1,684 research outputs found
4. ve 5. sınıf Fen ve Teknoloji kitaplarında “madde ve değişim” öğrenme alanı etkinliklerinin incelenmesi
No full textKırbaşlar, F. Gülay (Arel Author)Bu çalışmada İlköğretim 4. ve 5. sınıflarda kullanılan Fen ve Teknoloji Ders Kitaplarında “Madde ve Değişim” öğrenme alanındaki etkinliklerin Fen ve Teknoloji öğretim programında “Madde ve Değişim” öğrenme alanı’ nda yer alan kazanımlara uygunluk, kavram öğretimine yeterlilik, etkinlik sonrası verilen ifadelerin ve kavramların doğruluğu, ilgili konu ile uyumluluğunun incelenmesi amaçlanmıştır. Bu amaçla 2010-2011 Eğitim-Öğretim yılında kullanılan Milli Eğitim Bakanlığı’nın onay verdiği üç adet 4. Sınıf ve üç adet 5. Sınıf Fen ve Teknoloji ders kitapları incelenmiştir. İncelemeler sonucunda 4.sınıf ders kitaplarındaki etkinliklerin yarısından fazlasının, 5. Sınıf ders kitaplarında ise büyük çoğunluğunun ilgili kazanımlarla uyumlu olduğu; bazı etkinliklerin ait olduğu kazanımın bulunmadığı, bazı kazanımlara yönelik birden fazla etkinlik bulunduğu, bazı kazanımlara ait etkinlik bulunmadığı belirlenmiştir. Etkinlik sonrası verilen ifadelerle ilgili bulgular incelendiğinde eksik ve yanlış tanım ve ifadelere rastlanmıştır.The present study was conducted to investigate “Matter and Change” activities in the 4th and 5th Grade Science and Technology Textbook in Turkey in respect to “Science and Technology Programme” educational attainment, competency of concept teaching, accuracy of phrases and concepts after activities and in accordance with related subject. For this purpose, three 4th Grade and three 5th Grade Science and Technology Textbooks used in 2010-2011 terms and accepted as essential science textbook by Ministry of National Education were examined. Results show that more than half of the activities in the 4.th Grade textbooks and more activities in the 5.th Grade textbooks were consistent with educational attainments, some activities have no attainment, some attainments have more than one activity, and some attainments have no activities. Moreover, wrong or inaccurate definitions and phrases were determined
Radford and the Splashy Fen Concert
No full textThis document discusses how excited the author is for his trip in April and the Splashy Fen concert
Cytotoxic Activity of Red Fruit (Pandanus conoideus Lam.) Oil and Its Effect On Cyclooxygenase-2 Gene Expression in Raji Cells
No full textThe number of cancer patient is increasing, while a really effective therapy has not yet been discovered. One concept of carcinogenesis is the relation between chronic inflammation and cancer. Cyclooxygenase-2 (COX-2) has a carcinogenic effect in inflamed and malignant tissues. Red Fruit contains carotenoid that can suppress COX-2 gene expression and tocopherol, which is a potent inhibitor of COX-2. The purpose of this study is to determine cytotoxic activity of Red Fruit oil and its effect on COX-2 gene expression. The experiment used 5 dosages of Red Fruit, 100, 200, 300, 400, and 500 µg/mL, exposed to Raji cells. However, unexposed Raji cells were used as control. Cytotoxic activities were evaluated by MTT Assay, while Lethal Concentration50 (LC50) was determined through regression-correlation analysis. Red Fruit oil effect on COX-2 gene expression was evaluated by Reversed Transcriptase Chain Reaction (RT-PCR) method and electrophoresis. Electrophoresis bands were analyzed by Scion Image for Windows. Optical Integrated Density (OID) of unexposed and exposed groups were statistically analyzed with one way Analysis of Variance (ANOVA), followed by Duncan test with α=0.05. The results showed that Red Fruit had a cytotoxic activity on Raji cells with LC50 of331.42 µg/mL. Red Fruit suppressed COX-2 gene expression with an effective dosage obtained at 500 µg/mL. Keywords: red fruit, cytotoxicity, cox-2 gene expression, raji cells</jats:p
Author recognition for Turkish documents
No full textGünümüzde, yazar tanıma çalışmaları, teknolojinin gelişmesi ve bilginin yaygınlaşması ile ortaya çıkan bir takım sorunlara çözüm üretmek için yapılmaktadır. Bu sorunlardan bazıları yazarı belli olmayan dokümanların yazarlarının belirlenmesi ve yazarının kim olduğundan tam olarak emin olunamayan metinlerin yazarlarının belirlenmesidir. Bu çalışmada, Türkçe dokümanlar için yazar tanıma sistemleri geliştirilmiştir. Sistemlerin eğitilmesinde ve test edilmesinde kullanılmak üzere, gazetelerden seçilen 6 yazara ait köşe yazıları kullanılmıştır. Yazarların 70?er makalesinden oluşan 420 dokümandan oluşan bir derlem hazırlanmıştır. Bu dokümanlardan 20?şer tanesi eğitim için, 50?