673 research outputs found
A CALL TO FIDELITY: ON THE MORAL THEOLOGY OF CHARLES E. CURRAN
No full textForeword / James J. Walter -- Introduction: Charles E. Curran: Catholic theologian, priest, prophet / Daniel C. Maguire -- Pt.1: Fundamental moral theology -- Ch.1: The moral person: moral anthropology and the virtues / Timothy E. O'Connell -- Ch.2: The moral agent: actions and normative decision making / James F. Keenan -- Ch.3: Ethics, ecclesiology, and the grace of self-doubt / Margaret A. Farley -- Ch.4: Moral theology and academic freedom: the new context / James A. Coriden -- Pt.2: Sexual and medical ethics -- Ch.5: Divorce and remarriage / Kevin T. Kelly -- Ch.6: Sexual ethics / Lisa Sowle Cahill -- Ch.7: Perspectives on medical ethics: biotechnology and Genetic Medicine / James J. Walter -- Pt.3: Social and political ethics -- Ch.8: Hierarchical catholic social teaching: analysis and interpretation / Kenneth R. Himes - - Ch.9: Catholic social ethics in the United States / Thomas A. Shannon -- Ch.10: A catholic troeltsch? Curran on the social ministry of the church / J. Bryan Hehir -- Pt.4: Dialogue -- Ch.11: Charles Curran: ecumenical moral theologian par excellence / James M. Gustafson -- Ch.12: Curran's fundamental moral theology in comparison with European Catholic approaches / Raphael Gallagher - - Ch.13: Beyond revision: a younger moralist looks at Charles E. Curran / Bryan N. Massingale -- Bibliography of Charles E. Curran, 1961-2002: Forty-one years of Catholic moral theology -- Contributors -- Inde
Trichopalpus nigribasis Curran 1927
No full textTrichopalpus nigribasis Curran, 1927 Trichopalpus nigribasis Curran, 1927: 255. HOLOTYPE: J, Canada,Alta.[= Alberta], Banff, 23.viii.1922, No. 2606, C. B. G. Garrett leg. (CNC). Chaetosa pilirostris Ringdahl, 1936: 178. HOLOTYPE: J, Norway, ‘im nördlichen Norwegen [= in northern Norway], Ein J vom Verf. bei Tromsö [= one male collected by the author near Tromsø]’ (probably MZLU). Synonymized by GORODKOV (1986: 28). Distribution. Finland (HACKMAN 1980: 131); Norway (NELSON & GREVE 2002: 46); Nearctic region (VOCKEROTH 1965: 836).Published as part of Šifner, František, 2008, A catalogue of the Scathophagidae (Diptera) of the Palaearctic region, with notes on their taxonomy and faunistics, pp. 111-196 in Acta Entomologica Musei Nationalis Pragae 48 (1) on pages 140-141, DOI: 10.5281/zenodo.534249
A call to fidelity on the moral theology of Charles E. Curran
No full textA call to fidelity seeks to examine and critically evaluate the contributions that Charles E. Curran has made to the field of Catholic moral theology over the past forty years. It also seeks to assess the development of specific topics in contemporary moral theology to which Curran has made his unique mark, particularly in fundamental ethics, sexual and medical ethics, social and political ethics, and topics related to dialogue with other traditions and approaches to Catholic ethics. Reviewing the many years of his influential writings, thought, and scholarship, fourteen distinguished scholars examine his contributions and the current state of the topics under discussion--which are as far ranging as academic freedom, birth control, gay and lesbian relationships, and feminism. Each contributor also provides a critical evaluation of Curran's work and outlines how these areas will hold or undergo transformation as the church looks toward its relationship with society and culture in the coming decades
Letter from M.J. Curran to Hagan
No full textHolograph letter from M.[J.Curran], Rome, to Hagan. Sr. Rita progresses well; she does suffer from typhoid after all. Explaining the matter concerning the Enright Burse; a draft has been received. In Tivoli, a new municipal tax is imposed on all building materials; asking for advice. Latest progress on the Via Santi Quattro site. The Civiltà Cattolica has apparently excelled itself in an attack on the author of the Isola Smeralda; promising to send the issue
Promoting Diversity and Pluralism in Contemporary Communication Policies in the United States and the United Kingdom
No full textLack of quantitative training among early-career ecologists: a survey of the problem and potential solutions
