20,962 research outputs found
Jan Kapr's contribution to contemporary music : an essay about a composer and teacher
No full textThis creative project is a treatise on a leading personality of Czechoslovakian musical life, the composer, Jan Kapr. The author discusses the following:1. The complicated development of Kapr's career and work, 2. Kapr's method of organization of musical material in a composition, as described in his book Constants,3. His former and current style which is demonstrated in two of his compositions, Concert Variations, for flute and string orchestra and Testimonies for four solo instruments,4. Two of his recent works, Exercises for Gydli and the Symphony No. 7, Country of Childhood.Thesis (M.A.
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
ELEVEN FACES OF JAN GOGOL, JR.
No full textAuthor Jan Rendl in his thesis attempts to look at the world of ideas and educator Jan
Gogola ml. through the eleven chapters in which each chapter somehow characterizes itself by Jan Gogola ml. and each of them somehow determines its creative ideas of it through the metaphor of a football match when Jan Gogola, with its characters, movies himself a teammate, as well as defensively. It gives goals with their situations as well as occasionally digging his opponents ankles.
Jan Gogola ml. thus embodies one stage of the Department of Documentary Film at FAMU, which often stands at the intersection between teaching activities and Karel Vachek among students who applied by them during their seminars psychological methods that work must be peculiarly associated with the author of the film
Dr. Jan French – Faculty Author Interview
No full textDr. Jan French, Assistant Professor of Anthropology, discusses her new book, Legalizing Identities: Becoming Black or Indian in Brazil’s Northeast, which shows how law can successfully serve as the impetus for the transformation of cultural practices and collective identity
Jan Bernátek - organ works
No full textThis graduation thesis provides a more detailed view on compositoins of Jan Bernátek.The aim is to present this less well-known temporary czech author,who makes use of the organ in the majority of his work
The Theological Work of Jan Valerián Jirsík
No full textAnglická anotace The theological work of Jan Valerian Jirsík Jan Hamberger This thesis deals with the theological work of the Czech 19th century author Jan Valerián Jirsík (1798-1883). Its first part consists of an introduction into the Czech historical context of the 19th century and the life of the author. Its second part presents a survey of the literary-theological work of Jirsík in three life phases: the first phase is demarked by his activity as chaplain and vicar, the second phase by his editorial activity for Casopis pro katolické duchovenstvo (trans. Magazine for catholic clergy) and the last phase by his pontifical years in the diocese of Southern Bohemia. His literary work is divided by theme into various periods, shortly described and characterized. The last and major section of this thesis deals with the most comprehensive and renown work of Jan Valerián Jirsík - Populární dogmatika (trans. Popular doctrine). This pivotal work of theologian Jirsík is discussed at large and analyzed by tractate, both apologetic and dogmatic. The conclusion expresses the prevailing character of the entire work of Jirsík and its significance. Key words: Theology Apologetic theology Dogmatic theology Theological literature Catholic Churc
Actor Profile of Jan Vondracek
No full textDivided into seven chapters, the work treats seven roles of the Czech actor Jan Vondracek (born in 1966) in Divadlo v Dlouhe Theatre from 1997-2008. The author starts from the analysis of Vondracek's performances and describes the specifics of his
showmanship and generalizes the personality traits of his characters. She also ponders the meaning of Czech dramatic art based on
typical characters in the context of contemporary Czech theatre
The picture of Jan Palach in czech culture
No full textThis thesis deals with cultural image of Jan Palach. It focuses especially on symbols and myths contributing to construction of this image. The main emphasis is given on the concept of sacrifice - the study analyzes comparisons of Jan Palach to archetypes of Jesus Christ and young martyrs. In the second part author analyzes national dimension of Palach's cultural image. She deals with comparison of Palach to Jan Hus and analyzes Palach's funeral as a part of tradition of Czech public funerals - quiet national demonstrations. The methodology of the study is discourse analysis, which is applied not only on texts (fiction and nonfiction), but also on photographic and film footage
Discovery of new therapeutic targets in Neuroblastoma by means of proteomic approach and functional studies
No full textNeuroblatoma (NB) is an embryonal tumor of the sympathetic nervous system which arises from the neural crest cells. This disease rappresents the most common extracranial tumor in infants, accounting for 8% to 10% of all childhood cancer and for approximately 15% of cancer deaths in children.
NB is a heterogeneous tumor for which biology dictates clinical behaviour.
It comprises cases with divergent outcome ranging from spontaneous differentiation to metastatic forms with poor prognosis. The deep knowledge of NB biology is imperative toward the development of novel therapy.
The most favourable subset of NB (stage 4S) can spontaneously differentiate in neurons or regress to a benign tumour phenotype. Retinoic Acid (RA) is a known neural differentiation-inducing agent actually used in NB therapy. In order to get new insights in the molecular mechanism driving neuronal differentiation in vitro, two-Dimensional Differential In-Gel Electrophoresis (2D-DIGE) analyse was performed on the cytosolic and nuclear protein expression patterns of NB cells following RA treatment. The combination of a proteomic approach and sub-cellular fractionation of the proteome provides the identification of 33 differentially expressed proteins during RA treatment in NB. The identified proteins have important roles in a variety of pathways which may have role on NB development and in NB RA-induced differentiation. The results also strength the use of proteomics to discover new putative protein targets in cancer.
Expression of Trk receptors is an important prognostic factor in NB. TrkB and its ligand BDNF (brain derived neurotrophin factor) are preferentially expressed in NB with poor prognosis, conferring invasive and metastatic potential to the tumor cells as well as enhancing therapy resistance. TrkA in contrast is high expressed in tumor with good outcome. Galectin-1 (Gal-1), a very promising cancer target, is involved in modulating cell proliferation, cell death and cell migration and was found to be up-regulated in patients with aggressive, relapsing NB. Gal-1 is a down-stream mediator of TrkB signalling, since its espression is increased in human SY5Y NB cells upon activation of ectopically expressed TrkB (SY5Y-TrkB), but not TrkA (SY5Y-TrkA). Functional studies here presented underlined the Gal-1 role to mediate invasion and migration in TrkB over-expressing NB cells, thus being activated by BDNF. This establishes Gal-1 as a potential therapeutic marker in high-risk TrkB-expressing NB
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