şer tanesi test için kullanılmıştır. İlk olarak, 6 yazara ait dokümanlar toplanmış, daha sonra her yazara ait 20 doküman birleştirilerek tek bir doküman haline getirilmiştir. Bu şekilde elde edilen 6 doküman için sözcük, gövde, hece ve karakter n-gramlarının öznitelik vektörleri belirlenmiştir. K-En Yakın Komşu algoritması için öznitelik vektörleri belirlenirken her yazar için vektör uzunlukları 120, 180 ve 240 olarak seçilmiş, oluşan öznitelik vektörleri için K-En Yakın Komşu algoritmasıyla test edilmiştir. En başarılı sonuçlar, vektör boyu 120 olduğunda elde edildiğinden diğer metotlar için de vektör boyu 120 olarak kullanılmıştır. Geliştirilen sistemler eğitildikten sonra test edilerek doğruluk ve F-ölçüsü değerlerine göre birbirleriyle karşılaştırılmıştır.Today, the studies of author recognition have been made for providing the solutions of the problems which occur by developing and growing of information technology. Some of these problems are to specify the authors who the papers are exactly written by. In this study, some systems about author recognition for Turkish documents have been developed. For generating the systems, we have used the columns which belong to six authors in some newspapers. A corpus which includes totally 420 documents is constructed for training and testing of the systems. Each author has seventy documents. Twenty documents of every author are used for training operation. But, the other documents are utilized for testing stage. The features of word, stem, syllable, character and their n-grams are decided for each documents of these six author. Author recognition systems have been developed with the methods as K-Nearest Neighbor, Support Vector Machine, Multi-Layer Perceptron and Learning Vector Quantization. The feature vectors? lengths of the systems developed by K-Nearest Neighbor have been chosen as 120, 180 and 240. Because the most successful results are obtained as the length of the feature vectors is 120, we have used this length for the other methods. After the developed systems are trained the methods, the systems have been tested and evaluated according to accuracy and F-measure values
WRN-interacting region of FEN-1 is required for WRN stimulation of FEN-1 endonucleolytic cleavage of 5′ flap substrate
No full text<p><b>Copyright information:</b></p><p>Taken from "The interaction site of Flap Endonuclease-1 with WRN helicase suggests a coordination of WRN and PCNA"</p><p>Nucleic Acids Research 2005;33(21):6769-6781.</p><p>Published online 2 Dec 2005</p><p>PMCID:PMC1301591.</p><p>© The Author 2005. Published by Oxford University Press. All rights reserved</p> Reaction mixtures (20 µl) containing 10 fmol of the 26 nt 5′ flap substrate, the specified concentrations of wild-type FEN-1, FEN-1ΔC or FEN-1ΔP, and either WRN () or WRN () as indicated were incubated at 37°C for 15 min under standard conditions as described in Materials and Methods. Products were resolved on 20% polyacrylamide denaturing gels. Phosphorimages of typical gels are shown. For each gel: lane 1, no enzyme; lanes 2, 4 and 6 are wild-type FEN-1, FEN-1ΔP and FEN-1ΔC, respectively; lanes 3, 5 and 7 are wild-type FEN-1, FEN-1ΔP and FEN-1ΔC, respectively, in the presence of WRN (A) or WRN (B); lane 8, WRN (A) or WRN (B) alone. () Per cent incision (mean value of at least three independent experiments with SDs indicated by error bars). Quantitative data are shown for incision reactions with FEN-1, FEN-1ΔP or FEN-1ΔC alone (open bars), in the presence of WRN (light gray bars) or in the presence of WRN (gray bars)
BLM-interacting region of FEN-1 is required for BLM stimulation of FEN-1 endonucleolytic cleavage of 5′ flap substrate
No full text<p><b>Copyright information:</b></p><p>Taken from "The interaction site of Flap Endonuclease-1 with WRN helicase suggests a coordination of WRN and PCNA"</p><p>Nucleic Acids Research 2005;33(21):6769-6781.</p><p>Published online 2 Dec 2005</p><p>PMCID:PMC1301591.</p><p>© The Author 2005. Published by Oxford University Press. All rights reserved</p> Reaction mixtures (20 µl) containing 10 fmol of the 26 nt 5′ flap substrate, the specified concentrations of wild-type FEN-1, FEN-1ΔC or FEN-1ΔP, and BLM were incubated at 37°C for 15 min under standard conditions as described in Materials and Methods. Products were resolved on 20% polyacrylamide denaturing gels. () Phosphorimage of a typical gel is shown. Lane 1, no enzyme; lanes 2, 4 and 6 are wild-type FEN-1, FEN-1ΔP and FEN-1ΔC, respectively; lanes 3, 5 and 7 are wild-type FEN-1, FEN-1ΔP and FEN-1ΔC, respectively, in the presence of BLM; lane 8, BLM alone. () Per cent incision (mean value of at least three independent experiments with SD indicated by error bars). Quantitative data are shown for incision reactions with FEN-1 or FEN-1ΔC alone (open bars) or in the presence of BLM (light gray bars)
Fen mapping for the Rio Grande National Forest
