Chan and Lewenstein are possible for bounded monotone d-dimensional 3SUM
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Sarah L. Blum Author Visit - Warrior Nurse: PTSD and Healing
No full textHear Sarah L. Blum, author of Women Under Fire: Abuse in the Military, discuss her newest book, Warrior Nurse: PTSD and Healing followed by a Q&A and book signing.
Sarah L. Blum is a decorated Vietnam veteran who served as an operating room nurse during the intense fighting of 1967. In recognition of her service, she was awarded the Army Commendation Medal.
Sponsored by CWU Veterans Center and CWU Libraries.https://digitalcommons.cwu.edu/libraryevents/1252/thumbnail.jp
Transforming Growth Factor type beta and Smad family signaling in stem cell function.
No full textLigands of the Transforming Growth Factor type beta (TGF beta) family exert multiple and sometimes opposite effects on most cell types in vivo depending on cellular context, which mainly includes the stage of the target cell, the local environment of this cell or niche, and the identity and the dosage of the ligand. Significant progress has been made in the molecular dissection of the regulation of the activity of the ligands and their intracellular signal transduction pathways, including via the canonical Smad pathway where Smads interact with many transcription factors. This knowledge together with results from functional studies within the embryology and stem cell research fields is giving us insight in the role of individual ligands and other components of this signaling system and where and how it regulates many properties of embryonic and adult stem/progenitor cells, which is anticipated to contribute to successful cell-based therapy in the future.sponsorship: ES was a post-doctoral fellow with the Franqui Foundation (Belgium). Research in the DH lab was supported by FWO-Flanders (project G.0288.07), the inter-universitary attraction pole network (IUAP-PAI 6/20) and the EC FP6 Integrated Project Endotrack (LSHG-CT-2006-19050). AZ was supported by IUAP-PAI 6/20, and MS and CV each by Odysseus type grants from the Flanders Government, and CV by Center of Excellence funding from the University of Leuven. A collaborative project between the four groups that share authorship in this review paper was also supported by grant OT/09/053 from the Research Council of the University of Leuven. (FWO-Flanders|G.0288.07, inter-universitary attraction pole network|IUAP-PAI 6/20, EC|LSHG-CT-2006-19050, Flanders Government, University of Leuven|OT/09/053)status: Publishe
Lillian L. Lambert, Author, Speaker, and Entrepreneur
No full textLillian L. Lambert, Author, Speaker, and Entrepreneu
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