118,527 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Adaptive Page Ranking with Neural Networks
No full textRecent developments in the area of neural networks provided new models which are capable of processing general types of graph structures. Neural networks are well-known for their generalization capabilities. This paper explores the idea of applying a novel neural network model to a web graph to compute an adaptive ranking of pages. Some early experimental results indicate that the new neural network models generalize exceptionally well when trained on a relatively small number of pages
Square Dancing with the Stars to Enhance Dynamic Hirschman Linkages?
No full textIn this Presidential Address, the author takes the reader on a reconnaissance of his life and time as a regional scientist. He points out scenery he found scintillating along the way, hoping that some may pick up the banner and chew on a few of the ideas for a while. He suggests a revisit to Albert O. Hirschman’s notion of key sectors and more empirical analysis related to Marcus Berliant’s and Masahisa Fujita’s notion of knowledge creation and transfer.Presidential Address, San Antonio, Texas, March 29, 2014 (53rd Meetings of the Southern Regional Science Association
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Letter from unknown writer to Jesse L. Boyce
No full textLetter to Jesse L. Boyce from unknown author (possibly Jack) about the investigation into the powder magazine located in the Grand Canyon. Some personal news is included in the letter such as the writer's marriage to the daughter of C.A. Taylor, former Supervisor of Cochise County
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Notch signaling requiem : orchestral role of notch signaling in cancer and developmental disease
No full textNotch signaling is an evolutionary conserved contact-dependent cell-cell communication pathway. This “contact” spans from hydra to fruit flies to human; orchestrating development, homeostasis and cancer, thus the Requiem, a song of life and death. Upon the “contact” of Notch receptor and ligand, the intracellular domain NICD is released and translocates to the nucleus. NICD, together with the DNA binding protein CSL and other co-activators, activate downstream targets. In this thesis, I have investigated the role of Notch signaling in multiple contexts with a modular approach. This includes: the non-canonical role of CSL in breast cancer, crosstalk of Notch signaling with hypoxia signaling in cancer, canonical Notch signaling in blood development, a novel mouse model for Alagille syndrome, and the hyperactivated Notch during mammary development and tumourigenesis.Here I phrase them in five sections of a requiem (Mozart’s Requiem, 1791): Introitus: In Paper I, we found that ablation of CSL unleashed a hypoxic response in normoxic conditions and enhanced tumour growth in breast cancer. A large part of the deregulated genes in the CSL null cell line is Notch independent. We demonstrated a non-canonical role of CSL and the possible implication of loss of CSL in breast cancer. Kyrie: In Paper II, we established that Notch signaling can modulate hypoxia signaling in multiple cancer cell types. By siRNA knocked down of HIF2α, we found that Notch signaling requires HIF2α for regulating a subset of Notch targets in medulloblastoma cells. Differences in the effect of N1ICD and N2ICD were also shown in the medulloblastoma cells. Lastly, we presented evidence of Notch signaling contributing to the HIF1α-to-HIF2α switch. Dies Irae: In Paper III, we revealed that canonical Notch signaling is dispensable in adult steady-state and stress myelo-erythropoiesis by ablating CSL in the myeloid lineage. Some of the Notch targets were derepressed in some of the progenitor stages, indicating CSL could act as a repressor in some contexts. Rex tremendae: In Paper IV, we established and characterized a mouse model for Alagille syndrome in human, recapitulating defects in multiple organ-systems. We showed a mutation in Jag1 caused delay differentiation and structural abnormalities in the bile ducts. From transcriptomics of mice and patients samples, we also found some commonly affected genes across species. Lastly, we discovered that the mutated Jag1 failed to bind to Notch1 and reduced the extent of Notch2 and Notch3 activation. Lacrymosa: In Paper V, we observed that hyperactive Notch in the luminal lineage during lactation cause defect in ductal development and led to mammary tumour development. Furthermore, we showed that this lineage can contribute to a large part of the mammary tumour.List of scientific papersI. Loss of CSL Unlocks a Hypoxic Response and Enhanced Tumor Growth Potential in Breast Cancer Cells. Braune EB*, Tsoi YL*, Phoon YP*, Landor S, Silva Cascales H, Ramsköld D, Deng Q, Lindqvist A, Lian X, Sahlgren C, Jin SB, Lendahl U. Stem Cell Reports. 2016;6(5):643-651. *Co-first author. https://doi.org/10.1016/j.stemcr.2016.03.004 II. Notch signaling promotes a HIF2α-driven hypoxic response in multiple tumor cell types. Mutvei AP, Landor SK, Fox R, Braune EB, Tsoi YL, Phoon YP, Sahlgren C, Hartman J, Bergh J, Jin S, Lendahl U. Oncogene. 2018;37(46):6083-6095. https://doi.org/10.1038/s41388-018-0400-3 III. Canonical Notch signaling is dispensable for adult steady-state and stress myeloerythropoiesis. Duarte S, Woll PS, Buza-Vidas N, Chin DWL, Boukarabila H, Luís TC, Stenson L, Bouriez-Jones T, Ferry H, Mead AJ, Atkinson D, Jin S, Clark SA, Wu B, Repapi E, Gray N, Taylor S, Mutvei AP, Tsoi YL, Nerlov C, Lendahl U, Jacobsen SEW. Blood. 2018;131(15):1712-1719. https://doi.org/10.1182/blood-2017-06-788505 IV. Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations. Andersson ER, Chivukula IV, Hankeova S, Sjöqvist M, Tsoi YL, Ramsköld D, Masek J, Elmansuri A, Hoogendoorn A, Vazquez E, Storvall H, Netušilová J, Huch M, Fischler B, Ellis E, Contreras A, Nemeth A, Chien KC, Clevers H, Sandberg R, Bryja V, Lendahl U. Gastroenterology. 2018;154(4):1080-1095. https://doi.org/10.1053/j.gastro.2017.11.002 V. Notch activation in the mouse mammary luminal lineage leads to ductal hyperplasia and altered partitioning of luminal cell subtypes. Phoon YP, Chivukula IV, Tsoi YL, Kanatani S, Uhlén P, Kuiper R, Lendahl U. Experimental Cell Research. 2020;395(1):112156. https://doi.org/10.1016/j.yexcr.2020.112156 </p
Sarah L. Blum Author Visit - Warrior Nurse: PTSD and Healing
No full textHear Sarah L. Blum, author of Women Under Fire: Abuse in the Military, discuss her newest book, Warrior Nurse: PTSD and Healing followed by a Q&A and book signing.