No full textPrepared for: Rio Grande National Forest.April 2016.Includes bibliographical references (pages 27-28).The Rio Grande National Forest (RGNF) covers nearly two million acres within the Rio Grande Headwaters River Basin in south central Colorado. The diverse geography of the RGNF created an equally diverse set of wetlands that provide important ecological services to both RGNF and lands downstream. Organic soil wetlands known as fens are an irreplaceable resource that the U.S. Forest Service has determined should be managed for conservation and restoration. Fens are defined as groundwater-fed wetlands with organic soils that typically support sedges and low stature shrubs. In the arid west, organic soil formation can take thousands of years. Long-term maintenance of fens requires maintenance of both the hydrology and the plant communities that enable fen formation. ... The Rio Grande National Forest contains a rich resource of fen wetlands. This report and associated dataset provide the RGNF with a critical tool for conservation planning at both a local and Forest-wide scale. These data will be useful for the ongoing RGNF biological assessment required by the 2012 Forest Planning Rule, but can also be used for individual management actions, such as planning for timber sales, grazing allotments, and trail maintenance. Wherever possible, the Forest should avoid direct disturbance to the fens mapped through this project, and should also strive to protect the watersheds surrounding high concentrations of fens, thereby protecting their water sources
Tourist attractions in Shanghai, China / Ong Sheau Fen
No full textThe Mandarin for Tourism Curriculum for MOOC students is currently under development, with "Travel to Shanghai" as one of the new topics. As part of this update, the author is preparing travel-related information about Shanghai for the students. Therefore, the author shares this travel information with colleagues in this e-Lingua issue as well to assist those interested in visiting Shanghai. Traveling typically involves visiting interesting tourist attractions, shopping, tasting delicious food, and experiencing the culture. For interesting tourist spots, the Oriental Pearl Tower, the Bund, and Nanjing Road are must-visit locations in Shanghai
Endonuclease activity of XPG, FEN-1 and FEN-1-XPG on a single- and double-flap substrate
No full text<p><b>Copyright information:</b></p><p>Taken from "Domain swapping between FEN-1 and XPG defines regions in XPG that mediate nucleotide excision repair activity and substrate specificity"</p><p></p><p>Nucleic Acids Research 2007;35(9):3053-3063.</p><p>Published online 22 Apr 2007</p><p>PMCID:PMC1888826.</p><p>© 2007 The Author(s)</p> The endonuclease activity of XPG (), FEN-1-XPG () and FEN-1 () was assessed on a single 5′ flap substrate (lanes 1–7) or on a double-flap substrate with an additional 1-nt 3′ flap (lanes 8–14). 2.5 nM of substrate was incubated for 40 min at 30°C in the presence of 0.5 mM MnCl for XPG or 1 mM MnCl for FEN-1-XPG and FEN-1. The different protein concentrations for XPG, FEN1-XPG and FEN-1 are indicated (in nM) on the top of each gel. The position of the 5′P label on the substrate is indicated by the asterisk. The length of the products was determined by comparison with authentic standards and is indicated. The percentage of substrate cleavage versus protein concentration is presented graphically (right panels) for each protein. Graphs show the quantification of two independent experiments. Standard deviations are indicated by error bars
Shifts in Reproductive Patterns in China
No full textThe People's Republic of China, during the second half of the twentieth century, has been repeatedly affected by social and political upheavals associated with government policies. These have produced strong but unexpected impacts on Chinese demographic patterns. Many of these policies are of the sorts that alter reproductive costs and benefits. This study examines patterns in Hebei, Shaanxi, and Shanghai, three provinces with differing ecological, geographic, and economic characteristics. Government policies affected the three populations differentially; this was evident at both aggregate and individual levels. The Great Leap Forward and subsequent famine created higher birth deficits and mortality among the largely rural populations of Hebei and Shaanxi than the more urban Shanghai. In contrast, the Cultural Revolution and family planning resulted in lower fertility levels for women in Shanghai. The population history of China during the second half of last century thus reflects strong state interventions in the lives of its citizens. Government policies, along with regional variations in geographic, social, and economic conditions, strongly influence individual access to resources in China. Variations in timing and intensity of women's reproductive patterns reflect differential access to resources and subsequent trade-offs.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/43503/1/11111_2004_Article_489375.pd
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