No full textProficiency in mathematics and statistics is essential to modern ecological science, yet few studies have assessed the level of quantitative training received by ecologists. To do so, we conducted an online survey. The 937 respondents were mostly early-career scientists who studied biology as undergraduates. We found a clear self-perceived lack of quantitative training: 75% were not satisfied with their understanding of mathematical models; 75% felt that the level of mathematics was “too low” in their ecology classes; 90% wanted more mathematics classes for ecologists; and 95% more statistics classes. Respondents thought that 30% of classes in ecology-related degrees should be focused on quantitative disciplines, which is likely higher than for most existing programs. The main suggestion to improve quantitative training was to relate theoretical and statistical modeling to applied ecological problems. Improving quantitative training will require dedicated, quantitative classes for ecology-related degrees that contain good mathematical and statistical practice
Detailed optical and near-infrared polarimetry, spectroscopy and broad-band photometry of the afterglow of GRB 091018 : polarization evolution
No full textFollow-up observations of large numbers of gamma-ray burst (GRB) afterglows, facilitated by the Swift satellite, have produced a large sample of spectral energy distributions and light curves, from which their basic micro- and macro-physical parameters can in principle be derived. However, a number of phenomena have been observed that defy explanation by simple versions of the standard fireball model, leading to a variety of new models. Polarimetry can be a major independent diagnostic of afterglow physics, probing the magnetic field properties and internal structure of the GRB jets. In this paper we present the first high-quality multi-night polarimetric light curve of a Swift GRB afterglow, aimed at providing a well-calibrated data set of a typical afterglow to serve as a benchmark system for modelling afterglow polarization behaviour. In particular, our data set of the afterglow of GRB 091018 (at redshift z = 0.971) comprises optical linear polarimetry (R band, 0.13-2.3d after burst); circular polarimetry (R band) and near-infrared linear polarimetry (Ks band). We add to that high-quality optical and near-infrared broad-band light curves and spectral energy distributions as well as afterglow spectroscopy. The linear polarization varies between 0 and 3per cent, with both long and short time-scale variability visible. We find an achromatic break in the afterglow light curve, which corresponds to features in the polarimetric curve. We find that the data can be reproduced by jet break models only if an additional polarized component of unknown nature is present in the polarimetric curve. We probe the ordered magnetic field component in the afterglow through our deep circular polarimetry, finding P circ < 0.15per cent (2σ), the deepest limit yet for a GRB afterglow, suggesting ordered fields are weak, if at all present. Our simultaneous R- and Ks-band polarimetry shows that dust-induced polarization in the host galaxy is likely negligible
Early signaling dynamics of the epidermal growth factor receptor
No full textDespite extensive study of the EGF receptor (EGFR) signaling network, the immediate posttranslational changes that occur in response to growth factor stimulation remain poorly characterized; as a result, the biological mechanisms underlying signaling initiation remain obscured. To address this deficiency, we have used a mass spectrometry-based approach to measure system-wide phosphorylation changes throughout the network with 10-s resolution in the 80 s after stimulation in response to a range of eight growth factor concentrations. Significant changes were observed on proteins far downstream in the network as early as 10 s after stimulation, indicating a system capable of transmitting information quickly. Meanwhile, canonical members of the EGFR signaling network fall into clusters with distinct activation patterns. Src homology 2 domain containing transforming protein (Shc) and phosphoinositol 3-kinase (PI3K) phosphorylation levels increase rapidly, but equilibrate within 20 s, whereas proteins such as Grb2-associated binder-1 (Gab1) and SH2-containing tyrosine phosphatase (SHP2) show slower, sustained increases. Proximity ligation assays reveal that Shc and Gab1 phosphorylation patterns are representative of separate timescales for physical association with the receptor. Inhibition of phosphatases with vanadate reveals site-specific regulatory mechanisms and also uncovers primed activating components in the network, including Src family kinases, whose inhibition affects only a subset of proteins within the network. The results presented highlight the complexity of signaling initiation and provide a window into exploring mechanistic hypotheses about receptor tyrosine kinase (RTK) biology.National Institutes of Health (U.S.) (Grants U54CA112967, R01CA118705, and R01CA096504)National Institutes of Health (U.S.) (Biotechnology Training Grant T32GM008334