Sarah L. Blum is a decorated Vietnam veteran who served as an operating room nurse during the intense fighting of 1967. In recognition of her service, she was awarded the Army Commendation Medal.
Sponsored by CWU Veterans Center and CWU Libraries.https://digitalcommons.cwu.edu/libraryevents/1252/thumbnail.jp
On L² method for vanishing theorems in Kähler geometry.
No full textTsoi, Hung Ming.Thesis (M.Phil.)--Chinese University of Hong Kong, 2008.Includes bibliographical references (leaves 88-90).Abstracts in English and Chinese.Preface --- p.7Chapter 1 --- Kahler Manifold --- p.10Chapter 1.1 --- Hermitian Manifold --- p.12Chapter 1.2 --- Kahler Manifold --- p.13Chapter 1.2.1 --- "Positive (l,l)-form" --- p.15Chapter 2 --- Vector Bundle --- p.16Chapter 2.1 --- Holomorphic Vector Bundle and Connection --- p.17Chapter 2.2 --- Hermitian Connection and Chern Connection --- p.18Chapter 2.2.1 --- Existence of Chern connection on a holomorphic vector bundle --- p.19Chapter 2.3 --- Curvature --- p.21Chapter 2.4 --- Positivity of Vector Bundles --- p.23Chapter 2.5 --- Chern Classes and Holomorphic Line Bundle --- p.24Chapter 2.5.1 --- Chern class in axiomatic approach --- p.25Chapter 2.5.2 --- Chern class in algebraic topology --- p.26Chapter 2.5.3 --- Chern class in terms of curvature --- p.27Chapter 2.5.4 --- In the case of hermitian line bundle --- p.28Chapter 3 --- Analytic Technique on Kahler Manifold --- p.30Chapter 3.1 --- Dolbeault Cohomology --- p.30Chapter 3.2 --- Commutator Relations on Kahler Manifold --- p.31Chapter 3.2.1 --- Commutator relation on a line bundle --- p.32Chapter 3.3 --- Hodge Theory --- p.33Chapter 3.4 --- Bochner Technique --- p.35Chapter 3.4.1 --- Bochner-Kodaira-Nakano identity --- p.36Chapter 4 --- Kodaira Vanishing Theorem and L2 estimate of d --- p.38Chapter 4.1 --- Kodaira Vanishing Theorem --- p.39Chapter 4.2 --- Extension of Kodaira Vanishing Theorem by L2 Method --- p.44Chapter 4.2.1 --- Plurisubharmonic functions and weakly pseudoconvex Kahler manifold --- p.47Chapter 5 --- Multiplier Ideal Sheaf --- p.55Chapter 5.1 --- Algebraic Properties of Multiplier Ideal Sheaf --- p.56Chapter 5.2 --- Some Calculations of Multiplier Ideal Sheaf --- p.59Chapter 6 --- Nadel Vanishing Theorem --- p.62Chapter 6.1 --- Nadel Vanishing Theorem by L2 Estimate of d --- p.62Chapter 6.2 --- The Original Setting of Nadel --- p.64Chapter 6.2.1 --- S-bounded and S-null sequence --- p.65Chapter 6.2.2 --- Multiplier ideal sheaf by Nadel --- p.67Chapter 6.3 --- Nadel Vanishing Theorem by Computation of Cech Cohomology --- p.69Chapter 6.3.1 --- L2 estimate of d --- p.69Chapter 6.3.2 --- Koszul cochain --- p.70Chapter 6.3.3 --- The cohomology vanishing theorem --- p.73Chapter 7 --- Kawamata-Viehweg Vanishing Theorem --- p.77Chapter 7.1 --- Numerically Effective Line Bundle --- p.77Chapter 7.2 --- Kawamata-Viehweg Vanishing Theorem --- p.85Bibliography --- p.8
Web Spam Detection by Probability Mapping GraphSOMs and Graph Neural Networks
No full textIn this paper, we will apply, to the task of detecting web spam, a combination of the best of its breed algorithms for processing graph domain input data, namely, probability mapping graph self organizing maps and graph neural networks. The two connectionist models are organized into a layered architecture, consisting of a mixture of unsupervised and supervised learning methods. It is found that the results of this layered architecture approach are comparable to the best results obtained so far by others using very different approaches
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