196,073 research outputs found
Looking at COVID-19 from a Systems Biology Perspective
No full textThe sudden outbreak and worldwide spread of the SARS-CoV-2 pandemic pushed the scientific community to find fast solutions to cope with the health emergency. COVID-19 complexity, in terms of clinical outcomes, severity, and response to therapy suggested the use of multifactorial strategies, characteristic of the network medicine, to approach the study of the pathobiology. Proteomics and interactomics especially allow to generate datasets that, reduced and represented in the forms of networks, can be analyzed with the tools of systems biology to unveil specific pathways central to virus–human host interaction. Moreover, artificial intelligence tools can be implemented for the identification of druggable targets and drug repurposing. In this review article, we provide an overview of the results obtained so far, from a systems biology perspective, in the understanding of COVID-19 pathobiology and virus–host interactions, and in the development of disease classifiers and tools for drug repurposing
M&A and Market Reaction in the Luxury Industry: A Quantitative Study
No full textopenThis thesis investigates the market reaction to M&A transactions in the luxury goods sector. It begins by examining the concept and scope of luxury, the structure of the industry, its key players, and the strategic profiles that characterize the sector. The analysis then focuses on the specific characteristics of M&A deals, including valuation approaches and key success factors highlighted in the literature. The empirical section relies on a dataset from S&P Capital IQ, complemented with data from Refinitiv and AIDA, and estimates the stock market reaction using Cumulative Abnormal Returns (CAR), alongside additional control variables. The results offer insights into how investors respond to M&A activity in this distinctive industry context.This thesis investigates the market reaction to M&A transactions in the luxury goods sector. It begins by examining the concept and scope of luxury, the structure of the industry, its key players, and the strategic profiles that characterize the sector. The analysis then focuses on the specific characteristics of M&A deals, including valuation approaches and key success factors highlighted in the literature. The empirical section relies on a dataset from S&P Capital IQ, complemented with data from Refinitiv and AIDA, and estimates the stock market reaction using Cumulative Abnormal Returns (CAR), alongside additional control variables. The results offer insights into how investors respond to M&A activity in this distinctive industry context
Ligand-Based Regulation of Dynamics and Reactivity of Hemoproteins
No full textHemoproteins include several heme-binding proteins with distinct structure and function. The presence of the heme group confers specific reactivity and spectroscopic properties to hemoproteins. In this review, we provide an overview of five families of hemoproteins in terms of dynamics and reactivity. First, we describe how ligands modulate cooperativity and reactivity in globins, such as myoglobin and hemoglobin. Second, we move on to another family of hemoproteins devoted to electron transport, such as cytochromes. Later, we consider heme-based reactivity in hemopexin, the main heme-scavenging protein. Then, we focus on heme-albumin, a chronosteric hemoprotein with peculiar spectroscopic and enzymatic properties. Eventually, we analyze the reactivity and dynamics of the most recently discovered family of hemoproteins, i.e., nitrobindins
Valutazione Statistica della Terapia chirurgica per incoordinazione condilo-discale dell'A.T.M.
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Interfacial phenomena and magnetic properties of Fe/Al multilayers of different thickness
No full textMagnetic properties of thermally treated Fe/Al multilayers
No full textFe/Al multilayers, e-beam evaporated and thermally treated in UHV, were analyzed by Mössbauer and magnetic measurements. Al diffusion along grain boundaries into Fe gives rise to solid solution and paramagnetic compounds at interfaces. By decreasing Fe thickness, the grain size decreases and the surrounding paramagnetic compounds increase, justifying the changes in hysteresis loops and reversible susceptibility
[A statistical evaluation of the surgical therapy of TMJ condyle-disk incoordination].
No full textBiomechanical pathology of the TMJ occurs most frequently in 4 clinical variants: anterior dislocation of the jaw, reciprocal click, closed lock, osteoarthrotic degeneration. The aim of this study was to evaluate the efficacy of TMJ surgery, using statistical comparative analysis, in resolving condylo-meniscal incoordination. Eighty-one patients were included in the study who had been treated surgically for various symptoms of condylo-discal incoordination from 1982 to 1989, assessing a series of objective and subjective parameters and making a statistical comparison of results
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