MARQUIS: A multiplex method for absolute quantification of peptides and posttranslational modifications
No full textAbsolute quantification of protein expression and posttranslational modifications by mass spectrometry has been challenging due to a variety of factors, including the potentially large dynamic range of phosphorylation response. To address these issues, we have developed MARQUIS—Multiplex Absolute Regressed Quantification with Internal Standards—a novel mass spectrometry-based approach using a combination of isobaric tags and heavy-labelled standard peptides, to construct internal standard curves for peptides derived from key nodes in signal transduction networks. We applied MARQUIS to quantify phosphorylation dynamics within the EGFR network at multiple time points following stimulation with several ligands, enabling a quantitative comparison of EGFR phosphorylation sites and demonstrating that receptor phosphorylation is qualitatively similar but quantitatively distinct for each EGFR ligand tested. MARQUIS was also applied to quantify the effect of EGFR kinase inhibition on glioblastoma patient-derived xenografts. MARQUIS is a versatile method, broadly applicable and extendable to multiple mass spectrometric platforms.United States-Israel Binational Science FoundationNational Institutes of Health (U.S.) (Grant U54 CA112967)National Institutes of Health (U.S.) (Grant R01 CA118705)National Institutes of Health (U.S.) (Grant R01 CA096504)Mayo Brain Tumor SPORE CA10896
Response of Montane Plant Communities to Wildfires in the South Island of Aotearoa New Zealand
No full textMeasuring and predicting the response of plant communities to ecological disturbances require characterising community dynamics over multiple timescales, both before and after disturbance events. With global climate change, fire regimes are expected to increase in some regions, including parts of New Zealand. These increases are predicted to be particularly impactful in ecosystems in regions with historically low fire frequencies, such as montane plant communities in New Zealand’s South Island. Species functional traits or sets of traits such as those represented by growth form and biostatus, can influence the ecological effects of fire and are likely to influence rates of recovery of individual plants and plant communities after fire. Thus, flammability at the plant community level can be estimated using plant community composition, plant traits and experimental measurements of plant shoot flammability. In this thesis, I measured plant community structure and trait variation of plants within South Island montane plant communities that had been impacted by wildfires over a range of sites and timescales. This research showed that most plants in these communities can survive wildfires and that most aspects of plant community structure recover rapidly, in less than 15 months after fire. However, longer-term data from permanent monitoring plots showed that historical fires have a lasting signature on plant community composition. In addition, plants with different biostatus (native or exotic) and growth forms (forbs, graminoid, or woody) showed different responses to fire. These long- and short-term dynamics in plant community structure result in dynamics in estimated plant community flammability that primarily reflects changes in key plant traits and species’ relative abundance. However, both experimentally measured shoot flammability and plant traits, including leaf nutrient concentrations, show phylogenetic patterns suggesting both ecological and evolutionary processes that drive plant flammability, and therefore influence community flammability. This study highlights the need for ongoing future trait-based fire ecology research in these montane plant communities because, although native plants were not disproportionately impacted by these instances of wildfires compared to exotics, long-term data show that repeated fires are likely to alter community structure over longer timescales
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